ATE463568T1 - Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäure - Google Patents
Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäureInfo
- Publication number
- ATE463568T1 ATE463568T1 AT03792838T AT03792838T ATE463568T1 AT E463568 T1 ATE463568 T1 AT E463568T1 AT 03792838 T AT03792838 T AT 03792838T AT 03792838 T AT03792838 T AT 03792838T AT E463568 T1 ATE463568 T1 AT E463568T1
- Authority
- AT
- Austria
- Prior art keywords
- aldolases
- new
- keto acid
- substituted alpha
- producing substituted
- Prior art date
Links
- 102000003677 Aldehyde-Lyases Human genes 0.000 title 1
- 108090000072 Aldehyde-Lyases Proteins 0.000 title 1
- 150000004716 alpha keto acids Chemical class 0.000 title 1
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 abstract 2
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 abstract 1
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 abstract 1
- RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical compound C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 1
- 241000588698 Erwinia Species 0.000 abstract 1
- 241000589565 Flavobacterium Species 0.000 abstract 1
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 241000589634 Xanthomonas Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 abstract 1
- 229940107700 pyruvic acid Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/50—Polycarboxylic acids having keto groups, e.g. 2-ketoglutaric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002245980 | 2002-08-26 | ||
| JP2003171299 | 2003-06-16 | ||
| PCT/JP2003/010750 WO2004018672A1 (ja) | 2002-08-26 | 2003-08-26 | 新規アルドラーゼおよび置換α−ケト酸の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463568T1 true ATE463568T1 (de) | 2010-04-15 |
Family
ID=31949581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03792838T ATE463568T1 (de) | 2002-08-26 | 2003-08-26 | Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäure |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US7351569B2 (de) |
| EP (3) | EP2210943A1 (de) |
| JP (2) | JP4670347B2 (de) |
| KR (1) | KR100741650B1 (de) |
| CN (2) | CN103525847A (de) |
| AT (1) | ATE463568T1 (de) |
| AU (1) | AU2003261722A1 (de) |
| CA (2) | CA2714881C (de) |
| DE (1) | DE60332026D1 (de) |
| DK (1) | DK1533376T3 (de) |
| RU (1) | RU2307871C2 (de) |
| WO (1) | WO2004018672A1 (de) |
Families Citing this family (36)
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| WO2003056026A1 (en) * | 2001-12-27 | 2003-07-10 | Ajinomoto Co., Inc. | Process for production of glutamic acid derivatives |
| JP4196832B2 (ja) * | 2001-12-27 | 2008-12-17 | 味の素株式会社 | グルタミン酸化合物及びそれらの製造中間体の製造方法並びにそのための新規中間体 |
| US7297800B2 (en) | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| US8372989B2 (en) | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US7572607B2 (en) | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| DK1533376T3 (da) | 2002-08-26 | 2010-07-19 | Ajinomoto Kk | Nye aldolaser og fremgangsmåde til fremstilling af substitueret alfa-ketosyre |
| CN1723281B (zh) * | 2002-12-09 | 2012-08-15 | 味之素株式会社 | 突变的d-氨基转移酶和使用它们生产旋光性谷氨酸衍生物的方法 |
| US20050112260A1 (en) * | 2003-08-01 | 2005-05-26 | Cargill, Inc. | Monatin tabletop sweetener compositions and methods of making same |
| US20050106305A1 (en) * | 2003-08-25 | 2005-05-19 | Cargill, Inc. | Beverage compositions comprising monatin and methods of making same |
| CN1890377B (zh) | 2003-10-21 | 2013-06-05 | 嘉吉有限公司 | 生产莫纳甜和莫纳甜前体 |
| JP4604524B2 (ja) * | 2004-03-16 | 2011-01-05 | 味の素株式会社 | 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法 |
| US7935377B2 (en) * | 2004-06-04 | 2011-05-03 | Ajinomoto Co., Inc. | Crystals of free (2R, 4R)-monatin and use thereof |
| JP4797452B2 (ja) * | 2004-06-07 | 2011-10-19 | 味の素株式会社 | 新規アルドラーゼ並びに光学活性ｉｈｏｇ及びモナティンの製造方法 |
| CA2506247C (en) | 2004-06-07 | 2012-02-21 | Ajinomoto Co., Inc. | Novel aldolase, and method for producing optically active ihog and monatin |
| US7180370B2 (en) * | 2004-09-01 | 2007-02-20 | Micron Technology, Inc. | CMOS amplifiers with frequency compensating capacitors |
| KR20070062542A (ko) | 2004-10-05 | 2007-06-15 | 아지노모토 가부시키가이샤 | 하이드록시이미노산으로부터 아미노산 유도체의 제조방법 |
| US8158389B2 (en) | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| WO2006113897A2 (en) * | 2005-04-20 | 2006-10-26 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US7582455B2 (en) | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| EA029538B1 (ru) | 2006-03-07 | 2018-04-30 | Басф Энзаймс Ллк | Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида |
| EP2112227B1 (de) * | 2006-03-07 | 2013-05-15 | Cargill, Incorporated | Aldolasen, Nukleinsäuren zu ihrer Kodierung sowie Verfahren zu ihrer Herstellung und Verwendung |
| RU2338784C2 (ru) * | 2006-03-24 | 2008-11-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты) |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| CN101490249A (zh) | 2006-05-24 | 2009-07-22 | 嘉吉公司 | 提高平衡反应的产量的方法和系统 |
| RU2355767C2 (ru) * | 2006-08-30 | 2009-05-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ производства 4-гидрокси-l-изолейцина или его соли |
| CN101239941B (zh) | 2007-02-08 | 2012-02-29 | 味之素株式会社 | 光学活性化合物的制造方法 |
| WO2009028338A1 (ja) * | 2007-08-24 | 2009-03-05 | Ajinomoto Co., Inc. | 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法 |
| US8076107B2 (en) * | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| US8003361B2 (en) | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8367847B2 (en) | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| EP2107053A1 (de) * | 2008-03-11 | 2009-10-07 | Ajinomoto Co., Inc. | Hydratkristalle von (2R,4R)-Monatin Mononatrium-Salz |
| CN107098807B (zh) * | 2010-08-30 | 2020-07-10 | 阿泽达公司 | 用于生产乙酰丙酸、乙酰丙酸酯、戊内酯、以及其衍生物的发酵路径 |
| EP3630798B1 (de) * | 2017-05-27 | 2022-11-23 | Enzymaster (Ningbo) Bio-Engineering Co., Ltd. | Veränderte aldolase polypeptide und deren anwendung in der synthese von beta-hydroxy-alpha-aminosäuren |
| CN107306532B (zh) * | 2017-06-13 | 2021-09-07 | 南京农业大学 | 一种利用复合PAHs降解菌同时去除植物体内USEPA PAHs的方法 |
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| JP4196832B2 (ja) | 2001-12-27 | 2008-12-17 | 味の素株式会社 | グルタミン酸化合物及びそれらの製造中間体の製造方法並びにそのための新規中間体 |
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| DK1533376T3 (da) | 2002-08-26 | 2010-07-19 | Ajinomoto Kk | Nye aldolaser og fremgangsmåde til fremstilling af substitueret alfa-ketosyre |
| CN1723281B (zh) | 2002-12-09 | 2012-08-15 | 味之素株式会社 | 突变的d-氨基转移酶和使用它们生产旋光性谷氨酸衍生物的方法 |
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2003
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- 2003-08-26 EP EP10152890A patent/EP2210943A1/de not_active Withdrawn
- 2003-08-26 DE DE60332026T patent/DE60332026D1/de not_active Expired - Lifetime
- 2003-08-26 EP EP03792838A patent/EP1533376B1/de not_active Expired - Lifetime
- 2003-08-26 RU RU2005108605/13A patent/RU2307871C2/ru not_active IP Right Cessation
- 2003-08-26 CA CA2714881A patent/CA2714881C/en not_active Expired - Fee Related
- 2003-08-26 EP EP10177313A patent/EP2280068A1/de not_active Withdrawn
- 2003-08-26 WO PCT/JP2003/010750 patent/WO2004018672A1/ja not_active Ceased
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