DE60318321T2 - Pyrazolopyridine als hemmstoffe cyclin abhängiger kinasen - Google Patents

Pyrazolopyridine als hemmstoffe cyclin abhängiger kinasen Download PDF

Info

Publication number
DE60318321T2
DE60318321T2 DE60318321T DE60318321T DE60318321T2 DE 60318321 T2 DE60318321 T2 DE 60318321T2 DE 60318321 T DE60318321 T DE 60318321T DE 60318321 T DE60318321 T DE 60318321T DE 60318321 T2 DE60318321 T2 DE 60318321T2
Authority
DE
Germany
Prior art keywords
alkyl
aryl
group
heteroaryl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60318321T
Other languages
German (de)
English (en)
Other versions
DE60318321D1 (en
Inventor
Michael P. Scotch Plains DWYER
Timothy J. Chatham GUZI
Kamil Garwood PARUCH
Ronald J. Convent Station DOLL
Kartik M. East Windsor KEERTIKAR
Viyyoor M. Parsippany GIRIJAVALLABHAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE60318321D1 publication Critical patent/DE60318321D1/de
Application granted granted Critical
Publication of DE60318321T2 publication Critical patent/DE60318321T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60318321T 2002-09-19 2003-09-17 Pyrazolopyridine als hemmstoffe cyclin abhängiger kinasen Expired - Lifetime DE60318321T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41213802P 2002-09-19 2002-09-19
US412138P 2002-09-19
PCT/US2003/029841 WO2004026872A1 (en) 2002-09-19 2003-09-17 Pyrazolopyridines as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60318321D1 DE60318321D1 (en) 2008-02-07
DE60318321T2 true DE60318321T2 (de) 2008-12-11

Family

ID=32030811

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318321T Expired - Lifetime DE60318321T2 (de) 2002-09-19 2003-09-17 Pyrazolopyridine als hemmstoffe cyclin abhängiger kinasen

Country Status (18)

Country Link
US (1) US7151104B2 (enExample)
EP (1) EP1539750B1 (enExample)
JP (1) JP4845380B2 (enExample)
KR (1) KR20050072090A (enExample)
CN (1) CN100475812C (enExample)
AR (1) AR041292A1 (enExample)
AT (1) ATE382048T1 (enExample)
AU (1) AU2003270846B2 (enExample)
CA (1) CA2499593C (enExample)
DE (1) DE60318321T2 (enExample)
ES (1) ES2297203T3 (enExample)
IL (1) IL167432A (enExample)
MX (1) MXPA05003059A (enExample)
MY (1) MY136840A (enExample)
NZ (1) NZ538595A (enExample)
TW (1) TWI283243B (enExample)
WO (1) WO2004026872A1 (enExample)
ZA (1) ZA200502271B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2496477C (en) 2002-08-23 2012-10-16 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP5117189B2 (ja) * 2004-08-27 2013-01-09 サイクラセル リミテッド プリン及びピリミジンｃｄｋ阻害剤、並びに自己免疫疾患の治療のためのそれらの使用
JP5106098B2 (ja) * 2005-02-28 2012-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド化合物の抗癌剤との新規併用
US20090047278A1 (en) * 2005-02-28 2009-02-19 Eisai R & D Management Co., Ltd. Novel Combinational Use of Sulfonamide Compound
US7304074B2 (en) * 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
KR20080002935A (ko) * 2005-04-07 2008-01-04 데이진 화-마 가부시키가이샤 피라졸로［1,5-ａ］피리딘 유도체 또는 그 의학상 허용되는염
US7417053B2 (en) 2005-04-07 2008-08-26 Teijin Pharma Limited Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof
CN101300233A (zh) 2005-09-09 2008-11-05 先灵公司 氮杂稠合的细胞周期蛋白依赖性激酶抑制剂
KR20090094336A (ko) * 2006-11-27 2009-09-04 하. 룬트벡 아크티에 셀스카브 헤테로아릴 아미드 유도체
KR20090031122A (ko) * 2007-09-21 2009-03-25 주식회사 중외제약 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물
FR2940284B1 (fr) * 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
AU2016243529B2 (en) * 2015-03-27 2021-03-25 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
EP3377908B1 (en) 2015-11-18 2020-08-05 Genzyme Corporation Biomarker of polycystic kidney disease and uses thereof
CN109790160B (zh) * 2016-09-07 2022-11-15 上海海和药物研究开发股份有限公司 吡啶并五元芳香环类化合物、其制备方法及用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091346B1 (en) 1995-11-01 2006-08-15 Novartis Ag Purine derivatives and processes for their preparation
ES2281941T3 (es) 1997-12-13 2007-10-01 Bristol-Myers Squibb Company Uso de pirazolo(3,4-b)piridina como inhibidores de quinasa dependiente de ciclina.
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
FR2801308B1 (fr) * 1999-11-19 2003-05-09 Oreal COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES
CN100356979C (zh) * 2000-02-03 2007-12-26 卫材R&D管理有限公司 整联蛋白表达抑制剂
WO2002050079A1 (fr) * 2000-12-20 2002-06-27 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3)
CZ20032398A3 (cs) * 2001-03-08 2004-02-18 Astrazeneca Ab Nové použití derivátů 6-karboxamidoimidazo [1,2-a] pyridinu
CN1202896C (zh) * 2002-02-07 2005-05-25 北京燕化高新技术股份有限公司 空气分离时纯化空气的方法

Also Published As

Publication number Publication date
ES2297203T3 (es) 2008-05-01
CA2499593C (en) 2011-08-16
TWI283243B (en) 2007-07-01
CN1681816A (zh) 2005-10-12
NZ538595A (en) 2006-04-28
CA2499593A1 (en) 2004-04-01
HK1071758A1 (en) 2005-07-29
IL167432A (en) 2010-05-17
ZA200502271B (en) 2005-09-19
EP1539750B1 (en) 2007-12-26
JP2006503060A (ja) 2006-01-26
KR20050072090A (ko) 2005-07-08
JP4845380B2 (ja) 2011-12-28
AU2003270846B2 (en) 2006-11-23
ATE382048T1 (de) 2008-01-15
DE60318321D1 (en) 2008-02-07
MXPA05003059A (es) 2005-05-27
AU2003270846A1 (en) 2004-04-08
AR041292A1 (es) 2005-05-11
EP1539750A1 (en) 2005-06-15
CN100475812C (zh) 2009-04-08
US20040097516A1 (en) 2004-05-20
MY136840A (en) 2008-11-28
US7151104B2 (en) 2006-12-19
WO2004026872A1 (en) 2004-04-01
TW200409775A (en) 2004-06-16

Similar Documents

Publication Publication Date Title
DE60317353T2 (de) Imidazopyrazine als cdk-inhibitoren
DE60317077T2 (de) Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen
DE60317529T2 (de) Imidazopyridine als hemmstoffe cyclin abhängiger kinasen
DE60313872T2 (de) Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen
DE60314427T2 (de) Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen
DE60318321T2 (de) Pyrazolopyridine als hemmstoffe cyclin abhängiger kinasen
US7186740B2 (en) Imidazopyrazines as cyclin dependent kinase inhibitors
EP1720883B1 (en) Pyrazolotriazines as kinase inhibitors
US20100143384A1 (en) NOVEL 4-CYANO, 4-AMINO, AND 4-AMINOMETHYL DERIVATIVES OF PYRAZOLO[1,5-a]PYRIDINES, PYRAZOLO[1,5-c]PYRIMIDINES AND 2H-INDAZOLE COMPOUNDS AND 5-CYANO, 5-AMINO, AND 5-AMINOMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES, AND IMIDAZO[1,5-a]PYRAZINES AS CYCLIN DEPENDENT KINASE INHIBITORS
AU2007200401A1 (en) Imidazopyrazines as cyclin dependent kinase inhibitors
HK1071758B (en) Pyrazolopyridines as cyclin dependent kinase inhibitors
HK1072056B (en) Imidazopyrazines as cyclin dependent kinase inhibitors

Legal Events

Date Code Title Description
8364 No opposition during term of opposition