BR112021018925A2 - Modificação metabólica para consumo simultâneo de xilose e glicose para produção de produtos químicos a partir de açúcares de segunda geração - Google Patents
Modificação metabólica para consumo simultâneo de xilose e glicose para produção de produtos químicos a partir de açúcares de segunda geraçãoInfo
- Publication number
- BR112021018925A2 BR112021018925A2 BR112021018925A BR112021018925A BR112021018925A2 BR 112021018925 A2 BR112021018925 A2 BR 112021018925A2 BR 112021018925 A BR112021018925 A BR 112021018925A BR 112021018925 A BR112021018925 A BR 112021018925A BR 112021018925 A2 BR112021018925 A2 BR 112021018925A2
- Authority
- BR
- Brazil
- Prior art keywords
- glucose
- xylose
- metabolic modification
- simultaneous consumption
- produce chemicals
- Prior art date
Links
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P2203/00—Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
- C12Y503/01005—Xylose isomerase (5.3.1.5)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
modificação metabólica para consumo simultâneo de xilose e glicose para produção de produtos químicos a partir de açúcares de segunda geração. a presente invenção refere-se a métodos para modificar geneticamente micróbios para produzir um micróbio capaz de consumir, simultaneamente, xilose e glicose para aumentar a produtividade de produtos químicos desejados. a divulgação fornece, adicionalmente, bactérias modificadas que são capazes de consumir, simultaneamente, xilose e glicose, e composições que compreendem os micróbios.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962829398P | 2019-04-04 | 2019-04-04 | |
PCT/BR2020/050115 WO2020198830A1 (en) | 2019-04-04 | 2020-04-06 | Metabolic engineering for simultaneous consumption of xylose and glucose for production of chemicals from second generation sugars |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021018925A2 true BR112021018925A2 (pt) | 2022-01-18 |
Family
ID=70616878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021018925A BR112021018925A2 (pt) | 2019-04-04 | 2020-04-06 | Modificação metabólica para consumo simultâneo de xilose e glicose para produção de produtos químicos a partir de açúcares de segunda geração |
Country Status (6)
Country | Link |
---|---|
US (1) | US11746361B2 (pt) |
EP (1) | EP3935154A1 (pt) |
JP (1) | JP2022528894A (pt) |
CN (1) | CN114008197A (pt) |
BR (1) | BR112021018925A2 (pt) |
WO (1) | WO2020198830A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
JPWO2023032950A1 (pt) * | 2021-08-30 | 2023-03-09 | ||
DE102022119514A1 (de) * | 2022-08-03 | 2024-02-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Genetisch veränderte Zellen von Methylorubrum zur fermentativen Produktion von Glycolsäure und Milchsäure aus Cx-Verbindungen |
CN116240232A (zh) * | 2022-12-20 | 2023-06-09 | 天津科技大学 | 木葡糖酸醋杆菌中Weimberg木糖代谢途径的构建方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
US6033861A (en) | 1997-11-19 | 2000-03-07 | Incyte Genetics, Inc. | Methods for obtaining nucleic acid containing a mutation |
US20050214913A1 (en) | 2004-03-16 | 2005-09-29 | Marchenko Aleksey N | Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes |
WO2005113759A2 (en) * | 2004-05-19 | 2005-12-01 | Biotechnology Research And Development Corporation | Microbial production of xylitol via a hexose phosphate and a pentose phosphate intermediate |
WO2008076975A1 (en) | 2006-12-18 | 2008-06-26 | Advanced Bionutrition Corporation | A dry food product containing live probiotic |
JP2009112289A (ja) * | 2007-09-14 | 2009-05-28 | National Institute Of Advanced Industrial & Technology | キシロース発酵酵母およびそれを用いたエタノールの生産方法 |
EP2467490A1 (en) | 2009-08-21 | 2012-06-27 | Mascoma Corporation | Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms |
US10017793B2 (en) * | 2009-11-18 | 2018-07-10 | Myriant Corporation | Metabolic evolution of Escherichia coli strains that produce organic acids |
EP2407531A1 (en) * | 2010-07-16 | 2012-01-18 | Neste Oil Oyj | Microorganisms with extended substrate utilization range |
EP4273257A3 (en) * | 2012-08-05 | 2024-02-28 | ABSCI Corporation | Inducible coexpression system |
WO2014025747A1 (en) | 2012-08-07 | 2014-02-13 | Codexis, Inc. | Glucose and xylose co-utilization in e. coli |
AU2013359262C1 (en) | 2012-12-12 | 2021-05-13 | Massachusetts Institute Of Technology | CRISPR-Cas component systems, methods and compositions for sequence manipulation |
AU2014235968B2 (en) | 2013-03-21 | 2018-05-24 | Ospedale San Raffaele Srl | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
KR101488362B1 (ko) * | 2013-08-14 | 2015-02-02 | 국립대학법인 울산과학기술대학교 산학협력단 | 글루코스 및 자일로스를 동시에 이용할 수 있는 변이대장균의 제조방법 |
FR3028529B1 (fr) * | 2014-11-19 | 2016-12-30 | Inst Nat De La Rech Agronomique Inra | Procede de production d'au moins un metabolite d'interet par transformation d'un pentose dans un microorganisme |
US10415062B2 (en) | 2015-04-07 | 2019-09-17 | Metabolic Explorer | Modified microorganism for the optimized production of 2,4-dihydroxybutyrate |
US9951326B2 (en) * | 2015-07-13 | 2018-04-24 | MARA Renewables Corporation | Enhancing microbial metabolism of C5 organic carbon |
US10774347B2 (en) * | 2016-03-09 | 2020-09-15 | Braskem S.A. | Microorganisms and methods for the co-production of ethylene glycol and three carbon compounds |
-
2020
- 2020-04-06 CN CN202080041307.XA patent/CN114008197A/zh active Pending
- 2020-04-06 BR BR112021018925A patent/BR112021018925A2/pt unknown
- 2020-04-06 US US16/841,312 patent/US11746361B2/en active Active
- 2020-04-06 JP JP2021559112A patent/JP2022528894A/ja active Pending
- 2020-04-06 WO PCT/BR2020/050115 patent/WO2020198830A1/en unknown
- 2020-04-06 EP EP20724733.9A patent/EP3935154A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2020198830A1 (en) | 2020-10-08 |
EP3935154A1 (en) | 2022-01-12 |
JP2022528894A (ja) | 2022-06-16 |
CN114008197A (zh) | 2022-02-01 |
US11746361B2 (en) | 2023-09-05 |
US20200318146A1 (en) | 2020-10-08 |
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