AR091538A1 - Purificacion de particulas tipo virus - Google Patents
Purificacion de particulas tipo virusInfo
- Publication number
- AR091538A1 AR091538A1 ARP130102218A AR091538A1 AR 091538 A1 AR091538 A1 AR 091538A1 AR P130102218 A ARP130102218 A AR P130102218A AR 091538 A1 AR091538 A1 AR 091538A1
- Authority
- AR
- Argentina
- Prior art keywords
- purification
- virus type
- vlp
- type particles
- solution
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 239000000706 filtrate Substances 0.000 abstract 2
- 239000013592 cell lysate Substances 0.000 abstract 1
- 239000012228 culture supernatant Substances 0.000 abstract 1
- 239000006166 lysate Substances 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261663218P | 2012-06-22 | 2012-06-22 | |
| US201361794086P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR091538A1 true AR091538A1 (es) | 2015-02-11 |
Family
ID=49769461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130102218 AR091538A1 (es) | 2012-06-22 | 2013-06-24 | Purificacion de particulas tipo virus |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10167320B2 (enExample) |
| EP (1) | EP2864478B1 (enExample) |
| JP (1) | JP6553509B2 (enExample) |
| KR (1) | KR102110876B1 (enExample) |
| CN (2) | CN104583393A (enExample) |
| AR (1) | AR091538A1 (enExample) |
| AU (1) | AU2013277959B2 (enExample) |
| CA (1) | CA2879815A1 (enExample) |
| IN (1) | IN2015DN00089A (enExample) |
| JO (1) | JOP20130186B1 (enExample) |
| MX (1) | MX366234B (enExample) |
| SG (2) | SG10201610753YA (enExample) |
| TW (1) | TWI647310B (enExample) |
| UY (1) | UY34875A (enExample) |
| WO (1) | WO2013192604A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2601969B1 (en) | 2006-09-29 | 2016-03-30 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| CA2683977C (en) | 2007-03-14 | 2017-04-25 | Ligocyte Pharmaceuticals, Inc. | A method of norovirus virus-like particle purification comprising ion exchange chromatography |
| US10130696B2 (en) | 2007-09-18 | 2018-11-20 | Takeda Vaccines, Inc. | Method of conferring a protective immune response to norovirus |
| CR20190540A (es) | 2011-07-11 | 2022-04-04 | Takeda Vaccines Inc | FORMULACIONES PARENTERALES DE VACUNAS CONTRA LOS NOVOVIRUS (Divisional 2014-0069) |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| WO2015005430A1 (ja) * | 2013-07-11 | 2015-01-15 | タカラバイオ株式会社 | 非エンベロープウイルスの製造方法 |
| SG10202107054TA (en) | 2013-10-03 | 2021-08-30 | Takeda Vaccines Inc | Methods of detection and removal of rhabdoviruses from cell lines |
| CN103981084B (zh) * | 2014-05-29 | 2015-11-18 | 黑龙江省科学院微生物研究所 | 水中病毒分离提取装置及水中札幌病毒的提取方法 |
| JP6616329B2 (ja) * | 2015-01-09 | 2019-12-04 | タカラバイオ株式会社 | 非エンベロープウイルス粒子の製造方法 |
| US10920288B2 (en) | 2015-01-16 | 2021-02-16 | Takeda Vaccines, Inc. | Detection of particle-contained reverse transcriptase activity |
| CN105907729B (zh) * | 2015-05-05 | 2019-08-16 | 广东东阳光药业有限公司 | 一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法 |
| CN107034198B (zh) | 2015-07-15 | 2021-03-09 | 长春百克生物科技股份公司 | 一种嵌合诺如病毒p颗粒及其制备和应用 |
| WO2017040265A1 (en) * | 2015-08-28 | 2017-03-09 | Nanotherapeutics, Inc. | Norovirus vaccine |
| CN105779399A (zh) * | 2016-03-28 | 2016-07-20 | 广西壮族自治区林业科学研究院 | 一种昆虫杆状病毒纯化方法 |
| GB201614050D0 (en) | 2016-08-17 | 2016-09-28 | Glaxosmithkline Ip Dev Ltd | Method for purifying viral vectors |
| AR109564A1 (es) * | 2016-09-01 | 2018-12-26 | Takeda Vaccines Inc | Métodos para producir enterovirus c para la producción de vacunas |
| EP3420076B1 (en) | 2017-03-06 | 2024-02-21 | Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. | Methods of producing and characterizing virus vaccine and virus vaccine composition |
| EP4382183A3 (en) | 2017-03-06 | 2024-08-21 | Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. | Methods of producing and characterizing virus vaccine and virus vaccine composition |
| JP2021514391A (ja) | 2018-02-15 | 2021-06-10 | アイコン ジェネティクス ゲーエムベーハー | ノロウイルスに対する免疫応答を生成するための免疫原性組成物及びワクチン |
| CN108676781A (zh) * | 2018-05-18 | 2018-10-19 | 山东信得动物疫苗有限公司 | 一种重组禽流感病毒的工业化纯化方法 |
| CN111848749A (zh) * | 2018-05-23 | 2020-10-30 | 中国农业科学院兰州兽医研究所 | 猪细小病毒VLPs抗体检测试剂盒及其制备方法、应用 |
| KR20220021451A (ko) | 2019-03-12 | 2022-02-22 | 아이콘 제네틱스 지엠비에이치 | 안정성이 향상된 노로바이러스 유사 입자 |
| CN115279896A (zh) | 2019-09-30 | 2022-11-01 | 比奥维拉迪维治疗股份有限公司 | 慢病毒载体配制品 |
| US20240238401A1 (en) | 2021-05-21 | 2024-07-18 | Takeda Vaccines, Inc. | Solid composition, freeze-drying method and glass vial |
| MX2024000138A (es) * | 2021-06-28 | 2024-01-23 | VST LLC dba Medgene Labs | Vacunas contra el sapovirus. |
| CN116789773B (zh) * | 2022-11-30 | 2024-02-20 | 华北制药金坦生物技术股份有限公司 | 一种胞内表达病毒样颗粒的粗纯方法 |
| WO2025077800A1 (en) * | 2023-10-12 | 2025-04-17 | Chengdu Kanghua Biological Products Co., Ltd. | Purification of norovirus virus-like particles (vlps) |
| CN118126202B (zh) * | 2024-05-07 | 2024-07-30 | 上海瑞宙生物科技有限公司 | 一种诺如病毒类病毒颗粒及其应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2833106B2 (ja) | 1990-02-21 | 1998-12-09 | 株式会社島津製作所 | 液体クロマトグラフ |
| WO1994026087A2 (en) | 1993-05-14 | 1994-11-24 | Connor Kim C O | Recombinant protein production and insect cell culture and process |
| CN1152935A (zh) | 1994-05-16 | 1997-06-25 | 麦克公司 | 乳头状瘤病毒疫苗 |
| AR004464A1 (es) | 1994-11-14 | 1998-12-16 | Merck Sharp & Dohme | Un metodo para producir una proteina de capside de papilomavirus |
| JP3316325B2 (ja) | 1994-12-20 | 2002-08-19 | 富士シリシア化学株式会社 | ビール安定化処理用シリカゲル及びその製造方法並びにビールの安定化処理方法 |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| DE69739268D1 (de) | 1996-11-08 | 2009-04-02 | Us Gov Health & Human Serv | Herstellung und reinigung von hepatitis c virus-ähnlichen partikeln |
| DE69835294T2 (de) | 1997-09-05 | 2007-07-26 | Medimmune, Inc. | Methode zur in vitro auseinander- und wiederzusammensetzung von papillomavirus virusähnlichen teilchen (vlps) |
| DE19823814A1 (de) | 1998-05-27 | 1999-12-02 | Octapharma Ag Ziegelbruecke | Verfahren zur Trennung und/oder Isolierung von Plasmaproteinen mit annularer Chromatographie |
| AU760633B2 (en) | 1998-08-14 | 2003-05-22 | Merck Sharp & Dohme Corp. | Process for purifying human papillomavirus virus-like particles |
| DK1150712T3 (da) * | 1999-02-05 | 2009-02-02 | Merck & Co Inc | Vaccineformuleringer mod human papillomavirus |
| US6349843B1 (en) | 1999-04-01 | 2002-02-26 | The Vollrath Company Llc | Pan removal ramp |
| KR100771402B1 (ko) | 1999-06-22 | 2007-10-30 | 국립감염증연구소장이 대표하는 일본국 | Ｓｒｓｖ 검출 킷트 |
| DE10012732A1 (de) | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
| JP2003066021A (ja) | 2001-08-28 | 2003-03-05 | Hiroshi Shionoya | 連続分取液体クロマトグラフィー装置とそれを用いる方法 |
| WO2003068993A1 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Method for isolation and purification of expressed gene products in vitro |
| KR100788093B1 (ko) | 2002-04-26 | 2007-12-21 | 제넨테크, 인크. | 단백질의 비친화성 정제 |
| AU2003268210A1 (en) | 2002-08-28 | 2004-03-19 | Introgen Therapeutics Inc. | Chromatographic methods for adenovirus purification |
| WO2005032457A2 (en) | 2003-07-21 | 2005-04-14 | Boyce Thompson Institute For Plant Research, Inc. | Vectors and methods for immunization against norwalk virus using transgenic plants |
| US7481997B1 (en) | 2004-02-12 | 2009-01-27 | Montana State University | Snow mountain virus genome sequence, virus-like particles and methods of use |
| US8277819B2 (en) | 2005-06-16 | 2012-10-02 | Children's Hospital Medical Center | Norovirus particle for use as an antiviral or vaccine |
| EP1736538A1 (en) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| EP3868400A1 (en) | 2005-12-29 | 2021-08-25 | Boehringer Ingelheim Animal Health USA Inc. | Multivalent pcv2 immunogenic compositions and methods of producing such compositions |
| AU2007345768B2 (en) | 2006-07-27 | 2013-08-01 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
| EP2601969B1 (en) | 2006-09-29 | 2016-03-30 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| US8202967B2 (en) | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| CA2683977C (en) | 2007-03-14 | 2017-04-25 | Ligocyte Pharmaceuticals, Inc. | A method of norovirus virus-like particle purification comprising ion exchange chromatography |
| EP2027875A1 (en) | 2007-08-23 | 2009-02-25 | Octapharma AG | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
| US10130696B2 (en) * | 2007-09-18 | 2018-11-20 | Takeda Vaccines, Inc. | Method of conferring a protective immune response to norovirus |
| EP2235165A1 (en) | 2007-12-21 | 2010-10-06 | Cytos Biotechnology AG | Process for clarifying cell homogenates |
| NO2324113T3 (enExample) | 2008-08-08 | 2018-07-28 | ||
| AU2009319979B2 (en) | 2008-11-03 | 2016-10-20 | Takeda Vaccines, Inc. | Improved methods for isolating enveloped virus-based VLPs free of infectious agents |
| US8945895B2 (en) * | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
| CN102791286B (zh) | 2010-01-21 | 2017-08-08 | 莱戈赛特医药股份有限公司 | 杯状病毒病毒样颗粒上靶定异源抗原的呈递 |
| WO2012040216A1 (en) | 2010-09-20 | 2012-03-29 | Bio-Rad Laboratories, Inc. | Dissociation of product-complexed contaminants in chromatography |
| FI122520B (fi) | 2010-10-15 | 2012-03-15 | Vesna Blazevic | Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena |
| CN102260651A (zh) | 2011-06-24 | 2011-11-30 | 华中科技大学同济医学院附属协和医院 | 一种纯化病毒样颗粒蛋白的方法及其应用 |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| JP2015015931A (ja) | 2013-07-12 | 2015-01-29 | 株式会社Ｕｍｎファーマ | ウイルス様粒子を含む培養物の製造方法 |
-
2013
- 2013-06-19 JO JOP/2013/0186A patent/JOP20130186B1/ar active
- 2013-06-21 TW TW102122276A patent/TWI647310B/zh active
- 2013-06-24 JP JP2015518633A patent/JP6553509B2/ja active Active
- 2013-06-24 SG SG10201610753YA patent/SG10201610753YA/en unknown
- 2013-06-24 US US13/925,449 patent/US10167320B2/en active Active
- 2013-06-24 CA CA2879815A patent/CA2879815A1/en active Pending
- 2013-06-24 CN CN201380043618.XA patent/CN104583393A/zh active Pending
- 2013-06-24 AU AU2013277959A patent/AU2013277959B2/en active Active
- 2013-06-24 CN CN202111173161.7A patent/CN114085273B/zh active Active
- 2013-06-24 MX MX2014015842A patent/MX366234B/es active IP Right Grant
- 2013-06-24 SG SG11201408459VA patent/SG11201408459VA/en unknown
- 2013-06-24 UY UY0001034875A patent/UY34875A/es active IP Right Grant
- 2013-06-24 WO PCT/US2013/047249 patent/WO2013192604A1/en not_active Ceased
- 2013-06-24 AR ARP130102218 patent/AR091538A1/es active IP Right Grant
- 2013-06-24 EP EP13807804.3A patent/EP2864478B1/en active Active
- 2013-06-24 KR KR1020157001131A patent/KR102110876B1/ko active Active
-
2015
- 2015-01-06 IN IN89DEN2015 patent/IN2015DN00089A/en unknown
-
2018
- 2018-11-27 US US16/201,073 patent/US11091519B2/en active Active
-
2021
- 2021-08-11 US US17/399,731 patent/US12286456B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW201406956A (zh) | 2014-02-16 |
| AU2013277959B2 (en) | 2019-05-16 |
| KR20150051988A (ko) | 2015-05-13 |
| CN104583393A (zh) | 2015-04-29 |
| KR102110876B1 (ko) | 2020-05-14 |
| JP2015521628A (ja) | 2015-07-30 |
| SG11201408459VA (en) | 2015-01-29 |
| EP2864478B1 (en) | 2020-12-09 |
| JP6553509B2 (ja) | 2019-07-31 |
| US20190169236A1 (en) | 2019-06-06 |
| JOP20130186B1 (ar) | 2021-08-17 |
| SG10201610753YA (en) | 2017-02-27 |
| US10167320B2 (en) | 2019-01-01 |
| MX366234B (es) | 2019-07-03 |
| TWI647310B (zh) | 2019-01-11 |
| UY34875A (es) | 2013-12-31 |
| US20140004145A1 (en) | 2014-01-02 |
| CN114085273A (zh) | 2022-02-25 |
| IN2015DN00089A (enExample) | 2015-05-29 |
| WO2013192604A1 (en) | 2013-12-27 |
| EP2864478A4 (en) | 2015-12-02 |
| CA2879815A1 (en) | 2013-12-27 |
| US12286456B2 (en) | 2025-04-29 |
| CN114085273B (zh) | 2024-07-12 |
| HK1210210A1 (en) | 2016-04-15 |
| US11091519B2 (en) | 2021-08-17 |
| MX2014015842A (es) | 2015-09-07 |
| EP2864478A1 (en) | 2015-04-29 |
| US20220213147A1 (en) | 2022-07-07 |
| AU2013277959A1 (en) | 2015-01-22 |
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