AR115415A1 - Homoserina deshidrogenasa modificada y método para producir homoserina o l-aminoácido derivado de la homoserina usando la misma - Google Patents
Homoserina deshidrogenasa modificada y método para producir homoserina o l-aminoácido derivado de la homoserina usando la mismaInfo
- Publication number
- AR115415A1 AR115415A1 ARP190101364A ARP190101364A AR115415A1 AR 115415 A1 AR115415 A1 AR 115415A1 AR P190101364 A ARP190101364 A AR P190101364A AR P190101364 A ARP190101364 A AR P190101364A AR 115415 A1 AR115415 A1 AR 115415A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino acid
- homoserin
- substituted
- modified
- homoserine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01003—Homoserine dehydrogenase (1.1.1.3)
Abstract
La presente divulgación se refiere a la homoserina deshidrogenasa modificada y a un método para producir un L-aminoácido derivado de la homoserina utilizando la misma. Reivindicación 1: Homoserina deshidrogenasa modificada, en la que en la secuencia de aminoácidos de la SEQ ID Nº 1, el aminoácido en la posición de 285 está sustituido con isoleucina; el aminoácido en la posición 398 está sustituido con glutamina; o los aminoácidos en ambas posiciones están sustituidos con isoleucina y glutamina, respectivamente. Reivindicación 4: Un microorganismo del género Corynebacterium, que comprende la homoserina deshidrogenasa modificada, en donde en la secuencia de aminoácidos de la SEQ ID Nº 1, el aminoácido en la posición 285 está sustituido con isoleucina; el aminoácido en la posición 398 está sustituido con glutamina; o los aminoácidos en ambas posiciones están sustituidos con isoleucina y glutamina, respectivamente. Reivindicación 9: Un método para producir homoserina o un L-aminoácido derivado de la homoserina, que comprende: cultivar un microorganismo del género Corynebacterium, que comprende la homoserina deshidrogenasa modificada, en donde en la secuencia de aminoácidos de la SEQ ID Nº 1, el aminoácido en la posición 285 está sustituido con isoleucina; el aminoácido en la posición 398 está sustituido con glutamina; o los aminoácidos en ambas posiciones están sustituidos con isoleucina y glutamina, respectivamente, en un medio; y recuperar la homoserina o un L-aminoácido derivado de la homoserina del microorganismo o medio.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020180060445A KR101947959B1 (ko) | 2018-05-28 | 2018-05-28 | 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115415A1 true AR115415A1 (es) | 2021-01-13 |
Family
ID=65366474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190101364A AR115415A1 (es) | 2018-05-28 | 2019-05-22 | Homoserina deshidrogenasa modificada y método para producir homoserina o l-aminoácido derivado de la homoserina usando la misma |
Country Status (19)
Country | Link |
---|---|
US (2) | US11236374B2 (es) |
EP (1) | EP3597738B1 (es) |
JP (1) | JP6938795B2 (es) |
KR (1) | KR101947959B1 (es) |
CN (2) | CN110945121B (es) |
AR (1) | AR115415A1 (es) |
AU (1) | AU2019279282B2 (es) |
BR (1) | BR112019020697B1 (es) |
CA (1) | CA3091741C (es) |
ES (1) | ES2944588T3 (es) |
HU (1) | HUE062601T2 (es) |
MX (1) | MX2020007591A (es) |
PH (1) | PH12020551031A1 (es) |
PL (1) | PL3597738T3 (es) |
RU (1) | RU2733426C1 (es) |
SG (1) | SG11202006718YA (es) |
TW (1) | TWI740150B (es) |
WO (1) | WO2019231159A1 (es) |
ZA (1) | ZA202004021B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101947959B1 (ko) * | 2018-05-28 | 2019-02-13 | 씨제이제일제당 (주) | 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법 |
KR102175112B1 (ko) | 2019-04-22 | 2020-11-06 | 씨제이제일제당 주식회사 | L-쓰레오닌 생산능이 강화된 미생물 및 이를 이용한 쓰레오닌 생산방법 |
KR102207867B1 (ko) | 2020-01-21 | 2021-01-26 | 씨제이제일제당 주식회사 | Nadp 의존적 글리세르알데하이드-3-포스페이트 디하이드로지나제를 포함하는 미생물을 이용하여 l-아미노산을 생산하는 방법 |
KR102363913B1 (ko) * | 2020-06-26 | 2022-02-18 | 씨제이제일제당 (주) | L-쓰레오닌 디하이드라타아제의 신규 변이체 및 이를 이용한 l-이소류신 생산 방법 |
KR102527895B1 (ko) | 2021-01-11 | 2023-04-28 | 씨제이제일제당 (주) | GlxR 단백질 변이체 또는 이를 이용한 쓰레오닌 생산방법 |
KR102273639B1 (ko) * | 2021-04-20 | 2021-07-06 | 씨제이제일제당 주식회사 | 신규한 이중기능성 메틸렌테트라히드로폴레이트 탈수소효소/메테닐테트라하이드로폴레이트 사이클로하이드롤라아제 변이체 및 이를 이용한 xmp 또는 gmp 생산 방법 |
KR102377745B1 (ko) | 2021-05-12 | 2022-03-23 | 씨제이제일제당 주식회사 | 신규 프로모터 및 이의 용도 |
KR20220157144A (ko) | 2021-05-20 | 2022-11-29 | 씨제이제일제당 (주) | 신규 프로모터 및 이의 용도 |
KR102421911B1 (ko) * | 2022-02-16 | 2022-07-21 | 대상 주식회사 | 징크 바인딩 디하이드로게나제 신규 변이체 및 이를 이용한 l-방향족 아미노산 생산 방법 |
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KR101947959B1 (ko) * | 2018-05-28 | 2019-02-13 | 씨제이제일제당 (주) | 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법 |
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2018
- 2018-05-28 KR KR1020180060445A patent/KR101947959B1/ko active IP Right Grant
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2019
- 2019-05-21 SG SG11202006718YA patent/SG11202006718YA/en unknown
- 2019-05-21 PL PL19742120.9T patent/PL3597738T3/pl unknown
- 2019-05-21 AU AU2019279282A patent/AU2019279282B2/en active Active
- 2019-05-21 JP JP2020542785A patent/JP6938795B2/ja active Active
- 2019-05-21 RU RU2019122710A patent/RU2733426C1/ru active
- 2019-05-21 BR BR112019020697-3A patent/BR112019020697B1/pt active IP Right Grant
- 2019-05-21 MX MX2020007591A patent/MX2020007591A/es unknown
- 2019-05-21 US US16/483,309 patent/US11236374B2/en active Active
- 2019-05-21 EP EP19742120.9A patent/EP3597738B1/en active Active
- 2019-05-21 CN CN201980001666.XA patent/CN110945121B/zh active Active
- 2019-05-21 CA CA3091741A patent/CA3091741C/en active Active
- 2019-05-21 ES ES19742120T patent/ES2944588T3/es active Active
- 2019-05-21 HU HUE19742120A patent/HUE062601T2/hu unknown
- 2019-05-21 CN CN202011057257.2A patent/CN112143719B/zh active Active
- 2019-05-21 WO PCT/KR2019/006083 patent/WO2019231159A1/ko active Application Filing
- 2019-05-22 AR ARP190101364A patent/AR115415A1/es unknown
- 2019-05-27 TW TW108118247A patent/TWI740150B/zh active
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2020
- 2020-07-01 PH PH12020551031A patent/PH12020551031A1/en unknown
- 2020-07-01 ZA ZA2020/04021A patent/ZA202004021B/en unknown
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2021
- 2021-09-10 US US17/472,028 patent/US11555213B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BR112019020697A2 (pt) | 2021-02-17 |
US11555213B2 (en) | 2023-01-17 |
HUE062601T2 (hu) | 2023-11-28 |
ES2944588T3 (es) | 2023-06-22 |
AU2019279282A1 (en) | 2020-07-16 |
PH12020551031A1 (en) | 2021-08-16 |
TWI740150B (zh) | 2021-09-21 |
CN110945121A (zh) | 2020-03-31 |
SG11202006718YA (en) | 2020-08-28 |
BR112019020697B1 (pt) | 2022-04-26 |
CA3091741A1 (en) | 2019-12-05 |
AU2019279282B2 (en) | 2022-03-03 |
CN110945121B (zh) | 2021-09-28 |
RU2733426C1 (ru) | 2020-10-01 |
US20210002682A1 (en) | 2021-01-07 |
CA3091741C (en) | 2023-10-31 |
CN112143719B (zh) | 2023-11-24 |
EP3597738B1 (en) | 2023-04-05 |
WO2019231159A1 (ko) | 2019-12-05 |
US11236374B2 (en) | 2022-02-01 |
US20210403962A1 (en) | 2021-12-30 |
MX2020007591A (es) | 2021-01-15 |
TW202000914A (zh) | 2020-01-01 |
EP3597738A4 (en) | 2021-01-27 |
EP3597738A1 (en) | 2020-01-22 |
CN112143719A (zh) | 2020-12-29 |
JP6938795B2 (ja) | 2021-09-22 |
JP2021513341A (ja) | 2021-05-27 |
KR101947959B1 (ko) | 2019-02-13 |
ZA202004021B (en) | 2021-09-29 |
PL3597738T3 (pl) | 2023-07-17 |
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