ATE382048T1 - Pyrazolopyrimdine als hemmstoffe cyclin abhängiger kinasen - Google Patents

Pyrazolopyrimdine als hemmstoffe cyclin abhängiger kinasen

Info

Publication number
ATE382048T1
ATE382048T1 AT03752559T AT03752559T ATE382048T1 AT E382048 T1 ATE382048 T1 AT E382048T1 AT 03752559 T AT03752559 T AT 03752559T AT 03752559 T AT03752559 T AT 03752559T AT E382048 T1 ATE382048 T1 AT E382048T1
Authority
AT
Austria
Prior art keywords
pyrazolopyrimdines
inhibitors
cyclin dependent
dependent kinases
kinases
Prior art date
Application number
AT03752559T
Other languages
German (de)
English (en)
Inventor
Michael Dwyer
Timothy Guzi
Kamil Paruch
Ronald Doll
Kartik Keertikar
Viyyoor Girijavallabhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE382048T1 publication Critical patent/ATE382048T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03752559T 2002-09-19 2003-09-17 Pyrazolopyrimdine als hemmstoffe cyclin abhängiger kinasen ATE382048T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41213802P 2002-09-19 2002-09-19

Publications (1)

Publication Number Publication Date
ATE382048T1 true ATE382048T1 (de) 2008-01-15

Family

ID=32030811

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03752559T ATE382048T1 (de) 2002-09-19 2003-09-17 Pyrazolopyrimdine als hemmstoffe cyclin abhängiger kinasen

Country Status (18)

Country Link
US (1) US7151104B2 (enExample)
EP (1) EP1539750B1 (enExample)
JP (1) JP4845380B2 (enExample)
KR (1) KR20050072090A (enExample)
CN (1) CN100475812C (enExample)
AR (1) AR041292A1 (enExample)
AT (1) ATE382048T1 (enExample)
AU (1) AU2003270846B2 (enExample)
CA (1) CA2499593C (enExample)
DE (1) DE60318321T2 (enExample)
ES (1) ES2297203T3 (enExample)
IL (1) IL167432A (enExample)
MX (1) MXPA05003059A (enExample)
MY (1) MY136840A (enExample)
NZ (1) NZ538595A (enExample)
TW (1) TWI283243B (enExample)
WO (1) WO2004026872A1 (enExample)
ZA (1) ZA200502271B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2496477C (en) 2002-08-23 2012-10-16 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP5117189B2 (ja) * 2004-08-27 2013-01-09 サイクラセル リミテッド プリン及びピリミジンｃｄｋ阻害剤、並びに自己免疫疾患の治療のためのそれらの使用
JP5106098B2 (ja) * 2005-02-28 2012-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド化合物の抗癌剤との新規併用
US20090047278A1 (en) * 2005-02-28 2009-02-19 Eisai R & D Management Co., Ltd. Novel Combinational Use of Sulfonamide Compound
US7304074B2 (en) * 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
KR20080002935A (ko) * 2005-04-07 2008-01-04 데이진 화-마 가부시키가이샤 피라졸로［1,5-ａ］피리딘 유도체 또는 그 의학상 허용되는염
US7417053B2 (en) 2005-04-07 2008-08-26 Teijin Pharma Limited Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof
CN101300233A (zh) 2005-09-09 2008-11-05 先灵公司 氮杂稠合的细胞周期蛋白依赖性激酶抑制剂
KR20090094336A (ko) * 2006-11-27 2009-09-04 하. 룬트벡 아크티에 셀스카브 헤테로아릴 아미드 유도체
KR20090031122A (ko) * 2007-09-21 2009-03-25 주식회사 중외제약 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물
FR2940284B1 (fr) * 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
AU2016243529B2 (en) * 2015-03-27 2021-03-25 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
EP3377908B1 (en) 2015-11-18 2020-08-05 Genzyme Corporation Biomarker of polycystic kidney disease and uses thereof
CN109790160B (zh) * 2016-09-07 2022-11-15 上海海和药物研究开发股份有限公司 吡啶并五元芳香环类化合物、其制备方法及用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091346B1 (en) 1995-11-01 2006-08-15 Novartis Ag Purine derivatives and processes for their preparation
ES2281941T3 (es) 1997-12-13 2007-10-01 Bristol-Myers Squibb Company Uso de pirazolo(3,4-b)piridina como inhibidores de quinasa dependiente de ciclina.
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
FR2801308B1 (fr) * 1999-11-19 2003-05-09 Oreal COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES
CN100356979C (zh) * 2000-02-03 2007-12-26 卫材R&D管理有限公司 整联蛋白表达抑制剂
WO2002050079A1 (fr) * 2000-12-20 2002-06-27 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3)
CZ20032398A3 (cs) * 2001-03-08 2004-02-18 Astrazeneca Ab Nové použití derivátů 6-karboxamidoimidazo [1,2-a] pyridinu
CN1202896C (zh) * 2002-02-07 2005-05-25 北京燕化高新技术股份有限公司 空气分离时纯化空气的方法

Also Published As

Publication number Publication date
ES2297203T3 (es) 2008-05-01
CA2499593C (en) 2011-08-16
TWI283243B (en) 2007-07-01
CN1681816A (zh) 2005-10-12
NZ538595A (en) 2006-04-28
CA2499593A1 (en) 2004-04-01
HK1071758A1 (en) 2005-07-29
IL167432A (en) 2010-05-17
ZA200502271B (en) 2005-09-19
EP1539750B1 (en) 2007-12-26
JP2006503060A (ja) 2006-01-26
KR20050072090A (ko) 2005-07-08
JP4845380B2 (ja) 2011-12-28
AU2003270846B2 (en) 2006-11-23
DE60318321D1 (en) 2008-02-07
MXPA05003059A (es) 2005-05-27
AU2003270846A1 (en) 2004-04-08
DE60318321T2 (de) 2008-12-11
AR041292A1 (es) 2005-05-11
EP1539750A1 (en) 2005-06-15
CN100475812C (zh) 2009-04-08
US20040097516A1 (en) 2004-05-20
MY136840A (en) 2008-11-28
US7151104B2 (en) 2006-12-19
WO2004026872A1 (en) 2004-04-01
TW200409775A (en) 2004-06-16

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