AR036875A1 - Acidos hidroxamicos ciclicos como inhibidores de las metaloproteinasas de matriz y/o de la enzima de conversion del factor de necrosis de tumor alfa - Google Patents

Acidos hidroxamicos ciclicos como inhibidores de las metaloproteinasas de matriz y/o de la enzima de conversion del factor de necrosis de tumor alfa

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AR036875A1
AR036875A1 ARP020103499A ARP020103499A AR036875A1 AR 036875 A1 AR036875 A1 AR 036875A1 AR P020103499 A ARP020103499 A AR P020103499A AR P020103499 A ARP020103499 A AR P020103499A AR 036875 A1 AR036875 A1 AR 036875A1
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Argentina
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crara1
substituted
nrara1
carbon atoms
time
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ARP020103499A
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Gregory Ott
Xiao-Tao Chen
Jingwu Duan
Lu Zhonghui
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Bristol Myers Squibb Co
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Abstract

Compuestos que son útiles como inhibidores de las metaloproteinasas de matriz (MMP), enzima que convierte el TNF-a TACE, agrecanasa o una combinación de los mismos, composiciones farmacéuticas que contienen el mismo y métodos para usar el mismo. Reivindicación 1: Un compuesto de la fórmula (1) o un estereoisómero o una forma de sal farmacéuticamente aceptable del mismo; en donde el anillo B es un anillo heterocíclico o carbocíclico no aromático de 4-7 miembros que comprende: átomos de carbono, 0-3 grupos carbonilo, 0-3 enlaces dobles, y 0-2 heteroátomos de anillo seleccionados de O, N, NR1, y S(O)p, con la condición de que el anillo B contiene otros enlaces diferentes a S-S, O-O, ó S-O; R1 se selecciona de Q, alquileno C1-6-Q, alquenileno C2-6-Q, alquinileno C2-6-Q, (CRaRa1)qO(CRaRa1)s-Q, (CRaRa1)qNRa(CRaRa1)s-Q, (CRaRa1)rC(O)(CRaRa1)s-Q, (CRaRa1)rC(O)-alquenileno C2-6-Q, (CRaRa1)rC(O)O(CRaRa1)s-Q, (CRaRa1)rOC(O)O(CRaRa1)s-Q, (CRaRa1)rOC(O)NRa(CRaRa1)s-Q, (CRaRa1)rC(O)NRaRa1, (CRaRa1)rC(O)NRa(CRaRa1)s-Q, (CRaRa1)qNRaC(O)(CRaRa1)s-Q, (CRaRa1)qNRaC(O)O(CRaRa1)s-Q, (CRaRa1)qNRaC(O)NRa(CRaRa1)s-Q, (CRaRa1)rS(O)p(CRaRa1)s-Q, (CRaRa1)rNRaSO2(CRaRa1)s-Q, y (CRaRa1)rSO2NRa(CRaRa1)s-Q; R2 se selecciona de Q, alquileno C1-6-Q, alquenileno C2-6-Q, alquinileno C2-6-Q, (CRaRa1)rO (CRaRa1)s-Q, (CRaRa1)rNRa(CRaRa1)s-Q, (CRaRa1)rC(O)(CRaRa1)s-Q, (CRaRa1)rC(O)-alquenileno C2-6-Q, (CRaRa1)rC(O)O(CRaRa1)s-Q, (CRaRa1)rC(O)NRaRa1, (CRaRa1)rC(O)NRa(CRaRa1)s-Q, (CRaRa1)rNRaC(O)(CRaRa1)s-Q, (CRaRa1)rNRaC(O)O(CRaRa1)s-Q, (CRaRa1)rNRaC(O)NRa(CRaRa1)s-Q, (CRaRa1)rS(O)p(CRaRa1)s-Q, y (CRaRa1)rSO2NRa(CRaRa1)s-Q; Q se selecciona de H, un carbociclo C3-6 sustituido con 0-3 Rd, y un heterociclo de 5-10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados del grupo que consiste de N, O, y S(O)p, y sustituidos con 0-3 Rd; R3 se selecciona de Q1, Cl, F, alquileno C1-6-Q1, alquenileno C2-6-Q1, alquinileno C2-6-Q1, (CRaRa1)rO(CRaRa1)s-Q1, (CRaRa1)rNRa(CRaRa1)s-Q1, (CRaRa1)rNRaC(O)(CRaRa1)s-Q1, (CRaRa1)rC(O)NRa(CRaRa1)s-Q1, (CRaRa1)rC(O)(CRaRa1)s-Q1, (CRaRa1)rC(O)O(CRaRa1)s-Q1, (CRaRa12)rS(O)p(CRaRa1)s-Q1, y (CRaRa1)rSO2NRa(CRaRa1)s-Q1; Q1 se selecciona de H, fenilo sustituido con 0-3 Rd, naftilo sustituido con 0-3 Rd y un heterociclo de 5-10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados del grupo que consiste de N, O, y S(O)p, y sustituido con 0-3 Rd; Za se selecciona de del grupo de fórmulas (2); X es S, SO, SO2, O, ó NR14; Y es N ó CR17; R11 y R12, cada vez que se presentan, se seleccionan independientemente de H, Rc, alquilo C1-6 sustituido con 0-3 Rc1, carbociclo C3-10 sustituido con 0-3 Rc1, y heterociclo de 5-14 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, O, y S(O)p, y sustituido con 0-3 Rc1 ; R13 y R13a cada vez que se presentan, se seleccionan independientemente de H, Rc, alquilo C1-6 sustituido con 0-3 Rc1, carbociclo C3-10 sustituido con 0-3 Rc1, y un heterociclo de 5-14 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados del grupo que consiste de N, O, y S(O)p, y sustituido con 0-3 Rc1; alternativamente, cuando R13 y R13a se enlazan a átomos de carbono adyacentes, junto con los átomos de carbono a los cuales se enlazan, forman un anillo de 5-7 miembros que consiste de: átomos de carbono, 0-2 grupos carbonilo, 0-3 dobles enlaces, y 0-2 heteroátomos seleccionados del grupo que consiste de N, O, y S(O)p, y sustituido con 0-2 Rc1; R14, cada vez que se presenta, se selecciona independientemente de H, alquilo C1-4, fenilo, y bencilo; R15 y R16, cada vez que se presentan, se seleccionan independientemente de H, Rc1, alquilo C1-6 sustituido con 0-3 Rc1, carbociclo C3-10 sustituido con 0-3 Rc1, y un heterociclo de 5-14 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados del grupo que consiste de N, O, y S(O)p, y sustituido con 0-3 Rc1; alternativamente, cuando R15 y R16 se enlazan a los átomos de carbono adyacentes, junto con los átomos de carbono a los cuales se enlazan, forman un anillo de 5-7 miembros, que consiste de: átomos de carbono, 0-2 grupos carbonilo, 0-3 dobles enlaces, 0-2 heteroátomos seleccionados del grupo que consiste de N, O, y S(O)p; este anillo está sustituido con 0-2 Rc1; alternativamente, cuando R15 y R16 se enlazan al mismo átomo de carbono, junto con el átomo de carbono al cual están enlazados, forman un anillo de 3-7 miembros que consiste de: átomos de carbono, 0-2 grupos carbonilo, 0-3 dobles enlaces, y 0-2 heteroátomos seleccionados de N, O, y S(O)p; este anillo está sustituido con 0-2 Rc1; R17 se selecciona de H, Cl, F, y alquilo C1-4; Ra, cada vez que se presenta, se selecciona independientemente de H, alquilo C1-4, fenilo, y bencilo; Ra1, cada vez que se presenta, se selecciona independientemente de H y alquilo C1-4; Ra2, cada vez que se presenta, se selecciona independientemente de alquilo C1-4, fenilo, y bencilo; Rc, cada vez que se presenta, se selecciona independientemente de alquilo C1-6, ORa, Cl, F, Br, I, -CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, OCF3, CF2CF3, CH2F, y CHF2; Rc1, cada vez que se presenta, se selecciona independientemente de alquilo C1-6, ORa, Cl, F, Br, I, =O, -CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, OCF3, CF2CF3, CH2F, y CHF2; Rd, cada vez que se presenta, se selecciona independientemente de alquilo C1-6, ORa, Cl, F, Br, I, =O, -CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)O, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, OCF3, CF2CF3, carbociclo C3-10, y un heterociclo de 5-14 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados del grupo que consiste de N, O, y S(O)p; p, cada vez que se presenta, se selecciona de 0, 1, y 2; q, cada vez que se presenta, se selecciona de 1, 2, 3, y 4; r, cada vez que se presenta, se selecciona de 0, 1, 2, 3, y 4; y, s, cada vez que se presenta, se selecciona de 0, 1, 2, 3, y 4.
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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2275102E (pt) * 2002-03-13 2015-10-27 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1643836A4 (en) 2003-07-02 2006-12-06 Sugen Inc ARYLMETHYL TRIAZOLO AND IMIDAZOPYRAZINE C-MET INHIBITORS
CA2534649A1 (en) 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
US20050080075A1 (en) * 2003-08-25 2005-04-14 Nichols M. James Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
DE10348044A1 (de) * 2003-10-15 2005-05-19 Imtm Gmbh Duale Alanyl-Aminopeptidase- und Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
JP5463034B2 (ja) * 2005-05-20 2014-04-09 アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
WO2007016597A2 (en) * 2005-07-29 2007-02-08 The Regents Of The University Of California Targeting tnf-alpha converting enzyme (tace)-dependent growth factor shedding in cancer therapy
PE20070335A1 (es) 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067457B2 (en) * 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20100016289A1 (en) * 2005-11-01 2010-01-21 Kevin Sprott Compounds Useful as Antagonists of CCR2
ES2430139T3 (es) 2005-12-30 2013-11-19 Novartis Ag Compuestos de piperidina 3,5-sustituido como inhibidores de renina
MX2008013238A (es) * 2006-04-12 2008-10-21 Merck & Co Inc Antagonistas de los canales de calcio de tipo t de piridil amida.
ES2541107T3 (es) 2007-06-25 2015-07-16 Novartis Ag Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidindicarboxamida para su uso como inhibidores de renina
ATE494926T1 (de) 2008-03-25 2011-01-15 Affectis Pharmaceuticals Ag Neuartige p2x7r-antagonisten und ihre verwendung
EP2315987A2 (en) 2008-06-03 2011-05-04 Bsst Llc Thermoelectric heat pump
MX2011010810A (es) 2009-04-14 2012-01-12 Affectis Pharmaceuticals Ag Nuevos antagonistas de p2x7r y su uso.
WO2011054433A1 (en) * 2009-11-07 2011-05-12 Merck Patent Gmbh Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors
JPWO2012102297A1 (ja) * 2011-01-26 2014-06-30 杏林製薬株式会社 ピラゾロピリジン誘導体、またはその薬理学的に許容される塩
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
RS57919B1 (sr) * 2011-12-16 2019-01-31 Poseida Therapeutics Inc Trpc4 modulatori za primenu u lečenju ili prevenciji bola
RU2685234C1 (ru) * 2013-12-09 2019-04-17 Юсб Байофарма Спрл Конденсированные бициклические гетероароматические производные в качестве модуляторов активности tnf
GB201321739D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
BR112018001960A2 (pt) * 2015-08-03 2018-09-18 Bristol-Myers Squibb Company compostos heterocíclicos úteis como moduladores de tnf alfa
KR101772440B1 (ko) 2015-08-31 2017-08-30 한국식품연구원 4-(4-하이드록시-4-메틸펜틸)-3-사이클로-헥센-1-카복스알데하이드를 포함하는 신생혈관형성 촉진용 조성물
DK3860998T3 (da) 2018-10-05 2024-03-25 Annapurna Bio Inc Forbindelser og sammensætninger til behandlinger af tilstande, der er forbundet med APJ-receptoraktivitet
CN109439606B (zh) * 2018-11-14 2022-06-28 中国科学院青岛生物能源与过程研究所 一种提高间苯三酚产量的基因工程菌及其构建方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210079A (en) 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
WO1995026188A1 (en) * 1994-03-29 1995-10-05 Merck & Co., Inc. Treatment of atherosclerosis with angiotensin ii receptor blocking imidazoles
GB9929979D0 (en) * 1999-12-17 2000-02-09 Darwin Discovery Ltd Hydroxamic acid derivatives
BR0109467A (pt) 2000-03-17 2003-06-03 Bristol Myers Squibb Pharma Co Composto derivados de (beta)-aminoácidos cìclicos, composição farmacêutica, método de tratamento de condições ou doenças mediadas por mps, tnf, aggrecanase ou uma combinação destes em mamìferos e uso de composto
EP1373199A4 (en) * 2001-03-15 2004-04-07 Bristol Myers Squibb Pharma Co SPIROCYCLIC BETA-AMINOACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND THE CONVERSION ENZYME OF TNF-ALPHA (TAGE)

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