BR112017025309A2 - micro-organismos geneticamente modificados para a fabricação de produtos derivados de corismato - Google Patents

micro-organismos geneticamente modificados para a fabricação de produtos derivados de corismato

Info

Publication number
BR112017025309A2
BR112017025309A2 BR112017025309A BR112017025309A BR112017025309A2 BR 112017025309 A2 BR112017025309 A2 BR 112017025309A2 BR 112017025309 A BR112017025309 A BR 112017025309A BR 112017025309 A BR112017025309 A BR 112017025309A BR 112017025309 A2 BR112017025309 A2 BR 112017025309A2
Authority
BR
Brazil
Prior art keywords
corismato
genetically modified
modified microorganisms
manufacture
exogenous
Prior art date
Application number
BR112017025309A
Other languages
English (en)
Inventor
Bruce Yarnton Behrendorff James
Phuong Tran Loan
Koepke Michael
Eric Allen Wyatt
Original Assignee
Lanzatech New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Priority to BR122023023164-3A priority Critical patent/BR122023023164A2/pt
Priority to BR122023023155-4A priority patent/BR122023023155A2/pt
Priority to BR122023023156-2A priority patent/BR122023023156A2/pt
Publication of BR112017025309A2 publication Critical patent/BR112017025309A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/03—Oxo-acid-lyases (4.1.3)
    • C12Y401/0304—Chorismate lyase (4.1.3.40)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/99—Other carbon-oxygen lyases (4.2.99)
    • C12Y402/99021—Isochorismate lyase (4.2.99.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/04—Intramolecular transferases (5.4) transferring hydroxy groups (5.4.4)
    • C12Y504/04002—Isochorismate synthase (5.4.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99005—Chorismate mutase (5.4.99.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a invenção apresenta micro-organismos geneticamente modificados e métodos para fabricação de produtos derivados de corismato, tais como ácido para-hidroxibenzoico, salicilato, 2-aminobenzoato, 2,3-dihidroxibenzoato, e ácido carboxílico 4-hidróxi-ciclohexano. geralmente, o micro-organismo compreende pelo menos uma liase corismato piruvato exógena, (b) uma síntese isocorismato exógena, (c) uma liase isocorismato piruvato exógena, e (d) uma síntese do prefanato compreendendo uma mutação prejudicial.
BR112017025309A 2015-05-27 2016-05-26 micro-organismos geneticamente modificados para a fabricação de produtos derivados de corismato BR112017025309A2 (pt)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BR122023023164-3A BR122023023164A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação
BR122023023155-4A BR122023023155A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação
BR122023023156-2A BR122023023156A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562167101P 2015-05-27 2015-05-27
PCT/US2016/034495 WO2016191625A1 (en) 2015-05-27 2016-05-26 Genetically engineered microorganisms for the production of chorismate-derived products

Publications (1)

Publication Number Publication Date
BR112017025309A2 true BR112017025309A2 (pt) 2018-07-31

Family

ID=57393384

Family Applications (4)

Application Number Title Priority Date Filing Date
BR122023023155-4A BR122023023155A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação
BR122023023156-2A BR122023023156A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação
BR112017025309A BR112017025309A2 (pt) 2015-05-27 2016-05-26 micro-organismos geneticamente modificados para a fabricação de produtos derivados de corismato
BR122023023164-3A BR122023023164A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BR122023023155-4A BR122023023155A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação
BR122023023156-2A BR122023023156A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122023023164-3A BR122023023164A2 (pt) 2015-05-27 2016-05-26 Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação

Country Status (11)

Country Link
US (1) US10174303B2 (pt)
EP (1) EP3303594A4 (pt)
JP (1) JP6871870B2 (pt)
KR (1) KR102390716B1 (pt)
CN (2) CN113684167A (pt)
BR (4) BR122023023155A2 (pt)
CA (1) CA2985481C (pt)
EA (1) EA036334B9 (pt)
MY (1) MY186542A (pt)
WO (1) WO2016191625A1 (pt)
ZA (1) ZA201707234B (pt)

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KR101918673B1 (ko) 2017-04-17 2018-11-14 주식회사 콧데 해양 유래 신규 미생물 및 이를 이용한 화장품 조성물
EA202090616A1 (ru) 2017-09-08 2020-06-10 Ланцатек, Инк. Способы и системы для получения метаболита с использованием обогащенных водородом с1-содержащих субстратов
CN111225978A (zh) * 2017-09-28 2020-06-02 朗泽科技有限公司 Wood-ljungdahl微生物的基因敲除
WO2019126400A1 (en) 2017-12-19 2019-06-27 Lanzatech, Inc. Microorganisms and methods for the biological production of ethylene glycol
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JP2021185831A (ja) * 2020-05-29 2021-12-13 花王株式会社 没食子酸生産能を有する形質転換体
JP2023520257A (ja) 2020-06-06 2023-05-16 ランザテク，インコーポレイテッド アセトラクテートデカルボキシラーゼ遺伝子座位でのノックインを有する微生物
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Also Published As

Publication number Publication date
BR122023023155A2 (pt) 2024-03-05
EP3303594A4 (en) 2018-12-05
CN107636147B (zh) 2021-09-10
CN107636147A (zh) 2018-01-26
EP3303594A1 (en) 2018-04-11
KR102390716B1 (ko) 2022-04-26
JP2018522536A (ja) 2018-08-16
US10174303B2 (en) 2019-01-08
CA2985481A1 (en) 2016-12-01
EA036334B1 (ru) 2020-10-28
CA2985481C (en) 2019-04-30
EA201792544A1 (ru) 2018-05-31
BR122023023164A2 (pt) 2024-03-05
ZA201707234B (en) 2019-12-18
MY186542A (en) 2021-07-26
EA036334B9 (ru) 2020-12-24
WO2016191625A1 (en) 2016-12-01
KR20180002704A (ko) 2018-01-08
US20160348087A1 (en) 2016-12-01
BR122023023156A2 (pt) 2024-03-05
CN113684167A (zh) 2021-11-23
JP6871870B2 (ja) 2021-05-19

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Legal Events

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25G Requested change of headquarter approved

Owner name: LANZATECH NEW ZEALAND LIMITED (NZ)

B25G Requested change of headquarter approved

Owner name: LANZATECH NEW ZEALAND LIMITED (NZ)

B25G Requested change of headquarter approved

Owner name: LANZATECH NEW ZEALAND LIMITED (US)

B25D Requested change of name of applicant approved

Owner name: LANZATECH NZ, INC. (US)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B154 Notification of filing of divisional application [chapter 15.50 patent gazette]

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