AR080073A1 - Composicion vitrea seca que comprende un material bioactivo - Google Patents

Composicion vitrea seca que comprende un material bioactivo

Info

Publication number
AR080073A1
AR080073A1 ARP110100304A ARP110100304A AR080073A1 AR 080073 A1 AR080073 A1 AR 080073A1 AR P110100304 A ARP110100304 A AR P110100304A AR P110100304 A ARP110100304 A AR P110100304A AR 080073 A1 AR080073 A1 AR 080073A1
Authority
AR
Argentina
Prior art keywords
formulation
composition
protein
vitreous
bioactive material
Prior art date
Application number
ARP110100304A
Other languages
English (en)
Original Assignee
Advanced Bionutrition Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Bionutrition Corp filed Critical Advanced Bionutrition Corp
Publication of AR080073A1 publication Critical patent/AR080073A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/04—Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/175—Rhamnosus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/531—Lactis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Animal Husbandry (AREA)
  • Inorganic Chemistry (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Insects & Arthropods (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Birds (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pediatric Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Endocrinology (AREA)

Abstract

Formulaciones y métodos para estabilizar y proteger materiales biologicos en condiciones rigurosas de almacenamiento y uso, en donde las formulaciones se refieren a materiales biologicos y bioactivos incrustados, que incluyen bacterias vivas, en una matriz vítrea protectora. Reivindicacion 1: Una composicion caracterizada porque comprende un material bioactivo, al menos un agente formador de matrices y al menos dos agentes de formacion vítrea. Reivindicacion 2: La composicion de la reivindicacion 1, caracterizada porque la composicion es una composicion vítrea seca que comprende un material bioactivo. Reivindicacion 4: La composicion de la reivindicacion 1, caracterizada porque el material bioactivo comprende una célula, un microbio, un virus, un cultivo celular, una bacteria, una bacteria probiotica, una planta y una bacteria probiotica del suelo, una levadura, una proteína, una proteína recombinante, una enzima, un péptido, una hormona, una vacuna, un fármaco, un antibiotico, una vitamina, un carotenoide, un mineral, un microbiocida, un fungicida, un herbicida, un insecticida o un espermicida. Reivindicacion 5: La composicion de la reivindicacion 1, caracterizada porque el agente de formacion matrices es un polisacárido seleccionado del grupo integrado por: acetato ftalato de celulosa (CAP), carboximetil celulosa, pectina, alginato de sodio, sales de ácido algínico, hidroxipropil metil celulosa (HPMC), metil celulosa, carragenano, goma guar, goma acacia, goma xantano, goma garrofín, quitosán y derivados de quitosán, almidones y almidones modificados, ciclodextrinas, inulina, maltodextrinas, dextranos, y combinaciones de los mismos. Reivindicacion 6: La composicion de la reivindicacion 1, caracterizada porque el agente formador de matrices está presente en la formulacion en una cantidad que oscila desde aproximadamente 1 por ciento en peso hasta aproximadamente 20 por ciento en peso. Reivindicacion 8: La composicion de la reivindicacion 1, caracterizada porque los agentes de formacion vítrea son: proteínas tales como albumina de suero bovino y humano, albumina de huevo, gelatina, inmunoglobulinas, proteína de soja aislada, proteína de trigo, polvo de leche descremada, caseínato, proteína de suero, proteína de arveja y cualquier hidrolizado de proteína; carbohidratos que incluyen monosacáridos (galactosa, D-manosa, sorbosa, etc,), disacáridos que incluyen lactosa, trehalosa, sacarosa, etc.; un aminoácido tales como lisina, glutamato monosodico, glicina, alanina, arginina, o histidina, como también aminoácidos hidrofobicos (triptofano, tirosina, leucina, fenilalanina, etc.); una metilamina tal como betaína; un poliol tales alcoholes de azucar trihídricos o superiores, por ej., glicerina, eritritol, glicerol, arabitol, xilitol, sorbitol, manitol e isomalt; propilenglicol; polietilenglicol; tensioactivos tales como ésteres de ácido graso de azucar y fosfolípidos tales como lecitina; y combinaciones de los mismos. Reivindicacion 9: La composicion de la reivindicacion 1, caracterizada porque los agentes de formacion vítrea están presentes en la formulacion en una cantidad que oscila desde aproximadamente 1 por ciento en peso hasta aproximadamente 80 por ciento en peso. Reivindicacion 10: Un método para preparar una formulacion en polvo seca estable de la reivindicacion 1, caracterizado porque comprende: combinar un material bioactivo, un agente formador de matrices y dos agentes de formacion vítrea en un solvente acuoso para formar una suspension viscosa; congelar rápidamente la suspension en nitrogeno líquido para formar perlas congeladas solidas, gotitas o hilos; purgar la partícula congelada solida al vacío y la temperatura por debajo del punto de congelacion de la formulacion; el paso del secado del líquido primario de la formulacion por evaporacion, al vacío, a una temperatura de formulacion por encima de su temperatura de congelacion; secado secundario de la formulacion al vacío completo y una temperatura de 20°C o superior durante un tiempo suficiente para reducir la actividad acuosa de la formulacion hasta Aw - 0,3 o inferior. Reivindicacion 17: El método de la reivindicacion 11, caracterizado porque la formulacion seca se corta, se tritura, se muele o se pulveriza respectivamente en un polvo de fluidez libre. Reivindicacion 19: El método de la reivindicacion 11, caracterizado porque además comprende administrar la formulacion a animales y plantas en forma de un líquido reconstituido o en forma de polvo molido y en forma de alimento o pienso. Reivindicacion 20: El método de la reivindicacion 11, caracterizado porque además comprende mezclar la formulacion con un componente seleccionado del grupo integrado por formula para lactante, bebidas funcionales, y alimento para mascotas; y administrar a lactantes humanos, adultos humanos, animales o plantas.
ARP110100304A 2010-01-28 2011-01-28 Composicion vitrea seca que comprende un material bioactivo AR080073A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29931510P 2010-01-28 2010-01-28

Publications (1)

Publication Number Publication Date
AR080073A1 true AR080073A1 (es) 2012-03-14

Family

ID=44320129

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP110100304A AR080073A1 (es) 2010-01-28 2011-01-28 Composicion vitrea seca que comprende un material bioactivo
ARP220100490A AR125029A2 (es) 2010-01-28 2022-03-03 Método para preparar una composición seca en polvo de material bioactivo estable

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP220100490A AR125029A2 (es) 2010-01-28 2022-03-03 Método para preparar una composición seca en polvo de material bioactivo estable

Country Status (15)

Country Link
US (2) US8834951B2 (es)
EP (1) EP2529004B1 (es)
JP (1) JP5886763B2 (es)
CN (1) CN102725393B (es)
AR (2) AR080073A1 (es)
BR (1) BR112012018839B1 (es)
CA (1) CA2785815C (es)
DK (1) DK2529004T3 (es)
ES (1) ES2639397T3 (es)
MX (1) MX336076B (es)
NZ (1) NZ601017A (es)
PL (1) PL2529004T3 (es)
RU (1) RU2535869C2 (es)
SG (1) SG182317A1 (es)
WO (1) WO2011094469A2 (es)

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