DK1301485T3 - Nye heteroaryl-derivater og disses anvendelse som lægemiddel - Google Patents

Nye heteroaryl-derivater og disses anvendelse som lægemiddel

Info

Publication number
DK1301485T3
DK1301485T3 DK01969410T DK01969410T DK1301485T3 DK 1301485 T3 DK1301485 T3 DK 1301485T3 DK 01969410 T DK01969410 T DK 01969410T DK 01969410 T DK01969410 T DK 01969410T DK 1301485 T3 DK1301485 T3 DK 1301485T3
Authority
DK
Denmark
Prior art keywords
drug
heteroaryl derivatives
new heteroaryl
new
derivatives
Prior art date
Application number
DK01969410T
Other languages
Danish (da)
English (en)
Inventor
Peter Emig
Eckhard Guenther
Silke Baasner
Gerald Bacher
Thomas Beckers
Beate Aue
Bernd Nickel
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Application granted granted Critical
Publication of DK1301485T3 publication Critical patent/DK1301485T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK01969410T 2000-07-21 2001-07-18 Nye heteroaryl-derivater og disses anvendelse som lægemiddel DK1301485T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035927A DE10035927A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
PCT/EP2001/008263 WO2002008194A1 (de) 2000-07-21 2001-07-18 Acridin-derivate und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DK1301485T3 true DK1301485T3 (da) 2007-11-05

Family

ID=7649979

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01969410T DK1301485T3 (da) 2000-07-21 2001-07-18 Nye heteroaryl-derivater og disses anvendelse som lægemiddel

Country Status (28)

Country Link
US (1) US6706722B2 (enExample)
EP (1) EP1301485B1 (enExample)
JP (1) JP2004504382A (enExample)
KR (1) KR20030022296A (enExample)
CN (1) CN1296359C (enExample)
AR (1) AR033383A1 (enExample)
AT (1) ATE365717T1 (enExample)
AU (2) AU8967501A (enExample)
BG (1) BG107507A (enExample)
BR (1) BR0112591A (enExample)
CA (1) CA2353360A1 (enExample)
CY (1) CY1106890T1 (enExample)
CZ (1) CZ2003427A3 (enExample)
DE (2) DE10035927A1 (enExample)
DK (1) DK1301485T3 (enExample)
ES (1) ES2291349T3 (enExample)
HU (1) HUP0303729A3 (enExample)
IL (1) IL153476A0 (enExample)
MX (1) MXPA02012564A (enExample)
NO (1) NO324939B1 (enExample)
NZ (1) NZ524155A (enExample)
PL (1) PL358808A1 (enExample)
PT (1) PT1301485E (enExample)
RU (1) RU2267488C2 (enExample)
SK (1) SK1932003A3 (enExample)
UA (1) UA75085C2 (enExample)
WO (1) WO2002008194A1 (enExample)
ZA (1) ZA200210411B (enExample)

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DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
HRP20050092A2 (en) * 2002-06-29 2005-02-28 Zentaris Gmbh Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases
WO2004007470A1 (de) * 2002-07-17 2004-01-22 Zentaris Gmbh Neue anthracen-derivate und deren verwendung als arzneimittel
US7125461B2 (en) * 2003-05-07 2006-10-24 L & L Products, Inc. Activatable material for sealing, baffling or reinforcing and method of forming same
AR044586A1 (es) * 2003-06-04 2005-09-21 Aventis Pharma Sa Productos aril - heteroaromaticos, composiciones que los contienen y su utilizacion
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
US7249415B2 (en) * 2003-06-26 2007-07-31 Zephyros, Inc. Method of forming members for sealing or baffling
DE10331500A1 (de) * 2003-07-11 2005-02-24 Zentaris Gmbh Neue Acridin-Derivate und deren Verwendung als Arzneimittel
AU2006209079A1 (en) * 2005-01-27 2006-08-03 Alma Mater Studiorum-Universita' Di Bologna Organic compounds useful for the treatment of Alzheimer's disease, their use and method of preparation
US20070299093A1 (en) * 2005-01-27 2007-12-27 Alma Mater Studiorum-Universitá Di Bologna Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
US8835426B2 (en) * 2007-02-26 2014-09-16 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5470557B2 (ja) * 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
CA2715290A1 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
CA2723032A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2300461B1 (en) * 2008-05-01 2013-04-17 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2723039A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
PL2324018T3 (pl) 2008-07-25 2014-02-28 Boehringer Ingelheim Int Cykliczne inhibitory dehydrogenazy 11 beta-hydroksysteroidowej typu 1
WO2010127237A2 (en) * 2009-04-30 2010-11-04 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
CN103179960A (zh) 2010-11-02 2013-06-26 贝林格尔.英格海姆国际有限公司 治疗代谢疾病的药物组合

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FR2538388B1 (fr) 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
EP0318235A3 (en) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof
US5030631A (en) * 1989-11-27 1991-07-09 Schering Corporation Tricylclic arylsulfonamides
RU2126001C1 (ru) * 1995-01-10 1999-02-10 Самдзин Фармасьютикал Ко., Лтд Производные пиперазина и фармацевтическая композиция на их основе
ATE241600T1 (de) * 1996-06-29 2003-06-15 Samjin Pharm Co Ltd Piperazin-derivate und verfahren zu ihrer herstellung
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
FR2753706B1 (fr) 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
CA2342251A1 (en) 1998-08-28 2000-03-09 Scios Inc. Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase
WO2000051614A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferases

Also Published As

Publication number Publication date
NO20030301L (no) 2003-03-11
NO20030301D0 (no) 2003-01-20
UA75085C2 (en) 2006-03-15
BR0112591A (pt) 2003-07-22
US6706722B2 (en) 2004-03-16
DE50112669D1 (de) 2007-08-09
EP1301485A1 (de) 2003-04-16
JP2004504382A (ja) 2004-02-12
ZA200210411B (en) 2003-02-26
HUP0303729A2 (hu) 2004-03-01
HUP0303729A3 (en) 2009-01-28
CA2353360A1 (en) 2002-01-21
RU2267488C2 (ru) 2006-01-10
WO2002008194A8 (de) 2003-05-08
NZ524155A (en) 2005-04-29
ES2291349T3 (es) 2008-03-01
CY1106890T1 (el) 2012-09-26
CN1296359C (zh) 2007-01-24
AU2001289675B2 (en) 2005-04-07
CN1443172A (zh) 2003-09-17
DE10035927A1 (de) 2002-03-07
IL153476A0 (en) 2003-07-06
WO2002008194A1 (de) 2002-01-31
AU8967501A (en) 2002-02-05
KR20030022296A (ko) 2003-03-15
US20020132821A1 (en) 2002-09-19
PT1301485E (pt) 2007-08-30
HK1057549A1 (en) 2004-04-08
MXPA02012564A (es) 2003-09-22
PL358808A1 (en) 2004-08-23
NO324939B1 (no) 2008-01-07
BG107507A (bg) 2003-09-30
ATE365717T1 (de) 2007-07-15
CZ2003427A3 (cs) 2003-06-18
EP1301485B1 (de) 2007-06-27
SK1932003A3 (en) 2003-10-07
AR033383A1 (es) 2003-12-17

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