ATE216080T1 - HIGH FLOW AND LOW LIQUID VOLUME PATCH CLAMP DEVICE AND TECHNOLOGY - Google Patents

HIGH FLOW AND LOW LIQUID VOLUME PATCH CLAMP DEVICE AND TECHNOLOGY

Info

Publication number
ATE216080T1
ATE216080T1 AT95923258T AT95923258T ATE216080T1 AT E216080 T1 ATE216080 T1 AT E216080T1 AT 95923258 T AT95923258 T AT 95923258T AT 95923258 T AT95923258 T AT 95923258T AT E216080 T1 ATE216080 T1 AT E216080T1
Authority
AT
Austria
Prior art keywords
patch clamp
utilizing
novel
tested
small amounts
Prior art date
Application number
AT95923258T
Other languages
German (de)
Inventor
S Ren-Peter Olesen
Palle Christophersen
Original Assignee
Sophion Bioscience As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sophion Bioscience As filed Critical Sophion Bioscience As
Application granted granted Critical
Publication of ATE216080T1 publication Critical patent/ATE216080T1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Computer Hardware Design (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Abstract

Apparatus for carrying out patch clamp technique utilized in studying the effect of certain materials on ion transfer channels in biological tissue, and more particularly patch clamp apparatus utilizing an autosampler, such as those utilized with HPLC apparatus, to provide high throughput, is disclosed. The invention additionally includes novel microperfusion chamber assemblies capable of utilizing only small amounts of material to be tested and only small amounts of liquid carrier, thereby enabling many tests to be completed in a short period of time. The invention more broadly relates to a novel electrophysiology drug handling and application set up for screening of chemical substances while providing high throughput and requiring only low volume of solutions and samples to be tested. The invention also comprises several novel procedures for utilizing the apparatus of the invention.
AT95923258T 1994-10-28 1995-06-07 HIGH FLOW AND LOW LIQUID VOLUME PATCH CLAMP DEVICE AND TECHNOLOGY ATE216080T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK125294 1994-10-28
PCT/EP1995/002204 WO1996013721A1 (en) 1994-10-28 1995-06-07 Patch clamp apparatus and technique having high throughput and low fluid volume requirements

Publications (1)

Publication Number Publication Date
ATE216080T1 true ATE216080T1 (en) 2002-04-15

Family

ID=8102743

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95923258T ATE216080T1 (en) 1994-10-28 1995-06-07 HIGH FLOW AND LOW LIQUID VOLUME PATCH CLAMP DEVICE AND TECHNOLOGY

Country Status (12)

Country Link
US (2) US6063260A (en)
EP (1) EP0788600B1 (en)
JP (1) JP3688713B2 (en)
AT (1) ATE216080T1 (en)
AU (1) AU2788695A (en)
CA (1) CA2203886C (en)
DE (1) DE69526364T2 (en)
DK (1) DK0788600T3 (en)
ES (1) ES2171542T3 (en)
PT (1) PT788600E (en)
SI (1) SI0788600T1 (en)
WO (1) WO1996013721A1 (en)

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WO1999031503A1 (en) * 1997-12-17 1999-06-24 Horst Vogel Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
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US20020035459A1 (en) 1998-09-14 2002-03-21 George M. Grass Pharmacokinetic-based drug design tool and method
ATE513209T1 (en) 1998-12-05 2011-07-15 Xention Ltd INTERFACE PATCH CLAMP METHOD AND APPARATUS
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US6488829B1 (en) 1999-08-05 2002-12-03 Essen Instruments Inc High-throughput electrophysiological measurement apparatus
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US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
CA2441366A1 (en) 2001-03-24 2002-10-03 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
US6969489B2 (en) 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
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PT2404919E (en) 2005-11-08 2013-10-22 Vertex Pharma Heterocyclic compound useful as a modulator of atp-binding cassette transporters.
HUE049642T2 (en) 2007-12-07 2020-09-28 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
DK3150198T3 (en) 2010-04-07 2021-11-01 Vertex Pharma PHARMACEUTICAL COMPOSITIONS OF 3- (6- (1- (2,2-DIFLUOROBENZO [D] [1,3] DIOXOL-5-YL) -CYCLOPROPANCARBOXAMIDO) -3-METHYLPYRIODIN-2-YL) BENZOIC ACID AND ADMINISTRATION
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Also Published As

Publication number Publication date
AU2788695A (en) 1996-05-23
US6063260A (en) 2000-05-16
DE69526364T2 (en) 2002-11-28
JP3688713B2 (en) 2005-08-31
CA2203886A1 (en) 1996-05-09
WO1996013721A1 (en) 1996-05-09
DK0788600T3 (en) 2002-08-05
ES2171542T3 (en) 2002-09-16
JPH10509794A (en) 1998-09-22
EP0788600A1 (en) 1997-08-13
DE69526364D1 (en) 2002-05-16
CA2203886C (en) 2003-09-02
EP0788600B1 (en) 2002-04-10
US6117291A (en) 2000-09-12
PT788600E (en) 2002-07-31
SI0788600T1 (en) 2002-06-30

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Legal Events

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REN Ceased due to non-payment of the annual fee