ATE417836T1 - Verfahren und intermediate zur herstellung von retroviralen proteasehemmern - Google Patents
Verfahren und intermediate zur herstellung von retroviralen proteasehemmernInfo
- Publication number
- ATE417836T1 ATE417836T1 AT02079949T AT02079949T ATE417836T1 AT E417836 T1 ATE417836 T1 AT E417836T1 AT 02079949 T AT02079949 T AT 02079949T AT 02079949 T AT02079949 T AT 02079949T AT E417836 T1 ATE417836 T1 AT E417836T1
- Authority
- AT
- Austria
- Prior art keywords
- retroviral protease
- protease inhibitors
- producing retroviral
- formula
- disclosed
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000001177 retroviral effect Effects 0.000 title abstract 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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Applications Claiming Priority (2)
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US99811492A | 1992-12-29 | 1992-12-29 | |
US15858793A | 1993-12-02 | 1993-12-02 |
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ATE417836T1 true ATE417836T1 (de) | 2009-01-15 |
Family
ID=26855178
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02079949T ATE417836T1 (de) | 1992-12-29 | 1993-12-16 | Verfahren und intermediate zur herstellung von retroviralen proteasehemmern |
AT00124382T ATE230402T1 (de) | 1992-12-29 | 1993-12-16 | Hemmer der retroviralen protease |
AT94905429T ATE143262T1 (de) | 1992-12-29 | 1993-12-16 | Inhibitoren der retroviralen protease |
AT96106301T ATE213733T1 (de) | 1992-12-29 | 1993-12-16 | Zwischenprodukte zur herstellung retroviraler proteasehemmenden verbindungen |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
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AT00124382T ATE230402T1 (de) | 1992-12-29 | 1993-12-16 | Hemmer der retroviralen protease |
AT94905429T ATE143262T1 (de) | 1992-12-29 | 1993-12-16 | Inhibitoren der retroviralen protease |
AT96106301T ATE213733T1 (de) | 1992-12-29 | 1993-12-16 | Zwischenprodukte zur herstellung retroviraler proteasehemmenden verbindungen |
Country Status (18)
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US (6) | US5846987A (de) |
EP (4) | EP0674513B1 (de) |
JP (6) | JP2637847B2 (de) |
KR (4) | KR100360964B1 (de) |
AT (4) | ATE417836T1 (de) |
AU (3) | AU659575B2 (de) |
CA (5) | CA2585898C (de) |
DE (6) | DE69332616T2 (de) |
DK (4) | DK1302468T3 (de) |
ES (4) | ES2174992T3 (de) |
GR (2) | GR950300059T1 (de) |
HK (3) | HK130697A (de) |
HU (1) | HU211606A9 (de) |
IL (5) | IL112962A (de) |
LU (1) | LU90839I2 (de) |
NL (1) | NL300060I2 (de) |
PT (2) | PT727419E (de) |
WO (1) | WO1994014436A1 (de) |
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KR20160066554A (ko) | 2013-10-25 | 2016-06-10 | 파마싸이클릭스 엘엘씨 | 브루톤 타이로신 키나제 억제제 및 면역요법을 이용한 치료 |
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