ATE491788T1 - Proteasevarianten - Google Patents

Proteasevarianten

Info

Publication number
ATE491788T1
ATE491788T1 AT04762907T AT04762907T ATE491788T1 AT E491788 T1 ATE491788 T1 AT E491788T1 AT 04762907 T AT04762907 T AT 04762907T AT 04762907 T AT04762907 T AT 04762907T AT E491788 T1 ATE491788 T1 AT E491788T1
Authority
AT
Austria
Prior art keywords
variants
protease
relates
methods
well
Prior art date
Application number
AT04762907T
Other languages
English (en)
Inventor
Maria Leonardo De
Carsten Andersen
Lars Christensen
Soren Lassen
Peter Rahbek Ystergaard
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE491788T1 publication Critical patent/ATE491788T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
AT04762907T 2003-10-10 2004-10-08 Proteasevarianten ATE491788T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200301494 2003-10-10
DKPA200400333 2004-03-01
PCT/DK2004/000688 WO2005035747A1 (en) 2003-10-10 2004-10-08 Protease variants

Publications (1)

Publication Number Publication Date
ATE491788T1 true ATE491788T1 (de) 2011-01-15

Family

ID=34436496

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04762907T ATE491788T1 (de) 2003-10-10 2004-10-08 Proteasevarianten

Country Status (11)

Country Link
US (4) US7892808B2 (de)
EP (3) EP2308966A1 (de)
JP (2) JP2007509603A (de)
CN (1) CN1867668A (de)
AT (1) ATE491788T1 (de)
AU (1) AU2004279924B2 (de)
BR (1) BRPI0414959A (de)
CA (1) CA2539693A1 (de)
DE (1) DE602004030595D1 (de)
ES (1) ES2358092T3 (de)
WO (1) WO2005035747A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004211446B2 (en) * 2003-02-07 2009-05-28 Novozymes A/S Proteases
US20060236414A1 (en) * 2003-06-19 2006-10-19 Novozymes A/S Proteases and methods for producing them
CN1867668A (zh) * 2003-10-10 2006-11-22 诺维信公司 蛋白酶变体
MXPA06013239A (es) 2004-05-24 2007-02-28 Novozymes As Enzimas para uso farmaceutico.
BRPI0512341A (pt) * 2004-06-21 2008-03-04 Novozymes As polipeptìdeo isolado tendo atividade de protease, seqüência de ácido nucleico isolada, construto de ácido nucleico, vetor de expressão, célula hospedeira recombinante, planta ou parte vegetal transgênica, animal não humano transgênico, uso de pelo menos uma protease, métodos para produzir um polipeptìdeo, para melhorar o valor nutricional de uma ração animal e para tratar proteìnas, ração animal, e, aditivo de ração animal
US9668501B2 (en) 2006-07-13 2017-06-06 Dsm Ip Assets B.V. Use of bacterial amylases in feed for bovine animals
US9169474B2 (en) * 2006-12-22 2015-10-27 Novozymes A/S Method for producing a yeast extract
RU2010127329A (ru) 2007-12-04 2012-01-10 Новозимс А/С (Dk) Варианты протеаз для фармацевтического применения
US8691743B2 (en) 2008-05-14 2014-04-08 Novozymes A/S Liquid detergent compositions
EP2604125A1 (de) 2008-12-31 2013-06-19 Solae, Llc Proteinhydrolysatzusammensetzungen mit erhöhter CCK-Freisetzungsfähigkeit
AU2011231563B2 (en) * 2010-03-26 2015-01-29 Novozymes A/S Thermostable phytase variants
MX2013009772A (es) 2011-02-23 2013-10-01 Solae Llc Composiciones de hidrosilato de proteinas que tienen actividad liberadora mejorada de colecistoquina (cck) y peptido similar a glucagon-1 (glp-1).
ES2641039T3 (es) 2011-08-19 2017-11-07 Novozymes A/S Polipéptidos con actividad de proteasa
JP2014530598A (ja) 2011-09-22 2014-11-20 ノボザイムスアクティーゼルスカブ プロテアーゼ活性を有するポリペプチドおよびこれをコードするポリヌクレオチド
BR112014015705A8 (pt) 2011-12-28 2017-07-04 Novozymes A / S polipeptídeo isolado, composição, polinucleotídeo isolado,, construção de ácido nucleico ou vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo, para melhorar o valor nutritivo de uma ração parar animais e para o tratamento de proteínas, planta transgênica, parte de planta ou célula vegetal, uso de pelo menos um polipeptídeo, aditivo de ração para animal, ração para animais, e, composição detergente
ES2644007T3 (es) 2012-01-26 2017-11-27 Novozymes A/S Uso de polipéptidos con actividad de proteasa en piensos para animales y en detergentes
BR112014031882A2 (pt) 2012-06-20 2017-08-01 Novozymes As uso de um polipeptídeo isolado, polipeptídeo, composição, polinucleotídeo isolado, construto de ácido nucleico ou vetor de expressão, célula hospedeira de expressão recombinante, métodos para produção de um polipeptídeo, para melhoria do valor nutricional de uma ração animal, e para o tratamento de proteínas, uso de pelo menos um polipeptídeo, aditivo de ração animal, ração animal, e, composição detergente
CN104884615B (zh) 2012-09-05 2019-07-12 诺维信公司 具有蛋白酶活性的多肽
US9872937B2 (en) 2012-09-19 2018-01-23 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
CN104869841A (zh) 2012-12-21 2015-08-26 诺维信公司 具有蛋白酶活性的多肽和编码它的多核苷酸
WO2014122161A2 (en) 2013-02-06 2014-08-14 Novozymes A/S Polypeptides having protease activity
AU2015341922B2 (en) 2014-11-04 2021-06-24 Novozymes A/S Polypeptides having serine protease activity and polynucleotides encoding same and their application in animal feed
WO2016123419A1 (en) * 2015-01-30 2016-08-04 President And Fellows Of Harvard College Microscope-free imaging
DE102016204815A1 (de) * 2016-03-23 2017-09-28 Henkel Ag & Co. Kgaa Proteasen mit verbesserte Enzymstabilität in Waschmittel
DE102016204814A1 (de) * 2016-03-23 2017-09-28 Henkel Ag & Co. Kgaa Verbesserte Reinigungsleistung an Protein sensitiven Anschmutzungen
CN110168101A (zh) 2017-01-10 2019-08-23 哈佛学院院长及董事 多重信号放大
BR112019018983A2 (pt) 2017-03-15 2020-04-14 Dupont Nutrition Biosci Aps métodos de uso de uma serina protease archaeal
CN110727780A (zh) * 2019-10-17 2020-01-24 福建天晴数码有限公司 一种相识文本自动扩展的系统及其方法
CN115074345B (zh) * 2021-03-10 2024-04-05 中国农业科学院农业资源与农业区划研究所 耐热β-1，4-内切木聚糖酶及其编码基因与应用
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2723250A (en) * 1953-05-05 1955-11-08 Petrolite Corp Oxyalkylated derivatives of fusible acetylene-phenolic resins
GB1234445A (de) 1967-10-03 1971-06-03
GB1296839A (de) 1969-05-29 1972-11-22
DE2004328C3 (de) 1970-01-30 1979-10-18 Nippon Kokan K.K., Tokio Bodenkonstruktion für eine Gas-Flüssigkeits-Kontaktierkolonne
US3683069A (en) 1970-02-19 1972-08-08 Michel Hooreman Enzymatic products which optimize the viscosity of mucuses and their applications
US3823072A (en) 1970-02-19 1974-07-09 M Hooreman Analysis of proteolytic enzymes
GB1372034A (en) 1970-12-31 1974-10-30 Unilever Ltd Detergent compositions
GB1483591A (en) 1973-07-23 1977-08-24 Novo Industri As Process for coating water soluble or water dispersible particles by means of the fluid bed technique
US3868448A (en) 1973-12-07 1975-02-25 Grace W R & Co Method for bloat control
US3966971A (en) 1975-01-02 1976-06-29 Grain Processing Corporation Separation of protein from vegetable sources
GB1590432A (en) 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
US4073884A (en) 1976-09-27 1978-02-14 W. R. Grace & Co. Promotion of feed efficiency
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
DE3132936A1 (de) 1981-08-20 1983-03-03 Henkel KGaA, 4000 Düsseldorf "verfahren zur herstellung saurer protease und diese bildende mutanten der gattung rhizopus"
DD200432A1 (de) 1981-09-08 1983-05-04 Werner Fleck Verfahren zur herstellung eines proteolytischen enzym-praeparates
DE3149457A1 (de) 1981-12-14 1983-06-23 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung saurer protease und diese bildende mutanten von pilzen der gattung aspergillus
IE81141B1 (en) 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
DK263584D0 (da) 1984-05-29 1984-05-29 Novo Industri As Enzymholdige granulater anvendt som detergentadditiver
EP0218272B1 (de) 1985-08-09 1992-03-18 Gist-Brocades N.V. Lipolytische Enzyme und deren Anwendung in Reinigungsmitteln
CA1295566C (en) 1987-07-21 1992-02-11 Robert T. Garvin Characterization and structure of genes for protease a and protease b from streptomyces griseus
EG18543A (en) 1986-02-20 1993-07-30 Albright & Wilson Protected enzyme systems
FR2600340A1 (fr) 1986-06-20 1987-12-24 Hooremam Michel Procede de production d'un nouveau complexe proteolytique stimulant l'activite du pancreas et ses applications en zootechnie
DE3750450T2 (de) 1986-08-29 1995-01-05 Novo Industri As Enzymhaltiger Reinigungsmittelzusatz.
NZ221627A (en) 1986-09-09 1993-04-28 Genencor Inc Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios
DK564086A (da) * 1986-11-25 1988-06-17 Novo Industri As Enzymatisk detergent-additiv
ES2076939T3 (es) 1987-08-28 1995-11-16 Novo Nordisk As Lipasa recombinante de humicola y procedimiento para la produccion de lipasas recombinantes de humicola.
JPS6474992A (en) 1987-09-16 1989-03-20 Fuji Oil Co Ltd Dna sequence, plasmid and production of lipase
JP3079276B2 (ja) 1988-02-28 2000-08-21 天野製薬株式会社 組換え体ｄｎａ、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法
US5776757A (en) 1988-03-24 1998-07-07 Novo Nordisk A/S Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof
EP0406314B1 (de) 1988-03-24 1993-12-01 Novo Nordisk A/S Cellulosezubereitung
JPH02255081A (ja) 1989-03-30 1990-10-15 Snow Brand Milk Prod Co Ltd プロテアーゼ生産菌、該菌体から産生したプロテアーゼ、及びその精製方法
DK316989D0 (da) 1989-06-26 1989-06-26 Novo Nordisk As Enzymer
GB8915658D0 (en) 1989-07-07 1989-08-23 Unilever Plc Enzymes,their production and use
DE69008194T2 (de) 1990-01-11 1994-07-28 Novo Nordisk As Aus einem nocardiopsis-stamm stammendes bakteriolytisches enzym, seine herstellung und verwendung.
NZ237549A (en) 1990-03-23 1993-06-25 Gist Brocades Nv Production of enhanced levels of enzymes in the seeds of transgenic plants and the use of these seeds
DK0528828T4 (da) 1990-04-14 1998-08-31 Genencor Internat Gmbh Alkaliske bacillus-lipaser, DNA-sekvenser, der koder herfor, og bacilli der producerer sådanne lipaser
DK115890D0 (da) 1990-05-09 1990-05-09 Novo Nordisk As Enzym
EP0531372B2 (de) 1990-05-09 2004-04-14 Novozymes A/S Eine ein endoglucanase enzym enthaltende zellulasezubereitung
AU657278B2 (en) 1990-09-13 1995-03-09 Novo Nordisk A/S Lipase variants
EP0561907B1 (de) 1990-12-05 1998-09-02 Novo Nordisk A/S Proteine mit geänderten epitopen und verfahren zur deren herstellung
ATE159757T1 (de) 1990-12-21 1997-11-15 Novo Nordisk As Enzym-mutanten mit einer geringen variation der molekularladung über einen ph-bereich
DE69133035T2 (de) 1991-01-16 2003-02-13 Procter & Gamble Kompakte Waschmittelzusammensetzungen mit hochaktiven Cellulasen
CA2063892A1 (en) 1991-03-29 1992-09-30 Susan A. Anderson Alpha-lytic protease cleaning compositions
HU213044B (en) 1991-04-30 1997-01-28 Procter & Gamble Built liquid detergents with boric-polyol complex to inhibit proteolytic enzyme with additives improving detergent effect
EP0511456A1 (de) 1991-04-30 1992-11-04 The Procter & Gamble Company Flüssiges Reinigungsmittel mit einem aromatischen Boratester zur Inhibierung des proteolytischen Enzyms
EP0516200B1 (de) 1991-05-01 1996-07-24 Unilever N.V. Stabilisierte Enzyme enthaltende Waschmittelzusammensetzungen
DE69226182T2 (de) 1991-05-01 1999-01-21 Novo Nordisk As Stabilisierte enzyme und waschmittelzusammensetzungen
US5646028A (en) 1991-06-18 1997-07-08 The Clorox Company Alkaline serine protease streptomyces griseus var. alkaliphus having enhanced stability against urea or guanidine
US5811382A (en) 1991-12-20 1998-09-22 Novo Nordisk A/S Detergent compositions
ES2173888T3 (es) 1992-05-19 2002-11-01 Shionogi & Co Nueva proteasa.
DK72992D0 (da) 1992-06-01 1992-06-01 Novo Nordisk As Enzym
DK88892D0 (da) 1992-07-06 1992-07-06 Novo Nordisk As Forbindelse
DK91192D0 (da) 1992-07-10 1992-07-10 Novo Nordisk As Protein
ES2334590T3 (es) 1992-07-23 2010-03-12 Novozymes A/S Alfa-amilasa mutante, detergente y agente de lavado de vajilla.
JP3681750B2 (ja) 1992-10-06 2005-08-10 ノボザイムス アクティーゼルスカブ セルラーゼ変異体
PL310326A1 (en) 1993-02-11 1995-12-11 Genencor Int Novel oxidation-stable mutants of alpha-amylase as well as detergent and starch liquefaction compositions containing them
JP3618748B2 (ja) 1993-04-27 2005-02-09 ジェネンコー インターナショナル インコーポレイテッド 洗剤に使用する新しいリパーゼ変異体
DK81193D0 (da) 1993-07-06 1993-07-06 Novo Nordisk As Enzym
JP2859520B2 (ja) 1993-08-30 1999-02-17 ノボ ノルディスク アクティーゼルスカブ リパーゼ及びそれを生産する微生物及びリパーゼ製造方法及びリパーゼ含有洗剤組成物
EP0722490B2 (de) 1993-10-08 2013-10-23 Novozymes A/S Amylasevarianten
KR100338786B1 (ko) 1993-10-13 2002-12-02 노보자임스 에이/에스 H2o2-안정한퍼록시다제변이체
JPH07143883A (ja) 1993-11-24 1995-06-06 Showa Denko Kk リパーゼ遺伝子及び変異体リパーゼ
AU1911995A (en) 1994-02-14 1995-08-29 Quaker Oats Company, The Animal food palatability improving composition and process
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
MX9603542A (es) 1994-02-22 1997-03-29 Novo Nordisk As Metodo para preparar una variante de una enzima lipolitica.
DK0749473T3 (da) 1994-03-08 2006-02-27 Novozymes As Hidtil ukendte alkaliske cellulaser
US5689054A (en) 1994-03-17 1997-11-18 The United States Of America As Represented By The Secretary Of Agriculture Low phytic acid mutants and selection thereof
MX196038B (es) 1994-03-29 2000-04-14 Novo Nordisk As Amilasa de bacillus alcalino.
US5989600A (en) 1994-04-22 1999-11-23 Novo Nordisk A/S Method for improving the solubility of vegetable proteins
US6017866A (en) 1994-05-04 2000-01-25 Genencor International, Inc. Lipases with improved surfactant resistance
AU2884595A (en) 1994-06-20 1996-01-15 Unilever Plc Modified pseudomonas lipases and their use
WO1996000292A1 (en) 1994-06-23 1996-01-04 Unilever N.V. Modified pseudomonas lipases and their use
DE4422198C2 (de) 1994-06-24 1997-08-28 Audi Ag Verfahren zum Steuern der elektrischen Beheizung eines Katalysators
GB9416841D0 (en) 1994-08-19 1994-10-12 Finnfeeds Int Ltd An enzyme feed additive and animal feed including it
EP1995303A3 (de) 1994-10-06 2008-12-31 Novozymes A/S Ein Enzympräparat mit Enduglucanase-Aktivität
BE1008998A3 (fr) 1994-10-14 1996-10-01 Solvay Lipase, microorganisme la produisant, procede de preparation de cette lipase et utilisations de celle-ci.
US5827719A (en) 1994-10-26 1998-10-27 Novo Nordisk A/S Enzyme with lipolytic activity
WO1996016177A1 (en) 1994-11-24 1996-05-30 Novo Nordisk A/S A process for producing polypeptides with reduced allergenicity
MX9704137A (es) 1994-12-07 1997-09-30 Novo Nordisk As Polipeptidos de alergenicidad reducida.
US5877403A (en) * 1994-12-30 1999-03-02 Seminis Vegetable Seeds, Inc. Papaya ringspot virus protease gene
AR000862A1 (es) 1995-02-03 1997-08-06 Novozymes As Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del
JPH08228778A (ja) 1995-02-27 1996-09-10 Showa Denko Kk 新規なリパーゼ遺伝子及びそれを用いたリパーゼの製造方法
CN101173263A (zh) 1995-03-17 2008-05-07 诺沃奇梅兹有限公司 新的内切葡聚糖酶
ATE282087T1 (de) 1995-07-14 2004-11-15 Novozymes As Modifiziertes enzym mit lipolytischer aktivität
EP0851913B1 (de) 1995-08-11 2004-05-19 Novozymes A/S Neuartige lipolytische enzyme
WO1997007205A1 (en) 1995-08-11 1997-02-27 Novo Nordisk A/S Method for preparing polypeptide variants
DK1396A (de) 1996-01-09 1996-01-09 Novo Nordisk As
US5763385A (en) 1996-05-14 1998-06-09 Genencor International, Inc. Modified α-amylases having altered calcium binding properties
WO1998008940A1 (en) 1996-08-26 1998-03-05 Novo Nordisk A/S A novel endoglucanase
EP0937138B1 (de) 1996-09-17 2006-04-26 Novozymes A/S Cellulasevarianten
CN1232384A (zh) 1996-10-08 1999-10-20 诺沃挪第克公司 作为染料前体的二氨基苯甲酸衍生物
US5705379A (en) 1996-10-23 1998-01-06 Cornell Research Foundation, Inc. Nucleotide sequences encoding a thermostable alkaline protease
JP3504672B2 (ja) 1996-12-20 2004-03-08 ノボザイムス アクティーゼルスカブ ペニオフォラ・フィターゼ
CA2277618A1 (en) 1997-01-10 1998-07-16 Novo Nordisk A/S Enzyme coupled with polymeric molecules for skin care
JP2001511162A (ja) 1997-02-06 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体
JP4263248B2 (ja) 1997-03-18 2009-05-13 ノボザイムス アクティーゼルスカブ Ｄｎａのシャッフリングによるライブラリーの作成方法
EP1015575B1 (de) 1997-03-18 2010-05-19 Novozymes A/S Vermischen von heterologen dns-sequenzen
FI972521A (fi) 1997-06-13 1998-12-14 Cultor Oy Menetelmä ravinnollisen tuotteen valmistamiseksi ja näin valmistettu tuote
AU751880B2 (en) 1997-06-25 2002-08-29 Novozymes A/S A modified polypeptide
EP1002061A1 (de) 1997-07-04 2000-05-24 Novo Nordisk A/S Varianten der 6 endo-1,4-beta-glukanase und diese enthaldende reinigungszusammensetzungen
NZ330940A (en) 1997-07-24 2000-02-28 F Production of consensus phytases from fungal origin using computer programmes
US6835550B1 (en) 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
AU6078899A (en) 1998-10-13 2000-05-01 Novozymes A/S A modified polypeptide with reduced immune response
ATE390441T1 (de) 1998-10-30 2008-04-15 Novozymes As Niedrigallergene proteinvarianten
CA2348822A1 (en) 1998-10-30 2000-05-11 Novozymes A/S Glycosylated proteins having reduced allergenicity
JP4745503B2 (ja) 1999-03-31 2011-08-10 ノボザイムス アクティーゼルスカブ アルカリα−アミラーゼ活性を有するポリペプチド及びそれらをコードする核酸
EP1170994A1 (de) 1999-04-23 2002-01-16 University Of Guelph Transgene tiere, die speichelproteine exprimieren
US6855548B2 (en) 2000-02-08 2005-02-15 F. Hoffman-La Roche Ag Use of acid-stable proteases in animal feed
US6960462B2 (en) 2000-02-08 2005-11-01 Dsm Ip Assets B.V Use of acid-stable subtilisin proteases in animal feed
ATE311762T1 (de) * 2000-02-08 2005-12-15 Dsm Ip Assets Bv Verwendung von säurestabilen subtilisinproteasen in tierfutter
CN101532001A (zh) 2000-03-08 2009-09-16 诺维信公司 具有改变的特性的变体
US20020192792A1 (en) 2000-04-28 2002-12-19 Palle Schneider Laccase mutants
EP1389217B1 (de) 2001-05-04 2008-05-21 Novozymes A/S Antimikrobielles polypeptid
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
DK1448595T3 (da) 2001-11-20 2007-02-19 Novozymes As Antimikrobielle polypeptider
WO2003048148A2 (en) 2001-12-03 2003-06-12 Novozymes A/S Statin-like compounds
JP4137526B2 (ja) 2002-01-23 2008-08-20 Ｔｏｔｏ株式会社 ケラチナーゼおよびその製造法
JP4114046B2 (ja) 2002-07-12 2008-07-09 川村通商株式会社 酵素脱毛処理剤および酵素脱毛法
DK175871B1 (da) 2003-01-10 2005-05-02 Pedershaab Concrete Technologi Fremgangsmåde samt apparat til fremstilling af betonrör
JP4344950B2 (ja) 2003-02-06 2009-10-14 大和化成株式会社 獣毛繊維の防縮加工法
AU2004211446B2 (en) 2003-02-07 2009-05-28 Novozymes A/S Proteases
WO2004072279A2 (en) * 2003-02-07 2004-08-26 Novozymes A/S Proteases
WO2004111223A1 (en) 2003-06-19 2004-12-23 Novozymes A/S Proteases
US7485447B2 (en) 2003-06-19 2009-02-03 Novozymes A/S Proteases and methods for producing them
CA2526974A1 (en) 2003-06-19 2004-12-23 Novozymes A/S Proteases
WO2004111222A1 (en) 2003-06-19 2004-12-23 Novozymes A/S Proteases
US7208310B2 (en) * 2003-06-19 2007-04-24 Novozymes A/S Proteases
US20060236414A1 (en) 2003-06-19 2006-10-19 Novozymes A/S Proteases and methods for producing them
ES2346654T3 (es) 2003-06-19 2010-10-19 Novozymes A/S Proteasas.
DK1680503T3 (da) 2003-09-11 2011-10-03 Novozymes Adenium Biotech As Rekombinant produktion af antimikrobielle midler
CN1867668A (zh) * 2003-10-10 2006-11-22 诺维信公司 蛋白酶变体
MXPA06013239A (es) 2004-05-24 2007-02-28 Novozymes As Enzimas para uso farmaceutico.
EP1766000A1 (de) 2004-06-21 2007-03-28 Novozymes A/S Verbesserte verfahren zur herstellung heterologer proteasen
BRPI0512341A (pt) * 2004-06-21 2008-03-04 Novozymes As polipeptìdeo isolado tendo atividade de protease, seqüência de ácido nucleico isolada, construto de ácido nucleico, vetor de expressão, célula hospedeira recombinante, planta ou parte vegetal transgênica, animal não humano transgênico, uso de pelo menos uma protease, métodos para produzir um polipeptìdeo, para melhorar o valor nutricional de uma ração animal e para tratar proteìnas, ração animal, e, aditivo de ração animal
US8420070B2 (en) * 2006-05-22 2013-04-16 Westham Ltd. Controlling sugar feeding insects
US9169474B2 (en) * 2006-12-22 2015-10-27 Novozymes A/S Method for producing a yeast extract
US7618801B2 (en) 2007-10-30 2009-11-17 Danison US Inc. Streptomyces protease
RU2010127329A (ru) * 2007-12-04 2012-01-10 Новозимс А/С (Dk) Варианты протеаз для фармацевтического применения
EP2296487B1 (de) * 2008-06-03 2011-12-28 Novozymes A/S Verfahren zur herstellung eines weizenproteinhydrolysats
WO2009147105A2 (en) * 2008-06-03 2009-12-10 Novozymes A/S Method for producing a casein hydrolysate
US20110097448A1 (en) * 2008-06-20 2011-04-28 Solae, Llc Protein Hydrolysate Compositions Stable Under Acidic Conditions
US20100093633A1 (en) 2008-10-10 2010-04-15 Novozymes A/S Polypeptides having antimicrobial activity
AU2010230165B2 (en) 2009-04-02 2015-02-12 Novozymes A/S Process for making a milk-based protein hydrolysate

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EP1673451A1 (de) 2006-06-28
US20110097445A1 (en) 2011-04-28
EP2284259A2 (de) 2011-02-16
JP2007509603A (ja) 2007-04-19
CN1867668A (zh) 2006-11-22
ES2358092T3 (es) 2011-05-05
CA2539693A1 (en) 2005-04-21
US20140255550A1 (en) 2014-09-11
JP2012095666A (ja) 2012-05-24
AU2004279924B2 (en) 2010-09-30
AU2004279924A1 (en) 2005-04-21
US7892808B2 (en) 2011-02-22
US8772011B2 (en) 2014-07-08
EP1673451B1 (de) 2010-12-15
US9131711B2 (en) 2015-09-15
EP2284259A3 (de) 2011-06-15
US20090047387A1 (en) 2009-02-19
EP2308966A1 (de) 2011-04-13
DE602004030595D1 (de) 2011-01-27
WO2005035747A1 (en) 2005-04-21
US20130189732A1 (en) 2013-07-25
US8377677B2 (en) 2013-02-19
BRPI0414959A (pt) 2006-11-07

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