AR120149A1 - Polipéptido modificado con actividad atenuada de la citrato sintasa y procedimiento para producir l-aminoácido usando el mismo - Google Patents

Polipéptido modificado con actividad atenuada de la citrato sintasa y procedimiento para producir l-aminoácido usando el mismo

Info

Publication number
AR120149A1
AR120149A1 ARP200102745A ARP200102745A AR120149A1 AR 120149 A1 AR120149 A1 AR 120149A1 AR P200102745 A ARP200102745 A AR P200102745A AR P200102745 A ARP200102745 A AR P200102745A AR 120149 A1 AR120149 A1 AR 120149A1
Authority
AR
Argentina
Prior art keywords
producing
attenuated
amino acid
modified polypeptide
procedure
Prior art date
Application number
ARP200102745A
Other languages
English (en)
Inventor
Hayun Lee
Ji Hye Lee
Imsang Lee
Hyun Bae
- Kim Ju Eun Jung
Chan Hong Ann
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Publication of AR120149A1 publication Critical patent/AR120149A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/03003—Citrate (Re)-synthase (2.3.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/03001—Citrate (Si)-synthase (2.3.3.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente divulgación se refiere a un polipéptido modificado con actividad atenuada de la citrato sintasa, a un microorganismo que produce leucina que comprende el polipéptido modificado y a un procedimiento para producir un L-aminoácido utilizando el microorganismo.
ARP200102745A 2020-01-30 2020-10-02 Polipéptido modificado con actividad atenuada de la citrato sintasa y procedimiento para producir l-aminoácido usando el mismo AR120149A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020200010823A KR102285951B1 (ko) 2020-01-30 2020-01-30 시트레이트 신타아제의 활성이 약화된 신규한 변이형 폴리펩티드 및 이를 이용한 l-아미노산 생산 방법

Publications (1)

Publication Number Publication Date
AR120149A1 true AR120149A1 (es) 2022-02-02

Family

ID=77078215

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200102745A AR120149A1 (es) 2020-01-30 2020-10-02 Polipéptido modificado con actividad atenuada de la citrato sintasa y procedimiento para producir l-aminoácido usando el mismo

Country Status (11)

Country Link
US (1) US20230040524A1 (es)
EP (1) EP4047086A4 (es)
JP (1) JP2023506053A (es)
KR (1) KR102285951B1 (es)
AR (1) AR120149A1 (es)
AU (1) AU2020426558A1 (es)
BR (1) BR112022012576A2 (es)
CA (1) CA3163266A1 (es)
MX (1) MX2022008211A (es)
WO (1) WO2021153866A1 (es)
ZA (1) ZA202206108B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116555130A (zh) * 2022-01-27 2023-08-08 廊坊梅花生物技术开发有限公司 产苏氨酸基因工程菌的构建方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006032634A1 (de) * 2006-07-13 2008-01-17 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
BRPI0716980A2 (pt) * 2006-09-15 2013-10-22 Cj Cheiljedang Corp Corynebacteria com produtividade de l-lisina aumentada e método de produção da l-lisina usando a mesma
KR100838038B1 (ko) 2006-12-29 2008-06-12 씨제이제일제당 (주) Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용한 ｌ-라이신 생산 방법
RU2411289C2 (ru) * 2008-09-30 2011-02-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Бактерия, принадлежащая к роду pantoea, - продуцент l-аспартата или метаболита, являющегося производным l-аспартата, и способ получения l-аспартата или метаболита, являющегося производным l-аспартата
KR101117022B1 (ko) 2011-08-16 2012-03-16 씨제이제일제당 (주) Ｌ-발린 생산능이 향상된 미생물 및 이를 이용한 ｌ-발린 제조방법
KR101335789B1 (ko) * 2012-01-13 2013-12-02 씨제이제일제당 (주) Ｌ-이소루신을 생산하는 미생물 및 이를 이용한 ｌ-이소루신 제조방법
KR102011994B1 (ko) 2017-06-30 2019-08-20 씨제이제일제당 주식회사 신규한 아스파토키나제 변이체 및 이를 이용한 l-아미노산의 제조방법
KR101915433B1 (ko) * 2018-02-13 2018-11-05 씨제이제일제당 (주) 시트레이트 신타아제 (Citrate synthase)의 활성이 약화된 변이형 폴리펩타이드 및 이를 이용한 L-아미노산 생산방법

Also Published As

Publication number Publication date
US20230040524A1 (en) 2023-02-09
MX2022008211A (es) 2022-08-04
EP4047086A1 (en) 2022-08-24
BR112022012576A2 (pt) 2022-09-06
KR102285951B1 (ko) 2021-08-04
EP4047086A4 (en) 2023-01-18
CA3163266A1 (en) 2021-08-05
AU2020426558A1 (en) 2022-06-09
ZA202206108B (en) 2023-04-26
CN115175993A (zh) 2022-10-11
WO2021153866A1 (ko) 2021-08-05
JP2023506053A (ja) 2023-02-14

Similar Documents

Publication Publication Date Title
PH12020550844A1 (en) Modified polypeptide with attenuated activity of citrate synthase and method for producing l-amino acid using the same
AR115302A1 (es) Un promotor y un método para producir l-aminoácido utilizando el mismo
BR112013018385A2 (pt) microorganismo com produtividade de l-aminoácidos aumentada e processo de produção de l-aminoácidos usando o mesmo
BR112015029601A2 (pt) produção de diterpeno extracelular
AR114670A1 (es) Un promotor y un método para producir l-aminoácidos utilizando el mismo
ES2692918T3 (es) Métodos y composiciones para producir aldehídos grasos
BRPI0707229B8 (pt) método para produzir um l-aminoácido
PH12020551045A1 (en) A microorganism of the genus corynebacterium producing l-amino acids and method for producing l-amino acids using the same
AR115415A1 (es) Homoserina deshidrogenasa modificada y método para producir homoserina o l-aminoácido derivado de la homoserina usando la misma
EP3502263A3 (en) Method for producing objective substance
AR120771A1 (es) Procedimiento de producción fermentativa de ácido guanidinoacético
PH12020551274A1 (en) Mycosporine-like amino acid-producing microorganism and method for production of mycosporine-like amino acids by using same
PH12020550976A1 (en) Camp receptor protein variant and method of producing l-amino acid using the same
BR112021021193A2 (pt) Produção de produtos químicos a partir de fontes renováveis
MX2021012296A (es) Microorganismo que produce l-aminoacido y procedimiento de produccion de l-aminoacido mediante el uso del mismo.
BR112021018925A2 (pt) Modificação metabólica para consumo simultâneo de xilose e glicose para produção de produtos químicos a partir de açúcares de segunda geração
AR120149A1 (es) Polipéptido modificado con actividad atenuada de la citrato sintasa y procedimiento para producir l-aminoácido usando el mismo
BR112023024041A2 (pt) Micro-organismo, e método para a produção fermentativa de ácido guanidinoacético (gaa) e creatina
PH12021550347A1 (en) MICROORGANISM FOR PRODUCING L-AMINO ACID WITH ENHANCED ACTIVITY OF a-GLUCOSIDASE AND METHOD FOR PRODUCING L-AMINO ACID USING THE SAME
MX2023002783A (es) Un microorganismo recombinante para producir acido l-glutamico y un metodo para producir acido l-glutamico utilizando el mismo.
AR092618A1 (es) Proceso para preparar gelatina
MX2023010436A (es) Nueva variante de citrato sintasa y procedimiento para producir l-valina utilizando la misma.
MX2022008294A (es) Nuevo promotor y procedimiento para producir glutation usando el mismo.
MX2023010437A (es) Nueva variante de citrato sintasa y procedimiento de produccion de l-aminoacidos usando la misma.
BR112021017167A2 (pt) Processo para a produção de um caldo de fermentação