DE69535195D1 - Substituierte imide als tnf inhibitoren - Google Patents

Substituierte imide als tnf inhibitoren

Info

Publication number
DE69535195D1
DE69535195D1 DE69535195T DE69535195T DE69535195D1 DE 69535195 D1 DE69535195 D1 DE 69535195D1 DE 69535195 T DE69535195 T DE 69535195T DE 69535195 T DE69535195 T DE 69535195T DE 69535195 D1 DE69535195 D1 DE 69535195D1
Authority
DE
Germany
Prior art keywords
imids
substituted
tnf inhibitors
inhibitors
phthalimido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535195T
Other languages
English (en)
Other versions
DE69535195T2 (de
Inventor
George Muller
Mary Shire
I Stirling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of DE69535195D1 publication Critical patent/DE69535195D1/de
Application granted granted Critical
Publication of DE69535195T2 publication Critical patent/DE69535195T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
DE69535195T 1994-12-30 1995-11-20 Substituierte imide als tnf inhibitoren Expired - Lifetime DE69535195T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US366679 1982-04-08
US08/366,679 US6429221B1 (en) 1994-12-30 1994-12-30 Substituted imides
PCT/US1995/015384 WO1996020926A1 (en) 1994-12-30 1995-11-20 Substituted imides as tnf inhibitors

Publications (2)

Publication Number Publication Date
DE69535195D1 true DE69535195D1 (de) 2006-10-05
DE69535195T2 DE69535195T2 (de) 2007-07-12

Family

ID=23444039

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535195T Expired - Lifetime DE69535195T2 (de) 1994-12-30 1995-11-20 Substituierte imide als tnf inhibitoren

Country Status (20)

Country Link
US (3) US6429221B1 (de)
EP (1) EP0800514B1 (de)
JP (1) JP4118329B2 (de)
KR (2) KR20040007729A (de)
AT (1) ATE337301T1 (de)
AU (1) AU709719B2 (de)
CA (1) CA2208671C (de)
CZ (1) CZ203697A3 (de)
DE (1) DE69535195T2 (de)
DK (1) DK0800514T3 (de)
ES (1) ES2271948T3 (de)
FI (1) FI972709A (de)
HK (1) HK1004674A1 (de)
HU (1) HUT77124A (de)
NZ (1) NZ297324A (de)
PL (1) PL185361B1 (de)
PT (1) PT800514E (de)
RU (1) RU2162078C2 (de)
SK (1) SK86897A3 (de)
WO (1) WO1996020926A1 (de)

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US7776907B2 (en) * 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
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MXPA05004777A (es) * 2002-11-06 2005-07-22 Celgene Corp Metodos de uso y composiciones que comprenden farmacos inhibidores selectivos de citocina para el tratamiento y el manejo de padecimientos mieloproliferativos.
CA2506232A1 (en) * 2002-11-18 2004-06-03 Celgene Corporation Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
CN1738614A (zh) * 2002-11-18 2006-02-22 细胞基因公司 包含(－)－3－(3,4－二甲氧基－苯基)－3－(1－氧代－1,3－二氢－异吲哚－2－基)－丙酰胺的组合物及其使用方法
CA2511843C (en) 2002-12-30 2012-04-24 Celgene Corporation Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses
US20040175382A1 (en) * 2003-03-06 2004-09-09 Schafer Peter H. Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
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Also Published As

Publication number Publication date
PL185361B1 (pl) 2003-04-30
HUT77124A (hu) 1998-03-02
JPH10511946A (ja) 1998-11-17
KR980700968A (ko) 1998-04-30
CZ203697A3 (en) 1997-11-12
KR20040007729A (ko) 2004-01-24
US7329761B2 (en) 2008-02-12
DK0800514T3 (da) 2006-12-27
KR100466838B1 (ko) 2005-09-02
CA2208671C (en) 2009-02-10
WO1996020926A1 (en) 1996-07-11
SK86897A3 (en) 1998-01-14
NZ297324A (en) 2000-03-27
EP0800514A1 (de) 1997-10-15
PL321065A1 (en) 1997-11-24
FI972709A (fi) 1997-08-29
ES2271948T3 (es) 2007-04-16
PT800514E (pt) 2006-12-29
FI972709A0 (fi) 1997-06-23
DE69535195T2 (de) 2007-07-12
US6429221B1 (en) 2002-08-06
AU709719B2 (en) 1999-09-02
US6844359B2 (en) 2005-01-18
RU2162078C2 (ru) 2001-01-20
AU4246396A (en) 1996-07-24
ATE337301T1 (de) 2006-09-15
JP4118329B2 (ja) 2008-07-16
HK1004674A1 (en) 1998-12-04
CA2208671A1 (en) 1996-07-11
US20020143027A1 (en) 2002-10-03
EP0800514B1 (de) 2006-08-23
US20050090516A1 (en) 2005-04-28

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