AR096748A1 - Compuestos heteroaromáticos y su uso como ligandos d1 de dopamina - Google Patents

Compuestos heteroaromáticos y su uso como ligandos d1 de dopamina

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AR096748A1
AR096748A1 ARP140102420A ARP140102420A AR096748A1 AR 096748 A1 AR096748 A1 AR 096748A1 AR P140102420 A ARP140102420 A AR P140102420A AR P140102420 A ARP140102420 A AR P140102420A AR 096748 A1 AR096748 A1 AR 096748A1
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Argentina
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alkyl
cycloalkyl
group
haloalkyl
independently selected
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Pfizer
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Abstract

Compuestos útiles para utilizar como medicamentos para controlar trastornos psiquiátricos y neurológicos, y sales farmacéuticamente aceptables de los mismos; procesos como la preparación de intermediarios utilizados en la preparación de; y composiciones que contienen los compuestos o sales, y su usos para tratar los trastornos mediados por D1 (o asociados con D1) que incluyen, por ejemplo, esquizofrenia (por ejemplo, sus síntomas cognitivos y negativos), discapacidad cognitiva (por ejemplo, discapacidad cognitiva asociada con esquizofrenia, AD, PD, o terapia de farmacoterapia), declive cognitivo relacionado con la edad, demencia y enfermedad de Parkinson. Reivindicación 1: Un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo, en donde: cada uno de T¹, T², T³, y T⁴ se selecciona independientemente del grupo que consiste de H, halógeno, -CN, -SF₅, -OH, -N(Rᵃ)(Rᵇ), -C(=O)-N(Rᵃ)(Rᵇ), -C(=O)-ORᶜ, -C(=O)-Rᵈ, alquilo C₁₋₆, haloalquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, -S-(alquilo C₁₋₆), cicloalquilo C₃₋₇, heterocicloalquilo de 4 a 7 miembros, cicloalcoxi C₃₋₇ heteroarilo de 5 ó 6 miembros, ciclopropilmetilo, y ciclobutilmetilo, en donde cada uno del alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, -S-(alquilo C₁₋₆), y alcoxi C₁₋₆ se sustituye opcionalmente con uno o más sustituyentes cada uno seleccionado independientemente del grupo que consiste de halógeno, -OH, -CN, -N(Rᵃ)(Rᵇ), alcoxi C₁₋₄, haloalcoxi C₁₋₄, y -S-(alquilo C₁₋₄); y en donde cada uno del cicloalquilo C₃₋₇, heterocicloalquilo de 4 a 7 miembros, cicloalcoxi C₃₋₇, heteroarilo de 5 ó 6 miembros, ciclopropilmetilo, y ciclobutilmetilo de T¹, T², y T³ se sustituye opcionalmente con uno o más sustituyentes cada uno es seleccionado independientemente del grupo que consiste de halógeno, -OH, -CN, oxo, -N(Rᵃ)(Rᵇ), -C(=O)OH, -C(=O)-alquilo C₁₋₄, -C(=O)-O-alquilo C₁₋₄, -C(=O)-N(Rᵃ)(Rᵇ), alquilo C₁₋₄, haloalquilo C₁₋₄, hidroxilalquilo C₁₋₄, cianoalquilo C₁₋₄, alcoxi C₁₋₄, haloalcoxi C₁₋₄, y -S-(alquilo C₁₋₄); L¹ se selecciona del grupo que consiste de O, S, NH, N(alquilo C₁₋₄), N(-alquilo C₁₋₂-cicloalquilo C₃₋₄), y N(cicloalquilo C₃₋₆); cada uno de Rᵃ y Rᵇ se selección independientemente del grupo que consiste de H, alquilo C₁₋₄, cicloalquilo C₃₋₇, y ciclopropilmetilo; o Rᵃ y Rᵇ junto con el átomo N al cual se unen forman heterocicloalquilo de 4 a 7 miembros opcionalmente sustituido con uno o más sustituyentes cada uno seleccionado independientemente del grupo que consiste de halógeno, -OH, -CN, oxo, -NH₂, -NH(alquilo C₁₋₄), -N(alquilo C₁₋₄)₂, -C(=O)OH, -C(=O)-alquilo C₁₋₄, -C(=O)-O-alquilo C₁₋₄, -C(=O)-NH₂, -C(=O)-NH(alquilo C₁₋₄), -C(=O)-N(alquilo C₁₋₄)₂, alquilo C₁₋₄, haloalquilo C₁₋₄, hidroxilalquilo C₁₋₄, cianoalquilo C₁₋₄, alcoxi C₁₋₄, -S-(alquilo C₁₋₄), y haloalcoxi C₁₋₄; cada uno de Rᶜ y Rᵈ es independientemente alquilo C₁₋₄, cicloalquilo C₃₋₄-alquilo C₁₋₂-, o cicloalquilo C₃₋₄; Q¹ se selecciona del grupo que consiste de Q¹ᵃ, Q¹ᵇ, Q¹ᶜ, Q¹ᵈ y Q¹ᵉ del grupo de fórmulas (2); condición de (a) que un átomo de carbono del anillo Q¹ se encuentre unido al anillo benceno de la fórmula (1) y (b) que cuando L¹ es NH, entonces el anillo Q¹ se sustituya con al menos uno que no sea H R⁹, R¹⁰, R¹¹, R¹², R¹³, R⁹A, R¹⁰A, R¹⁰B, R¹¹A, R¹²A ó R¹³A; cada uno de X¹ y X² es independientemente O ó S; cada uno de R¹, R², R³, y R⁴ se selecciona independientemente del grupo que consiste de H, halógeno, -OH, -NO₂, -CN, -SF₅, alquilo C₁₋₆, haloalquilo C₁₋₆ haloalcoxi C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₇, heterocicloalquilo de 4 a 10 miembros, -N(R⁵)(R⁶), -N(R⁷)(C(=O)R⁸), -C(=O)-(R⁵)(R⁶), -C(=O)-R⁸, -C(=O)-OR⁸, -N(R⁷)(S(=O)₂R⁸), -S(=O)₂-N(R⁵)(R⁶), -SR⁸, y -OR⁸, en donde cada uno del alquilo C₁₋₆, cicloalquilo C₃₋₇, y heterocicloalquilo se sustituye opcionalmente con 1, 2, ó 3 sustituyentes cada uno seleccionado independientemente del grupo que consiste de halógeno, -CN, oxo, -OH, alquilo C₁₋₄, alcoxi C₁₋₄, haloalquilo C₁₋₄, haloalcoxi C₁₋₄, cicloalquilo C₃₋₆, -N(R⁵)(R⁶), -N(R⁷)(C(=O)R⁸), -C(=O)-OR⁸, -C(=O)H, -C(=O)R⁸, -C(=O)N(R⁵)(R⁶), -N(R⁷)(S(=O)₂R⁸), -S(=O)₂-N(R⁵)(R⁶), -SR⁸, y -OR⁸; o R² y R⁴ junto con los dos átomos al cual se unen forman un heteroarilo fusionado de 5 ó 6 miembros, un anillo heterocicloalquilo fusionado de 5 ó 6 miembros, un anillo cicloalquilo fusionado de 5 ó 6 miembros, o un anillo benceno fusionado, en donde cada uno de los anillos fusionados se sustituye opcionalmente con 1, 2, ó 3 sustituyentes cada uno seleccionado independientemente del grupo que consiste de halo, -CN, -OH, alquilo C₁₋₄, alcoxi C₁₋₄, haloalquilo C₁₋₄, y haloalcoxi C₁₋₄, y en donde el anillo heterocicloalquilo fusionado o anillo cicloalquilo fusionado además se sustituye opcionalmente con 1, 2, ó 3 oxo; R⁵ es H, alquilo C₁₋₄, haloalquilo C₁₋₄, o cicloalquilo C₃₋₇; R⁶ es H o se selecciona del grupo que consiste de alquilo C₁₋₄, haloalquilo C₁₋₄, cicloalquilo C₃₋₇, heterocicloalquilo de 4 a 10 miembros, arilo C₆₋₁₀, un heteroarilo de 5 a 10 miembros, (cicloalquilo C₃₋₇)-alquilo C₁₋₄-, (heterocicloalquilo de 4 a 10 miembros)-alquilo C₁₋₄-, (arilo C₆₋₁₀)-alquilo C₁₋₄-, y (heteroarilo de 5 a 10 miembros)-alquilo C₁₋₄-, en donde cada uno se selecciona del grupo que se sustituye opcionalmente con 1, 2, 3, ó 4 sustituyentes cada uno seleccionado independientemente del grupo que consiste de -OH, -CN, alquilo C₁₋₄, cicloalquilo C₃₋₇, hidroxilalquilo C₁₋₄, -S-alquilo C₁₋₄, -C(=O)H, -C(=O)-alquilo C₁₋₄, -C(=O)-O-alquilo C₁₋₄, -C(=O)-NH₂, -C(=O)-N(alquilo C₁₋₄)₂, haloalquilo C₁₋₄, alcoxi C₁₋₄, y haloalcoxi C₁₋₄; o R⁵ y R⁶ junto con el átomo N al cual se unen forman heterocicloalquilo de 4 a 10 miembros o un heteroarilo de 5 a 10 miembros, cada uno opcionalmente sustituido con 1, 2, 3, 4, ó 5 sustituyentes cada uno seleccionado independientemente del grupo que consiste de halógeno, -OH, oxo, -C(=O)H, -C(=O)-alquilo C₁₋₄, -C(=O)OH, -C(=O)-O-alquilo C₁₋₄, -C(=O)-NH₂, -C(=O)-N(alquilo C₁₋₄)₂, -CN, alquilo C₁₋₄, alcoxi C₁₋₄, hidroxilalquilo C₁₋₄, haloalquilo C₁₋₄, y haloalcoxi C₁₋₄; R⁷ se selecciona del grupo que consiste de H, alquilo C₁₋₄, y cicloalquilo C₃₋₇; R⁸ se selecciona del grupo que consiste de alquilo C₁₋₆, cicloalquilo C₃₋₇, heterocicloalquilo de 4 a 10 miembros, arilo C₁₋₆, un heteroarilo de 5 a 10 miembros, (cicloalquilo C₃₋₄)-alquilo C₁₋₄-, (heterocicloalquilo de 4 a 10 miembros)-alquilo C₁₋₄-, (arilo C₆₋₁₀)-alquilo C₁₋₄-, y (heteroarilo de 5 a 10 miembros)-alquilo C₁₋₄-, en donde cada uno se selecciona del grupo que se sustituye opcionalmente con 1, 2, ó 3 sustituyentes cada uno seleccionado independientemente del grupo que consiste de halógeno, -CF₃, -CN, -OH, oxo, -S-alquilo C₁₋₄, alquilo C₁₋₄, haloalquilo C₁₋₄, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₇, alcoxi C₁₋₄, y haloalcoxi C₁₋₄; cada R⁹ y R¹² se selecciona independientemente del grupo que consiste de halógeno, -OH, -CN, -SF₅,
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5857168B2 (ja) 2012-11-08 2016-02-10 ファイザー・インク ドーパミンｄ１リガンドとしての複素芳香族化合物およびその使用
DK3013813T3 (da) 2013-06-27 2019-06-03 Pfizer Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander
MA39914A (fr) 2014-04-25 2017-03-01 Pfizer Composés hétéroaromatiques et leur utilisation comme ligands de la dopamine d1
US9868744B2 (en) 2014-04-25 2018-01-16 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
WO2015162515A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
EP3137469B1 (en) 2014-04-28 2019-10-09 Pfizer Inc Heterocyclic compounds and their use as dopamine d1 ligands
WO2015166370A1 (en) 2014-04-28 2015-11-05 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
CN111153859B (zh) * 2015-04-15 2021-09-03 江苏恩华药业股份有限公司 哒嗪酮类衍生物及其应用
CN108368087B (zh) 2015-10-14 2022-04-12 百时美施贵宝公司 作为apj激动剂的2，4-二羟基-烟酰胺
SI3389727T1 (sl) 2015-12-18 2020-10-30 Janssen Pharmaceutica Nv Radioaktivno označeni ligandi PET MGLUR2/3
US11045562B2 (en) 2015-12-18 2021-06-29 Janssen Pharmaceutica Nv Radiolabelled mGluR2/3 PET ligands
ES2837018T3 (es) * 2016-01-15 2021-06-29 Pfizer Ligandos del receptor D3 de dopamina de 6,7,8,9-tetrahidro-5H-pirido[2,3-d]azepina
EP3433247B1 (en) 2016-03-24 2021-09-08 Bristol-Myers Squibb Company 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists
CA3015201C (en) 2016-03-30 2023-07-04 Ishihara Sangyo Kaisha, Ltd. Pyridazinone compound or its salt, and herbicide containing it
US11555009B2 (en) 2017-03-02 2023-01-17 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences 2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof
JP2023522949A (ja) 2020-04-23 2023-06-01 オプナ バイオ ソシエテ アノニム Ｃｄ７３調節のための化合物及び方法並びにそれらの表示
CA3239783A1 (en) 2021-12-03 2023-06-08 Zuzana Przeczkova Solid state forms of tavapadon and processes for preparation thereof
WO2023143321A1 (zh) * 2022-01-29 2023-08-03 苏州科睿思制药有限公司 他伐帕敦的晶型及其制备方法和用途

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5025142B1 (es) 1969-07-30 1975-08-21
JPS5039272B1 (es) 1970-07-14 1975-12-16
JPS5025142A (es) 1973-07-06 1975-03-17
JPS5039272A (es) 1973-08-10 1975-04-11
JPS5516432B2 (es) 1974-05-28 1980-05-01
JPS51113899A (en) 1975-03-27 1976-10-07 Yoshitomi Pharmaceut Ind Ltd Method for preparing novel tetrazole derivatives
JPS522031A (en) 1975-06-24 1977-01-08 Japan Niyuupureito Hokushiyou Sunshade device
EP0002812B1 (de) 1978-01-02 1982-02-03 Ciba-Geigy Ag Phenoxy-alkyl-oxazoline, ihre Herstellung, sie enthaltende Mittel sowie deren Verwendung als Herbizide
EP0101662A3 (de) 1982-06-25 1985-12-04 Ciba-Geigy Ag Benzoylparabansäuren
US4550108A (en) 1983-08-17 1985-10-29 Ciba Geigy Corporation 1,3,5-Oxadiazine-2,4-diones and pesticidal use
US4723015A (en) 1983-10-17 1988-02-02 Ciba-Geigy Corporation Certain insecticidal N-2-pyridyloxyphenylbenzimidates
IL73611A0 (en) 1983-12-06 1985-02-28 Nippon Soda Co 1,2,4-oxa-and thiadiazolin-3-one derivatives,their preparation and their use as insecticides and fungicides
JPS61275271A (ja) 1985-05-30 1986-12-05 Nippon Soda Co Ltd １，２，４−オキサ（チア）ジアゾリン誘導体、その製造方法，殺虫剤及び農園芸用殺菌剤
DE3545569A1 (de) 1985-12-21 1987-06-25 Hoechst Ag Neue pyridin-derivate, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als schaedlingsbekaempfungsmittel
DE3545786A1 (de) 1985-12-21 1987-06-25 Schering Ag Pyrazolinderivate, ihre herstellung und ihre verwendung als mittel mit insektizider wirkung
DE3631511A1 (de) 1986-09-12 1988-03-24 Schering Ag 5-halogen-1,2,4-triazole, verfahren zu ihrer herstellung und ihre verwendung als akarizide und insektizide mittel
EP0296518A1 (de) 1987-06-22 1988-12-28 Ciba-Geigy Ag Neue Phenylether-derivate als Mikrobizide, Verfahren zu deren Herstellung und deren Verwendung
DE3826855A1 (de) * 1988-08-06 1990-02-15 Cassella Ag 4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung
JPH0259574A (ja) 1988-08-23 1990-02-28 Mitsubishi Kasei Corp ピラジノン誘導体又はその塩類
JPH0259573A (ja) 1988-08-23 1990-02-28 Mitsubishi Kasei Corp ２（１ｈ）−ピリミジノン誘導体又はその塩類
US5066667A (en) 1989-06-26 1991-11-19 Ciba-Geigy Corporation Thioxotetrazolines and insecticidal use thereof
DE69104071T2 (de) 1990-01-18 1995-05-11 Nissan Chemical Ind Ltd Uracilderivate und Pestizide, die diese als wirksame Stoffe enthalten.
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
JPH03261783A (ja) 1990-03-12 1991-11-21 Suntory Ltd １，２，４―トリアジンジオン化合物及びそれを有効成分とする抗コクシジウム剤
DE4030042A1 (de) 1990-05-17 1991-11-21 Bayer Ag Verwendung von substituierten 1,2,4-triazindionen
JP3018422B2 (ja) 1990-07-27 2000-03-13 日東紡績株式会社 床 材
US5630962A (en) 1990-12-19 1997-05-20 Hoechst Aktiengesellschaft 2-Fluoropyridines, their preparation and their use in liquid crystal mixtures
JPH0539272A (ja) 1991-01-09 1993-02-19 Nissan Chem Ind Ltd ピリミジンジオン誘導体および除草剤
JPH0525142A (ja) 1991-07-12 1993-02-02 Nissan Chem Ind Ltd ウラシル誘導体及び有害生物防除剤
JPH05202031A (ja) 1992-01-28 1993-08-10 Nissan Chem Ind Ltd Ｎ−アミノピリミジンジオン誘導体および除草剤
EP0630370A1 (en) 1992-03-11 1994-12-28 E.I. Du Pont De Nemours And Company Fungicidal oxazolidinones
US5482951A (en) 1992-05-29 1996-01-09 Kumiai Chemical Industry Co., Ltd. Triazole derivatives as well as insecticide and acaricide
AU4950793A (en) 1992-08-31 1994-03-29 Ciba-Geigy Ag 4,5-dicyanoimidazole derivatives and pesticidal compositions containing them
KR0151364B1 (ko) 1992-12-25 1998-10-15 시모무라 도오루 헤테로 고리 유도체 및 유해 생물 방제제
JP3261783B2 (ja) 1993-02-04 2002-03-04 ミノルタ株式会社 光変調素子
JP3682075B2 (ja) 1993-04-16 2005-08-10 クミアイ化学工業株式会社 トリアゾール誘導体及び殺虫、殺ダニ剤
EP0712847A4 (en) 1993-08-11 1997-05-28 Nippon Soda Co IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS A PEST CONTROL
JPH0873446A (ja) 1994-04-22 1996-03-19 Nippon Soda Co Ltd ヘテロ環化合物および殺虫・殺ダニ剤
JPH0827120A (ja) 1994-07-08 1996-01-30 Nissan Chem Ind Ltd テトラヒドロピリミジノン誘導体
JPH08217777A (ja) 1995-02-10 1996-08-27 Nippon Nohyaku Co Ltd ２−ピラゾリン−５−オン誘導体及びその中間体並びに除草剤
DE19518681A1 (de) 1995-05-22 1996-11-28 Bayer Ag Verfahren zur Herstellung von 5,6-Dihydro-1,3-oxazinen
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
JPH09291282A (ja) 1996-04-26 1997-11-11 Sumitomo Chem Co Ltd 安定化した液晶材料およびこれを用いた液晶素子
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO1999021837A1 (en) * 1997-10-27 1999-05-06 Isk Americas Incorporated Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them
US6521641B1 (en) 1998-10-08 2003-02-18 Allergan, Inc. Male anti-fertility agents
BR9915534B1 (pt) 1998-10-23 2011-04-19 1-piridil substituìdo)-1,2,4-triazóis inseticidas.
GB9903671D0 (en) * 1999-02-17 1999-04-14 Cenes Ltd Dopamine D-1 receptor agonist compounds
PL357589A1 (en) 2000-01-18 2004-07-26 Pfizer Products Inc. Corticotropin releasing factor antagonists
CN1431896A (zh) 2000-04-04 2003-07-23 盐野义制药株式会社 含有高脂溶性药物的油性组合物
US6599926B2 (en) 2000-06-23 2003-07-29 Bristol-Myers Squibb Company Heteroaryl-phenyl substituted factor Xa inhibitors
US6476055B1 (en) 2001-03-28 2002-11-05 Nippon Soda Co. Ltd. 5,5-disubstituted thiazolidine derivative pesticides
US7501429B2 (en) 2001-04-11 2009-03-10 Queen's University At Kingston Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents
US20020193403A1 (en) 2001-05-03 2002-12-19 Allergan Sales, Inc. Methods of treating hyperlipidemia
BR0209499A (pt) 2001-05-09 2004-07-06 Sumitomo Chem Takeda Agro Co Composto, processo para produzir o composto, e, composição pesticida
AR036873A1 (es) 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
ES2421511T3 (es) 2001-12-21 2013-09-03 X Ceptor Therapeutics Inc Moduladores de LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
WO2003079986A2 (en) 2002-03-18 2003-10-02 Bristol-Myers Squibb Company Uracil derivatives as inhibitors of tnf-alpha converting enzyme (tace) and matrix metalloproteinases
WO2004018410A1 (ja) 2002-08-26 2004-03-04 Nissan Chemical Industries, Ltd. 置換ベンズアニリド化合物及び有害生物防除剤
JP2006514110A (ja) 2002-11-11 2006-04-27 バイエル・ヘルスケア・アクチェンゲゼルシャフト Ｉｐ受容体アンタゴニストとしてのフェニルまたはヘテロアリールアミノアルカン誘導体
US20040171075A1 (en) 2002-12-31 2004-09-02 Flynn Daniel L Modulation of protein functionalities
US7244739B2 (en) 2003-05-14 2007-07-17 Torreypines Therapeutics, Inc. Compounds and uses thereof in modulating amyloid beta
US6969744B2 (en) 2003-06-19 2005-11-29 University Of Southern Mississippi Living and quasiliving cationic telechelic polymers quenched by N-substituted pyrrole and methods for their preparation
ES2441206T3 (es) 2003-09-03 2014-02-03 Raqualia Pharma Inc. Compuestos de fenil o piridilamida como antagonistas de la prostaglandina E2
JP4451849B2 (ja) 2003-11-28 2010-04-14 日本曹達株式会社 アリール複素環誘導体および農園芸用殺菌剤および殺虫剤
JP2005272452A (ja) 2004-02-23 2005-10-06 Nissan Chem Ind Ltd 置換ベンズアニリド化合物及び有害生物防除剤
BRPI0509993A (pt) 2004-04-20 2007-10-16 Pfizer Prod Inc combinações compreendendo ligandos de alfa-2-delta
JP5097539B2 (ja) 2004-05-07 2012-12-12 アムジエン・インコーポレーテツド タンパク質キナーゼ調節剤および使用方法
TW200612827A (en) 2004-08-25 2006-05-01 Sumitomo Chemical Co Insecticide composition
ES2396365T3 (es) * 2005-07-29 2013-02-21 Concert Pharmaceuticals Inc. Nuevos derivados de benzo[D][1,3]-dioxol deuterados como inhibidores de la recaptación de serotonina
US7973060B2 (en) 2005-10-13 2011-07-05 Crystalgenomics, Inc. Fab I inhibitor and process for preparing same
GB0524786D0 (en) 2005-12-05 2006-01-11 Glaxo Group Ltd Compounds
US7560551B2 (en) 2006-01-23 2009-07-14 Amgen Inc. Aurora kinase modulators and method of use
US8735595B2 (en) 2006-02-15 2014-05-27 Abbvie Inc. Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
JP5025142B2 (ja) 2006-02-27 2012-09-12 株式会社東芝 モータ制御装置
AU2007225836A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
AU2007246172A1 (en) 2006-04-28 2007-11-08 Avexa Limited Integrase inhibitors 3
US8269010B2 (en) 2006-09-21 2012-09-18 Piramal Healthcare Limited 3-amino-pyridine derivatives for the treatment of metabolic disorders
EP2256496A3 (en) 2006-09-21 2011-03-16 Piramal Life Sciences Limited Method for identifying compounds that act as insulin-sensitizers
KR20140104060A (ko) 2006-10-19 2014-08-27 시그날 파마소티칼 엘엘씨 헤테로아릴 화합물, 이들의 조성물 그리고 단백질 키나아제 억제제로서의 이들의 용도
EP1916240A1 (en) 2006-10-25 2008-04-30 Syngeta Participations AG Pyridazine derivatives
DE102007003036A1 (de) 2006-12-20 2008-06-26 Bayer Cropscience Ag Pyrimidinylpyrazole
CL2008000252A1 (es) 2007-01-29 2008-03-14 Xenon Pharmaceuticals Inc Compuestos derivados de quinazolinona o pirimidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades mediadas por los canales de calcio, tales como dolor, depresion, enfermedades cardiovasculares, respir
UA109896C2 (xx) 2007-02-22 2015-10-26 Похідні імінопіридину та їх застосування як мікробіоцидів
TW200900065A (en) * 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900391A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-phenyl-piperidin-1-yl)-pyridin-2-one derivatives
CN101294257B (zh) 2007-04-23 2014-06-18 株式会社神户制钢所 焊接热影响部的韧性优异的钢材及其制造方法
JP2009062290A (ja) 2007-09-04 2009-03-26 Takeda Chem Ind Ltd シクロプロパン化合物
EP2200985B1 (en) * 2007-09-14 2011-07-13 Ortho-McNeil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
CN101687802B (zh) * 2007-10-31 2014-02-26 Abbvie德国有限责任两合公司 适于治疗对多巴胺d3受体调节有反应的病症的苯磺酰胺化合物
JP2011507910A (ja) 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
CA2721452A1 (en) 2008-04-16 2009-10-22 Biolipox Ab Bis-aryl compounds for use as medicaments
US20110112193A1 (en) 2008-05-14 2011-05-12 Peter Nilsson Bis-aryl compounds for use as medicaments
EP2328586A2 (en) 2008-05-20 2011-06-08 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
KR20110031355A (ko) 2008-06-25 2011-03-25 엔비보 파마슈티칼즈, 인코퍼레이티드 １,２―이치환된 헤테로사이클릭 화합물
WO2010029299A1 (en) * 2008-09-12 2010-03-18 Biolipox Ab Pyrimidinone derivaties for use as medicaments
JP5636286B2 (ja) 2008-12-03 2014-12-03 日本農薬株式会社 ピリミジン誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
WO2010068788A1 (en) 2008-12-10 2010-06-17 Cgi Pharmaceuticals, Inc. Heterocyclic amides as btk inhibitors
BRPI1006128A2 (pt) 2009-01-12 2016-11-01 Cagen Inc derivados de sulfonamida
EP2246335A1 (de) 2009-02-17 2010-11-03 Bayer CropScience AG Aminopyrimidinamide als Schädlingsbekämpfungsmittel
MX336711B (es) * 2010-03-04 2016-01-28 Merck Sharp & Dohme Inhibidores de catecol o-metil transferasa y su uso en el tratamiento de transtornos psicoticos.
US8927561B2 (en) 2010-04-23 2015-01-06 Kineta, Inc. Pyrimidinedione anti-viral compounds
KR20120018236A (ko) 2010-07-23 2012-03-02 현대약품 주식회사 치환된 피리미디닐 유도체 및 이의 제조방법
PE20131116A1 (es) 2010-08-10 2013-10-24 Takeda Pharmaceutical Compuestos heterociclicos potenciadores de ampa
AU2011303597A1 (en) 2010-09-17 2013-04-11 Purdue Pharma L.P. Pyridine compounds and the uses thereof
DK2753606T3 (en) * 2011-09-02 2017-10-02 Purdue Pharma Lp PYRIMIDINES AS SODIUM CHANNEL BLOCKERS
JP5857168B2 (ja) * 2012-11-08 2016-02-10 ファイザー・インク ドーパミンｄ１リガンドとしての複素芳香族化合物およびその使用
BR112015010412A2 (pt) 2012-11-08 2017-07-11 Pfizer compostos heteroaromáticos e seu uso como ligantes de dopamina d1
WO2014119770A1 (ja) * 2013-01-30 2014-08-07 住友化学株式会社 ピリダジノン化合物及びそれを含有する除草剤
DK3013813T3 (da) * 2013-06-27 2019-06-03 Pfizer Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander

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