ATE335006T1 - Verfahren zur aufreinigung von albumin - Google Patents
Verfahren zur aufreinigung von albuminInfo
- Publication number
- ATE335006T1 ATE335006T1 AT03725953T AT03725953T ATE335006T1 AT E335006 T1 ATE335006 T1 AT E335006T1 AT 03725953 T AT03725953 T AT 03725953T AT 03725953 T AT03725953 T AT 03725953T AT E335006 T1 ATE335006 T1 AT E335006T1
- Authority
- AT
- Austria
- Prior art keywords
- matrix
- rhsa
- cation exchange
- bimodal
- cell culture
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 102000009027 Albumins Human genes 0.000 title 1
- 108010088751 Albumins Proteins 0.000 title 1
- 239000011159 matrix material Substances 0.000 abstract 5
- 230000002902 bimodal effect Effects 0.000 abstract 3
- 238000005341 cation exchange Methods 0.000 abstract 3
- 238000004113 cell culture Methods 0.000 abstract 2
- 239000012228 culture supernatant Substances 0.000 abstract 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 1
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 1
- 238000005349 anion exchange Methods 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201518A SE526227C2 (sv) | 2002-05-15 | 2002-05-15 | Metod för rening av rekombinant humant serumalbumin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE335006T1 true ATE335006T1 (de) | 2006-08-15 |
Family
ID=20287916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03725953T ATE335006T1 (de) | 2002-05-15 | 2003-05-09 | Verfahren zur aufreinigung von albumin |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7423124B2 (https=) |
| EP (2) | EP1504031B1 (https=) |
| JP (2) | JP2006502098A (https=) |
| CN (1) | CN100463921C (https=) |
| AT (1) | ATE335006T1 (https=) |
| AU (2) | AU2003228193B2 (https=) |
| BR (2) | BRPI0309992B8 (https=) |
| CA (2) | CA2483612A1 (https=) |
| DE (1) | DE60307262T2 (https=) |
| ES (1) | ES2268362T3 (https=) |
| IL (1) | IL164844A (https=) |
| SE (1) | SE526227C2 (https=) |
| WO (2) | WO2003097692A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8802146B2 (en) * | 1998-11-06 | 2014-08-12 | Neomend, Inc. | Systems, methods, and compositions for prevention of tissue adhesion |
| ES2424840T3 (es) * | 2003-01-28 | 2013-10-09 | E.I. Du Pont De Nemours And Company | Insecticidas tipo ciano antranilamida |
| CN1756587A (zh) * | 2003-03-12 | 2006-04-05 | 弗雷泽纽斯卡比德国有限公司 | 重组白蛋白在肝衰竭后透析中的用途 |
| HRP20060362A2 (en) * | 2004-04-23 | 2007-03-31 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| CN1854155B (zh) * | 2005-04-29 | 2010-11-17 | 华北制药集团新药研究开发有限责任公司 | 一种纯化rHSA的方法 |
| CL2008002053A1 (es) | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
| AR067536A1 (es) * | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea |
| EP2261661A4 (en) * | 2008-03-31 | 2011-04-20 | Sekisui Medical Co Ltd | CLEANED SERUM ALBUMIN AND IMMUNOLOGY MEASUREMENT PROCESS |
| US8753868B2 (en) * | 2008-08-04 | 2014-06-17 | General Electric Company | Method and system for selective isolation of target biological molecules in a general purpose system |
| CN101768206B (zh) * | 2008-12-31 | 2013-05-15 | 华北制药集团新药研究开发有限责任公司 | 一种重组人血清白蛋白的纯化方法及其应用 |
| JP2012518409A (ja) | 2009-02-20 | 2012-08-16 | ベントリア・バイオサイエンス | タンパク質の組み合わせを含有する細胞培養培地 |
| KR101976853B1 (ko) | 2010-05-25 | 2019-05-09 | 제넨테크, 인크. | 폴리펩티드의 정제 방법 |
| CN102127164B (zh) | 2010-12-20 | 2013-01-30 | 武汉禾元生物科技有限公司 | 一种从水稻种子中提取重组人血清白蛋白的方法 |
| CN102532254B (zh) * | 2010-12-24 | 2015-06-24 | 武汉禾元生物科技股份有限公司 | 一种从水稻种子中分离纯化重组人血清白蛋白的方法 |
| US9669402B2 (en) | 2012-03-08 | 2017-06-06 | Bio-Rad Laboratories, Inc. | Anionic exchange-hydrophobic mixed mode |
| CN103880947B (zh) | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
| CN103923211A (zh) * | 2014-05-08 | 2014-07-16 | 齐智 | 一种医药级重组人血清白蛋白的纯化方法 |
| EP3307876B1 (en) | 2015-06-10 | 2023-09-13 | ImmunityBio, Inc. | Modified nk-92 cells for treating cancer |
| CN106146631A (zh) * | 2015-12-09 | 2016-11-23 | 烟台大学 | 一种离心技术结合疏水层析介质制备藻红蛋白的方法 |
| CN106117347A (zh) * | 2015-12-09 | 2016-11-16 | 烟台大学 | 一种疏水层析制备高纯度藻红蛋白的方法 |
| CN106117326A (zh) * | 2015-12-09 | 2016-11-16 | 烟台大学 | 一种离心法结合阴离子交换层析介质制备藻红蛋白的方法 |
| WO2021061790A1 (en) * | 2019-09-24 | 2021-04-01 | Regeneron Pharmaceuticals, Inc. | Systems and methods for chromatography use and regeneration |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| KR20230060524A (ko) | 2020-12-08 | 2023-05-04 | 통화 안레이트 바이오파마슈티컬 컴퍼니 리미티드 | 재조합 단백질의 정제 방법 |
| JP2024500994A (ja) | 2020-12-28 | 2024-01-10 | デボル，インコーポレイテッド | タンパク質及び多官能化変性ポリエチレングリコール系架橋剤を含む反応性乾燥粉末状止血用材料 |
| CN113461804A (zh) * | 2021-08-09 | 2021-10-01 | 山东健通生物科技有限公司 | 减少重组人血白蛋白发酵过程中色素的方法 |
| CN113880908B (zh) * | 2021-08-25 | 2024-05-14 | 北京伟德杰生物科技有限公司 | 纯化重组人血清白蛋白的融合蛋白的方法 |
| CN113735962B (zh) * | 2021-08-27 | 2023-11-10 | 常熟纳微生物科技有限公司 | 一种从猪血中纯化重组人血清白蛋白的方法及应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093612A (en) | 1975-08-04 | 1978-06-06 | Research Corporation | Selective removal of albumin from blood fluids and compositions therefore |
| FR2403098A1 (fr) | 1977-09-19 | 1979-04-13 | Merieux Inst | Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application |
| US5849874A (en) * | 1991-07-12 | 1998-12-15 | Gist-Brocades, N.V. | Process for the purification of serum albumin |
| EP0933083A1 (en) * | 1991-07-12 | 1999-08-04 | Dsm N.V. | Process for the purification of serum albumin |
| US5440018A (en) * | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| JPH07102148B2 (ja) * | 1992-05-20 | 1995-11-08 | 株式会社ミドリ十字 | 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物 |
| US5521287A (en) * | 1992-05-20 | 1996-05-28 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| CA2116385A1 (en) * | 1993-02-25 | 1994-08-26 | Akinori Sumi | Human serum albumin and process for producing the same |
| DK0658569T3 (da) | 1993-12-17 | 2005-02-07 | Mitsubishi Pharma Corp | Fremgangsmåde til affarvning af humant serumalbumin |
| JP3840674B2 (ja) * | 1994-08-31 | 2006-11-01 | 三菱ウェルファーマ株式会社 | 遺伝子操作に由来するヒト血清アルブミンの精製方法 |
| DK0699687T3 (da) * | 1994-08-31 | 2004-04-26 | Mitsubishi Pharma Corp | Fremgangsmåde til oprensning af rekombinant humant serumalbumin |
| GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| SE0002688D0 (sv) * | 2000-07-17 | 2000-07-17 | Amersham Pharm Biotech Ab | Adsorption method and ligands |
| JP4798832B2 (ja) * | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
-
2002
- 2002-05-15 SE SE0201518A patent/SE526227C2/sv not_active IP Right Cessation
-
2003
- 2003-05-09 DE DE60307262T patent/DE60307262T2/de not_active Expired - Lifetime
- 2003-05-09 EP EP03725953A patent/EP1504031B1/en not_active Expired - Lifetime
- 2003-05-09 US US10/514,536 patent/US7423124B2/en not_active Expired - Lifetime
- 2003-05-09 JP JP2004506364A patent/JP2006502098A/ja active Pending
- 2003-05-09 CN CNB031235026A patent/CN100463921C/zh not_active Expired - Fee Related
- 2003-05-09 ES ES03725953T patent/ES2268362T3/es not_active Expired - Lifetime
- 2003-05-09 BR BRPI0309992A patent/BRPI0309992B8/pt active IP Right Grant
- 2003-05-09 AU AU2003228193A patent/AU2003228193B2/en not_active Ceased
- 2003-05-09 CA CA002483612A patent/CA2483612A1/en not_active Abandoned
- 2003-05-09 BR BRPI0309992-0A patent/BRPI0309992B1/pt active IP Right Grant
- 2003-05-09 WO PCT/SE2003/000766 patent/WO2003097692A1/en not_active Ceased
- 2003-05-09 AT AT03725953T patent/ATE335006T1/de not_active IP Right Cessation
- 2003-05-15 CA CA002483616A patent/CA2483616A1/en not_active Abandoned
- 2003-05-15 WO PCT/SE2003/000792 patent/WO2003097693A1/en not_active Ceased
- 2003-05-15 US US10/514,544 patent/US7351801B2/en not_active Expired - Fee Related
- 2003-05-15 EP EP03752962A patent/EP1504032A1/en not_active Withdrawn
- 2003-05-15 JP JP2004506365A patent/JP4559216B2/ja not_active Expired - Fee Related
- 2003-05-15 AU AU2003232704A patent/AU2003232704A1/en not_active Abandoned
-
2004
- 2004-10-26 IL IL164844A patent/IL164844A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100463921C (zh) | 2009-02-25 |
| US20050215765A1 (en) | 2005-09-29 |
| DE60307262T2 (de) | 2007-06-28 |
| JP2006512283A (ja) | 2006-04-13 |
| SE526227C2 (sv) | 2005-08-02 |
| SE0201518D0 (sv) | 2002-05-15 |
| ES2268362T3 (es) | 2007-03-16 |
| WO2003097693A1 (en) | 2003-11-27 |
| IL164844A (en) | 2009-09-01 |
| IL164844A0 (en) | 2005-12-18 |
| JP2006502098A (ja) | 2006-01-19 |
| US7351801B2 (en) | 2008-04-01 |
| CA2483616A1 (en) | 2003-11-27 |
| CA2483612A1 (en) | 2003-11-27 |
| BR0309992A (pt) | 2005-03-01 |
| BRPI0309992B1 (pt) | 2020-12-22 |
| US20050214902A1 (en) | 2005-09-29 |
| BRPI0309992B8 (pt) | 2023-03-21 |
| AU2003232704A1 (en) | 2003-12-02 |
| AU2003228193A1 (en) | 2003-12-02 |
| DE60307262D1 (de) | 2006-09-14 |
| JP4559216B2 (ja) | 2010-10-06 |
| EP1504032A1 (en) | 2005-02-09 |
| CN1496993A (zh) | 2004-05-19 |
| WO2003097692A1 (en) | 2003-11-27 |
| AU2003228193B2 (en) | 2009-05-07 |
| US7423124B2 (en) | 2008-09-09 |
| EP1504031A1 (en) | 2005-02-09 |
| EP1504031B1 (en) | 2006-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1504031 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |