ATE365717T1 - Acridin-derivate und deren verwendung als arzneimittel - Google Patents

Acridin-derivate und deren verwendung als arzneimittel

Info

Publication number
ATE365717T1
ATE365717T1 AT01969410T AT01969410T ATE365717T1 AT E365717 T1 ATE365717 T1 AT E365717T1 AT 01969410 T AT01969410 T AT 01969410T AT 01969410 T AT01969410 T AT 01969410T AT E365717 T1 ATE365717 T1 AT E365717T1
Authority
AT
Austria
Prior art keywords
medicinal products
acridine derivatives
acridine
derivatives
medicinal
Prior art date
Application number
AT01969410T
Other languages
German (de)
English (en)
Inventor
Peter Emig
Eckhard Guenther
Silke Baasner
Gerald Bacher
Thomas Beckers
Beate Aue
Bernd Nickel
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Application granted granted Critical
Publication of ATE365717T1 publication Critical patent/ATE365717T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01969410T 2000-07-21 2001-07-18 Acridin-derivate und deren verwendung als arzneimittel ATE365717T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10035927A DE10035927A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ATE365717T1 true ATE365717T1 (de) 2007-07-15

Family

ID=7649979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01969410T ATE365717T1 (de) 2000-07-21 2001-07-18 Acridin-derivate und deren verwendung als arzneimittel

Country Status (28)

Country Link
US (1) US6706722B2 (enExample)
EP (1) EP1301485B1 (enExample)
JP (1) JP2004504382A (enExample)
KR (1) KR20030022296A (enExample)
CN (1) CN1296359C (enExample)
AR (1) AR033383A1 (enExample)
AT (1) ATE365717T1 (enExample)
AU (2) AU2001289675B2 (enExample)
BG (1) BG107507A (enExample)
BR (1) BR0112591A (enExample)
CA (1) CA2353360A1 (enExample)
CY (1) CY1106890T1 (enExample)
CZ (1) CZ2003427A3 (enExample)
DE (2) DE10035927A1 (enExample)
DK (1) DK1301485T3 (enExample)
ES (1) ES2291349T3 (enExample)
HU (1) HUP0303729A3 (enExample)
IL (1) IL153476A0 (enExample)
MX (1) MXPA02012564A (enExample)
NO (1) NO324939B1 (enExample)
NZ (1) NZ524155A (enExample)
PL (1) PL358808A1 (enExample)
PT (1) PT1301485E (enExample)
RU (1) RU2267488C2 (enExample)
SK (1) SK1932003A3 (enExample)
UA (1) UA75085C2 (enExample)
WO (1) WO2002008194A1 (enExample)
ZA (1) ZA200210411B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
UA79286C2 (en) * 2002-06-29 2007-06-11 Zentaris Gmbh Arylcarbonylpipererazines and heteroarylcarbonylpiperazines and their use in the treatment of benign and malignant tumors
EP1521748A1 (de) * 2002-07-17 2005-04-13 Zentaris GmbH Neue anthracen-derivate und deren verwendung als arzneimittel
US7125461B2 (en) * 2003-05-07 2006-10-24 L & L Products, Inc. Activatable material for sealing, baffling or reinforcing and method of forming same
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
PE20050226A1 (es) * 2003-06-04 2005-05-18 Aventis Pharma Sa Productos aril-heteroaromaticos y composiciones que los contienen
US7249415B2 (en) * 2003-06-26 2007-07-31 Zephyros, Inc. Method of forming members for sealing or baffling
DE10331500A1 (de) * 2003-07-11 2005-02-24 Zentaris Gmbh Neue Acridin-Derivate und deren Verwendung als Arzneimittel
US20070299093A1 (en) * 2005-01-27 2007-12-27 Alma Mater Studiorum-Universitá Di Bologna Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
CA2595994A1 (en) * 2005-01-27 2006-08-03 Alma Mater Studiorum - Universita' Di Bologna Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation
CA2678577A1 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
JP5470557B2 (ja) * 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2009117109A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
US8242111B2 (en) * 2008-05-01 2012-08-14 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
EP2291370B1 (en) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
RU2531272C2 (ru) 2008-05-01 2014-10-20 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
GEP20156309B (en) * 2009-04-30 2015-07-10 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
WO2012059416A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
EP0318235A3 (en) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof
US5030631A (en) * 1989-11-27 1991-07-09 Schering Corporation Tricylclic arylsulfonamides
RU2126001C1 (ru) * 1995-01-10 1999-02-10 Самдзин Фармасьютикал Ко., Лтд Производные пиперазина и фармацевтическая композиция на их основе
SK27598A3 (en) * 1996-06-29 1998-11-04 Samjin Pharm Co Ltd Piperazine derivatives and process for the preparation thereof
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
FR2753706B1 (fr) 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
MXPA01002173A (es) 1998-08-28 2003-07-14 Scios Inc Inhibidores de p38-alfa cinasa.
AU3248600A (en) 1999-03-03 2000-09-21 Merck & Co., Inc. Inhibitors of prenyl-protein transferases

Also Published As

Publication number Publication date
DK1301485T3 (da) 2007-11-05
BG107507A (bg) 2003-09-30
KR20030022296A (ko) 2003-03-15
JP2004504382A (ja) 2004-02-12
WO2002008194A8 (de) 2003-05-08
CN1296359C (zh) 2007-01-24
US20020132821A1 (en) 2002-09-19
NZ524155A (en) 2005-04-29
CY1106890T1 (el) 2012-09-26
NO20030301L (no) 2003-03-11
DE50112669D1 (de) 2007-08-09
AU8967501A (en) 2002-02-05
AR033383A1 (es) 2003-12-17
SK1932003A3 (en) 2003-10-07
ES2291349T3 (es) 2008-03-01
CZ2003427A3 (cs) 2003-06-18
CN1443172A (zh) 2003-09-17
WO2002008194A1 (de) 2002-01-31
CA2353360A1 (en) 2002-01-21
BR0112591A (pt) 2003-07-22
AU2001289675B2 (en) 2005-04-07
NO20030301D0 (no) 2003-01-20
HUP0303729A3 (en) 2009-01-28
UA75085C2 (en) 2006-03-15
RU2267488C2 (ru) 2006-01-10
HK1057549A1 (en) 2004-04-08
ZA200210411B (en) 2003-02-26
PT1301485E (pt) 2007-08-30
DE10035927A1 (de) 2002-03-07
EP1301485B1 (de) 2007-06-27
HUP0303729A2 (hu) 2004-03-01
MXPA02012564A (es) 2003-09-22
PL358808A1 (en) 2004-08-23
IL153476A0 (en) 2003-07-06
NO324939B1 (no) 2008-01-07
US6706722B2 (en) 2004-03-16
EP1301485A1 (de) 2003-04-16

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Legal Events

Date Code Title Description
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee