SK86897A3 - Substituted imides compounds as tnf-alpha inhibitors, pharmaceutical composition and use such compounds - Google Patents
Substituted imides compounds as tnf-alpha inhibitors, pharmaceutical composition and use such compounds Download PDFInfo
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- SK86897A3 SK86897A3 SK868-97A SK86897A SK86897A3 SK 86897 A3 SK86897 A3 SK 86897A3 SK 86897 A SK86897 A SK 86897A SK 86897 A3 SK86897 A3 SK 86897A3
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- SK
- Slovakia
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- group
- carbon atoms
- substituted
- alkyl
- amino
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- -1 imides compounds Chemical class 0.000 title claims description 49
- 150000001875 compounds Chemical class 0.000 title claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 title description 2
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 title description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract description 49
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims abstract description 48
- 230000010076 replication Effects 0.000 claims abstract description 9
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 47
- 125000001424 substituent group Chemical group 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 35
- 125000004432 carbon atom Chemical group C* 0.000 claims description 32
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 20
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 20
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical class 0.000 claims description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 11
- 241000124008 Mammalia Species 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims description 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 7
- 125000003277 amino group Chemical group 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims description 6
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 230000001177 retroviral effect Effects 0.000 claims description 4
- 229910052717 sulfur Chemical group 0.000 claims description 4
- 239000011593 sulfur Chemical group 0.000 claims description 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 3
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims description 3
- 125000004450 alkenylene group Chemical group 0.000 claims description 3
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- GRKUXCWELVWVMZ-UHFFFAOYSA-N amino acetate Chemical compound CC(=O)ON GRKUXCWELVWVMZ-UHFFFAOYSA-N 0.000 claims description 3
- 125000006165 cyclic alkyl group Chemical group 0.000 claims description 3
- 125000005724 cycloalkenylene group Chemical group 0.000 claims description 3
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 claims description 3
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000004076 pyridyl group Chemical group 0.000 claims description 3
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 1
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- GODXRDNLVMRFSG-UHFFFAOYSA-N 2-[1-(3,4-dimethoxyphenyl)propan-2-yl]isoindole-1,3-dione Chemical group C1=C(OC)C(OC)=CC=C1CC(C)N1C(=O)C2=CC=CC=C2C1=O GODXRDNLVMRFSG-UHFFFAOYSA-N 0.000 abstract description 3
- 150000003949 imides Chemical class 0.000 abstract description 3
- 239000003112 inhibitor Substances 0.000 abstract description 2
- 241001430294 unidentified retrovirus Species 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 49
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 42
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/366,679 US6429221B1 (en) | 1994-12-30 | 1994-12-30 | Substituted imides |
| PCT/US1995/015384 WO1996020926A1 (en) | 1994-12-30 | 1995-11-20 | Substituted imides as tnf inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK86897A3 true SK86897A3 (en) | 1998-01-14 |
Family
ID=23444039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK868-97A SK86897A3 (en) | 1994-12-30 | 1995-11-20 | Substituted imides compounds as tnf-alpha inhibitors, pharmaceutical composition and use such compounds |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6429221B1 (de) |
| EP (1) | EP0800514B1 (de) |
| JP (1) | JP4118329B2 (de) |
| KR (2) | KR20040007729A (de) |
| AT (1) | ATE337301T1 (de) |
| AU (1) | AU709719B2 (de) |
| CA (1) | CA2208671C (de) |
| CZ (1) | CZ203697A3 (de) |
| DE (1) | DE69535195T2 (de) |
| DK (1) | DK0800514T3 (de) |
| ES (1) | ES2271948T3 (de) |
| FI (1) | FI972709A (de) |
| HK (1) | HK1004674A1 (de) |
| HU (1) | HUT77124A (de) |
| NZ (1) | NZ297324A (de) |
| PL (1) | PL185361B1 (de) |
| PT (1) | PT800514E (de) |
| RU (1) | RU2162078C2 (de) |
| SK (1) | SK86897A3 (de) |
| WO (1) | WO1996020926A1 (de) |
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| US20040087558A1 (en) | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
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| MXPA05004777A (es) * | 2002-11-06 | 2005-07-22 | Celgene Corp | Metodos de uso y composiciones que comprenden farmacos inhibidores selectivos de citocina para el tratamiento y el manejo de padecimientos mieloproliferativos. |
| CN1735412A (zh) | 2002-11-06 | 2006-02-15 | 细胞基因公司 | 利用选择性细胞因子抑制药物治疗和控制癌症和其它疾病的方法和组合物 |
| BR0316256A (pt) * | 2002-11-18 | 2005-10-04 | Celgene Corp | Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto |
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| CA2563377A1 (en) * | 2004-04-23 | 2005-11-03 | Celgene Corporation | Methods of using and compositions comprising pde4 modulators for the treatment and management of pulmonary hypertension |
| WO2006028963A2 (en) * | 2004-09-03 | 2006-03-16 | Celgene Corporation | Substituted heterocyclic compounds and uses thereof |
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| JP2008518924A (ja) * | 2004-10-28 | 2008-06-05 | セルジーン・コーポレーション | 中枢神経系損傷の治療及び管理のためのｐｄｅ４モジュレータを使用する方法及び組成物 |
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-
1994
- 1994-12-30 US US08/366,679 patent/US6429221B1/en not_active Expired - Fee Related
-
1995
- 1995-11-20 SK SK868-97A patent/SK86897A3/sk unknown
- 1995-11-20 NZ NZ297324A patent/NZ297324A/xx not_active IP Right Cessation
- 1995-11-20 ES ES95940847T patent/ES2271948T3/es not_active Expired - Lifetime
- 1995-11-20 DK DK95940847T patent/DK0800514T3/da active
- 1995-11-20 CA CA002208671A patent/CA2208671C/en not_active Expired - Fee Related
- 1995-11-20 EP EP95940847A patent/EP0800514B1/de not_active Expired - Lifetime
- 1995-11-20 AT AT95940847T patent/ATE337301T1/de not_active IP Right Cessation
- 1995-11-20 HU HU9701849A patent/HUT77124A/hu unknown
- 1995-11-20 RU RU97112858/04A patent/RU2162078C2/ru not_active IP Right Cessation
- 1995-11-20 KR KR10-2003-7016455A patent/KR20040007729A/ko not_active Application Discontinuation
- 1995-11-20 KR KR1019970704510A patent/KR100466838B1/ko not_active IP Right Cessation
- 1995-11-20 JP JP52098696A patent/JP4118329B2/ja not_active Expired - Fee Related
- 1995-11-20 PL PL95321065A patent/PL185361B1/pl not_active IP Right Cessation
- 1995-11-20 WO PCT/US1995/015384 patent/WO1996020926A1/en active IP Right Grant
- 1995-11-20 DE DE69535195T patent/DE69535195T2/de not_active Expired - Lifetime
- 1995-11-20 PT PT95940847T patent/PT800514E/pt unknown
- 1995-11-20 CZ CZ972036A patent/CZ203697A3/cs unknown
- 1995-11-20 AU AU42463/96A patent/AU709719B2/en not_active Ceased
-
1997
- 1997-06-23 FI FI972709A patent/FI972709A/fi unknown
-
1998
- 1998-02-17 HK HK98101231A patent/HK1004674A1/xx not_active IP Right Cessation
-
2002
- 2002-03-25 US US10/105,833 patent/US6844359B2/en not_active Expired - Fee Related
-
2004
- 2004-11-16 US US10/989,945 patent/US7329761B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ297324A (en) | 2000-03-27 |
| KR100466838B1 (ko) | 2005-09-02 |
| RU2162078C2 (ru) | 2001-01-20 |
| PL321065A1 (en) | 1997-11-24 |
| ES2271948T3 (es) | 2007-04-16 |
| US20050090516A1 (en) | 2005-04-28 |
| AU4246396A (en) | 1996-07-24 |
| KR20040007729A (ko) | 2004-01-24 |
| US6844359B2 (en) | 2005-01-18 |
| DE69535195D1 (de) | 2006-10-05 |
| FI972709A (fi) | 1997-08-29 |
| WO1996020926A1 (en) | 1996-07-11 |
| US7329761B2 (en) | 2008-02-12 |
| US20020143027A1 (en) | 2002-10-03 |
| HUT77124A (hu) | 1998-03-02 |
| EP0800514B1 (de) | 2006-08-23 |
| KR980700968A (ko) | 1998-04-30 |
| CA2208671C (en) | 2009-02-10 |
| ATE337301T1 (de) | 2006-09-15 |
| CA2208671A1 (en) | 1996-07-11 |
| DE69535195T2 (de) | 2007-07-12 |
| DK0800514T3 (da) | 2006-12-27 |
| HK1004674A1 (en) | 1998-12-04 |
| PL185361B1 (pl) | 2003-04-30 |
| PT800514E (pt) | 2006-12-29 |
| EP0800514A1 (de) | 1997-10-15 |
| JPH10511946A (ja) | 1998-11-17 |
| CZ203697A3 (en) | 1997-11-12 |
| JP4118329B2 (ja) | 2008-07-16 |
| US6429221B1 (en) | 2002-08-06 |
| FI972709A0 (fi) | 1997-06-23 |
| AU709719B2 (en) | 1999-09-02 |
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