ATE463568T1 - Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäure - Google Patents
Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäureInfo
- Publication number
- ATE463568T1 ATE463568T1 AT03792838T AT03792838T ATE463568T1 AT E463568 T1 ATE463568 T1 AT E463568T1 AT 03792838 T AT03792838 T AT 03792838T AT 03792838 T AT03792838 T AT 03792838T AT E463568 T1 ATE463568 T1 AT E463568T1
- Authority
- AT
- Austria
- Prior art keywords
- aldolases
- new
- keto acid
- substituted alpha
- producing substituted
- Prior art date
Links
- 102000003677 Aldehyde-Lyases Human genes 0.000 title 1
- 108090000072 Aldehyde-Lyases Proteins 0.000 title 1
- 150000004716 alpha keto acids Chemical class 0.000 title 1
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 abstract 2
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 abstract 1
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 abstract 1
- RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical compound C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 1
- 241000588698 Erwinia Species 0.000 abstract 1
- 241000589565 Flavobacterium Species 0.000 abstract 1
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 241000589634 Xanthomonas Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 abstract 1
- 229940107700 pyruvic acid Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/50—Polycarboxylic acids having keto groups, e.g. 2-ketoglutaric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002245980 | 2002-08-26 | ||
| JP2003171299 | 2003-06-16 | ||
| PCT/JP2003/010750 WO2004018672A1 (ja) | 2002-08-26 | 2003-08-26 | 新規アルドラーゼおよび置換α−ケト酸の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463568T1 true ATE463568T1 (de) | 2010-04-15 |
Family
ID=31949581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03792838T ATE463568T1 (de) | 2002-08-26 | 2003-08-26 | Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäure |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US7351569B2 (de) |
| EP (3) | EP2280068A1 (de) |
| JP (2) | JP4670347B2 (de) |
| KR (1) | KR100741650B1 (de) |
| CN (2) | CN1678742B (de) |
| AT (1) | ATE463568T1 (de) |
| AU (1) | AU2003261722A1 (de) |
| CA (2) | CA2714881C (de) |
| DE (1) | DE60332026D1 (de) |
| DK (1) | DK1533376T3 (de) |
| RU (1) | RU2307871C2 (de) |
| WO (1) | WO2004018672A1 (de) |
Families Citing this family (36)
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| EP2330211A3 (de) * | 2001-12-27 | 2013-03-27 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von Glutaminsäurederivaten |
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| CA2471847C (en) * | 2001-12-27 | 2012-05-15 | Ajinomoto Co., Inc. | Processes of producing glutamic acid compounds and production intermediates therefor and novel intermediate for the processes |
| US7572607B2 (en) | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US8372989B2 (en) | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| EP2280068A1 (de) | 2002-08-26 | 2011-02-02 | Ajinomoto Co., Inc. | Neuartige Aldolase und Herstellungsverfahren für substituierte Alpha-Ketosäuren |
| JP4544154B2 (ja) * | 2002-12-09 | 2010-09-15 | 味の素株式会社 | 変異型ｄ−アミノトランスフェラーゼおよびこれを用いた光学活性グルタミン酸誘導体の製造方法 |
| CN1832690A (zh) * | 2003-08-01 | 2006-09-13 | 嘉吉有限公司 | 莫纳甜桌面甜味剂组合物及其制造方法 |
| AU2004268594A1 (en) * | 2003-08-25 | 2005-03-10 | Cargill, Incorporated | Beverage compositions comprising monatin and methods of making same |
| RU2006117353A (ru) | 2003-10-21 | 2007-12-27 | Карджилл, Инкорпорейтед (Us) | Получение монатина и предшественников монатина |
| JP4604524B2 (ja) * | 2004-03-16 | 2011-01-05 | 味の素株式会社 | 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法 |
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| JP4797452B2 (ja) * | 2004-06-07 | 2011-10-19 | 味の素株式会社 | 新規アルドラーゼ並びに光学活性ｉｈｏｇ及びモナティンの製造方法 |
| CA2506247C (en) | 2004-06-07 | 2012-02-21 | Ajinomoto Co., Inc. | Novel aldolase, and method for producing optically active ihog and monatin |
| US7180370B2 (en) * | 2004-09-01 | 2007-02-20 | Micron Technology, Inc. | CMOS amplifiers with frequency compensating capacitors |
| RU2007116971A (ru) | 2004-10-05 | 2008-11-27 | Адзиномото Ко., Инк. (Jp) | Способ получения производного аминокислоты из гидроксииминокислоты |
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| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| EP3153580A3 (de) * | 2006-03-07 | 2017-04-19 | BASF Enzymes LLC | Aldolasen, nukleinsäuren zur codierung davon sowie verfahren zur herstellung und verwendung davon |
| EP2112227B1 (de) * | 2006-03-07 | 2013-05-15 | Cargill, Incorporated | Aldolasen, Nukleinsäuren zu ihrer Kodierung sowie Verfahren zu ihrer Herstellung und Verwendung |
| RU2338784C2 (ru) * | 2006-03-24 | 2008-11-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты) |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| US7888081B2 (en) | 2006-05-24 | 2011-02-15 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| RU2355767C2 (ru) * | 2006-08-30 | 2009-05-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ производства 4-гидрокси-l-изолейцина или его соли |
| CN101239941B (zh) | 2007-02-08 | 2012-02-29 | 味之素株式会社 | 光学活性化合物的制造方法 |
| CN102027117B (zh) | 2007-08-24 | 2012-11-07 | 味之素株式会社 | 新的氧化酶基因及使用该基因生产3-吲哚-丙酮酸的方法 |
| US8003361B2 (en) | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8367847B2 (en) | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) * | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
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| CN107306532B (zh) * | 2017-06-13 | 2021-09-07 | 南京农业大学 | 一种利用复合PAHs降解菌同时去除植物体内USEPA PAHs的方法 |
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| EP2280068A1 (de) | 2002-08-26 | 2011-02-02 | Ajinomoto Co., Inc. | Neuartige Aldolase und Herstellungsverfahren für substituierte Alpha-Ketosäuren |
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2003
- 2003-08-26 EP EP10177313A patent/EP2280068A1/de not_active Withdrawn
- 2003-08-26 DK DK03792838.9T patent/DK1533376T3/da active
- 2003-08-26 CN CN038198991A patent/CN1678742B/zh not_active Expired - Fee Related
- 2003-08-26 KR KR1020057003173A patent/KR100741650B1/ko not_active Expired - Fee Related
- 2003-08-26 EP EP10152890A patent/EP2210943A1/de not_active Withdrawn
- 2003-08-26 AT AT03792838T patent/ATE463568T1/de not_active IP Right Cessation
- 2003-08-26 JP JP2004530621A patent/JP4670347B2/ja not_active Expired - Fee Related
- 2003-08-26 WO PCT/JP2003/010750 patent/WO2004018672A1/ja not_active Ceased
- 2003-08-26 CA CA2714881A patent/CA2714881C/en not_active Expired - Fee Related
- 2003-08-26 EP EP03792838A patent/EP1533376B1/de not_active Expired - Lifetime
- 2003-08-26 RU RU2005108605/13A patent/RU2307871C2/ru not_active IP Right Cessation
- 2003-08-26 DE DE60332026T patent/DE60332026D1/de not_active Expired - Lifetime
- 2003-08-26 CA CA2484871A patent/CA2484871C/en not_active Expired - Fee Related
- 2003-08-26 CN CN201310231146.2A patent/CN103525847A/zh active Pending
- 2003-08-26 AU AU2003261722A patent/AU2003261722A1/en not_active Abandoned
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2005
- 2005-02-28 US US11/066,542 patent/US7351569B2/en not_active Expired - Fee Related
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2009
- 2009-11-06 US US12/613,839 patent/US20100279365A1/en not_active Abandoned
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