ATE231148T1 - Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren - Google Patents

Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren

Info

Publication number
ATE231148T1
ATE231148T1 AT97933661T AT97933661T ATE231148T1 AT E231148 T1 ATE231148 T1 AT E231148T1 AT 97933661 T AT97933661 T AT 97933661T AT 97933661 T AT97933661 T AT 97933661T AT E231148 T1 ATE231148 T1 AT E231148T1
Authority
AT
Austria
Prior art keywords
tyrosine kinase
kinase inhibitors
protein tyrosine
heteroaromatic compounds
bicyclic heteroaromatic
Prior art date
Application number
AT97933661T
Other languages
German (de)
English (en)
Inventor
George Stuart Cockerill
Malcolm Clive Carter
Stephen Barry Guntrip
Kathryn Jane Smith
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614756.6A external-priority patent/GB9614756D0/en
Priority claimed from GBGB9625495.8A external-priority patent/GB9625495D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE231148T1 publication Critical patent/ATE231148T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C07C217/86—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97933661T 1996-07-13 1997-07-11 Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren ATE231148T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9614756.6A GB9614756D0 (en) 1996-07-13 1996-07-13 Heterocyclic compounds
GBGB9625495.8A GB9625495D0 (en) 1996-12-07 1996-12-07 Heterocyclic compounds
PCT/EP1997/003673 WO1998002437A1 (en) 1996-07-13 1997-07-11 Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE231148T1 true ATE231148T1 (de) 2003-02-15

Family

ID=26309691

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97933661T ATE231148T1 (de) 1996-07-13 1997-07-11 Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren

Country Status (22)

Country Link
US (1) US6207669B1 (en:Method)
EP (1) EP0912572B1 (en:Method)
JP (1) JP2000515136A (en:Method)
KR (1) KR20000023813A (en:Method)
CN (1) CN1230185A (en:Method)
AP (1) AP9901435A0 (en:Method)
AR (1) AR007855A1 (en:Method)
AT (1) ATE231148T1 (en:Method)
AU (1) AU3693697A (en:Method)
BR (1) BR9710362A (en:Method)
CA (1) CA2260058A1 (en:Method)
CZ (1) CZ8799A3 (en:Method)
DE (1) DE69718472T2 (en:Method)
EA (1) EA199900021A1 (en:Method)
ES (1) ES2191187T3 (en:Method)
ID (1) ID19430A (en:Method)
IS (1) IS4936A (en:Method)
NO (1) NO990123L (en:Method)
PE (1) PE91098A1 (en:Method)
PL (1) PL331154A1 (en:Method)
TR (1) TR199900048T2 (en:Method)
WO (1) WO1998002437A1 (en:Method)

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US6207669B1 (en) 2001-03-27
IS4936A (is) 1998-12-29
EP0912572A1 (en) 1999-05-06
NO990123L (no) 1999-01-13
ID19430A (id) 1998-07-09
CZ8799A3 (cs) 1999-06-16
EP0912572B1 (en) 2003-01-15
JP2000515136A (ja) 2000-11-14
NO990123D0 (no) 1999-01-12
ES2191187T3 (es) 2003-09-01
BR9710362A (pt) 1999-08-17
WO1998002437A1 (en) 1998-01-22
CA2260058A1 (en) 1998-01-22
AR007855A1 (es) 1999-11-24
AP9901435A0 (en) 1999-03-31
TR199900048T2 (xx) 1999-04-21
KR20000023813A (en) 2000-04-25
PL331154A1 (en) 1999-06-21
DE69718472D1 (de) 2003-02-20
CN1230185A (zh) 1999-09-29
EA199900021A1 (ru) 1999-08-26
PE91098A1 (es) 1999-01-15
DE69718472T2 (de) 2003-11-06
AU3693697A (en) 1998-02-09

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