KR20050072090A - 사이클린 의존성 키나제 억제제로서의 피라졸로피리딘 - Google Patents
사이클린 의존성 키나제 억제제로서의 피라졸로피리딘 Download PDFInfo
- Publication number
- KR20050072090A KR20050072090A KR1020057004435A KR20057004435A KR20050072090A KR 20050072090 A KR20050072090 A KR 20050072090A KR 1020057004435 A KR1020057004435 A KR 1020057004435A KR 20057004435 A KR20057004435 A KR 20057004435A KR 20050072090 A KR20050072090 A KR 20050072090A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- aryl
- group
- heteroaryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 208000005069 pulmonary fibrosis Diseases 0.000 description 1
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- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000006085 pyrrolopyridyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
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- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- BTIHMVBBUGXLCJ-OAHLLOKOSA-N seliciclib Chemical compound C=12N=CN(C(C)C)C2=NC(N[C@@H](CO)CC)=NC=1NCC1=CC=CC=C1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 0.000 description 1
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- 239000007909 solid dosage form Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 208000002320 spinal muscular atrophy Diseases 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 102000009076 src-Family Kinases Human genes 0.000 description 1
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- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000004426 substituted alkynyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
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- 102000013498 tau Proteins Human genes 0.000 description 1
- 108010026424 tau Proteins Proteins 0.000 description 1
- 229940061353 temodar Drugs 0.000 description 1
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- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
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- 125000001544 thienyl group Chemical group 0.000 description 1
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- 125000003944 tolyl group Chemical group 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
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- 230000016596 traversing start control point of mitotic cell cycle Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| US41213802P | 2002-09-19 | 2002-09-19 | |
| US60/412,138 | 2002-09-19 |
Publications (1)
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|---|---|
| KR20050072090A true KR20050072090A (ko) | 2005-07-08 |
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| EP (1) | EP1539750B1 (enExample) |
| JP (1) | JP4845380B2 (enExample) |
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| CN (1) | CN100475812C (enExample) |
| AR (1) | AR041292A1 (enExample) |
| AT (1) | ATE382048T1 (enExample) |
| AU (1) | AU2003270846B2 (enExample) |
| CA (1) | CA2499593C (enExample) |
| DE (1) | DE60318321T2 (enExample) |
| ES (1) | ES2297203T3 (enExample) |
| IL (1) | IL167432A (enExample) |
| MX (1) | MXPA05003059A (enExample) |
| MY (1) | MY136840A (enExample) |
| NZ (1) | NZ538595A (enExample) |
| TW (1) | TWI283243B (enExample) |
| WO (1) | WO2004026872A1 (enExample) |
| ZA (1) | ZA200502271B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2273083C (en) | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| SI1767535T1 (sl) | 2002-08-23 | 2010-03-31 | Sloan Kettering Inst Cancer | Sinteza epotilonov njihovih intermediatov analogov in uporaba le teh |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US20080125404A1 (en) * | 2004-08-27 | 2008-05-29 | Cyclacel Limited | Purine and Pyrimidine Cdk Inhitbitors and Their use for The Treatment of Autoimmune Diseases |
| US20090047365A1 (en) * | 2005-02-28 | 2009-02-19 | Eisai R & D Management Co., Ltd. | Novel Concomitant Use of Sulfonamide Compound with Anti-Cancer Agent |
| JPWO2006090930A1 (ja) * | 2005-02-28 | 2008-07-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の新規併用 |
| US7304074B2 (en) | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| JPWO2006109867A1 (ja) * | 2005-04-07 | 2008-11-20 | 帝人ファーマ株式会社 | ピラゾロ［１，５−ａ］ピリジン誘導体またはその医学上許容される塩 |
| US7417053B2 (en) | 2005-04-07 | 2008-08-26 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
| WO2007032936A2 (en) | 2005-09-09 | 2007-03-22 | Schering Corporation | Azafused cyclin dependent kinase inhibitors |
| CN101621931A (zh) * | 2006-11-27 | 2010-01-06 | H.隆德贝克有限公司 | 杂芳基酰胺衍生物 |
| KR20090031122A (ko) * | 2007-09-21 | 2009-03-25 | 주식회사 중외제약 | 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물 |
| FR2940284B1 (fr) * | 2008-12-19 | 2011-02-18 | Sanofi Aventis | Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique |
| UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| JP6861166B2 (ja) * | 2015-03-27 | 2021-04-21 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
| MX2018006250A (es) | 2015-11-18 | 2018-09-05 | Genzyme Corp | Biomarcador de enfermedad poliquistica renal y usos del mismo. |
| EA038701B1 (ru) * | 2016-09-07 | 2021-10-07 | Хайхэ Биофарма Ко., Лтд. | Пиридо пятичленное ароматическое циклическое соединение, способ его получения и применение |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066147C (zh) | 1995-11-01 | 2001-05-23 | 诺瓦提斯公司 | 嘌呤衍生物及其制备方法 |
| CA2314355A1 (en) * | 1997-12-13 | 1999-06-24 | Bristol-Myers Squibb Company | Use of pyrazolo ¢3,4-b! pyridine as cyclin dependent kinase inhibitors |
| SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
| FR2801308B1 (fr) * | 1999-11-19 | 2003-05-09 | Oreal | COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES |
| JP4039856B2 (ja) * | 2000-02-03 | 2008-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | インテグリン発現阻害剤 |
| US20040048849A1 (en) | 2000-12-20 | 2004-03-11 | Gregoire Prevost | Cyclin-dependent kinase (cdk) and glycolene synthase kinase-3 (gsk-3) inhibitors |
| BR0207762A (pt) * | 2001-03-08 | 2004-06-01 | Astrazeneca Ab | Uso de um composto ou um sal farmaceuticamente aceitável do mesmo, combinação, formulação farmacêutica, kit, método para a prevenção da úlcera gástrica induzida por medicamento, e, composição farmacêutica oral |
| CN1202896C (zh) * | 2002-02-07 | 2005-05-25 | 北京燕化高新技术股份有限公司 | 空气分离时纯化空气的方法 |
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2003
- 2003-09-17 NZ NZ538595A patent/NZ538595A/en not_active IP Right Cessation
- 2003-09-17 KR KR1020057004435A patent/KR20050072090A/ko not_active Abandoned
- 2003-09-17 AR ARP030103374A patent/AR041292A1/es active IP Right Grant
- 2003-09-17 CA CA2499593A patent/CA2499593C/en not_active Expired - Fee Related
- 2003-09-17 US US10/664,337 patent/US7151104B2/en not_active Expired - Lifetime
- 2003-09-17 CN CNB038220113A patent/CN100475812C/zh not_active Expired - Fee Related
- 2003-09-17 ES ES03752559T patent/ES2297203T3/es not_active Expired - Lifetime
- 2003-09-17 MX MXPA05003059A patent/MXPA05003059A/es active IP Right Grant
- 2003-09-17 TW TW092125613A patent/TWI283243B/zh not_active IP Right Cessation
- 2003-09-17 JP JP2004538405A patent/JP4845380B2/ja not_active Expired - Fee Related
- 2003-09-17 AU AU2003270846A patent/AU2003270846B2/en not_active Ceased
- 2003-09-17 WO PCT/US2003/029841 patent/WO2004026872A1/en not_active Ceased
- 2003-09-17 AT AT03752559T patent/ATE382048T1/de not_active IP Right Cessation
- 2003-09-17 MY MYPI20033535A patent/MY136840A/en unknown
- 2003-09-17 DE DE60318321T patent/DE60318321T2/de not_active Expired - Lifetime
- 2003-09-17 EP EP03752559A patent/EP1539750B1/en not_active Expired - Lifetime
-
2005
- 2005-03-15 IL IL167432A patent/IL167432A/en not_active IP Right Cessation
- 2005-03-17 ZA ZA200502271A patent/ZA200502271B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200502271B (en) | 2005-09-19 |
| TW200409775A (en) | 2004-06-16 |
| AR041292A1 (es) | 2005-05-11 |
| CA2499593A1 (en) | 2004-04-01 |
| NZ538595A (en) | 2006-04-28 |
| TWI283243B (en) | 2007-07-01 |
| WO2004026872A1 (en) | 2004-04-01 |
| AU2003270846A1 (en) | 2004-04-08 |
| IL167432A (en) | 2010-05-17 |
| CN100475812C (zh) | 2009-04-08 |
| HK1071758A1 (en) | 2005-07-29 |
| ATE382048T1 (de) | 2008-01-15 |
| CA2499593C (en) | 2011-08-16 |
| US7151104B2 (en) | 2006-12-19 |
| MY136840A (en) | 2008-11-28 |
| EP1539750B1 (en) | 2007-12-26 |
| JP2006503060A (ja) | 2006-01-26 |
| AU2003270846B2 (en) | 2006-11-23 |
| DE60318321T2 (de) | 2008-12-11 |
| MXPA05003059A (es) | 2005-05-27 |
| DE60318321D1 (en) | 2008-02-07 |
| ES2297203T3 (es) | 2008-05-01 |
| CN1681816A (zh) | 2005-10-12 |
| US20040097516A1 (en) | 2004-05-20 |
| EP1539750A1 (en) | 2005-06-15 |
| JP4845380B2 (ja) | 2011-12-28 |
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