ATE216080T1 - Patch-clamp-vorrichtung und -technik mit hohem durchfluss und niedrigen flüssigkeitsvolumenanforderungen - Google Patents

Patch-clamp-vorrichtung und -technik mit hohem durchfluss und niedrigen flüssigkeitsvolumenanforderungen

Info

Publication number
ATE216080T1
ATE216080T1 AT95923258T AT95923258T ATE216080T1 AT E216080 T1 ATE216080 T1 AT E216080T1 AT 95923258 T AT95923258 T AT 95923258T AT 95923258 T AT95923258 T AT 95923258T AT E216080 T1 ATE216080 T1 AT E216080T1
Authority
AT
Austria
Prior art keywords
patch clamp
utilizing
novel
tested
small amounts
Prior art date
Application number
AT95923258T
Other languages
English (en)
Inventor
S Ren-Peter Olesen
Palle Christophersen
Original Assignee
Sophion Bioscience As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sophion Bioscience As filed Critical Sophion Bioscience As
Application granted granted Critical
Publication of ATE216080T1 publication Critical patent/ATE216080T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Computer Hardware Design (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
AT95923258T 1994-10-28 1995-06-07 Patch-clamp-vorrichtung und -technik mit hohem durchfluss und niedrigen flüssigkeitsvolumenanforderungen ATE216080T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK125294 1994-10-28
PCT/EP1995/002204 WO1996013721A1 (en) 1994-10-28 1995-06-07 Patch clamp apparatus and technique having high throughput and low fluid volume requirements

Publications (1)

Publication Number Publication Date
ATE216080T1 true ATE216080T1 (de) 2002-04-15

Family

ID=8102743

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95923258T ATE216080T1 (de) 1994-10-28 1995-06-07 Patch-clamp-vorrichtung und -technik mit hohem durchfluss und niedrigen flüssigkeitsvolumenanforderungen

Country Status (12)

Country Link
US (2) US6063260A (de)
EP (1) EP0788600B1 (de)
JP (1) JP3688713B2 (de)
AT (1) ATE216080T1 (de)
AU (1) AU2788695A (de)
CA (1) CA2203886C (de)
DE (1) DE69526364T2 (de)
DK (1) DK0788600T3 (de)
ES (1) ES2171542T3 (de)
PT (1) PT788600E (de)
SI (1) SI0788600T1 (de)
WO (1) WO1996013721A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU729397B2 (en) 1997-05-01 2001-02-01 Sophion Bioscience A/S An automatic electrode positioning apparatus
SE9702112D0 (sv) 1997-06-04 1997-06-04 Holdingbolaget Vid Goeteborgs Method and apparatus for detection of a receptor antagonist
DE19744649C2 (de) * 1997-10-09 2003-03-27 Fraunhofer Ges Forschung Verfahren zur Messung bioelektrischer Signale von Zellen nach der Patch-Clamp-Methode sowie Verwendung einer Vorrichtung hierzu
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
CA2316966C (en) * 1997-12-17 2008-04-08 Horst Vogel Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
DE19815696C2 (de) * 1998-04-08 2000-06-29 Gsf Forschungszentrum Umwelt Temperaturgeregelte Überströmapparatur für biologische Proben
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US20020035459A1 (en) 1998-09-14 2002-03-21 George M. Grass Pharmacokinetic-based drug design tool and method
JP4335460B2 (ja) 1998-12-05 2009-09-30 ゼンション ディスカバリー リミティド 界面パッチクランプ
DE19936302A1 (de) * 1999-08-02 2001-02-15 Niels Fertig Vorrichtungen und Verfahren zur Untersuchung von Ionenkanälen in Membranen
US6488829B1 (en) 1999-08-05 2002-12-03 Essen Instruments Inc High-throughput electrophysiological measurement apparatus
DE10008373C2 (de) * 2000-02-23 2002-11-28 Helmut Adelsberger Verfahren und Vorrichtung zur Bestimmung der Ionenkanalaktivität
US20030139336A1 (en) * 2000-03-21 2003-07-24 Norwood James Henry Interface patch clamping
US6541243B1 (en) * 2000-06-05 2003-04-01 Axon Instruments, Inc. Perfusion chamber for electrophysiological testing of oocytes
GB0013584D0 (en) * 2000-06-06 2000-07-26 Cenes Ltd Automated flow patch-clamp system
US20030129581A1 (en) * 2000-06-06 2003-07-10 Owen David Geraint Patch-clamping method and apparatus
US7615356B2 (en) * 2000-07-10 2009-11-10 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
US7399599B2 (en) 2000-07-10 2008-07-15 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
US7270730B2 (en) * 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
WO2002059597A1 (en) * 2001-01-26 2002-08-01 Cytion Sa Methods and devices for the electrically tight adhesion of a cell to a surface
US6815197B2 (en) * 2001-02-16 2004-11-09 Multi Channel System Mcs Gmbh Apparatus for conducting electrophysiological measurements on cells
EP1233268A3 (de) * 2001-02-16 2004-07-07 Multi Channel Systems MCS GmbH Vorrichtung zum Durchführen elektrophysiologischer Messungen an Zellen
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
EP1372828A4 (de) * 2001-03-24 2008-10-29 Aviva Biosciences Corp Biochips mit ionentransporterfassungsstrukturen und verwendungsverfahren
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US6969489B2 (en) 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
EP1434850A2 (de) * 2001-09-05 2004-07-07 Essen Instruments, Inc. Elektrophysiologisches messsystem mit hohem durchsatz
JP2005528081A (ja) * 2001-11-30 2005-09-22 ブリストル−マイヤーズ　スクイブ　カンパニー 細胞電気特性計測用のピペット形態及びそのアレイ
JP2005511039A (ja) * 2001-11-30 2005-04-28 ブリストル−マイヤーズ　スクイブ　カンパニー 自動パッチクランプ記録用液体界面形態
DE10202887B4 (de) * 2002-01-25 2004-05-06 Advalytix Ag Zellanalyseverfahren
CA2475348A1 (en) * 2002-02-12 2003-08-21 Cellectricon Ab Systems and methods for rapidly changing the solution environment around sensors
WO2003086637A1 (en) * 2002-04-12 2003-10-23 Instrumentation Laboratory Company Immunoassay probe
EP1501924A4 (de) * 2002-05-04 2006-05-24 Aviva Biosciences Corp Vorrichtung mit strukturen nachweisendem ionentransport und verwendungsverfahren
US20030215872A1 (en) * 2002-05-20 2003-11-20 Clark-Mxr, Inc. Screening apparatus and method for making
US20030215815A1 (en) * 2002-05-20 2003-11-20 Clark William G. Screening method
JP4552423B2 (ja) * 2003-11-21 2010-09-29 パナソニック株式会社 細胞外電位測定デバイスおよびこれを用いた細胞外電位の測定方法
US8202439B2 (en) * 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
FR2844052B1 (fr) 2002-08-28 2005-07-01 Commissariat Energie Atomique Dispositif de mesure de l'activite electrique d'elements biologiques et ses applications
WO2004036202A1 (en) 2002-10-16 2004-04-29 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
AU2003283663A1 (en) * 2002-11-01 2004-05-25 Cellectricon Ab Computer programs,workstations, systems and methods for microfluidic substrates in cell
US8323955B1 (en) 2003-03-05 2012-12-04 Sandia Corporation Micromachined patch-clamp apparatus
SE0400421D0 (sv) * 2004-02-23 2004-02-23 Astrazeneca Ab Assay
US20050241940A1 (en) * 2004-05-03 2005-11-03 Wyeth Fast perfusion system and patch clamp technique utilizing an interface chamber system having high throughput and low volume requirements
US7465558B2 (en) * 2004-05-12 2008-12-16 Wyeth Perfusion system and apparatus for automated multi-channel patch-clamp recordings utilizing inside-out whole-cell configuration
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
KR20150041174A (ko) 2005-11-08 2015-04-15 버텍스 파마슈티칼스 인코포레이티드 Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제
NZ585880A (en) 2007-12-07 2012-08-31 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
ES3017582T3 (en) 2010-04-07 2025-05-13 Vertex Pharma Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
CN108066306B (zh) 2012-01-25 2021-09-07 沃泰克斯药物股份有限公司 药物制剂及其制备方法
US9086401B2 (en) * 2013-03-06 2015-07-21 Wisconsin Alumni Research Foundation Radio-frequency ion channel antenna
CN107110831B (zh) * 2014-11-18 2020-02-21 弗特克斯药品有限公司 进行高通量试验高效液相色谱的方法
US10479972B2 (en) * 2015-04-20 2019-11-19 Rush University Medical Center Chamber for imaging cells and method of use thereof
US10324080B2 (en) * 2015-11-17 2019-06-18 Purdue Research Foundation Systems and methods for automated image-guided patch-clamp electrophysiology in vitro
JP7086072B2 (ja) * 2016-12-02 2022-06-17 ソフィオン・バイオサイエンス・アクティーゼルスカブ シールエンハンサー
US11073508B2 (en) 2017-03-28 2021-07-27 Arizona Board Of Regents On Behalf Of The University Of Arizona Rapid conductance based ion channel analysis
WO2022214558A1 (en) * 2021-04-07 2022-10-13 Norgren LLC Bioprocessing systems

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3526481A (en) * 1968-01-29 1970-09-01 Jeanette L Rubricius Blood oxygenator
US3726597A (en) * 1972-03-09 1973-04-10 Us Health Education & Welfare Controlled environment culture system for light microscopy
US4128456A (en) * 1977-10-11 1978-12-05 Lee Kai S Suction electrode for intracellular potential measurement
US4299919A (en) * 1980-06-30 1981-11-10 St. Louis University Perfusate redox potential controller
EP0162907B1 (de) * 1983-11-08 1992-01-15 Bar Ilan University System und verfahren für zellenauslese
US4713974A (en) * 1986-04-18 1987-12-22 Varian Associates, Inc./Scientific Systems, Inc. Autosampler
NL8702370A (nl) * 1987-10-05 1989-05-01 Groningen Science Park Werkwijze en stelsel voor glucosebepaling en daarvoor bruikbaar meetcelsamenstel.
US4889691A (en) * 1988-07-05 1989-12-26 Thomas Michael Argentieri Modular tissue superfusion chamber
EP0581983B1 (de) * 1992-08-04 1996-10-23 Hewlett-Packard GmbH Vorrichtung für die Kapillarelektrophorese
EP0581984B1 (de) * 1992-08-04 1998-02-04 Hewlett-Packard GmbH Vorrichtung zur Behandlung von Fiolen in einem "Analyseapparat"
DE4305405C1 (de) * 1993-02-22 1994-05-26 Hering Steffen Dr Sc Med Vorrichtung zum Untersuchen eines Objekts, das sich in einer ein Substrat bedeckenden Perfusionsflüssigkeit befindet
EP0649628B1 (de) * 1993-10-22 1999-01-07 Siemens-Elema AB Verfahren und Vorrichtung zur kontinuierlichen Überwachung eines Anolytpegels

Also Published As

Publication number Publication date
DE69526364T2 (de) 2002-11-28
ES2171542T3 (es) 2002-09-16
WO1996013721A1 (en) 1996-05-09
JPH10509794A (ja) 1998-09-22
AU2788695A (en) 1996-05-23
CA2203886A1 (en) 1996-05-09
DK0788600T3 (da) 2002-08-05
DE69526364D1 (de) 2002-05-16
CA2203886C (en) 2003-09-02
EP0788600A1 (de) 1997-08-13
US6117291A (en) 2000-09-12
JP3688713B2 (ja) 2005-08-31
EP0788600B1 (de) 2002-04-10
SI0788600T1 (en) 2002-06-30
US6063260A (en) 2000-05-16
PT788600E (pt) 2002-07-31

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