DK2305248T3 - Substituerede phenethylsulfoner og fremgangsmåde til reduktion af tnf-alfa-niveauer - Google Patents

Substituerede phenethylsulfoner og fremgangsmåde til reduktion af tnf-alfa-niveauer

Info

Publication number
DK2305248T3
DK2305248T3 DK10166855.6T DK10166855T DK2305248T3 DK 2305248 T3 DK2305248 T3 DK 2305248T3 DK 10166855 T DK10166855 T DK 10166855T DK 2305248 T3 DK2305248 T3 DK 2305248T3
Authority
DK
Denmark
Prior art keywords
alpha levels
reducing tnf
substituted phenethylsulfones
phenethylsulfones
alpha
Prior art date
Application number
DK10166855.6T
Other languages
English (en)
Inventor
George W Muller
Hon-Wah Man
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of DK2305248T3 publication Critical patent/DK2305248T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DK10166855.6T 1998-10-30 1999-10-19 Substituerede phenethylsulfoner og fremgangsmåde til reduktion af tnf-alfa-niveauer DK2305248T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/183,049 US6020358A (en) 1998-10-30 1998-10-30 Substituted phenethylsulfones and method of reducing TNFα levels
EP06023050A EP1752148B1 (en) 1998-10-30 1999-10-19 Substituted phenethylsulfones for the treatment of inflammatory, infectious, immunological or malignant disease

Publications (1)

Publication Number Publication Date
DK2305248T3 true DK2305248T3 (da) 2013-07-29

Family

ID=22671217

Family Applications (3)

Application Number Title Priority Date Filing Date
DK06023050.5T DK1752148T3 (da) 1998-10-30 1999-10-19 Substituerede phenethylsulfoner til behandling af inflammatorisk, infektiøs, immunologisk eller ondartet lidelse
DK10166855.6T DK2305248T3 (da) 1998-10-30 1999-10-19 Substituerede phenethylsulfoner og fremgangsmåde til reduktion af tnf-alfa-niveauer
DK99971317T DK1126839T3 (da) 1998-10-30 1999-10-19 Substituerede phenethylsulfoner og fremgangsmåde til reduktion af niveauerne af TNF-alfa og PDE-IV

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK06023050.5T DK1752148T3 (da) 1998-10-30 1999-10-19 Substituerede phenethylsulfoner til behandling af inflammatorisk, infektiøs, immunologisk eller ondartet lidelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK99971317T DK1126839T3 (da) 1998-10-30 1999-10-19 Substituerede phenethylsulfoner og fremgangsmåde til reduktion af niveauerne af TNF-alfa og PDE-IV

Country Status (16)

Country Link
US (2) US6020358A (da)
EP (3) EP1126839B1 (da)
JP (1) JP4530543B2 (da)
AT (2) ATE350033T1 (da)
AU (1) AU756308B2 (da)
BR (2) BRPI9915201B8 (da)
CA (1) CA2348993C (da)
CY (3) CY1107499T1 (da)
DE (2) DE69934708T2 (da)
DK (3) DK1752148T3 (da)
ES (3) ES2421153T3 (da)
HK (2) HK1038696B (da)
NO (1) NO319790B1 (da)
NZ (1) NZ511253A (da)
PT (3) PT1126839E (da)
WO (1) WO2000025777A1 (da)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6429221B1 (en) * 1994-12-30 2002-08-06 Celgene Corporation Substituted imides
US6518281B2 (en) * 1995-08-29 2003-02-11 Celgene Corporation Immunotherapeutic agents
TW432073B (en) * 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
EP1361210B1 (en) * 1996-08-12 2008-12-24 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
US6673828B1 (en) * 1998-05-11 2004-01-06 Children's Medical Center Corporation Analogs of 2-Phthalimidinoglutaric acid
US7629360B2 (en) * 1999-05-07 2009-12-08 Celgene Corporation Methods for the treatment of cachexia and graft v. host disease
US6667316B1 (en) * 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
US7182953B2 (en) * 1999-12-15 2007-02-27 Celgene Corporation Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders
US6326388B1 (en) 1999-12-21 2001-12-04 Celgene Corporation Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
US6699899B1 (en) * 1999-12-21 2004-03-02 Celgene Corporation Substituted acylhydroxamic acids and method of reducing TNFα levels
MXPA02009665A (es) * 2000-03-31 2005-09-08 Celgene Corp Inhibicion de actividad de ciclooxigenasa-2.
US8030343B2 (en) 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
WO2002064083A2 (en) * 2000-11-30 2002-08-22 The Children's Medical Center Corporation Synthesis of 3-amino-thalidomide and its enantiomers
US7091353B2 (en) * 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
US7491634B2 (en) * 2006-04-28 2009-02-17 Asm International N.V. Methods for forming roughened surfaces and applications thereof
US7276529B2 (en) * 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7208516B2 (en) * 2002-03-20 2007-04-24 Celgene Corporation Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
CN1965823B (zh) * 2002-03-20 2010-05-12 细胞基因公司 (+)-2-[1-(3-乙氧基-4-甲氧基苯基)-2-甲磺酰基乙基]-4-乙酰氨基异吲哚啉-1,3-二酮、其合成方法及其组合物
AU2003222034A1 (en) * 2002-03-20 2003-10-08 Celgene Corporation (-)-2-(1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl)-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
US20050118715A1 (en) * 2002-04-12 2005-06-02 Hariri Robert J. Modulation of stem and progenitor cell differentiation, assays, and uses thereof
NZ536050A (en) 2002-04-12 2007-11-30 Celgene Corp Methods of identifying modulators of angiogenesis using stem cells with the proviso the stems cells are not totipotent
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US20100129363A1 (en) * 2002-05-17 2010-05-27 Zeldis Jerome B Methods and compositions using pde4 inhibitors for the treatment and management of cancers
USRE48890E1 (en) 2002-05-17 2022-01-11 Celgene Corporation Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
US7393862B2 (en) * 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
KR101059041B1 (ko) * 2002-05-17 2011-08-24 셀진 코포레이션 암과 다른 질병의 치료 및 처리를 위한 선택적 사이토카인억제 약물을 사용하는 방법 및 조성물
DE60331537D1 (de) * 2002-05-17 2010-04-15 Celgene Corp Kombinationen zur behandlung von multiplem myelom
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
WO2004004834A1 (en) * 2002-07-02 2004-01-15 Qlt Inc. Compounds and methods for treating cancer and inflammation
US7189740B2 (en) * 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
US8404717B2 (en) * 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes using lenalidomide
US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US8404716B2 (en) * 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
MXPA05003889A (es) * 2002-10-15 2005-06-22 Celgene Corp Farmacos inhibidores de citosina selectiva para tratar sindrome mielodisplastico.
US20040087558A1 (en) * 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
US20050203142A1 (en) * 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US7776907B2 (en) * 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
NZ540185A (en) * 2002-10-31 2008-01-31 Celgene Corp Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment and management of macular degeneration
TW200501945A (en) 2002-11-06 2005-01-16 Celgene Corp Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
MXPA05004777A (es) * 2002-11-06 2005-07-22 Celgene Corp Metodos de uso y composiciones que comprenden farmacos inhibidores selectivos de citocina para el tratamiento y el manejo de padecimientos mieloproliferativos.
BR0316256A (pt) * 2002-11-18 2005-10-04 Celgene Corp Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto
EP1581205A1 (en) * 2002-11-18 2005-10-05 Celgene Corporation Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
DE60330187D1 (de) * 2002-12-30 2009-12-31 Celgene Corp Fluoralkoxy-substituierte 1, 3-dihydro-isoindolyl-verbindungen und ihre pharmazeutischen verwendungen
EP1601358B1 (en) * 2003-03-03 2007-12-19 F. Hoffmann-La Roche Ag 2,5-substituted tetrahydroisoquinolines for use as 5-ht6 modulators
BRPI0408113A (pt) * 2003-03-06 2006-03-01 Celgene Corp métodos para tratar ou prevenir um distúrbio do sistema nervoso central, para controlar um distúrbio do sistema nervoso central e para reduzir ou evitar um efeito adverso associado com a administração de um ingrediente ativo secundário em um paciente que sofre de um distúrbio do sistema nervoso central, e, composição farmacêutica
US20040175382A1 (en) * 2003-03-06 2004-09-09 Schafer Peter H. Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
BRPI0408223A (pt) * 2003-03-12 2006-03-01 Celgene Corp composto, isÈmeros, composição farmacêutica, e, métodos de inibir pde4 e mmp, de modular a produção de tnf-alfa em um mamìfero e de tratar, previnir ou controlar uma doença ou condição
AU2004251717B2 (en) * 2003-06-23 2010-03-11 Bellus Health (International) Limited Treatment of amyloid- and epileptogenesis-associated diseases
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
UA83504C2 (en) * 2003-09-04 2008-07-25 Селджин Корпорейшн Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
CA2543132A1 (en) * 2003-10-23 2005-05-19 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
AP2006003637A0 (en) * 2003-11-06 2006-06-30 Celgene Corp Methods and compositions using thalidomide for thetreatment and management of cancers and other diseases
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
NZ547689A (en) 2003-11-19 2009-05-31 Signal Pharm Llc Indazole compounds and methods of use thereof as protein kinase inhibitors
WO2005055929A2 (en) * 2003-12-02 2005-06-23 Celgene Corporation Methods and compositions for the treatment and management of hemoglobinopathy and anemia
AU2004319758A1 (en) * 2004-04-14 2005-11-24 Celgene Corporation Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
CN1972686A (zh) * 2004-04-14 2007-05-30 细胞基因公司 选择性细胞因子抑制药在髓发育不良综合征中的用途
AU2005234783A1 (en) * 2004-04-23 2005-11-03 Celgene Corporation Methods of using and compositions comprising PDE4 modulators for the treatment and management of pulmonary hypertension
AU2004319814A1 (en) * 2004-05-05 2005-12-01 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
US20070190070A1 (en) * 2004-09-03 2007-08-16 Zeldis Jerome B Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
MX2007005040A (es) 2004-10-28 2007-06-19 Celgene Corp Metodos y composiciones usando moduladores de pde4 para el tratamiento y manejo de lesion al sistema nervioso central.
JP2008523102A (ja) * 2004-12-13 2008-07-03 セルジーン・コーポレーション Ｐｄｅ４モジュレーターを含有する組成物及び気道炎症の治療又は予防のためのそれらの使用
US20060270707A1 (en) * 2005-05-24 2006-11-30 Zeldis Jerome B Methods and compositions using 4-[(cyclopropanecarbonylamino)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione for the treatment or prevention of cutaneous lupus
US20080138295A1 (en) * 2005-09-12 2008-06-12 Celgene Coporation Bechet's disease using cyclopropyl-N-carboxamide
US20070155791A1 (en) * 2005-12-29 2007-07-05 Zeldis Jerome B Methods for treating cutaneous lupus using aminoisoindoline compounds
TW200804347A (en) 2006-01-10 2008-01-16 Janssen Pharmaceutica Nv Urotensin II receptor antagonists
CN101522197B (zh) 2006-07-31 2013-12-11 詹森药业有限公司 尾加压素ⅱ受体拮抗剂
CL2007002218A1 (es) * 2006-08-03 2008-03-14 Celgene Corp Soc Organizada Ba Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
PA8782701A1 (es) * 2007-06-07 2009-01-23 Janssen Pharmaceutica Nv Antagonistas del receptor de urotensina ii
US7893045B2 (en) 2007-08-07 2011-02-22 Celgene Corporation Methods for treating lymphomas in certain patient populations and screening patients for said therapy
CN102036663A (zh) * 2008-03-24 2011-04-27 细胞基因公司 用环丙基-n-{2-[(1s)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲磺酰基)乙基]-3-氧代异吲哚啉-4基}甲酰胺治疗银屑病或者银屑病关节炎
EP2687213B1 (en) 2008-03-27 2019-01-23 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
CA2718601A1 (en) 2008-03-27 2009-10-01 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
WO2010017105A1 (en) * 2008-08-02 2010-02-11 Janssen Pharmaceutica N.V. Urotensin ii receptor antagonists
EP2334639B1 (en) * 2008-09-10 2013-01-23 Celgene Corporation Processes for the preparation of aminosulfone compounds
PE20151143A1 (es) 2009-02-10 2015-08-07 Celgene Corp Metodos para utilizar y composiciones que comprenden moduladores pde4 para tratamiento, prevencion y control de tuberculosis
WO2010130224A1 (zh) 2009-05-14 2010-11-18 天津和美生物技术有限公司 噻吩衍生物
PL2443089T3 (pl) * 2009-06-18 2014-09-30 Concert Pharmaceuticals Inc Deuterowane pochodne izoindolino-1,3-dionu jako inhibitory pde4 i tnf-alfa
MY183201A (en) 2009-10-09 2021-02-18 Celgene Corp Processes for the preparation of 2-(1-phenylethyl)isoindolin-1-one compounds
JP5937060B2 (ja) 2010-04-07 2016-06-22 セルジーン コーポレイション 呼吸器ウイルス感染症の治療方法
MX341896B (es) 2010-06-15 2016-09-07 Celgene Corp * Biomarcadores para el tratamiento de psoriasis.
WO2012083153A1 (en) * 2010-12-16 2012-06-21 Nektar Therapeutics Oligomer-containing apremilast moiety compounds
CN102558022B (zh) * 2010-12-22 2016-06-15 康塞特医药品有限公司 取代的异吲哚啉-1,3二酮衍生物
US8853175B2 (en) 2011-01-10 2014-10-07 Celgene Corporation Phenethylsulfone isoindoline derivatives and their use
WO2012097116A2 (en) 2011-01-14 2012-07-19 Celgene Corporation Isotopologues of isoindole derivatives
JP2014511393A (ja) 2011-03-07 2014-05-15 セルジーン コーポレイション イソインドリン化合物を用いた疾患の治療方法
CA2834355A1 (en) 2011-04-28 2012-11-01 Celgene Corporation Methods and compositions using pde4 inhibitors for the treatment and management of autoimmune and inflammatory diseases
SI2797581T1 (sl) * 2011-12-27 2020-08-31 Amgen (Europe) GmbH Formulacije (+)-2-(1-(3-etoksi-4-metoksi-fenil)-2-metansulfonil-etil)- 4-acetil aminoizoindolin-1,3-diona
AR090100A1 (es) * 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
EP2730278A1 (en) 2012-11-08 2014-05-14 Ratiopharm GmbH Composition melt
CN105050624A (zh) 2013-03-14 2015-11-11 细胞基因公司 利用阿普斯特来治疗银屑病关节炎的方法
WO2014204825A1 (en) 2013-06-17 2014-12-24 Celgene Corporation Tablet formulations of (+)-2-[1 -(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
IN2014MU01283A (da) 2014-04-04 2015-10-09 Cadila Healthcare Ltd
WO2015173792A1 (en) 2014-05-11 2015-11-19 Mapi Pharma Ltd. Amorphous form of apremilast
EP3142748B1 (en) 2014-05-15 2019-09-11 Celgene Corporation Use of pde4 inhibitors and combinations thereof for the treatment of cystic fibrosis
WO2015175956A1 (en) 2014-05-16 2015-11-19 Celgene Corporation Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators
EP2949645A1 (en) 2014-05-28 2015-12-02 LEK Pharmaceuticals d.d. Processes for the preparation of ß-aminosulfone compounds
ES2749433T3 (es) 2014-06-23 2020-03-20 Celgene Corp Apremilast para el tratamiento de una enfermedad hepática o una anomalía de la función hepática
EP3188745A1 (en) 2014-08-15 2017-07-12 Celgene Corporation Dosage titration of apremilast for the treatment of diseases ameliorated by pde4 inhibition
SI3182996T1 (sl) 2014-08-22 2023-04-28 Celgene Corporation Postopki zdravljenja multiplega mieloma z imunomodulatornimi spojinami v kombinaciji s protitelesi
CN105461610B (zh) * 2014-09-10 2018-04-13 杭州普晒医药科技有限公司 一种阿普斯特的晶型及其制备方法、药物组合物和用途
CN104761484B (zh) * 2014-11-24 2018-03-27 上海优拓医药科技有限公司 一种稳定的不含溶剂化物的阿普司特晶型ii及其制备方法
CN104496886A (zh) * 2014-12-11 2015-04-08 杭州新博思生物医药有限公司 一种高纯度阿普斯特b晶型的制备方法
CN107635962A (zh) 2015-03-19 2018-01-26 印度商西伯拉有限公司 用于制备阿普斯特的改进工艺
EP3280701B1 (en) 2015-04-09 2019-10-16 Zentiva K.S. A method of chiral resolution of the key intermediate of the synthesis of apremilast and its use for the preparation of pure apremilast
WO2016169533A1 (en) 2015-04-24 2016-10-27 Zentiva, K.S. A solid form of apremilast and a process for preparing the same
US10370329B2 (en) * 2015-04-27 2019-08-06 Mylan Laboratories Limited Process for the enantiomeric resolution of apremilast intermediates
CN104945306B (zh) * 2015-05-25 2017-07-21 山东铭康医药技术有限公司 制备光学纯阿普斯特的方法
CZ2015383A3 (cs) 2015-06-05 2016-12-14 Zentiva, K.S. Způsob přípravy klíčového intermediátu apremilastu, využívající enzymatické štěpení racemických aminů
EP3106457A1 (en) 2015-06-15 2016-12-21 LEK Pharmaceuticals d.d. A novel synthetic pathway towards apremilast
JP2018527302A (ja) 2015-06-26 2018-09-20 セルジーン コーポレイション 免疫調節化合物を用いたカポジ肉腫またはｋｓｈｖ誘発性リンパ腫の治療方法、及びバイオマーカーの使用
EP3144393A1 (en) 2015-09-18 2017-03-22 LEK Pharmaceuticals d.d. A synthetic pathway towards apremilast
WO2017059040A1 (en) 2015-09-29 2017-04-06 Pliva Hrvatska D.O.O. Processes for the preparation of apremilast and intermediates thereof
WO2017070291A1 (en) 2015-10-21 2017-04-27 Celgene Corporation Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris)
WO2017085568A1 (en) * 2015-11-19 2017-05-26 Alembic Pharmaceuticals Limited An improved process and novel polymorphic form of apremilast
CN105294533A (zh) * 2015-12-02 2016-02-03 宋彤云 一种治疗骨病的药物组合物
US10774041B2 (en) 2016-04-15 2020-09-15 Davuluri Ramamohan Rao Process for the preparation of apremilast
CN109310624A (zh) 2016-06-15 2019-02-05 托伦特药物有限公司 阿普斯特的局部组合物
US10196355B2 (en) 2016-06-20 2019-02-05 Johnson Matthey Public Limited Company Forms of apremilast
CN106543050B (zh) * 2016-09-28 2018-04-10 中南大学湘雅医院 一种阿普斯特中间体的合成工艺
WO2018157779A1 (zh) * 2017-02-28 2018-09-07 康朴生物医药技术（上海）有限公司 一种新的异二氢吲哚衍生物、其药物组合物及应用
US10689332B2 (en) 2017-04-04 2020-06-23 Quimica Sintetica, S.A. Racemic beta-aminosulfone compounds
EP3606908B1 (en) 2017-04-04 2020-06-17 Quimica Sintetica, S.A. Resolution of racemic beta-aminosulfone compounds
US10919855B2 (en) 2017-05-04 2021-02-16 Unichem Laboratories Ltd Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide
CN109422671B (zh) * 2017-08-31 2022-06-07 重庆医药工业研究院有限责任公司 一种阿普斯特中间体的制备方法
US20200254093A1 (en) 2017-09-14 2020-08-13 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer
WO2019081235A1 (en) 2017-10-23 2019-05-02 Boehringer Ingelheim International Gmbh NEW ASSOCIATION OF ACTIVE AGENTS FOR THE TREATMENT OF PROGRESSIVE FIBROSANT INTERSTITIAL PNEUMOPATHY (PF-ILD)
WO2019142124A1 (en) 2018-01-17 2019-07-25 Cadila Healthcare Limited Pharmaceutical compositions for treatment of vitiligo
US20210139498A1 (en) 2018-05-02 2021-05-13 Tianjin Hemay Pharmaceutical Sci-Tech Co., Ltd Crystal forms of thiophene derivatives
CN110746376A (zh) * 2018-07-22 2020-02-04 上海星叶医药科技有限公司 苯并异硒唑酮胺类化合物及其制备方法和用途
CN110423213B (zh) * 2019-08-22 2021-06-04 上海英诺富成生物科技有限公司 一种阿普斯特衍生物及其制备方法与应用
EP3929179A1 (en) 2020-06-22 2021-12-29 Biohorm, S.L. Anti-inflammatory compounds and methods for their manufacture
CN114790164B (zh) 2021-08-13 2022-12-27 苏州璞正医药有限公司 一种取代的异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173652A (en) * 1976-12-18 1979-11-06 Akzona Incorporated Pharmaceutical hydroxamic acid compositions and uses thereof
SE434638B (sv) * 1980-06-06 1984-08-06 Lekemedelsfabriken Medica Ab Nya terapeutiska verdefulla taurinderivat och deras framstellning
US4820828A (en) * 1987-03-04 1989-04-11 Ortho Pharmaceutical Corporation Cinnamohydroxamic acids
US5236917A (en) * 1989-05-04 1993-08-17 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
US5698579A (en) * 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US5703098A (en) * 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
ES2151156T3 (es) * 1995-07-26 2000-12-16 Pfizer Derivados de acidos n-(aroil)glicina hidroxamicos y compuestos relacionados.
US5728844A (en) * 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents
US5728845A (en) * 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic nitriles
US5658940A (en) * 1995-10-06 1997-08-19 Celgene Corporation Succinimide and maleimide cytokine inhibitors
DE69728375T2 (de) * 1996-01-02 2005-02-10 Aventis Pharmaceuticals Inc. Substituierte (aryl, heteroaryl, arylmethyl oder heteroarylmethyl) hydroxamisaeureverbindungen

Also Published As

Publication number Publication date
ES2343744T3 (es) 2010-08-09
HK1038696A1 (en) 2002-03-28
DK1126839T3 (da) 2007-05-14
CA2348993C (en) 2009-12-29
EP2305248B1 (en) 2013-05-08
BRPI9915201B8 (pt) 2021-07-06
JP2002528496A (ja) 2002-09-03
AU756308B2 (en) 2003-01-09
DE69934708T2 (de) 2007-10-18
US6020358A (en) 2000-02-01
ES2421153T3 (es) 2013-08-29
PT2305248E (pt) 2013-08-22
DE69942532D1 (de) 2010-08-05
AU1447200A (en) 2000-05-22
ATE350033T1 (de) 2007-01-15
EP1126839B1 (en) 2007-01-03
EP1752148B1 (en) 2010-06-23
BRPI9915201A (pt) 2001-10-30
EP1752148A3 (en) 2007-03-14
NO20012021D0 (no) 2001-04-24
ATE471718T1 (de) 2010-07-15
DK1752148T3 (da) 2010-09-27
WO2000025777A1 (en) 2000-05-11
CY1114304T1 (el) 2016-08-31
HK1103224A1 (en) 2007-12-14
NZ511253A (en) 2003-02-28
BR9915201A (pt) 2001-10-30
ES2278467T3 (es) 2007-08-01
BRPI9915201B1 (pt) 2012-02-22
HK1038696B (zh) 2007-08-03
CA2348993A1 (en) 2000-05-11
CY1107499T1 (el) 2013-03-13
CY1110752T1 (el) 2015-06-10
PT1752148E (pt) 2010-09-28
US6011050A (en) 2000-01-04
JP4530543B2 (ja) 2010-08-25
NO319790B1 (no) 2005-09-12
DE69934708D1 (de) 2007-02-15
EP1126839A4 (en) 2004-10-27
PT1126839E (pt) 2007-03-30
EP2305248A1 (en) 2011-04-06
EP1126839A1 (en) 2001-08-29
NO20012021L (no) 2001-06-26
EP1752148A2 (en) 2007-02-14

Similar Documents

Publication Publication Date Title
DK2305248T3 (da) Substituerede phenethylsulfoner og fremgangsmåde til reduktion af tnf-alfa-niveauer
PT1242413E (pt) 1,3,4-oxadiazolos substituidos e um metodo para reduzir niveis de tnf-alfa
TR200002627T2 (tr) İkameli 2-(2,6- (Diokso-3-floropiperidin-3-İI) -izoindolinler ve TNF alfa seviyelerini düşürmek için kullanılmaları
TR200801878T2 (tr) Sübstitüe edilmiş 2-(2,6-dioksopiperidin-3-il)-ftalimidler ve -1-oksoizoindolinler ve tnfa seviyelerini düşürmek için yöntem.
PT925294E (pt) 2-(2,6-dioxopiperidin-3-il)-ftalimidas e -1-oxoisoindolinas substituidas e metodo de reducao dos niveis de tnf-alfa
DE69735613D1 (de) Halbleiter-Bauelement das als Gegentaktverstärker mit Eintaktausgang verbindbar ist
NO20002529L (no) Substituerte 2-(2,6-diokso-3-fluorpiperidin-3-yl)- isoindoliner og deres anvendelse for Õ redusere tnf<alfa> nivÕer
DE69618242D1 (de) Bremskraftverstärker mit verbessertem ventil
DE69620247T2 (de) Bremskraftverstärker mit verbessertem ventil