DE69229800D1 - Neue potente induktoren der terminalen differenzierung und methoden ihrer verwendung - Google Patents
Neue potente induktoren der terminalen differenzierung und methoden ihrer verwendungInfo
- Publication number
- DE69229800D1 DE69229800D1 DE69229800T DE69229800T DE69229800D1 DE 69229800 D1 DE69229800 D1 DE 69229800D1 DE 69229800 T DE69229800 T DE 69229800T DE 69229800 T DE69229800 T DE 69229800T DE 69229800 D1 DE69229800 D1 DE 69229800D1
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 230000011712 cell development Effects 0.000 title abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000005170 neoplastic cell Anatomy 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- -1 pyridineamino Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/771,760 US5369108A (en) | 1991-10-04 | 1991-10-04 | Potent inducers of terminal differentiation and methods of use thereof |
PCT/US1992/008454 WO1993007148A1 (en) | 1991-10-04 | 1992-10-05 | Novel potent inducers of terminal differentiation and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69229800D1 true DE69229800D1 (de) | 1999-09-16 |
DE69229800T2 DE69229800T2 (de) | 2000-04-27 |
Family
ID=25092893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69229800T Expired - Lifetime DE69229800T2 (de) | 1991-10-04 | 1992-10-05 | Neue potente induktoren der terminalen differenzierung und methoden ihrer verwendung |
Country Status (14)
Country | Link |
---|---|
US (3) | US5369108A (de) |
EP (1) | EP0642509B1 (de) |
JP (4) | JP3432823B2 (de) |
KR (2) | KR100263264B1 (de) |
AT (1) | ATE183185T1 (de) |
AU (1) | AU668696B2 (de) |
CA (1) | CA2120619C (de) |
CL (1) | CL2008002943A1 (de) |
DE (1) | DE69229800T2 (de) |
ES (1) | ES2134815T3 (de) |
FI (1) | FI941537A (de) |
HU (1) | HU225497B1 (de) |
RU (1) | RU2128643C1 (de) |
WO (1) | WO1993007148A1 (de) |
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- 1992-10-05 HU HU9400959A patent/HU225497B1/hu unknown
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- 1992-10-05 RU RU94021660A patent/RU2128643C1/ru active Protection Beyond IP Right Term
- 1992-10-05 EP EP92922033A patent/EP0642509B1/de not_active Expired - Lifetime
- 1992-10-05 WO PCT/US1992/008454 patent/WO1993007148A1/en active Application Filing
- 1992-10-05 DE DE69229800T patent/DE69229800T2/de not_active Expired - Lifetime
- 1992-10-05 KR KR1019940701095A patent/KR100263264B1/ko not_active IP Right Cessation
- 1992-10-05 AT AT92922033T patent/ATE183185T1/de active
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1994
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- 1994-04-04 US US08/222,685 patent/US5932616A/en not_active Expired - Lifetime
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- 1999-05-18 US US09/314,195 patent/US6087367A/en not_active Expired - Fee Related
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DE69229800T2 (de) | 2000-04-27 |
EP0642509A4 (de) | 1995-01-31 |
KR100258680B1 (en) | 2000-05-15 |
JP2007291110A (ja) | 2007-11-08 |
US5932616A (en) | 1999-08-03 |
CA2120619C (en) | 2006-11-21 |
US6087367A (en) | 2000-07-11 |
CL2008002943A1 (es) | 2009-03-06 |
CA2120619A1 (en) | 1993-04-15 |
EP0642509B1 (de) | 1999-08-11 |
AU668696B2 (en) | 1996-05-16 |
AU2870392A (en) | 1993-05-03 |
HU9400959D0 (en) | 1994-06-28 |
HU225497B1 (en) | 2007-01-29 |
JPH07502494A (ja) | 1995-03-16 |
US5369108A (en) | 1994-11-29 |
EP0642509A1 (de) | 1995-03-15 |
FI941537A (fi) | 1994-05-31 |
JP2008069158A (ja) | 2008-03-27 |
JP2003226680A (ja) | 2003-08-12 |
RU2128643C1 (ru) | 1999-04-10 |
HUT67421A (en) | 1995-04-28 |
FI941537A0 (fi) | 1994-03-31 |
ES2134815T3 (es) | 1999-10-16 |
WO1993007148A1 (en) | 1993-04-15 |
ATE183185T1 (de) | 1999-08-15 |
JP3432823B2 (ja) | 2003-08-04 |
KR100263264B1 (ko) | 2000-08-01 |
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