BRPI0309992B8 - método para purificar albumina de soro humano recombinante (rhsa) de uma solução - Google Patents

método para purificar albumina de soro humano recombinante (rhsa) de uma solução

Info

Publication number
BRPI0309992B8
BRPI0309992B8 BRPI0309992A BRPI0309992A BRPI0309992B8 BR PI0309992 B8 BRPI0309992 B8 BR PI0309992B8 BR PI0309992 A BRPI0309992 A BR PI0309992A BR PI0309992 A BRPI0309992 A BR PI0309992A BR PI0309992 B8 BRPI0309992 B8 BR PI0309992B8
Authority
BR
Brazil
Prior art keywords
rhsa
matrix
cation exchange
serum albumin
human serum
Prior art date
Application number
BRPI0309992A
Other languages
English (en)
Portuguese (pt)
Inventor
Belew Makonnen
Yan Li Mei
Zhang Wei
Original Assignee
Ge Healthcare Bio Sciences Ab
North China Pharmaceutical Group Corp
Cytiva Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Bio Sciences Ab, North China Pharmaceutical Group Corp, Cytiva Sweden Ab filed Critical Ge Healthcare Bio Sciences Ab
Publication of BRPI0309992B8 publication Critical patent/BRPI0309992B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BRPI0309992A 2002-05-15 2003-05-09 método para purificar albumina de soro humano recombinante (rhsa) de uma solução BRPI0309992B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0201518A SE526227C2 (sv) 2002-05-15 2002-05-15 Metod för rening av rekombinant humant serumalbumin
PCT/SE2003/000766 WO2003097692A1 (en) 2002-05-15 2003-05-09 Method for albumin purification

Publications (1)

Publication Number Publication Date
BRPI0309992B8 true BRPI0309992B8 (pt) 2023-03-21

Family

ID=20287916

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0309992A BRPI0309992B8 (pt) 2002-05-15 2003-05-09 método para purificar albumina de soro humano recombinante (rhsa) de uma solução
BRPI0309992-0A BRPI0309992B1 (pt) 2002-05-15 2003-05-09 método para purificar albumina de soro humano recombinante (rhsa) de uma solução

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0309992-0A BRPI0309992B1 (pt) 2002-05-15 2003-05-09 método para purificar albumina de soro humano recombinante (rhsa) de uma solução

Country Status (13)

Country Link
US (2) US7423124B2 (https=)
EP (2) EP1504031B1 (https=)
JP (2) JP2006502098A (https=)
CN (1) CN100463921C (https=)
AT (1) ATE335006T1 (https=)
AU (2) AU2003228193B2 (https=)
BR (2) BRPI0309992B8 (https=)
CA (2) CA2483612A1 (https=)
DE (1) DE60307262T2 (https=)
ES (1) ES2268362T3 (https=)
IL (1) IL164844A (https=)
SE (1) SE526227C2 (https=)
WO (2) WO2003097692A1 (https=)

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ES2424840T3 (es) * 2003-01-28 2013-10-09 E.I. Du Pont De Nemours And Company Insecticidas tipo ciano antranilamida
CN1756587A (zh) * 2003-03-12 2006-04-05 弗雷泽纽斯卡比德国有限公司 重组白蛋白在肝衰竭后透析中的用途
HRP20060362A2 (en) * 2004-04-23 2007-03-31 Conjuchem Biotechnologies Inc. Method for the purification of albumin conjugates
CN1854155B (zh) * 2005-04-29 2010-11-17 华北制药集团新药研究开发有限责任公司 一种纯化rHSA的方法
CL2008002053A1 (es) 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
AR067536A1 (es) * 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
EP2261661A4 (en) * 2008-03-31 2011-04-20 Sekisui Medical Co Ltd CLEANED SERUM ALBUMIN AND IMMUNOLOGY MEASUREMENT PROCESS
US8753868B2 (en) * 2008-08-04 2014-06-17 General Electric Company Method and system for selective isolation of target biological molecules in a general purpose system
CN101768206B (zh) * 2008-12-31 2013-05-15 华北制药集团新药研究开发有限责任公司 一种重组人血清白蛋白的纯化方法及其应用
JP2012518409A (ja) 2009-02-20 2012-08-16 ベントリア・バイオサイエンス タンパク質の組み合わせを含有する細胞培養培地
KR101976853B1 (ko) 2010-05-25 2019-05-09 제넨테크, 인크. 폴리펩티드의 정제 방법
CN102127164B (zh) 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) * 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
US9669402B2 (en) 2012-03-08 2017-06-06 Bio-Rad Laboratories, Inc. Anionic exchange-hydrophobic mixed mode
CN103880947B (zh) 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
CN103923211A (zh) * 2014-05-08 2014-07-16 齐智 一种医药级重组人血清白蛋白的纯化方法
EP3307876B1 (en) 2015-06-10 2023-09-13 ImmunityBio, Inc. Modified nk-92 cells for treating cancer
CN106146631A (zh) * 2015-12-09 2016-11-23 烟台大学 一种离心技术结合疏水层析介质制备藻红蛋白的方法
CN106117347A (zh) * 2015-12-09 2016-11-16 烟台大学 一种疏水层析制备高纯度藻红蛋白的方法
CN106117326A (zh) * 2015-12-09 2016-11-16 烟台大学 一种离心法结合阴离子交换层析介质制备藻红蛋白的方法
WO2021061790A1 (en) * 2019-09-24 2021-04-01 Regeneron Pharmaceuticals, Inc. Systems and methods for chromatography use and regeneration
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
KR20230060524A (ko) 2020-12-08 2023-05-04 통화 안레이트 바이오파마슈티컬 컴퍼니 리미티드 재조합 단백질의 정제 방법
JP2024500994A (ja) 2020-12-28 2024-01-10 デボル，インコーポレイテッド タンパク質及び多官能化変性ポリエチレングリコール系架橋剤を含む反応性乾燥粉末状止血用材料
CN113461804A (zh) * 2021-08-09 2021-10-01 山东健通生物科技有限公司 减少重组人血白蛋白发酵过程中色素的方法
CN113880908B (zh) * 2021-08-25 2024-05-14 北京伟德杰生物科技有限公司 纯化重组人血清白蛋白的融合蛋白的方法
CN113735962B (zh) * 2021-08-27 2023-11-10 常熟纳微生物科技有限公司 一种从猪血中纯化重组人血清白蛋白的方法及应用

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FR2403098A1 (fr) 1977-09-19 1979-04-13 Merieux Inst Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application
US5849874A (en) * 1991-07-12 1998-12-15 Gist-Brocades, N.V. Process for the purification of serum albumin
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US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
JPH07102148B2 (ja) * 1992-05-20 1995-11-08 株式会社ミドリ十字 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
CA2116385A1 (en) * 1993-02-25 1994-08-26 Akinori Sumi Human serum albumin and process for producing the same
DK0658569T3 (da) 1993-12-17 2005-02-07 Mitsubishi Pharma Corp Fremgangsmåde til affarvning af humant serumalbumin
JP3840674B2 (ja) * 1994-08-31 2006-11-01 三菱ウェルファーマ株式会社 遺伝子操作に由来するヒト血清アルブミンの精製方法
DK0699687T3 (da) * 1994-08-31 2004-04-26 Mitsubishi Pharma Corp Fremgangsmåde til oprensning af rekombinant humant serumalbumin
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JP4798832B2 (ja) * 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法

Also Published As

Publication number Publication date
CN100463921C (zh) 2009-02-25
US20050215765A1 (en) 2005-09-29
DE60307262T2 (de) 2007-06-28
JP2006512283A (ja) 2006-04-13
SE526227C2 (sv) 2005-08-02
SE0201518D0 (sv) 2002-05-15
ES2268362T3 (es) 2007-03-16
WO2003097693A1 (en) 2003-11-27
IL164844A (en) 2009-09-01
IL164844A0 (en) 2005-12-18
JP2006502098A (ja) 2006-01-19
US7351801B2 (en) 2008-04-01
CA2483616A1 (en) 2003-11-27
CA2483612A1 (en) 2003-11-27
BR0309992A (pt) 2005-03-01
BRPI0309992B1 (pt) 2020-12-22
US20050214902A1 (en) 2005-09-29
AU2003232704A1 (en) 2003-12-02
AU2003228193A1 (en) 2003-12-02
DE60307262D1 (de) 2006-09-14
JP4559216B2 (ja) 2010-10-06
EP1504032A1 (en) 2005-02-09
CN1496993A (zh) 2004-05-19
WO2003097692A1 (en) 2003-11-27
AU2003228193B2 (en) 2009-05-07
US7423124B2 (en) 2008-09-09
EP1504031A1 (en) 2005-02-09
EP1504031B1 (en) 2006-08-02
ATE335006T1 (de) 2006-08-15

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/05/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF