ATE302951T1 - Hochdurchsatz-screening - Google Patents
Hochdurchsatz-screeningInfo
- Publication number
- ATE302951T1 ATE302951T1 AT99957097T AT99957097T ATE302951T1 AT E302951 T1 ATE302951 T1 AT E302951T1 AT 99957097 T AT99957097 T AT 99957097T AT 99957097 T AT99957097 T AT 99957097T AT E302951 T1 ATE302951 T1 AT E302951T1
- Authority
- AT
- Austria
- Prior art keywords
- substrate
- membrane
- ion channel
- biological membrane
- perforated
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0851—Bottom walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9812783.0A GB9812783D0 (en) | 1998-06-12 | 1998-06-12 | High throuoghput screen |
PCT/GB1999/001871 WO1999066329A1 (en) | 1998-06-12 | 1999-06-14 | High throughput screen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE302951T1 true ATE302951T1 (de) | 2005-09-15 |
Family
ID=10833717
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05076930T ATE428115T1 (de) | 1998-06-12 | 1999-06-14 | Screening-system mit hohem durchsatz |
AT99957097T ATE302951T1 (de) | 1998-06-12 | 1999-06-14 | Hochdurchsatz-screening |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05076930T ATE428115T1 (de) | 1998-06-12 | 1999-06-14 | Screening-system mit hohem durchsatz |
Country Status (17)
Country | Link |
---|---|
US (5) | US6936462B1 (de) |
EP (2) | EP1621888B1 (de) |
JP (1) | JP4499284B2 (de) |
AT (2) | ATE428115T1 (de) |
AU (1) | AU768862B2 (de) |
CA (1) | CA2334770C (de) |
DE (2) | DE69926883T3 (de) |
DK (2) | DK1621888T3 (de) |
ES (1) | ES2249041T3 (de) |
GB (1) | GB9812783D0 (de) |
HU (1) | HUP0102915A3 (de) |
IL (2) | IL140199A0 (de) |
MX (1) | MXPA00012345A (de) |
NO (1) | NO20006295L (de) |
PL (1) | PL201770B1 (de) |
WO (1) | WO1999066329A1 (de) |
ZA (1) | ZA200007296B (de) |
Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9812783D0 (en) | 1998-06-12 | 1998-08-12 | Cenes Ltd | High throuoghput screen |
ATE513209T1 (de) | 1998-12-05 | 2011-07-15 | Xention Ltd | Grenzflächen-patch-clamp-verfahren und -gerät |
US6488829B1 (en) | 1999-08-05 | 2002-12-03 | Essen Instruments Inc | High-throughput electrophysiological measurement apparatus |
US6682649B1 (en) | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
GB9930719D0 (en) * | 1999-12-24 | 2000-02-16 | Central Research Lab Ltd | Apparatus for and method of making electrical measurements on an object in a m edium |
EP1292388A2 (de) * | 2000-06-08 | 2003-03-19 | 1428388 Ontario Limited | Räumlich adressierbare elektrolyseplattform und verfahren zur anwendung |
EP1311848A2 (de) * | 2000-07-07 | 2003-05-21 | Bristol-Myers Squibb Company | Hochdurchfluss-screening zur entdeckung von arzneimitteln sowie dafür geeignete electrophysiologie-vorrichtung |
ATE342959T1 (de) * | 2000-07-14 | 2006-11-15 | Transform Pharmaceuticals Inc | System und verfahren zum optimieren des gewebebarrieretransfers von verbindungen |
EP1178315A1 (de) | 2000-07-31 | 2002-02-06 | Albrecht Dr.med. Priv.Doz. Lepple-Wienhues | Verfahren und Vorrichtung zur Untersuchung von Zellen mit Hilfe der Patch Clamp-Methode |
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1999
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- 1999-06-14 WO PCT/GB1999/001871 patent/WO1999066329A1/en active IP Right Grant
- 1999-06-14 DE DE69926883T patent/DE69926883T3/de not_active Expired - Lifetime
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- 1999-06-14 JP JP2000555097A patent/JP4499284B2/ja not_active Expired - Lifetime
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- 1999-06-14 DK DK05076930T patent/DK1621888T3/da active
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- 1999-06-14 AU AU42835/99A patent/AU768862B2/en not_active Ceased
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2000
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2005
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2010
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2013
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2014
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