AR078254A1 - Inmunoglobulinas con dominio variable dual y usos de las mismas - Google Patents
Inmunoglobulinas con dominio variable dual y usos de las mismasInfo
- Publication number
- AR078254A1 AR078254A1 ARP100103210A ARP100103210A AR078254A1 AR 078254 A1 AR078254 A1 AR 078254A1 AR P100103210 A ARP100103210 A AR P100103210A AR P100103210 A ARP100103210 A AR P100103210A AR 078254 A1 AR078254 A1 AR 078254A1
- Authority
- AR
- Argentina
- Prior art keywords
- mtx
- seq
- variable domain
- heavy chain
- immunoglobulins
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 229940072221 immunoglobulins Drugs 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 3
- 108091008324 binding proteins Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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| CN102741288B (zh) | 2009-08-29 | 2015-08-19 | Abbvie公司 | 治疗用dll4结合蛋白 |
| CN102612524A (zh) * | 2009-09-01 | 2012-07-25 | 雅培制药有限公司 | 双重可变结构域免疫球蛋白及其用途 |
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| CN105037543B (zh) | 2010-03-02 | 2020-11-03 | Abbvie 公司 | 治疗性dll4结合蛋白 |
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| DK2906253T3 (en) | 2012-10-12 | 2018-10-22 | Adc Therapeutics Sa | Pyrrolobenzodiazepine anti-PSMA antibody conjugates |
| US9217042B2 (en) * | 2012-10-23 | 2015-12-22 | Abbott Cardiovascular Systems Inc. | Method of reducing MACE in diabetic patients subsequent to stent placement |
| US20140227252A1 (en) | 2012-10-31 | 2014-08-14 | Oncomed Pharmaceuticals , Inc. | Methods and Monitoring of Treatment with a DLL4 Antagonist |
| WO2014071074A2 (en) | 2012-11-01 | 2014-05-08 | Abbvie Inc. | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
| US20170275367A1 (en) | 2012-11-21 | 2017-09-28 | Janssen Biotech, Inc. | Bispecific EGFR/C-Met Antibodies |
| PT3447069T (pt) | 2012-11-21 | 2020-11-13 | Janssen Biotech Inc | Anticorpos biespecíficos de egfr/c-met |
| US9989524B2 (en) | 2013-02-05 | 2018-06-05 | Sanofi | Immuno imaging agent for use with antibody-drug conjugate therapy |
| US9844607B2 (en) | 2013-02-05 | 2017-12-19 | Sanofi | Immuno imaging agent for use with antibody-drug conjugate therapy |
| SG10201707391QA (en) * | 2013-02-05 | 2017-10-30 | Sanofi Sa | Immuno imaging agent for use with antibody-drug conjugate therapy |
| CN105143272A (zh) * | 2013-02-05 | 2015-12-09 | 赛诺菲 | 用于与抗体药物偶联物疗法一起使用的免疫成像剂 |
| TW202146054A (zh) * | 2013-03-15 | 2021-12-16 | 德商艾伯維德國有限及兩合公司 | 抗-egfr抗體藥物結合物調配物 |
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| JP2017510624A (ja) | 2014-02-10 | 2017-04-13 | パタラ ファーマ リミテッド ライアビリティ カンパニー | 肥満細胞安定剤による全身性障害の治療 |
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| CN102149825B (zh) | 2008-07-08 | 2015-07-22 | Abbvie公司 | 前列腺素e2双重可变结构域免疫球蛋白及其用途 |
| CN104829718A (zh) | 2008-07-08 | 2015-08-12 | 艾伯维公司 | 前列腺素e2结合蛋白及其用途 |
| EP2373692A4 (en) | 2008-12-04 | 2013-11-20 | Abbvie Inc | IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE |
| MX2011009362A (es) | 2009-03-05 | 2011-09-26 | Abbott Lab | Proteinas de union a il-17. |
| MX2011011670A (es) | 2009-05-01 | 2011-11-18 | Abbott Lab | Inmunoglobulinas de dominio variable dual y usos de las mismas. |
| AU2010242830C1 (en) * | 2009-05-01 | 2014-02-13 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| TW201109438A (en) | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CN102612524A (zh) * | 2009-09-01 | 2012-07-25 | 雅培制药有限公司 | 双重可变结构域免疫球蛋白及其用途 |
| WO2011047262A2 (en) | 2009-10-15 | 2011-04-21 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| UY32949A (es) | 2009-10-15 | 2011-02-28 | Abbott Lab | Proteínas de unión a il-1 |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| US20110318349A1 (en) | 2010-06-24 | 2011-12-29 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| RU2013113225A (ru) | 2010-08-26 | 2014-10-10 | Эббви Инк. | Иммуноглобулины с двумя вариабельными доменами и их применение |
| WO2012061558A2 (en) * | 2010-11-04 | 2012-05-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
-
2010
- 2010-09-01 CN CN2010800491395A patent/CN102612524A/zh active Pending
- 2010-09-01 KR KR1020127008445A patent/KR20120060877A/ko not_active Withdrawn
- 2010-09-01 AR ARP100103210A patent/AR078254A1/es not_active Application Discontinuation
- 2010-09-01 MX MX2012002651A patent/MX2012002651A/es not_active Application Discontinuation
- 2010-09-01 JP JP2012527113A patent/JP2013503607A/ja not_active Withdrawn
- 2010-09-01 TW TW099129545A patent/TW201119673A/zh unknown
- 2010-09-01 CA CA2772628A patent/CA2772628A1/en not_active Abandoned
- 2010-09-01 AU AU2010289527A patent/AU2010289527C1/en not_active Ceased
- 2010-09-01 WO PCT/US2010/047543 patent/WO2011028811A2/en active Application Filing
- 2010-09-01 PE PE2012000278A patent/PE20121530A1/es not_active Application Discontinuation
- 2010-09-01 BR BR112012004710A patent/BR112012004710A2/pt not_active IP Right Cessation
- 2010-09-01 UY UY0001032870A patent/UY32870A/es not_active Application Discontinuation
- 2010-09-01 EP EP10814433.8A patent/EP2473524A4/en not_active Withdrawn
- 2010-09-01 IN IN2737DEN2012 patent/IN2012DN02737A/en unknown
- 2010-09-01 US US12/873,926 patent/US8586714B2/en active Active
- 2010-09-01 SG SG2012014411A patent/SG178602A1/en unknown
- 2010-09-01 RU RU2012112550/10A patent/RU2012112550A/ru not_active Application Discontinuation
- 2010-09-01 NZ NZ598929A patent/NZ598929A/en not_active IP Right Cessation
-
2012
- 2012-02-29 IL IL218402A patent/IL218402A0/en unknown
- 2012-03-01 GT GT201200058A patent/GT201200058A/es unknown
- 2012-03-01 CL CL2012000559A patent/CL2012000559A1/es unknown
- 2012-03-01 DO DO2012000055A patent/DOP2012000055A/es unknown
- 2012-03-14 EC ECSP12011730 patent/ECSP12011730A/es unknown
- 2012-03-20 CO CO12047117A patent/CO6511254A2/es unknown
- 2012-03-27 CR CR20120154A patent/CR20120154A/es unknown
- 2012-03-28 ZA ZA2012/02268A patent/ZA201202268B/en unknown
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2013
- 2013-10-17 US US14/056,116 patent/US20140134171A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010289527C1 (en) | 2014-10-30 |
| UY32870A (es) | 2011-02-28 |
| IL218402A0 (en) | 2012-04-30 |
| US20140134171A1 (en) | 2014-05-15 |
| DOP2012000055A (es) | 2012-07-31 |
| PE20121530A1 (es) | 2012-12-22 |
| CA2772628A1 (en) | 2011-03-10 |
| IN2012DN02737A (h) | 2015-09-11 |
| CO6511254A2 (es) | 2012-08-31 |
| TW201119673A (en) | 2011-06-16 |
| MX2012002651A (es) | 2012-05-22 |
| RU2012112550A (ru) | 2013-10-10 |
| GT201200058A (es) | 2014-01-28 |
| NZ598929A (en) | 2014-05-30 |
| WO2011028811A2 (en) | 2011-03-10 |
| CR20120154A (es) | 2012-07-19 |
| CL2012000559A1 (es) | 2012-10-12 |
| CN102612524A (zh) | 2012-07-25 |
| ZA201202268B (en) | 2014-09-25 |
| US8586714B2 (en) | 2013-11-19 |
| US20110091372A1 (en) | 2011-04-21 |
| EP2473524A2 (en) | 2012-07-11 |
| EP2473524A4 (en) | 2013-05-22 |
| BR112012004710A2 (pt) | 2016-08-16 |
| JP2013503607A (ja) | 2013-02-04 |
| AU2010289527B2 (en) | 2014-04-17 |
| ECSP12011730A (es) | 2012-04-30 |
| SG178602A1 (en) | 2012-04-27 |
| KR20120060877A (ko) | 2012-06-12 |
| WO2011028811A3 (en) | 2011-04-28 |
| AU2010289527A1 (en) | 2012-04-19 |
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