DE69811962T2 - Substituierte 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindoline und ihre verwendung zur verminderung des tnfa spiegels - Google Patents

Substituierte 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindoline und ihre verwendung zur verminderung des tnfa spiegels

Info

Publication number
DE69811962T2
DE69811962T2 DE69811962T DE69811962T DE69811962T2 DE 69811962 T2 DE69811962 T2 DE 69811962T2 DE 69811962 T DE69811962 T DE 69811962T DE 69811962 T DE69811962 T DE 69811962T DE 69811962 T2 DE69811962 T2 DE 69811962T2
Authority
DE
Germany
Prior art keywords
dioxo
fluoropiperidin
isoindoline
reduce
tnfa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69811962T
Other languages
English (en)
Other versions
DE69811962D1 (de
Inventor
W Muller
I Stirling
Shen-Chu Chen
Hon-Wah Man
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/976,140 external-priority patent/US5874448A/en
Priority claimed from US09/042,274 external-priority patent/US5955476A/en
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of DE69811962D1 publication Critical patent/DE69811962D1/de
Application granted granted Critical
Publication of DE69811962T2 publication Critical patent/DE69811962T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69811962T 1997-11-18 1998-11-17 Substituierte 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindoline und ihre verwendung zur verminderung des tnfa spiegels Expired - Lifetime DE69811962T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/976,140 US5874448A (en) 1997-11-18 1997-11-18 Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
US09/042,274 US5955476A (en) 1997-11-18 1998-03-13 Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
PCT/US1998/024453 WO1999046258A1 (en) 1998-03-13 1998-11-17 SUBSTITUTED 2-(2,6-DIOXO-3-FLUOROPIPERIDIN-3-YL)-ISOINDOLINES AND THEIR USE TO REDUCE TNFα LEVELS

Publications (2)

Publication Number Publication Date
DE69811962D1 DE69811962D1 (de) 2003-04-10
DE69811962T2 true DE69811962T2 (de) 2003-08-28

Family

ID=26719049

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69834668T Expired - Lifetime DE69834668T2 (de) 1997-11-18 1998-11-17 Substituierte 2-(2,6-dioxo-3-fluoropiperidine-3-yl)-isoindoline und ihre Verwendung zum reduzieren des TNF-alpha spiegels
DE69811962T Expired - Lifetime DE69811962T2 (de) 1997-11-18 1998-11-17 Substituierte 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindoline und ihre verwendung zur verminderung des tnfa spiegels

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69834668T Expired - Lifetime DE69834668T2 (de) 1997-11-18 1998-11-17 Substituierte 2-(2,6-dioxo-3-fluoropiperidine-3-yl)-isoindoline und ihre Verwendung zum reduzieren des TNF-alpha spiegels

Country Status (14)

Country Link
EP (3) EP1062214B1 (de)
AT (2) ATE327228T1 (de)
AU (1) AU752958B2 (de)
CY (1) CY1106100T1 (de)
CZ (1) CZ299808B6 (de)
DE (2) DE69834668T2 (de)
DK (1) DK1308444T3 (de)
ES (2) ES2262753T3 (de)
FI (1) FI20001192A (de)
HK (1) HK1054381B (de)
NO (1) NO318737B1 (de)
PT (1) PT1308444E (de)
SI (1) SI1308444T1 (de)
SK (1) SK7382000A3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9908811A (pt) * 1998-03-16 2000-12-05 Celgene Corp Composto, composição farmacêutica e seu uso no tratamento de mamìferos
US20050100529A1 (en) * 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1531492A (en) * 1991-02-14 1992-09-15 Rockefeller University, The Method for controlling abnormal concentration tnf alpha in human tissues
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
DE4422237A1 (de) * 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
ATE530542T1 (de) * 1996-07-24 2011-11-15 Celgene Corp Amino substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide zur verringerung der tnf-alpha-stufen
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines

Also Published As

Publication number Publication date
CZ299808B6 (cs) 2008-12-03
FI20001192A (fi) 2000-07-14
PT1308444E (pt) 2006-08-31
NO20002529L (no) 2000-06-30
NO20002529D0 (no) 2000-05-16
EP1308444B1 (de) 2006-05-24
CY1106100T1 (el) 2011-06-08
ES2192342T3 (es) 2003-10-01
HK1054381B (zh) 2006-10-13
ATE327228T1 (de) 2006-06-15
AU752958B2 (en) 2002-10-03
DE69811962D1 (de) 2003-04-10
DK1308444T3 (da) 2006-09-18
EP1308444A1 (de) 2003-05-07
DE69834668D1 (de) 2006-06-29
CZ20001822A3 (cs) 2000-11-15
ATE233753T1 (de) 2003-03-15
DE69834668T2 (de) 2007-01-11
NO318737B1 (no) 2005-05-02
AU1413899A (en) 1999-09-27
SK7382000A3 (en) 2000-12-11
EP1062214A1 (de) 2000-12-27
HK1054381A1 (en) 2003-11-28
ES2262753T3 (es) 2006-12-01
SI1308444T1 (sl) 2007-04-30
EP1062214B1 (de) 2003-03-05
EP1710242A1 (de) 2006-10-11

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