MXPA05011013A - Procedimiento para preparar la fenilamida del acido 5-(4-fluorofenil) -1-[2- ((2r, 4r)- 4-hidroxi-6 -oxo-tetrahidropiran -2-il) etil]-2 -isopropil-4 -fenil-1h- pirrol -3-carboxilico. - Google Patents
Procedimiento para preparar la fenilamida del acido 5-(4-fluorofenil) -1-[2- ((2r, 4r)- 4-hidroxi-6 -oxo-tetrahidropiran -2-il) etil]-2 -isopropil-4 -fenil-1h- pirrol -3-carboxilico.Info
- Publication number
- MXPA05011013A MXPA05011013A MXPA05011013A MXPA05011013A MXPA05011013A MX PA05011013 A MXPA05011013 A MX PA05011013A MX PA05011013 A MXPA05011013 A MX PA05011013A MX PA05011013 A MXPA05011013 A MX PA05011013A MX PA05011013 A MXPA05011013 A MX PA05011013A
- Authority
- MX
- Mexico
- Prior art keywords
- pyran
- fluorophenyl
- pyrrole
- tetrahydro
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describe un procedimiento para preparar la fenilamida del acido 5-(4-fluorofenil) -1-[2- ((2R, 4R)-4- hidroxi-6- oxo-tetrahidropiran- 2-il) etil]-2 -isopropil-4 -fenil- 1h-pirrol -3-carboxilico (I), un intermedio clave en la sintesis de atorvastatina de calcio (ver formula (I)).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46261303P | 2003-04-14 | 2003-04-14 | |
PCT/IB2004/001120 WO2004089894A1 (en) | 2003-04-14 | 2004-03-31 | Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05011013A true MXPA05011013A (es) | 2005-12-12 |
Family
ID=33159855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05011013A MXPA05011013A (es) | 2003-04-14 | 2004-03-31 | Procedimiento para preparar la fenilamida del acido 5-(4-fluorofenil) -1-[2- ((2r, 4r)- 4-hidroxi-6 -oxo-tetrahidropiran -2-il) etil]-2 -isopropil-4 -fenil-1h- pirrol -3-carboxilico. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060205804A1 (es) |
EP (1) | EP1615883A1 (es) |
JP (1) | JP2006523670A (es) |
KR (1) | KR100780984B1 (es) |
CN (1) | CN1774421A (es) |
AR (1) | AR043848A1 (es) |
AU (1) | AU2004228463A1 (es) |
BR (1) | BRPI0409333A (es) |
CA (1) | CA2521903A1 (es) |
CL (1) | CL2004000777A1 (es) |
MX (1) | MXPA05011013A (es) |
RS (1) | RS20050760A (es) |
RU (1) | RU2337905C2 (es) |
TW (2) | TW200920745A (es) |
WO (1) | WO2004089894A1 (es) |
ZA (1) | ZA200507174B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1648866A1 (en) | 2003-07-25 | 2006-04-26 | Avecia Pharmaceuticals Limited | Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin |
GB0514612D0 (en) * | 2005-07-15 | 2005-08-24 | Sasol Technology Uk Ltd | The use of a phosphorus containing ligand and a cyclic organic ligand in a metathesis catalyst |
EP2473515A4 (en) | 2009-09-04 | 2013-11-27 | Univ Toledo | METHODS OF MAKING OPTICALLY PURE BETA-LACTONES FROM ALDEHYDES AND COMPOSITIONS OBTAINED THEREFROM |
JP5184565B2 (ja) * | 2010-03-10 | 2013-04-17 | 独立行政法人科学技術振興機構 | 水系溶媒中での含窒素化合物の製造方法 |
CN101892276B (zh) * | 2010-06-12 | 2012-11-21 | 郝志艳 | 一种阿托伐他汀钙化合物及其新方法 |
CN104356118B (zh) * | 2014-10-17 | 2017-03-22 | 上海应用技术学院 | 多取代吡咯类他汀内酯脱水化合物及其用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
US5149837A (en) * | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
US5245047A (en) * | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5097045A (en) * | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5124482A (en) * | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
US5216174A (en) * | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US5103024A (en) * | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5248793A (en) * | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5155251A (en) * | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
HRP960313B1 (en) * | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
PL193479B1 (pl) * | 1995-07-17 | 2007-02-28 | Warner Lambert Co | Formy krystaliczne hydratu atorwastatyny, kompozycja farmaceutyczna zawierająca formę krystaliczną I hydratu atorwastatyny oraz jej zastosowanie |
US6087511A (en) * | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
IL127058A (en) * | 1996-07-29 | 2001-07-24 | Warner Lambert Co | Process for the synthesis of protected esters of acid (S) - 4,3 dehydroxybutyric |
US6476235B2 (en) * | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
RS20050105A (en) * | 2002-08-06 | 2007-11-15 | Warner-Lambert Company Llc., | Process for preparing 5-(4-(54) fluorophenyl)-1-(2-((2r,4r)-4- hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl)- 2-isopropyl-4- phenyl-1h-pyrrole-3- carboxylic acid phenylamide |
-
2004
- 2004-03-31 AU AU2004228463A patent/AU2004228463A1/en not_active Abandoned
- 2004-03-31 CA CA002521903A patent/CA2521903A1/en not_active Abandoned
- 2004-03-31 EP EP04724674A patent/EP1615883A1/en not_active Withdrawn
- 2004-03-31 RS RSP-2005/0760A patent/RS20050760A/sr unknown
- 2004-03-31 US US10/552,747 patent/US20060205804A1/en not_active Abandoned
- 2004-03-31 KR KR1020057019419A patent/KR100780984B1/ko not_active IP Right Cessation
- 2004-03-31 RU RU2005131853/04A patent/RU2337905C2/ru not_active IP Right Cessation
- 2004-03-31 BR BRPI0409333-0A patent/BRPI0409333A/pt not_active IP Right Cessation
- 2004-03-31 MX MXPA05011013A patent/MXPA05011013A/es active IP Right Grant
- 2004-03-31 CN CNA2004800100752A patent/CN1774421A/zh active Pending
- 2004-03-31 WO PCT/IB2004/001120 patent/WO2004089894A1/en active Application Filing
- 2004-03-31 JP JP2006506465A patent/JP2006523670A/ja not_active Withdrawn
- 2004-04-08 CL CL200400777A patent/CL2004000777A1/es unknown
- 2004-04-12 AR ARP040101212A patent/AR043848A1/es not_active Application Discontinuation
- 2004-04-12 TW TW097134271A patent/TW200920745A/zh unknown
- 2004-04-12 TW TW093110141A patent/TW200426149A/zh unknown
-
2005
- 2005-09-07 ZA ZA200507174A patent/ZA200507174B/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW200920745A (en) | 2009-05-16 |
WO2004089894A8 (en) | 2005-12-01 |
BRPI0409333A (pt) | 2006-04-25 |
RU2337905C2 (ru) | 2008-11-10 |
CN1774421A (zh) | 2006-05-17 |
JP2006523670A (ja) | 2006-10-19 |
ZA200507174B (en) | 2006-10-25 |
EP1615883A1 (en) | 2006-01-18 |
KR20050110042A (ko) | 2005-11-22 |
CA2521903A1 (en) | 2004-10-21 |
WO2004089894A1 (en) | 2004-10-21 |
CL2004000777A1 (es) | 2005-03-04 |
TW200426149A (en) | 2004-12-01 |
RS20050760A (sr) | 2008-04-04 |
KR100780984B1 (ko) | 2007-11-29 |
RU2005131853A (ru) | 2006-03-10 |
AU2004228463A1 (en) | 2004-10-21 |
US20060205804A1 (en) | 2006-09-14 |
AR043848A1 (es) | 2005-08-17 |
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