ATE349209T1 - Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren - Google Patents

Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren

Info

Publication number
ATE349209T1
ATE349209T1 AT02787554T AT02787554T ATE349209T1 AT E349209 T1 ATE349209 T1 AT E349209T1 AT 02787554 T AT02787554 T AT 02787554T AT 02787554 T AT02787554 T AT 02787554T AT E349209 T1 ATE349209 T1 AT E349209T1
Authority
AT
Austria
Prior art keywords
pde4
inhibitors
production
naphthyridine derivatives
phosphodiesterase isoenzyme
Prior art date
Application number
AT02787554T
Other languages
English (en)
Inventor
Alastair Denholm
Thomas H Keller
Clive Mccarthy
Neil J Press
Roger J Taylor
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0126511A external-priority patent/GB0126511D0/en
Priority claimed from GB0209882A external-priority patent/GB0209882D0/en
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE349209T1 publication Critical patent/ATE349209T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/12—Antihypertensives

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  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Pulmonology (AREA)
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  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
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  • Obesity (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
AT02787554T 2001-11-05 2002-11-04 Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren ATE349209T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0126511A GB0126511D0 (en) 2001-11-05 2001-11-05 Organic compounds
GB0209882A GB0209882D0 (en) 2002-04-30 2002-04-30 Organic compounds

Publications (1)

Publication Number Publication Date
ATE349209T1 true ATE349209T1 (de) 2007-01-15

Family

ID=26246741

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02787554T ATE349209T1 (de) 2001-11-05 2002-11-04 Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren

Country Status (26)

Country Link
US (1) US7273875B2 (de)
EP (1) EP1443925B8 (de)
JP (1) JP4150672B2 (de)
KR (1) KR100623548B1 (de)
CN (1) CN1298324C (de)
AR (1) AR037517A1 (de)
AT (1) ATE349209T1 (de)
BR (1) BR0213877A (de)
CA (1) CA2462211C (de)
CY (1) CY1107532T1 (de)
DE (1) DE60217160T2 (de)
DK (1) DK1443925T3 (de)
ES (1) ES2275935T3 (de)
HK (1) HK1069970A1 (de)
HU (1) HUP0402311A3 (de)
IL (2) IL161257A0 (de)
MX (1) MXPA04004264A (de)
MY (1) MY130622A (de)
NO (1) NO329093B1 (de)
NZ (1) NZ532586A (de)
PE (1) PE20030535A1 (de)
PL (1) PL368286A1 (de)
PT (1) PT1443925E (de)
RU (1) RU2296764C2 (de)
TW (1) TWI320784B (de)
WO (1) WO2003039544A1 (de)

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US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
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GEP201706639B (en) 2009-08-17 2017-03-27 Intellikine Llc Heterocyclic compounds and uses thereof
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US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
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US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
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US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
EP2673277A1 (de) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4] triazolo [4, 3]pyridazinverbindungen als inhibitoren dec-met-tyrosinkinase
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NO329093B1 (no) 2010-08-23
DE60217160T2 (de) 2007-10-04
DE60217160D1 (de) 2007-02-08
BR0213877A (pt) 2004-08-31
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