ATE337301T1 - Substituierte imide als tnf inhibitoren - Google Patents

Substituierte imide als tnf inhibitoren

Info

Publication number
ATE337301T1
ATE337301T1 AT95940847T AT95940847T ATE337301T1 AT E337301 T1 ATE337301 T1 AT E337301T1 AT 95940847 T AT95940847 T AT 95940847T AT 95940847 T AT95940847 T AT 95940847T AT E337301 T1 ATE337301 T1 AT E337301T1
Authority
AT
Austria
Prior art keywords
tnf inhibitors
substituted imides
imides
inhibitors
substituted
Prior art date
Application number
AT95940847T
Other languages
English (en)
Inventor
George Muller
Mary Shire
David I Stirling
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of ATE337301T1 publication Critical patent/ATE337301T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
AT95940847T 1994-12-30 1995-11-20 Substituierte imide als tnf inhibitoren ATE337301T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/366,679 US6429221B1 (en) 1994-12-30 1994-12-30 Substituted imides

Publications (1)

Publication Number Publication Date
ATE337301T1 true ATE337301T1 (de) 2006-09-15

Family

ID=23444039

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95940847T ATE337301T1 (de) 1994-12-30 1995-11-20 Substituierte imide als tnf inhibitoren

Country Status (19)

Country Link
US (3) US6429221B1 (de)
EP (1) EP0800514B1 (de)
JP (1) JP4118329B2 (de)
KR (2) KR100466838B1 (de)
AT (1) ATE337301T1 (de)
AU (1) AU709719B2 (de)
CA (1) CA2208671C (de)
CZ (1) CZ203697A3 (de)
DE (1) DE69535195T2 (de)
DK (1) DK0800514T3 (de)
ES (1) ES2271948T3 (de)
FI (1) FI972709A7 (de)
HU (1) HUT77124A (de)
NZ (1) NZ297324A (de)
PL (1) PL185361B1 (de)
PT (1) PT800514E (de)
RU (1) RU2162078C2 (de)
SK (1) SK86897A3 (de)
WO (1) WO1996020926A1 (de)

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BR0316256A (pt) * 2002-11-18 2005-10-04 Celgene Corp Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto
CA2511843C (en) * 2002-12-30 2012-04-24 Celgene Corporation Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses
US20040175382A1 (en) * 2003-03-06 2004-09-09 Schafer Peter H. Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
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JP2008518924A (ja) * 2004-10-28 2008-06-05 セルジーン・コーポレーション 中枢神経系損傷の治療及び管理のためのｐｄｅ４モジュレータを使用する方法及び組成物
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Also Published As

Publication number Publication date
FI972709L (fi) 1997-08-29
FI972709A0 (fi) 1997-06-23
NZ297324A (en) 2000-03-27
SK86897A3 (en) 1998-01-14
JP4118329B2 (ja) 2008-07-16
US20050090516A1 (en) 2005-04-28
CA2208671A1 (en) 1996-07-11
JPH10511946A (ja) 1998-11-17
US6844359B2 (en) 2005-01-18
US20020143027A1 (en) 2002-10-03
PL185361B1 (pl) 2003-04-30
CZ203697A3 (en) 1997-11-12
FI972709A7 (fi) 1997-08-29
DE69535195T2 (de) 2007-07-12
PL321065A1 (en) 1997-11-24
HK1004674A1 (en) 1998-12-04
RU2162078C2 (ru) 2001-01-20
EP0800514B1 (de) 2006-08-23
CA2208671C (en) 2009-02-10
DK0800514T3 (da) 2006-12-27
WO1996020926A1 (en) 1996-07-11
KR980700968A (ko) 1998-04-30
AU4246396A (en) 1996-07-24
PT800514E (pt) 2006-12-29
US7329761B2 (en) 2008-02-12
KR100466838B1 (ko) 2005-09-02
ES2271948T3 (es) 2007-04-16
EP0800514A1 (de) 1997-10-15
DE69535195D1 (de) 2006-10-05
US6429221B1 (en) 2002-08-06
AU709719B2 (en) 1999-09-02
KR20040007729A (ko) 2004-01-24
HUT77124A (hu) 1998-03-02

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