BR112021021193A2 - Produção de produtos químicos a partir de fontes renováveis - Google Patents

Produção de produtos químicos a partir de fontes renováveis

Info

Publication number
BR112021021193A2
BR112021021193A2 BR112021021193A BR112021021193A BR112021021193A2 BR 112021021193 A2 BR112021021193 A2 BR 112021021193A2 BR 112021021193 A BR112021021193 A BR 112021021193A BR 112021021193 A BR112021021193 A BR 112021021193A BR 112021021193 A2 BR112021021193 A2 BR 112021021193A2
Authority
BR
Brazil
Prior art keywords
chemicals
production
renewable sources
pentanediol
hexanediol
Prior art date
Application number
BR112021021193A
Other languages
English (en)
Inventor
Harshal Chokhawala
Jonathan Kuchenreuther
Jorge-Alonso Gutierrez
Yi-Shu Tai
Original Assignee
Zymochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymochem Inc filed Critical Zymochem Inc
Publication of BR112021021193A2 publication Critical patent/BR112021021193A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/05—Oxidoreductases acting on NADH or NADPH (1.6) with a quinone or similar compound as acceptor (1.6.5)
    • C12Y106/05005—NADPH:quinone reductase (1.6.5.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01004—Acetoacetate decarboxylase (4.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02034—4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase (4.1.2.34)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02045—Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (4.1.2.45)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/0103—Glycerol dehydratase (4.2.1.30)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01034—(S)-2-Methylmalate dehydratase (4.2.1.34)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/101—Plasmid DNA for bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

produção de produtos químicos a partir de fontes renováveis. entre outras coisas, a presente divulgação fornece polipeptídeos de biossíntese, métodos e organismos microbianos de ocorrência não natural para preparação de diversos compostos, tais como 1,5-pentanodiol, ácido adípico, 1,6- hexanodiol, ácido 6-hidroxi-hexanoico e ácidos 2-cetocarboxílicos.
BR112021021193A 2019-04-25 2020-04-25 Produção de produtos químicos a partir de fontes renováveis BR112021021193A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962838793P 2019-04-25 2019-04-25
US201962868824P 2019-06-28 2019-06-28
PCT/US2020/029981 WO2020220001A1 (en) 2019-04-25 2020-04-25 Production of chemicals from renewable sources

Publications (1)

Publication Number Publication Date
BR112021021193A2 true BR112021021193A2 (pt) 2022-01-04

Family

ID=72941776

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021021193A BR112021021193A2 (pt) 2019-04-25 2020-04-25 Produção de produtos químicos a partir de fontes renováveis

Country Status (9)

Country Link
US (2) US20220372528A1 (pt)
EP (1) EP3959328A4 (pt)
JP (1) JP2022530467A (pt)
KR (1) KR20220012847A (pt)
CN (1) CN114026246A (pt)
AU (1) AU2020262490A1 (pt)
BR (1) BR112021021193A2 (pt)
CA (1) CA3134763A1 (pt)
WO (1) WO2020220001A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12104160B2 (en) 2013-09-17 2024-10-01 Zymochem, Inc. Production of 4,6-dihydroxy-2-oxo-hexanoic acid
AU2020262490A1 (en) 2019-04-25 2021-11-25 Zymochem, Inc. Production of chemicals from renewable sources
CN113336336B (zh) * 2021-06-04 2022-03-29 中国科学院重庆绿色智能技术研究院 卓贝尔氏菌在高效除氨氮中的应用
WO2024020161A2 (en) * 2022-07-20 2024-01-25 Zymochem, Inc. Purification technologies
WO2024018981A1 (ja) * 2022-07-22 2024-01-25 Dic株式会社 １，６－ヘキサンジオール組成物、ポリマー、硬化性樹脂組成物及び塗料

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582455B2 (en) 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
CN101437954B (zh) * 2006-03-07 2015-09-09 嘉吉公司 醛缩酶和编码醛缩酶的核酸以及它们的制备和使用方法
CL2008002960A1 (es) 2007-10-04 2009-05-08 Bio Arch Lab Inc Método para producir 2-ceto-3-desoxi d-gluconato (kdg), basado en proporciopnar acido-desoxi l-eritro hexocelulosa uronico (dehu), y contactar dicha molecula con un microorganismo recombinante que codofica una dehu-hidrogenasa.
US8986963B2 (en) 2008-02-23 2015-03-24 James Weifu Lee Designer calvin-cycle-channeled production of butanol and related higher alcohols
CN103555643B (zh) 2008-03-27 2016-08-10 基因组股份公司 用于产生己二酸和其他化合物的微生物
KR101930540B1 (ko) 2009-05-07 2019-03-15 게노마티카 인코포레이티드 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법
CA2845697C (en) * 2010-08-30 2020-05-05 Arzeda Corp. Fermentation route for the production of levulinic acid, levulinate esters, valerolactone, and derivatives thereof
CN104220601A (zh) 2011-12-16 2014-12-17 英威达技术有限责任公司 经与碳储存相关的CoA 依赖性碳链延长制备6 碳化学品的方法
ES2800341T3 (es) * 2012-07-11 2020-12-29 Adisseo France Sas Método para la preparación de 2,4-dihidroxibutirato
CN103305450B (zh) * 2013-06-04 2015-05-20 南京师范大学 一种大肠杆菌表达菌株及用其生产n-乙酰-d-神经氨酸的方法
BR112016005689A2 (pt) 2013-09-17 2018-01-30 Zymochem Inc rota de alto rendimento para a produção de compostos a partir de fontes renováveis
AU2020262490A1 (en) 2019-04-25 2021-11-25 Zymochem, Inc. Production of chemicals from renewable sources

Also Published As

Publication number Publication date
WO2020220001A1 (en) 2020-10-29
US20230109883A1 (en) 2023-04-13
US20220372528A1 (en) 2022-11-24
KR20220012847A (ko) 2022-02-04
EP3959328A4 (en) 2024-01-17
CA3134763A1 (en) 2020-10-29
US11692208B2 (en) 2023-07-04
CN114026246A (zh) 2022-02-08
JP2022530467A (ja) 2022-06-29
EP3959328A1 (en) 2022-03-02
AU2020262490A1 (en) 2021-11-25

Similar Documents

Publication Publication Date Title
BR112021021193A2 (pt) Produção de produtos químicos a partir de fontes renováveis
PH12020550441A1 (en) Fermentative production of n-acetylneuraminic acid
WO2015042201A3 (en) A high yield route for the production of compounds from renewable sources
ZA202004080B (en) Microorganisms and methods for the biological production of ethylene glycol
PE20180743A1 (es) Metodo para produccion de l-aminoacido
SG10201805672UA (en) Compositions and methods for biological production of amino acids in hydrogenotrophic microorganisms
BR112017025309A2 (pt) micro-organismos geneticamente modificados para a fabricação de produtos derivados de corismato
AR070058A1 (es) Enzima bacteriana asociada con la sintesis de ecuol
ES2692918T3 (es) Métodos y composiciones para producir aldehídos grasos
MY195408A (en) Novel Aspartokinase Variant and Method for Producing L- Amino Acid Using the Same
MX2018012003A (es) Composiciones producidas por microorganismos con actividad estimuladora sobre las plantas.
EP3502263A3 (en) Method for producing objective substance
BR112015020904A2 (pt) microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato
MX2019010195A (es) Nuevo medio de fermentacion para crecimiento de bacterias metanotrofas y metodo para producir dicho medio.
CL2020000222A1 (es) Producción eficiente de levaduras pichia y su uso para mejorar la vida animal y vegetal.
CL2019000318A1 (es) Método para producir un l-aminoácido tal como l-lisina.
BR112012020122A2 (pt) engenharia molecular de um indutor floral para melhoramento de cultura
BR112017019631A2 (pt) ?microrganismo recombinante, composição, métodos para produzir um microrganismo recombinante, para produzir piruvato, succinato, aspartato, malato, lactato, valina, leucina e/ou alanina, e para cultivar ou desenvolver um microrganismo geneticamente modificado, uso de um microrganismo recombinante, processo para produção fermentativa de piruvato, succinato, aspartato, malato, lactato, valina, leucina e/ou alanina, construção de expressão recombinante, e, vetor recombinante?
WO2016033572A8 (en) Process for enhancing the viable counts of lactic acid bacteria and useful compositions thereof
MY193587A (en) Genetically modified microorganism for improved production of fine chemicals on sucrose
MX2015001542A (es) Metodo.
MX2017007503A (es) Metodos novedosos para conjugacion de polipeptido mediada por enzimas usando sortasa.
BR112022000026A2 (pt) Métodos e composições compreendendo nível reduzido de proteínas de células hospedeiras
EP4339279A3 (en) Frozen enzyme pellets
WO2014044626A3 (en) Process for producing gelatin employing aspergillopepsin ii