DK1308444T3 - Substitueret 2(2,6 dioxo-3-fluorpiperidin-3-yl)-isoindoliner og deres anvendelse til reduktion af TNFalfa-niveau'er - Google Patents

Substitueret 2(2,6 dioxo-3-fluorpiperidin-3-yl)-isoindoliner og deres anvendelse til reduktion af TNFalfa-niveau'er

Info

Publication number
DK1308444T3
DK1308444T3 DK02028237T DK02028237T DK1308444T3 DK 1308444 T3 DK1308444 T3 DK 1308444T3 DK 02028237 T DK02028237 T DK 02028237T DK 02028237 T DK02028237 T DK 02028237T DK 1308444 T3 DK1308444 T3 DK 1308444T3
Authority
DK
Denmark
Prior art keywords
dioxo
fluoropiperidin
isoindolines
levels
tnfalfa
Prior art date
Application number
DK02028237T
Other languages
English (en)
Inventor
Hon-Wah Man
George W Muller
David I Stirling
Roger Shen-Chu Chen
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/976,140 external-priority patent/US5874448A/en
Priority claimed from US09/042,274 external-priority patent/US5955476A/en
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of DK1308444T3 publication Critical patent/DK1308444T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK02028237T 1997-11-18 1998-11-17 Substitueret 2(2,6 dioxo-3-fluorpiperidin-3-yl)-isoindoliner og deres anvendelse til reduktion af TNFalfa-niveau'er DK1308444T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/976,140 US5874448A (en) 1997-11-18 1997-11-18 Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
US09/042,274 US5955476A (en) 1997-11-18 1998-03-13 Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
EP98958016A EP1062214B1 (en) 1997-11-18 1998-11-17 Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and their use to reduce tnfa levels

Publications (1)

Publication Number Publication Date
DK1308444T3 true DK1308444T3 (da) 2006-09-18

Family

ID=26719049

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02028237T DK1308444T3 (da) 1997-11-18 1998-11-17 Substitueret 2(2,6 dioxo-3-fluorpiperidin-3-yl)-isoindoliner og deres anvendelse til reduktion af TNFalfa-niveau'er

Country Status (14)

Country Link
EP (3) EP1062214B1 (da)
AT (2) ATE233753T1 (da)
AU (1) AU752958B2 (da)
CY (1) CY1106100T1 (da)
CZ (1) CZ299808B6 (da)
DE (2) DE69834668T2 (da)
DK (1) DK1308444T3 (da)
ES (2) ES2262753T3 (da)
FI (1) FI20001192A (da)
HK (1) HK1054381B (da)
NO (1) NO318737B1 (da)
PT (1) PT1308444E (da)
SI (1) SI1308444T1 (da)
SK (1) SK7382000A3 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200101503T2 (tr) * 1998-03-16 2002-06-21 Celgene Corporation 2-(2,6-dioksopiperidin-3-il) izoindolin türevleri, bunların hazırlanması ve enflamatuar sitokinlerin inhibitörleri olarak kullanımı
US20050100529A1 (en) * 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014455A1 (en) * 1991-02-14 1992-09-03 The Rockefeller University METHOD FOR CONTROLLING ABNORMAL CONCENTRATION TNF α IN HUMAN TISSUES
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
DE4422237A1 (de) * 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
EP2070920B8 (en) * 1996-07-24 2011-04-27 Celgene Corporation Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines and method of reducing TNF alpha levels

Also Published As

Publication number Publication date
CZ20001822A3 (cs) 2000-11-15
CY1106100T1 (el) 2011-06-08
SI1308444T1 (sl) 2007-04-30
EP1062214A1 (en) 2000-12-27
DE69811962T2 (de) 2003-08-28
EP1710242A1 (en) 2006-10-11
PT1308444E (pt) 2006-08-31
ATE233753T1 (de) 2003-03-15
NO20002529D0 (no) 2000-05-16
HK1054381B (zh) 2006-10-13
EP1308444A1 (en) 2003-05-07
AU1413899A (en) 1999-09-27
ATE327228T1 (de) 2006-06-15
NO318737B1 (no) 2005-05-02
DE69811962D1 (de) 2003-04-10
EP1308444B1 (en) 2006-05-24
AU752958B2 (en) 2002-10-03
ES2262753T3 (es) 2006-12-01
HK1054381A1 (en) 2003-11-28
FI20001192A (fi) 2000-07-14
DE69834668D1 (de) 2006-06-29
DE69834668T2 (de) 2007-01-11
NO20002529L (no) 2000-06-30
CZ299808B6 (cs) 2008-12-03
EP1062214B1 (en) 2003-03-05
SK7382000A3 (en) 2000-12-11
ES2192342T3 (es) 2003-10-01

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