ATE183185T1 - Neue potente induktoren der terminalen differenzierung und methoden ihrer verwendung - Google Patents
Neue potente induktoren der terminalen differenzierung und methoden ihrer verwendungInfo
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- ATE183185T1 ATE183185T1 AT92922033T AT92922033T ATE183185T1 AT E183185 T1 ATE183185 T1 AT E183185T1 AT 92922033 T AT92922033 T AT 92922033T AT 92922033 T AT92922033 T AT 92922033T AT E183185 T1 ATE183185 T1 AT E183185T1
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- 230000011712 cell development Effects 0.000 title abstract 2
- 230000003389 potentiating effect Effects 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000005170 neoplastic cell Anatomy 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- -1 pyridineamino Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Networks Using Active Elements (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/771,760 US5369108A (en) | 1991-10-04 | 1991-10-04 | Potent inducers of terminal differentiation and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE183185T1 true ATE183185T1 (de) | 1999-08-15 |
Family
ID=25092893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92922033T ATE183185T1 (de) | 1991-10-04 | 1992-10-05 | Neue potente induktoren der terminalen differenzierung und methoden ihrer verwendung |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US5369108A (de) |
| EP (1) | EP0642509B1 (de) |
| JP (4) | JP3432823B2 (de) |
| KR (2) | KR100263264B1 (de) |
| AT (1) | ATE183185T1 (de) |
| AU (1) | AU668696B2 (de) |
| CA (1) | CA2120619C (de) |
| CL (1) | CL2008002943A1 (de) |
| DE (1) | DE69229800T2 (de) |
| ES (1) | ES2134815T3 (de) |
| FI (1) | FI941537A7 (de) |
| HU (1) | HU225497B1 (de) |
| RU (1) | RU2128643C1 (de) |
| WO (1) | WO1993007148A1 (de) |
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| CH421933A (fr) * | 1964-02-03 | 1966-10-15 | Rhodiaceta | Procédé de fabrication d'amides mixtes d'acides carboxyliques |
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| FR1479260A (fr) * | 1965-12-06 | 1967-05-05 | Nouveaux dérivés acylés de la nu-hydroxyglycine | |
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| US4882346A (en) * | 1987-06-16 | 1989-11-21 | The United States Of America As Reprsented By The Department Of Health And Human Services | Chemical differentiating agents |
| US5330744A (en) * | 1988-11-14 | 1994-07-19 | Sloan-Kettering Institute For Cancer Research | Method for increasing sensitivity to chemically induced terminal differentiation |
| US5055608A (en) * | 1988-11-14 | 1991-10-08 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of thermal differentiation and method of use thereof |
| US5175191A (en) * | 1988-11-14 | 1992-12-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| AU5927190A (en) * | 1989-06-30 | 1991-01-17 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of terminal differentiation and methods of use thereof |
| DE69032871T2 (de) * | 1989-11-14 | 1999-09-09 | Sloan-Kettering Institute For Cancer Research | Neue potente induktoren terminaler differenzierung und verfahren zu ihrer verwendung |
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| US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| HU211995B (en) * | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
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- 1991-10-04 US US07/771,760 patent/US5369108A/en not_active Ceased
-
1992
- 1992-10-05 KR KR1019940701095A patent/KR100263264B1/ko not_active Expired - Lifetime
- 1992-10-05 EP EP92922033A patent/EP0642509B1/de not_active Expired - Lifetime
- 1992-10-05 AT AT92922033T patent/ATE183185T1/de active
- 1992-10-05 WO PCT/US1992/008454 patent/WO1993007148A1/en not_active Ceased
- 1992-10-05 DE DE69229800T patent/DE69229800T2/de not_active Expired - Lifetime
- 1992-10-05 CA CA002120619A patent/CA2120619C/en not_active Expired - Lifetime
- 1992-10-05 JP JP50710993A patent/JP3432823B2/ja not_active Expired - Lifetime
- 1992-10-05 RU RU94021660A patent/RU2128643C1/ru active Protection Beyond IP Right Term
- 1992-10-05 AU AU28703/92A patent/AU668696B2/en not_active Expired
- 1992-10-05 ES ES92922033T patent/ES2134815T3/es not_active Expired - Lifetime
- 1992-10-05 HU HU9400959A patent/HU225497B1/hu unknown
-
1994
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- 1994-04-04 US US08/222,685 patent/US5932616A/en not_active Expired - Lifetime
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1999
- 1999-05-18 US US09/314,195 patent/US6087367A/en not_active Expired - Fee Related
- 1999-10-30 KR KR1019997010081A patent/KR100258680B1/ko not_active Expired - Lifetime
-
2002
- 2002-11-20 JP JP2002337049A patent/JP2003226680A/ja not_active Withdrawn
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2007
- 2007-04-24 JP JP2007114876A patent/JP2007291110A/ja not_active Withdrawn
- 2007-09-19 JP JP2007242963A patent/JP2008069158A/ja not_active Withdrawn
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2008
- 2008-10-02 CL CL2008002943A patent/CL2008002943A1/es unknown
Also Published As
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|---|---|
| US5369108A (en) | 1994-11-29 |
| HUT67421A (en) | 1995-04-28 |
| HU9400959D0 (en) | 1994-06-28 |
| US5932616A (en) | 1999-08-03 |
| FI941537A0 (fi) | 1994-03-31 |
| JPH07502494A (ja) | 1995-03-16 |
| RU2128643C1 (ru) | 1999-04-10 |
| AU2870392A (en) | 1993-05-03 |
| AU668696B2 (en) | 1996-05-16 |
| CA2120619C (en) | 2006-11-21 |
| US6087367A (en) | 2000-07-11 |
| DE69229800T2 (de) | 2000-04-27 |
| JP2007291110A (ja) | 2007-11-08 |
| KR100258680B1 (en) | 2000-05-15 |
| KR100263264B1 (ko) | 2000-08-01 |
| EP0642509A4 (de) | 1995-01-31 |
| EP0642509B1 (de) | 1999-08-11 |
| FI941537A7 (fi) | 1994-05-31 |
| JP2008069158A (ja) | 2008-03-27 |
| HU225497B1 (en) | 2007-01-29 |
| CA2120619A1 (en) | 1993-04-15 |
| EP0642509A1 (de) | 1995-03-15 |
| ES2134815T3 (es) | 1999-10-16 |
| JP2003226680A (ja) | 2003-08-12 |
| CL2008002943A1 (es) | 2009-03-06 |
| JP3432823B2 (ja) | 2003-08-04 |
| DE69229800D1 (de) | 1999-09-16 |
| WO1993007148A1 (en) | 1993-04-15 |
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