AR041292A1 - Pirazolopiridinas como inhibidores de quinasa dependientes de ciclina - Google Patents
Pirazolopiridinas como inhibidores de quinasa dependientes de ciclinaInfo
- Publication number
- AR041292A1 AR041292A1 ARP030103374A ARP030103374A AR041292A1 AR 041292 A1 AR041292 A1 AR 041292A1 AR P030103374 A ARP030103374 A AR P030103374A AR P030103374 A ARP030103374 A AR P030103374A AR 041292 A1 AR041292 A1 AR 041292A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- alkyl
- cycloalkyl
- nr5r6
- heteroaryl
- Prior art date
Links
- 230000001419 dependent effect Effects 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 23
- 125000003118 aryl group Chemical group 0.000 abstract 23
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 22
- 125000000623 heterocyclic group Chemical group 0.000 abstract 17
- 125000001072 heteroaryl group Chemical group 0.000 abstract 15
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 12
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 12
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 11
- 229910052736 halogen Inorganic materials 0.000 abstract 10
- 150000002367 halogens Chemical class 0.000 abstract 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 9
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 7
- 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 229910006069 SO3H Inorganic materials 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108091007914 CDKs Proteins 0.000 abstract 1
- 125000004946 alkenylalkyl group Chemical group 0.000 abstract 1
- -1 alkylalkyl Chemical group 0.000 abstract 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 abstract 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000006872 improvement Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- DVUBDHRTVYLIPA-UHFFFAOYSA-N pyrazolo[1,5-a]pyridine Chemical class C1=CC=CN2N=CC=C21 DVUBDHRTVYLIPA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41213802P | 2002-09-19 | 2002-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041292A1 true AR041292A1 (es) | 2005-05-11 |
Family
ID=32030811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030103374A AR041292A1 (es) | 2002-09-19 | 2003-09-17 | Pirazolopiridinas como inhibidores de quinasa dependientes de ciclina |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7151104B2 (enExample) |
| EP (1) | EP1539750B1 (enExample) |
| JP (1) | JP4845380B2 (enExample) |
| KR (1) | KR20050072090A (enExample) |
| CN (1) | CN100475812C (enExample) |
| AR (1) | AR041292A1 (enExample) |
| AT (1) | ATE382048T1 (enExample) |
| AU (1) | AU2003270846B2 (enExample) |
| CA (1) | CA2499593C (enExample) |
| DE (1) | DE60318321T2 (enExample) |
| ES (1) | ES2297203T3 (enExample) |
| IL (1) | IL167432A (enExample) |
| MX (1) | MXPA05003059A (enExample) |
| MY (1) | MY136840A (enExample) |
| NZ (1) | NZ538595A (enExample) |
| TW (1) | TWI283243B (enExample) |
| WO (1) | WO2004026872A1 (enExample) |
| ZA (1) | ZA200502271B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2273083C (en) * | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| DK1767535T3 (da) | 2002-08-23 | 2010-04-12 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| ES2403558T3 (es) * | 2004-08-27 | 2013-05-20 | Cyclacel Limited | Inhibidores purínicos y pirimidínicos de CDK y su uso para el tratamiento de enfermedades autoinmunitarias |
| KR20070108270A (ko) * | 2005-02-28 | 2007-11-08 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 술폰아미드 화합물의 신규 병용 |
| WO2006090931A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の抗癌剤との新規併用 |
| US7304074B2 (en) | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| WO2006109867A1 (ja) * | 2005-04-07 | 2006-10-19 | Teijin Pharma Limited | ピラゾロ［１，５-ａ］ピリジン誘導体またはその医学上許容される塩 |
| US7417053B2 (en) | 2005-04-07 | 2008-08-26 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
| WO2007032936A2 (en) | 2005-09-09 | 2007-03-22 | Schering Corporation | Azafused cyclin dependent kinase inhibitors |
| WO2008066789A2 (en) * | 2006-11-27 | 2008-06-05 | H. Lundbeck A/S | Heteroaryl amide derivatives |
| KR20090031122A (ko) * | 2007-09-21 | 2009-03-25 | 주식회사 중외제약 | 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물 |
| FR2940284B1 (fr) * | 2008-12-19 | 2011-02-18 | Sanofi Aventis | Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique |
| UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| WO2016160617A2 (en) * | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| WO2017087409A1 (en) | 2015-11-18 | 2017-05-26 | Genzyme Corporation | Biomarker of polycystic kidney disease and uses thereof |
| MX390117B (es) * | 2016-09-07 | 2025-03-20 | Haihe Biopharma Co Ltd | Compuesto de anillo aromatico de pirido de cinco elementos, metodo de preparacion y uso del mismo. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69627195T2 (de) | 1995-11-01 | 2004-01-29 | Novartis Ag | Purinderivate und verfahren zu ihrer herstellung |
| EP1043998B1 (en) | 1997-12-13 | 2007-03-07 | Bristol-Myers Squibb Company | USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS |
| SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
| FR2801308B1 (fr) * | 1999-11-19 | 2003-05-09 | Oreal | COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES |
| WO2001056607A1 (en) * | 2000-02-03 | 2001-08-09 | Eisai Co., Ltd. | Integrin expression inhibitors |
| AU2002225096B8 (en) * | 2000-12-20 | 2006-07-27 | Ipsen Pharma S.A.S. | Cyclin-dependent kinase (CDK) and glycogen synthase kinase-3 (GSK-3) inhibitors |
| IL157461A0 (en) * | 2001-03-08 | 2004-03-28 | Astrazeneca Ab Astrazeneca Ab | Use of carboxamido imidazo [1,2] pyridine deivatives in the preparation of medicaments for treating or preventing gastric ulcer |
| CN1202896C (zh) * | 2002-02-07 | 2005-05-25 | 北京燕化高新技术股份有限公司 | 空气分离时纯化空气的方法 |
-
2003
- 2003-09-17 JP JP2004538405A patent/JP4845380B2/ja not_active Expired - Fee Related
- 2003-09-17 KR KR1020057004435A patent/KR20050072090A/ko not_active Abandoned
- 2003-09-17 AU AU2003270846A patent/AU2003270846B2/en not_active Ceased
- 2003-09-17 EP EP03752559A patent/EP1539750B1/en not_active Expired - Lifetime
- 2003-09-17 AR ARP030103374A patent/AR041292A1/es active IP Right Grant
- 2003-09-17 MX MXPA05003059A patent/MXPA05003059A/es active IP Right Grant
- 2003-09-17 MY MYPI20033535A patent/MY136840A/en unknown
- 2003-09-17 TW TW092125613A patent/TWI283243B/zh not_active IP Right Cessation
- 2003-09-17 CA CA2499593A patent/CA2499593C/en not_active Expired - Fee Related
- 2003-09-17 DE DE60318321T patent/DE60318321T2/de not_active Expired - Lifetime
- 2003-09-17 ES ES03752559T patent/ES2297203T3/es not_active Expired - Lifetime
- 2003-09-17 NZ NZ538595A patent/NZ538595A/en not_active IP Right Cessation
- 2003-09-17 US US10/664,337 patent/US7151104B2/en not_active Expired - Lifetime
- 2003-09-17 WO PCT/US2003/029841 patent/WO2004026872A1/en not_active Ceased
- 2003-09-17 AT AT03752559T patent/ATE382048T1/de not_active IP Right Cessation
- 2003-09-17 CN CNB038220113A patent/CN100475812C/zh not_active Expired - Fee Related
-
2005
- 2005-03-15 IL IL167432A patent/IL167432A/en not_active IP Right Cessation
- 2005-03-17 ZA ZA200502271A patent/ZA200502271B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ538595A (en) | 2006-04-28 |
| ATE382048T1 (de) | 2008-01-15 |
| EP1539750B1 (en) | 2007-12-26 |
| CN100475812C (zh) | 2009-04-08 |
| ZA200502271B (en) | 2005-09-19 |
| TW200409775A (en) | 2004-06-16 |
| CN1681816A (zh) | 2005-10-12 |
| JP4845380B2 (ja) | 2011-12-28 |
| IL167432A (en) | 2010-05-17 |
| EP1539750A1 (en) | 2005-06-15 |
| WO2004026872A1 (en) | 2004-04-01 |
| JP2006503060A (ja) | 2006-01-26 |
| AU2003270846A1 (en) | 2004-04-08 |
| US7151104B2 (en) | 2006-12-19 |
| TWI283243B (en) | 2007-07-01 |
| MY136840A (en) | 2008-11-28 |
| CA2499593C (en) | 2011-08-16 |
| DE60318321T2 (de) | 2008-12-11 |
| HK1071758A1 (en) | 2005-07-29 |
| AU2003270846B2 (en) | 2006-11-23 |
| KR20050072090A (ko) | 2005-07-08 |
| US20040097516A1 (en) | 2004-05-20 |
| MXPA05003059A (es) | 2005-05-27 |
| ES2297203T3 (es) | 2008-05-01 |
| CA2499593A1 (en) | 2004-04-01 |
| DE60318321D1 (en) | 2008-02-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR041291A1 (es) | Imidazopiridinas como inhibidores de quinasa dependientes de ciclina | |
| AR041292A1 (es) | Pirazolopiridinas como inhibidores de quinasa dependientes de ciclina | |
| AR041347A1 (es) | Derivados de imidazol[1,2-a]pirazinas como inhibidores de quinasas dependientes de ciclinas | |
| AR041134A1 (es) | Pirazolopirimidinas como inhibidores de la quinasa dependiente de ciclina | |
| AR041346A1 (es) | Derivados de imidazol[1,2-a]pirazinas como inhibidores de quinasas dependientes de ciclinas | |
| AR041133A1 (es) | Pirazolopirimidinas como inhibidores de la quinasa dependientes de la ciclina | |
| AR063581A1 (es) | Imidazopirazinas como inhibidores de proteina quinasa | |
| AR043508A1 (es) | 1-amino 1-h-imidazoquinolinas y su uso como inmunomoduladores | |
| AR054560A1 (es) | Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer | |
| AR061072A1 (es) | Pirazolo [1,5- a ] pirimidinas | |
| AR037019A1 (es) | Tioacetamidas sustituidas | |
| AR082937A1 (es) | Fosforamidatos de nucleosido | |
| AR041135A1 (es) | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas | |
| AR083367A1 (es) | Compuestos de tipo quinazolinona como antagonistas de crth | |
| BRPI0413452A (pt) | composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv | |
| AR049300A1 (es) | Compuestos triciclicos antagonistas de mglur1 como agentes terapeuticos | |
| BRPI0409198A (pt) | derivados quinolin-2-ona para o tratamento de doenças de vias aéreas | |
| ES2564010T3 (es) | Composición farmacéutica para tratar o prevenir el glaucoma | |
| AR036875A1 (es) | Acidos hidroxamicos ciclicos como inhibidores de las metaloproteinasas de matriz y/o de la enzima de conversion del factor de necrosis de tumor alfa | |
| CY1108792T1 (el) | Παραγωγα διοξανιου-2-αλκυλκαρβαμικου, η παρασκευη τους και η εφαρμογη τους στην θεραπευτικη αγωγη | |
| UY28333A1 (es) | Inhibidores de caspasa y sus usos. | |
| AR101280A1 (es) | Tieno[3,2-d]pirimidina, furo[3,2-d]pirimidina y pirrolo[3,2-d]pirimidinas útiles para el tratamiento de infecciones respiratorias por virus sincicial | |
| CL2020002157A1 (es) | Derivados de triazina para el tratamiento de enfermedades relacionadas con neurotrofinas. | |
| EA202092558A1 (ru) | КРИСТАЛЛИЧЕСКАЯ ФОРМА ИНГИБИТОРА c-MET, ЕГО СОЛЕВАЯ ФОРМА И СПОСОБ ИХ ПОЛУЧЕНИЯ | |
| AR116474A1 (es) | DERIVADOS DEL ÁCIDO 6,7-DIHIDRO-2H-BENZOFURO[2,3-a]QUINOLIZIN-3-CARBOXÍLICO COMO AGENTES ANTIVIRALES PARA EL TRATAMIENTO O PREVENCIÓN DE UNA INFECCIÓN POR HBV |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |