AR075224A1 - Derivado de acido hialuronico polisulfatado de bajo peso molecular y productos farmaceuticos que lo contienen - Google Patents
Derivado de acido hialuronico polisulfatado de bajo peso molecular y productos farmaceuticos que lo contienenInfo
- Publication number
- AR075224A1 AR075224A1 ARP100100285A ARP100100285A AR075224A1 AR 075224 A1 AR075224 A1 AR 075224A1 AR P100100285 A ARP100100285 A AR P100100285A AR P100100285 A ARP100100285 A AR P100100285A AR 075224 A1 AR075224 A1 AR 075224A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- so3h
- nz1z2
- formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
Abstract
Proveer un derivado de ácido hialuronico polisulfatado de bajo peso molecular util para la prevencion y/o tratamiento de una enfermedad alérgica. Un agente para la prevencion y/o tratamiento de una enfermedad alérgica seleccionada de polinosis, rinitis alérgica, conjuntivitis alérgica, dermatitis atopica, y asma, que lo comprende. Reivindicacion 1: Un agente para la prevencion y/o tratamiento de una enfermedad alérgica seleccionada de polinosis, rinitis alérgica, conjuntivitis alérgica, dermatitis atopica, y asma, caracterizado porque comprende un derivado de ácido hialuronico polisulfatado de bajo peso molecular representado por la siguiente formula general (1A) o (1B), o una sal aceptable para uso farmacéutico del mismo corno un componente activo: donde n representa un numero de 0 a 15; X representa la formula (a) o (b); Y representa la formula (c), (d) o (e); cada R representa en forma independiente un átomo de hidrogeno o un grupo SO3H, con la condicion de que los grupos SO3H representen de 80 a 100% del numero total de R; R1 representa -OH, -OSO3H, o -NZ1Z2, donde Z1 y Z2 representan cada uno en forma independiente un átomo de hidrogeno, -SO3H, un grupo alquilo inferior opcionalmente sustituido, un grupo arilo inferior opcionalmente sustituido, un grupo aralquilo opcionalmente sustituido, o un grupo heteroarilo opcionalmente sustituido, o -NZ1Z2 representa colectivamente un residuo de aminoácido o un residuo peptídico; y cada * representa un sitio de union con un átomo de oxígeno; en la formula (1B) n representa un numero de 0 a 15; W representa la formula (f) o (g); cada R representa en forma independiente un átomo de hidrogeno o un grupo SO3H, con la condicion de que los grupos SO3H representen de 80 a 100% del numero total de R; R1 representa -OH, -OSO3H, o -NZ1Z2, donde Z1 y Z2 representan cada uno en forma independiente un átomo de hidrogeno, -SO3H, un grupo alquilo inferior opcionalmente sustituido, un grupo arilo inferior opcionalmente sustituido, un grupo aralquilo opcionalmente sustituido, o un grupo heteroarilo opcionalmente sustituido, o -NZ1Z2 representa colectivamente un residuo de aminoácido o un residuo peptídico; y cada * representa un sitio de union con un átomo de oxígeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009021820 | 2009-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075224A1 true AR075224A1 (es) | 2011-03-16 |
Family
ID=42395469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100100285A AR075224A1 (es) | 2009-02-02 | 2010-02-02 | Derivado de acido hialuronico polisulfatado de bajo peso molecular y productos farmaceuticos que lo contienen |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8993536B2 (es) |
| EP (1) | EP2392579B1 (es) |
| JP (2) | JP4884559B2 (es) |
| KR (1) | KR101678429B1 (es) |
| CN (1) | CN102300870B (es) |
| AR (1) | AR075224A1 (es) |
| BR (1) | BRPI1007325A2 (es) |
| CA (1) | CA2750188C (es) |
| CO (1) | CO6362026A2 (es) |
| ES (1) | ES2610240T3 (es) |
| HK (1) | HK1159642A1 (es) |
| IL (1) | IL213323A (es) |
| MX (1) | MX2011008119A (es) |
| MY (1) | MY160359A (es) |
| NZ (1) | NZ594854A (es) |
| RU (1) | RU2519781C2 (es) |
| SG (2) | SG173470A1 (es) |
| TW (1) | TWI539955B (es) |
| UA (1) | UA105781C2 (es) |
| WO (1) | WO2010087207A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102177180A (zh) | 2008-04-04 | 2011-09-07 | 犹他州大学研究基金会 | 烷基化半合成的糖胺聚糖醚及其制备和使用方法 |
| EP2397484A1 (en) * | 2010-06-11 | 2011-12-21 | Immunovo B.V. | Trisaccharide derivates, and their use as adjuvants |
| JP2012046511A (ja) * | 2010-07-30 | 2012-03-08 | Otsuka Chem Co Ltd | 低分子量多硫酸化ヒアルロン酸誘導体を含有する医薬 |
| JP6062917B2 (ja) | 2011-03-23 | 2017-01-18 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション | 泌尿器科の炎症の治療及び予防の方法 |
| JP5871500B2 (ja) * | 2011-06-20 | 2016-03-01 | 公益財団法人先端医療振興財団 | α−Ｋｌｏｔｈｏ／ＦＧＦ２３複合体形成阻害化合物 |
| JP6273199B2 (ja) * | 2012-03-22 | 2018-01-31 | 大塚製薬株式会社 | オリゴ糖化合物及びその製造方法とその中間体 |
| CN102579478A (zh) * | 2012-03-30 | 2012-07-18 | 济南康众医药科技开发有限公司 | 玻璃酸钠在制备药物中的应用 |
| JP2014047155A (ja) * | 2012-08-30 | 2014-03-17 | Tottori Univ | 保護硫酸化オリゴ糖化合物及びその製造方法 |
| SE538503C2 (en) | 2014-11-11 | 2016-08-16 | Tx Medic Ab | New dextran sulfate |
| ITUB20155623A1 (it) * | 2015-11-16 | 2017-05-16 | Fidia Farm Spa | Processo migliorato per la produzione di HA solfatato di elevata purezza |
| JP6225321B1 (ja) | 2016-08-31 | 2017-11-08 | 王子ホールディングス株式会社 | ポリ硫酸ペントサンの製造方法 |
| WO2018043667A1 (ja) | 2016-08-31 | 2018-03-08 | 王子ホールディングス株式会社 | 酸性キシロオリゴ糖の製造方法及び酸性キシロオリゴ糖 |
| WO2018053111A1 (en) | 2016-09-15 | 2018-03-22 | University Of Utah Research Foundation | In situ gelling compositions for the treatment or prevention of inflammation and tissue damage |
| JP6281659B1 (ja) | 2017-02-28 | 2018-02-21 | 王子ホールディングス株式会社 | ポリ硫酸ペントサン、医薬組成物及び抗凝固剤 |
| JP7330893B2 (ja) | 2017-03-10 | 2023-08-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法 |
| SG10201913607WA (en) | 2017-05-31 | 2020-03-30 | Oji Holdings Corp | Moisturizing topical preparation |
| US11993627B2 (en) | 2017-07-03 | 2024-05-28 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides |
| BR112020004787A2 (pt) | 2017-09-12 | 2020-09-24 | Oji Holdings Corporation | polissulfato de pentosano, composição farmacêutica, anticoagulante, e, método para produzir polissulfato de pentosano |
| WO2019090203A1 (en) | 2017-11-03 | 2019-05-09 | The University Of North Carolina At Chapel Hill | Sulfated oligosaccharides having anti-inflammatory activity |
| PL3730521T3 (pl) | 2017-12-20 | 2023-10-09 | Oji Holdings Corporation | Polisiarczan pentozanu i lek zawierający polisiarczan pentozanu |
| JP7538724B2 (ja) * | 2018-06-20 | 2024-08-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 細胞保護の方法と組成物 |
| CN111228653A (zh) | 2018-11-13 | 2020-06-05 | 格莱科米拉治疗公司 | 用电离辐射加强癌症治疗的方法 |
| WO2024072942A2 (en) | 2022-09-29 | 2024-04-04 | Adora Animal Health Corporation | Skin penetrating formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996024362A1 (fr) | 1995-02-07 | 1996-08-15 | Shiseido Company, Ltd. | Agents anti-inflammatoires |
| JPH08277224A (ja) | 1995-02-07 | 1996-10-22 | Shiseido Co Ltd | 抗炎症剤 |
| JPH10195107A (ja) | 1997-01-10 | 1998-07-28 | Shiseido Co Ltd | オリゴ硫酸化ヒアルロン酸 |
| JPH11147901A (ja) | 1997-11-19 | 1999-06-02 | Maruho Co Ltd | カリクレイン−キニン系阻害剤 |
| JPH11269077A (ja) | 1998-03-19 | 1999-10-05 | Maruho Co Ltd | ホスホリパーゼａ２阻害用医薬組成物 |
| US6689748B1 (en) | 1998-04-08 | 2004-02-10 | Theoharis C. Theoharides | Method of treating mast cell activation-induced diseases with a proteoglycan |
| JPH11335288A (ja) | 1998-05-20 | 1999-12-07 | Maruho Co Ltd | アレルギー性疾患の予防または治療薬 |
| WO2000069917A1 (fr) | 1999-05-18 | 2000-11-23 | Maruho Kabushikikaisha | Compositions medicinales destinees a inhiber le systeme kallikreine-kinine ou la phospholipase a¿2? |
| JP2004059506A (ja) * | 2002-07-29 | 2004-02-26 | Taisho Pharmaceut Co Ltd | セレクチン及びケモカインに作用する過硫酸化オリゴ糖 |
| US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| FR2845686B1 (fr) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| JP5164572B2 (ja) * | 2004-08-05 | 2013-03-21 | アイバックス ドラッグ リサーチ インスティテュート エルティーディー． | 多硫酸化グリコシド及びその塩 |
-
2010
- 2010-02-01 MX MX2011008119A patent/MX2011008119A/es active IP Right Grant
- 2010-02-01 CA CA2750188A patent/CA2750188C/en active Active
- 2010-02-01 US US13/143,129 patent/US8993536B2/en active Active
- 2010-02-01 WO PCT/JP2010/000583 patent/WO2010087207A1/ja active Application Filing
- 2010-02-01 KR KR1020117017561A patent/KR101678429B1/ko active IP Right Grant
- 2010-02-01 NZ NZ594854A patent/NZ594854A/xx unknown
- 2010-02-01 ES ES10735677.6T patent/ES2610240T3/es active Active
- 2010-02-01 CN CN201080005887.3A patent/CN102300870B/zh active Active
- 2010-02-01 BR BRPI1007325A patent/BRPI1007325A2/pt not_active IP Right Cessation
- 2010-02-01 JP JP2010539078A patent/JP4884559B2/ja active Active
- 2010-02-01 UA UAA201110592A patent/UA105781C2/uk unknown
- 2010-02-01 MY MYPI2011003178A patent/MY160359A/en unknown
- 2010-02-01 EP EP10735677.6A patent/EP2392579B1/en active Active
- 2010-02-01 SG SG2011054913A patent/SG173470A1/en unknown
- 2010-02-01 SG SG2014006985A patent/SG2014006985A/en unknown
- 2010-02-01 RU RU2011136250/04A patent/RU2519781C2/ru not_active IP Right Cessation
- 2010-02-02 AR ARP100100285A patent/AR075224A1/es unknown
- 2010-02-02 TW TW099103059A patent/TWI539955B/zh not_active IP Right Cessation
-
2011
- 2011-03-14 JP JP2011055681A patent/JP5554738B2/ja active Active
- 2011-06-02 IL IL213323A patent/IL213323A/en not_active IP Right Cessation
- 2011-07-21 CO CO11090783A patent/CO6362026A2/es active IP Right Grant
-
2012
- 2012-01-05 HK HK12100063.8A patent/HK1159642A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ594854A (en) | 2013-03-28 |
| TWI539955B (zh) | 2016-07-01 |
| US8993536B2 (en) | 2015-03-31 |
| EP2392579A4 (en) | 2012-09-26 |
| KR20110117118A (ko) | 2011-10-26 |
| CN102300870A (zh) | 2011-12-28 |
| RU2519781C2 (ru) | 2014-06-20 |
| CO6362026A2 (es) | 2012-01-20 |
| EP2392579A1 (en) | 2011-12-07 |
| MX2011008119A (es) | 2011-08-24 |
| BRPI1007325A2 (pt) | 2019-09-24 |
| AU2010209200A1 (en) | 2011-06-30 |
| EP2392579B1 (en) | 2016-11-23 |
| JPWO2010087207A1 (ja) | 2012-08-02 |
| JP2011168591A (ja) | 2011-09-01 |
| HK1159642A1 (zh) | 2012-08-03 |
| CA2750188A1 (en) | 2010-08-05 |
| JP4884559B2 (ja) | 2012-02-29 |
| US20110281819A1 (en) | 2011-11-17 |
| RU2011136250A (ru) | 2013-03-10 |
| IL213323A (en) | 2014-12-31 |
| IL213323A0 (en) | 2011-07-31 |
| UA105781C2 (uk) | 2014-06-25 |
| SG173470A1 (en) | 2011-09-29 |
| ES2610240T3 (es) | 2017-04-26 |
| WO2010087207A1 (ja) | 2010-08-05 |
| MY160359A (en) | 2017-02-28 |
| JP5554738B2 (ja) | 2014-07-23 |
| SG2014006985A (en) | 2014-04-28 |
| TW201032814A (en) | 2010-09-16 |
| CA2750188C (en) | 2016-11-29 |
| KR101678429B1 (ko) | 2016-11-22 |
| CN102300870B (zh) | 2014-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR075224A1 (es) | Derivado de acido hialuronico polisulfatado de bajo peso molecular y productos farmaceuticos que lo contienen | |
| CY1119015T1 (el) | 4'-αζιδο-3'φθορο υποκατεστημενα νουκλεοζιδιου παραγωγα ως αναστολεις αντιγραφης hcv rna | |
| CY1119056T1 (el) | Παραγωγα 2',4',-διφθορο-2'-μεθυλ υποκατεστημενου νουκλεοσιδιου ως αναστολεις αντιγραφης hcv rna | |
| CY1120031T1 (el) | Αποπτωτικοι υποκινητες ν-ακυλοσουλφοναμιδης | |
| CY1118859T1 (el) | 6-αλκινυλο-πυριδινες ως μιμητες smac | |
| BR112015004111A2 (pt) | novos derivados bicíclicos | |
| CO6690768A2 (es) | Derivados de triazina-oxadiazoles, útiles como inhibidores de los canales de sodio navi.7 | |
| BR112012012947B8 (pt) | sal de hemitartarato e composição farmacêutica compreendendo o mesmo | |
| EA201190235A1 (ru) | Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 | |
| BR112012033402A2 (pt) | moduladores de canais de íons conforme os compostos heterocíclicos fundidos | |
| GEP20135863B (en) | Substituted piperidines as ccr3 antagonists | |
| PH12014502141A1 (en) | New indanyloxydihydrobenzofuranylacetic acid derivatives and their use as gpr40 receptor agonists | |
| EA201490357A1 (ru) | Индазолы | |
| BRPI0910388A2 (pt) | agentes terapêutico antivirais. | |
| CY1115708T1 (el) | Τοπικες συνθεσεις για τη διατηρηση ή την ανακτηση της ακεραιοτητας των βλεννογονων | |
| BR112013006344A2 (pt) | lactamas substituídas por piperdinila como moduladores de gpr119, composição farmacêutica as compreendendo, uso e processso para preparação das mesmas | |
| EA201500426A1 (ru) | Производные пирролотриазинона в качестве ингибиторов pi3k | |
| UY31612A1 (es) | Derivados de incol 2-carboxamidas y de azaindol 2-carboxamidas sustituidos con un grupo silanilo, su preparación y su aplicación en terapéutica | |
| UY31606A1 (es) | Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica | |
| EA201290296A1 (ru) | Циклические пептиды, специфичные к рецептору меланокортина-1 | |
| EA201291217A1 (ru) | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 1-(β-D-ГЛЮКОПИРАНОЗИЛ)-2-ТИЕНИЛМЕТИЛБЕНЗОЛА КАК ИНГИБИТОРЫ НЗПГ | |
| UY34955A (es) | 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos | |
| EA201490846A1 (ru) | Новые производные арилхинолина | |
| CU20090048A7 (es) | Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| CY1116168T1 (el) | Συγκρυσταλλοι και αλατα αναστολεων toy ccr3 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |