ATA333087A - Pharmazeutisches präparat für die intravenöse wirkstoffapplikation mit hydrosolen im nanometerbereich - Google Patents
Pharmazeutisches präparat für die intravenöse wirkstoffapplikation mit hydrosolen im nanometerbereichInfo
- Publication number
- ATA333087A ATA333087A AT0333087A AT333087A ATA333087A AT A333087 A ATA333087 A AT A333087A AT 0333087 A AT0333087 A AT 0333087A AT 333087 A AT333087 A AT 333087A AT A333087 A ATA333087 A AT A333087A
- Authority
- AT
- Austria
- Prior art keywords
- hydrosols
- active substance
- pharmaceutical preparation
- substance application
- nanometer area
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title 1
- 239000008131 herbal destillate Substances 0.000 title 1
- 238000001990 intravenous administration Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3643392 | 1986-12-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA333087A true ATA333087A (de) | 1993-12-15 |
| AT397914B AT397914B (de) | 1994-08-25 |
Family
ID=6316557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0333087A AT397914B (de) | 1986-12-19 | 1987-12-17 | Pharmazeutisches präparat für die intravenöse wirkstoffapplikation mit hydrosolen im nanometerbereich |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5389382A (de) |
| JP (1) | JP2617958B2 (de) |
| KR (1) | KR960005136B1 (de) |
| AT (1) | AT397914B (de) |
| BE (1) | BE1000848A3 (de) |
| CA (1) | CA1308656C (de) |
| CH (1) | CH679451A5 (de) |
| DD (1) | DD281344A5 (de) |
| DE (1) | DE3742473C2 (de) |
| DK (2) | DK173319B1 (de) |
| ES (1) | ES2028492A6 (de) |
| FR (1) | FR2608427B1 (de) |
| GB (1) | GB2200048B (de) |
| GR (1) | GR871938B (de) |
| HU (1) | HU205861B (de) |
| IE (1) | IE61179B1 (de) |
| IL (1) | IL84855A (de) |
| IT (1) | IT1230118B (de) |
| LU (1) | LU87079A1 (de) |
| MY (1) | MY102037A (de) |
| NL (1) | NL194638C (de) |
| NZ (1) | NZ222964A (de) |
| PT (1) | PT86399B (de) |
| SE (1) | SE503020C2 (de) |
| ZA (1) | ZA879533B (de) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5399363A (en) * | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| DE4140185C2 (de) * | 1991-12-05 | 1996-02-01 | Alfatec Pharma Gmbh | Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung |
| DE4140179C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Ibuprofen enthaltendes Arzneimittel |
| DK0615445T3 (da) * | 1991-12-05 | 1996-06-03 | Alfatec Pharma Gmbh | Farmaceutisk administrerbar nanosol og fremgangsmåde til fremstilling deraf |
| DE4140195C2 (de) * | 1991-12-05 | 1994-10-27 | Alfatec Pharma Gmbh | Pharmazeutisch applizierbares Nanosol und Verfahren zu seiner Herstellung |
| DE4140194C2 (de) * | 1991-12-05 | 1998-02-19 | Alfatec Pharma Gmbh | Ein Dihydropyridinderivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung |
| DE4140191C2 (de) * | 1991-12-05 | 1998-02-19 | Alfatec Pharma Gmbh | Retardform für ein Indometacin oder Acemetacin enthaltendes Arzneimittel und seine Herstellung |
| DE4140184C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Flurbiprofen enthaltendes Arzneimittel |
| DE4140183C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Retardform für ein Flurbiprofen enthaltendes Arzneimittel |
| DE4140172C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Retardform für ein Ibuprofen enthaltendes Arzneimittel |
| CZ278863B6 (en) * | 1992-09-07 | 1994-07-13 | Galena | Medicinal preparations with n-methylated cyclic undecapeptides |
| KR0146671B1 (ko) * | 1994-02-25 | 1998-08-17 | 김충환 | 사이클로스포린-함유 분말 조성물 |
| DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| US5766629A (en) * | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5834017A (en) * | 1995-08-25 | 1998-11-10 | Sangstat Medical Corporation | Oral cyclopsporin formulations |
| US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| EP1369111A1 (de) * | 1996-10-03 | 2003-12-10 | Hermes Biosciences, Inc. | Hydrophile Mikropartikel und Verfahren zu deren Herstellung |
| US6249717B1 (en) * | 1996-11-08 | 2001-06-19 | Sangstat Medical Corporation | Liquid medication dispenser apparatus |
| US6346511B1 (en) | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
| US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
| US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| DE69840586D1 (de) | 1997-10-08 | 2009-04-02 | Isotechnika Inc | Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien |
| DE19856432A1 (de) * | 1998-12-08 | 2000-06-15 | Basf Ag | Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen |
| US6447806B1 (en) | 1999-02-25 | 2002-09-10 | Novartis Ag | Pharmaceutical compositions comprised of stabilized peptide particles |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US20040121014A1 (en) * | 1999-03-22 | 2004-06-24 | Control Delivery Systems, Inc. | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| US6656504B1 (en) | 1999-09-09 | 2003-12-02 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| DE10040707A1 (de) * | 2000-08-17 | 2002-03-14 | Braun Melsungen Ag | Kolloidale Pharmakomodulation injizierter Arzneimittel |
| DE60231570D1 (de) | 2001-10-19 | 2009-04-23 | Isotechnika Inc | Synthese von Cyclosporinanalogen |
| PT1435910E (pt) * | 2001-10-19 | 2009-09-07 | Isotechnika Inc | Novos pré-concentrados de microemulsão de análogos da ciclosporina |
| DE10205362A1 (de) * | 2002-02-08 | 2003-08-21 | Abbott Gmbh & Co Kg | Verfahren zur Herstellung wasserdispergierbarer Trockenpulver von in Wasser schwer löslichen Verbindungen |
| US8871241B2 (en) * | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| US7838034B2 (en) | 2002-07-30 | 2010-11-23 | Grunenthal Gmbh | Intravenous pharmaceutical form of administration |
| DE10234784A1 (de) * | 2002-07-30 | 2004-02-19 | Günenthal GmbH | Intravenös applizierbare, pharmazeutische Darreichungsform |
| WO2004071494A2 (en) * | 2003-02-13 | 2004-08-26 | Phares Pharmaceutical Research N.V. | Lipophilic compositions |
| US20060003002A1 (en) * | 2003-11-03 | 2006-01-05 | Lipocine, Inc. | Pharmaceutical compositions with synchronized solubilizer release |
| US7754243B2 (en) * | 2004-08-03 | 2010-07-13 | Clemson University Research Foundation | Aqueous suspension of nanoscale drug particles from supercritical fluid processing |
| DE102005011786A1 (de) * | 2005-03-11 | 2006-09-14 | Pharmasol Gmbh | Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen |
| CA2604770C (en) * | 2005-04-13 | 2013-09-24 | Abbott Gmbh & Co. Kg | Method for carefully producing ultrafine particle suspensions and ultrafine particles and use thereof |
| DE102005053862A1 (de) * | 2005-11-04 | 2007-05-10 | Pharmasol Gmbh | Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel |
| US9561178B2 (en) * | 2006-07-25 | 2017-02-07 | Allergan, Inc. | Cyclosporin compositions |
| WO2008058755A1 (en) | 2006-11-17 | 2008-05-22 | Abbott Gmbh & Co. Kg | Nanocrystals for use in topical cosmetic formulations and method of production thereof |
| DE102007001473A1 (de) | 2007-01-08 | 2008-07-10 | Andreas Lemke | Verfahren zur Herstellung und Anwendung von Mikro- und/oder Nanosuspensionen durch aufbauende Mikronisierung in Gegenwart von Trockeneis und hohem Druck |
| WO2009007992A2 (en) * | 2007-04-20 | 2009-01-15 | Sun Pharmaceutical Industries Limited | Pharmaceutical composition produced by microprecipitation |
| JP5149585B2 (ja) * | 2007-10-02 | 2013-02-20 | 浜松ホトニクス株式会社 | 微粒子分散液製造方法 |
| US20090087460A1 (en) * | 2007-10-02 | 2009-04-02 | Hamamatsu Photonics K.K. | Solid composition, microparticles, microparticle dispersion liquid, and manufacturing methods for these |
| JP5161528B2 (ja) * | 2007-10-02 | 2013-03-13 | 浜松ホトニクス株式会社 | パクリタキセル微粒子、パクリタキセル微粒子分散液、および、これらの製造方法 |
| US8861813B2 (en) * | 2008-03-13 | 2014-10-14 | Mallinckrodt Llc | Multi-function, foot-activated controller for imaging system |
| HU230862B1 (hu) | 2008-04-28 | 2018-10-29 | DARHOLDING Vagyonkezelő Kft | Berendezés és eljárás nanorészecskék folyamatos üzemű előállítására |
| DE102008037025C5 (de) | 2008-08-08 | 2016-07-07 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| CA2785468A1 (en) * | 2009-12-23 | 2011-06-30 | Psivida Us, Inc. | Sustained release delivery devices |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| EP2583672A1 (de) | 2011-10-17 | 2013-04-24 | PharmaSol GmbH | Nanokristalle und amorphe Nanopartikel und Verfahren zur Herstellung davon mit einem Niederspannungsverfahren |
| WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| US11559530B2 (en) | 2016-11-28 | 2023-01-24 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| EP3824296A4 (de) | 2018-07-20 | 2022-04-27 | Lipocine Inc. | Lebererkrankung |
| EP3616688A1 (de) * | 2018-08-27 | 2020-03-04 | Centre National de la Recherche Scientifique - CNRS | Herstellung von nanosuspensionshaltigen nanokristallen von pharmazeutischen wirkstoffen mit geringen oder keinen stabilisatoren |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US107288A (en) * | 1870-09-13 | Improvement in thread-spools | ||
| DE738604C (de) * | 1935-07-09 | 1943-08-23 | Rudolf Degkwitz Dr | Verfahren zur Herstellung von Hydrosolen mit waehlbarer Gestalt und waehlbarer Groesse der kolloiden Teilchen |
| JPS5831210B2 (ja) * | 1973-04-09 | 1983-07-05 | 武田薬品工業株式会社 | アンテイナスイセイケンダクエキノセイゾウホウ |
| DE2362785A1 (de) * | 1973-12-18 | 1975-06-26 | Atmos Fritzsching & Co Gmbh | Verfahren zum haltbarmachen von kristallsuspensionen |
| FR2257266B1 (de) * | 1974-01-10 | 1977-07-01 | Pasteur Institut | |
| US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| CA1098444A (en) * | 1975-05-26 | 1981-03-31 | Leo Geller | Peptide preparations with prolonged action |
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| IT1142172B (it) * | 1978-10-19 | 1986-10-08 | Sandoz Ag | Nuovo impiego in terapeutica della ciclosporina-a e della diidrociclosporina-c |
| DE3013839A1 (de) * | 1979-04-13 | 1980-10-30 | Freunt Ind Co Ltd | Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung |
| US4361580A (en) * | 1980-06-20 | 1982-11-30 | The Upjohn Manufacturing Company | Aluminum ibuprofen pharmaceutical suspensions |
| IT1209276B (it) * | 1980-11-05 | 1989-07-16 | Magis Farmaceutici | Composizione farmaceutica per la somministrazione orale del metilestere dell'acido 13a-etil-2,3,5,6,12,13,13a,13b-ottaidro-12-idrossi1h-indolo-[3,2,1-de] pirido [3,2,1-ij] [1,5] naftiridina -12-carbossilico |
| PT75550B (en) * | 1981-09-22 | 1984-12-12 | Gist Brocades Nv | Bismuth containing composition and method for the preparation thereof |
| GB8322364D0 (en) * | 1983-08-19 | 1983-09-21 | May & Baker Ltd | Compositions of matter |
| CA1239349A (en) * | 1983-10-10 | 1988-07-19 | Eberhard F. Gottwald | Pharmaceutical composition containing cimetidine |
| EP0138216B1 (de) * | 1983-10-14 | 1993-01-07 | Sumitomo Pharmaceuticals Company, Limited | IFN-Präparat mit verzögerter Abgabe für parentale Verabreichung |
| JPS60139688A (ja) * | 1983-12-28 | 1985-07-24 | Tokyo Tanabe Co Ltd | 無定形ジヒドロピリジン粉末製剤 |
| DE3347579A1 (de) * | 1983-12-30 | 1985-07-11 | Hoechst Ag, 6230 Frankfurt | Zubereitungen schwer wasserloeslicher anthelminthika und verfahren zu ihrer herstellung |
| CA1282405C (en) * | 1984-05-21 | 1991-04-02 | Michael R. Violante | Method for making uniformly sized particles from water-insoluble organic compounds |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| DE3515335C2 (de) * | 1985-04-27 | 1995-01-26 | Bayer Ag | Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung |
-
1987
- 1987-12-11 HU HU875601A patent/HU205861B/hu unknown
- 1987-12-11 NL NL8702998A patent/NL194638C/nl not_active IP Right Cessation
- 1987-12-15 CH CH4885/87A patent/CH679451A5/de not_active IP Right Cessation
- 1987-12-15 DE DE3742473A patent/DE3742473C2/de not_active Expired - Lifetime
- 1987-12-17 DD DD87310651A patent/DD281344A5/de not_active IP Right Cessation
- 1987-12-17 DK DK198706641A patent/DK173319B1/da not_active IP Right Cessation
- 1987-12-17 FR FR878717792A patent/FR2608427B1/fr not_active Expired - Lifetime
- 1987-12-17 SE SE8705043A patent/SE503020C2/sv not_active IP Right Cessation
- 1987-12-17 AT AT0333087A patent/AT397914B/de not_active IP Right Cessation
- 1987-12-17 PT PT86399A patent/PT86399B/pt not_active IP Right Cessation
- 1987-12-17 LU LU87079A patent/LU87079A1/fr unknown
- 1987-12-17 NZ NZ222964A patent/NZ222964A/xx unknown
- 1987-12-17 BE BE8701461A patent/BE1000848A3/fr not_active IP Right Cessation
- 1987-12-17 GB GB8729404A patent/GB2200048B/en not_active Expired - Lifetime
- 1987-12-17 IL IL84855A patent/IL84855A/xx not_active IP Right Cessation
- 1987-12-17 CA CA000554625A patent/CA1308656C/en not_active Expired - Lifetime
- 1987-12-17 GR GR871938A patent/GR871938B/el unknown
- 1987-12-17 IE IE342587A patent/IE61179B1/en not_active IP Right Cessation
- 1987-12-18 KR KR1019870014499A patent/KR960005136B1/ko not_active Expired - Lifetime
- 1987-12-18 JP JP62322622A patent/JP2617958B2/ja not_active Expired - Lifetime
- 1987-12-18 IT IT8748729A patent/IT1230118B/it active
- 1987-12-18 MY MYPI87003217A patent/MY102037A/en unknown
- 1987-12-18 ES ES8703635A patent/ES2028492A6/es not_active Expired - Lifetime
- 1987-12-18 ZA ZA879533A patent/ZA879533B/xx unknown
-
1991
- 1991-01-16 US US07/642,106 patent/US5389382A/en not_active Expired - Lifetime
-
2000
- 2000-02-21 DK DK200000266A patent/DK173345B1/da not_active IP Right Cessation
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| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee | ||
| ELA | Expired due to lapse of time |