AR052446A1 - Piperidinas 3,4-sustituidas - Google Patents
Piperidinas 3,4-sustituidasInfo
- Publication number
- AR052446A1 AR052446A1 ARP050105578A ARP050105578A AR052446A1 AR 052446 A1 AR052446 A1 AR 052446A1 AR P050105578 A ARP050105578 A AR P050105578A AR P050105578 A ARP050105578 A AR P050105578A AR 052446 A1 AR052446 A1 AR 052446A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- formula
- hydroxyl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Reivindicacion 1: Un compuesto de la formula (1) en donde: R1 es H, alquilo insustituido o sustituido, alquenilo insustituido o sustituido, alquinilo insustituido o sustituido, arilo insustituido o sustituido, heterociclilo insustituido o sustituido, o cicloalquilo insustituido o sustituido; R2 es alquilo insustituido o sustituido, alquenilo insustituido o sustituido, alquinilo insustituido o sustituido, arilo insustituido o sustituido, heterociclilo insustituido o sustituido, cicloalquilo insustituido o sustituido, o acilo; W es una fraccion seleccionada a partir de aquellas de las formulas (1A), (1B), y (1C) en donde el asterisco (*) denota la posicion en donde se enlaza la fraccion W con el átomo de C-4 en el anillo d3 piperidina de la formula (1), y en donde: X1, X2, X3, X4, y X5 se seleccionan independientemente a partir de C y N, en donde X4 en la formula 1B, y X1 en la formula 1C pueden tener uno de estos significados, o se pueden seleccionar adicionalmente a partir de S y O, en donde los átomos de C y N del anillo pueden llevar el numero requerido de H o sustituyentes R3 o - si está presente dentro de las limitaciones dadas más adelante- R4 para completar el numero de enlaces que surjan desde un C del anillo hasta 4, desde un N del anillo hasta 3; con la condicion de que, en la formula 1A, cuando menos 2, y de preferencia cuando menos 3 de X1 a X5 son C, y en las formulas 1B y 1C cuando menos uno de X1 a X4 es C, de preferencia dos de X1 a X4 son C; y es 0, 1, 2, o 3; z es 0, 1, 2, 3 o 4; R3, que solamente se puede enlazar a cualquiera de X1, X2, X4, y X4 es H, o de preferencia alquilo C1-7 insustituido o sustituido, alquenilo C2-7 insustituido o sustituido, alquinilo C2-7 insustituido o sustituido, arilo insustituido o sustituido,, heterociclilo insustituido o sustituido,, cicloalquilo insustituido o sustituido, halogeno, hidroxilo, hidroxilo eterificado o esterificado, mercapto insustituido o sustituido, sulfinilo insustituido o sustituido,, sulfonilo insustituido o sustituido, amino, amino mono- o di- sustituido, carboxilo, carboxilo esterificado o amidado, sulfamoilo insustituido o sustituido,, nitro o ciano, con la condicion de que si R3 es H, y y z son 0; R4 -si y o z es 2 o más, independientemente - se selecciona a partir de un grupo de sustituyentes que consisten en alquilo C1-7 insustituido o sustituido, alquenilo C2-7 insustituido o sustituido, alquinilo C2-7 insustituido o sustituido, halogeno, hidroxilo, hidroxilo eterificado o esterificado, mercapto insustituido o sustituido, sulfinilo insustituido o sustituido, sulfonilo insustituido o sustituido, amino, amino mono- o di-sustituido, carboxilo, carboxilo esterificado o amidado, sulfamoilo insustituido o sustituido, nitro, y ciano; T es metileno (-CH2-) o carbonilo (-C(=O)-), y R11 es H, hidroxilo, halogeno, alquilo C1-7, halo-alquilo C1-7, cicloalquilo, cicloalquilo sustituido por halogeno, alcoxilo C1-7, halo-alcoxilo C1-7, o ciano, o una sal del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0428526.8A GB0428526D0 (en) | 2004-12-30 | 2004-12-30 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR052446A1 true AR052446A1 (es) | 2007-03-21 |
Family
ID=34179049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050105578A AR052446A1 (es) | 2004-12-30 | 2005-12-28 | Piperidinas 3,4-sustituidas |
Country Status (21)
Country | Link |
---|---|
US (2) | US8084450B2 (es) |
EP (2) | EP1833816B1 (es) |
JP (1) | JP5188814B2 (es) |
KR (1) | KR20070091174A (es) |
CN (1) | CN101094848B (es) |
AR (1) | AR052446A1 (es) |
AT (1) | ATE448217T1 (es) |
AU (1) | AU2005321475B2 (es) |
BR (1) | BRPI0519769A2 (es) |
CA (1) | CA2587348A1 (es) |
DE (1) | DE602005017665D1 (es) |
ES (1) | ES2336470T3 (es) |
GB (1) | GB0428526D0 (es) |
GT (1) | GT200500359A (es) |
MX (1) | MX2007008078A (es) |
PE (1) | PE20061332A1 (es) |
PL (1) | PL1833816T3 (es) |
PT (1) | PT1833816E (es) |
RU (1) | RU2411239C2 (es) |
TW (1) | TW200635915A (es) |
WO (1) | WO2006069788A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
GB0505969D0 (en) * | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
GB0510810D0 (en) * | 2005-05-26 | 2005-06-29 | Novartis Ag | Organic compounds |
NZ564689A (en) * | 2005-05-27 | 2011-02-25 | Actelion Pharmaceuticals Ltd | Novel piperidine carboxylic acid amide derivatives |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
ES2430139T3 (es) | 2005-12-30 | 2013-11-19 | Novartis Ag | Compuestos de piperidina 3,5-sustituido como inhibidores de renina |
CA2637546A1 (en) | 2006-02-02 | 2007-08-09 | Actelion Pharmaceuticals Ltd | Secondary amines as renin inhibitors |
US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
US20100056497A1 (en) | 2007-01-31 | 2010-03-04 | Dainippon Sumitomo Pharma Co., Ltd | Amide derivative |
WO2008128832A1 (en) * | 2007-04-18 | 2008-10-30 | Nicox S.A. | Nitroderivatives of non-peptidic renin inhibitors for the treatment of cardiovascular, renal and chronic liver disease, inflammations and metabolic syndrome |
WO2008141462A1 (en) * | 2007-05-24 | 2008-11-27 | Merck Frosst Canada Ltd. | Novel case of renin inhibitors |
TWI452044B (zh) * | 2007-06-15 | 2014-09-11 | Mitsubishi Tanabe Pharma Corp | 嗎啉衍生物 |
CN101687847B (zh) | 2007-06-25 | 2013-11-06 | 诺华股份有限公司 | 用作肾素抑制剂的n5-(2-乙氧基乙基)-n3-(2-吡啶基)-3,5-哌啶二甲酰胺衍生物 |
KR20100033419A (ko) | 2007-07-19 | 2010-03-29 | 메타볼렉스, 인코포레이티드 | 당뇨병 및 대사 장애의 치료를 위한 rup3 또는 gpr119 수용체의 작용제로서 n-아자시클릭 치환된 피롤, 피라졸, 이미다졸, 트리아졸 및 테트라졸 유도체 |
JP5375616B2 (ja) | 2007-11-01 | 2013-12-25 | 宇部興産株式会社 | スルホン酸フェニル化合物、それを用いた非水電解液及びリチウム電池 |
TWI434690B (zh) * | 2007-12-19 | 2014-04-21 | Dainippon Sumitomo Pharma Co | 雜雙環衍生物 |
EP2276737A1 (en) * | 2008-04-17 | 2011-01-26 | Pfizer Inc. | 4- [3- (aryloxy) benzylidene]-3-methyl piperidine aryl carboxamide compounds useful as faah inhibitors |
SG192543A1 (en) | 2008-05-05 | 2013-08-30 | Merck Canada Inc | 3, 4 - substituted piperidine derivatives as renin inhibitors |
CA2728476C (en) | 2008-06-19 | 2017-03-21 | Takeda Pharmaceutical Company Limited | Heterocyclic carboxamide compounds and their use in the prophylaxis or treatment of hypertension |
JP2011524917A (ja) * | 2008-06-20 | 2011-09-08 | メタボレックス, インコーポレイテッド | アリールgpr119作動薬およびその使用 |
CA2747279A1 (en) * | 2008-12-10 | 2010-06-17 | Merck Canada Inc. | 3,4 - substituted piperidine derivatives as renin inhibitors |
EA023754B1 (ru) * | 2009-06-19 | 2016-07-29 | Басф Се | Гербицидные бензоксазиноны |
WO2010150840A1 (ja) | 2009-06-24 | 2010-12-29 | 大日本住友製薬株式会社 | N-置換-環状アミノ誘導体 |
TWI472524B (zh) * | 2009-09-28 | 2015-02-11 | Actelion Pharmaceuticals Ltd | 腎素抑制劑 |
JP5909185B2 (ja) | 2009-10-01 | 2016-04-26 | シマベイ セラピューティクス, インコーポレーテッド | 置換テトラゾール−1−イルフェノキシメチルチアゾール−2−イルピペリジニルピリミジン塩 |
CA2802541A1 (en) | 2010-06-23 | 2011-12-29 | Metabolex, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
US9278944B2 (en) | 2011-03-16 | 2016-03-08 | Mitsubishi Tanabe Pharma Corporation | Nitrogen-containing saturated heterocyclic compound |
US9783513B2 (en) | 2012-08-16 | 2017-10-10 | Ohio State Innovation Foundation | STAT3 inhibitors and their anticancer use |
US9556159B2 (en) | 2012-09-14 | 2017-01-31 | Mitsubishi Tanabe Pharma Corporation | Renin inhibitor |
WO2014065413A1 (ja) * | 2012-10-26 | 2014-05-01 | 日本たばこ産業株式会社 | トリアゾール・イソオキサゾール化合物およびその医薬用途 |
FR3002736B1 (fr) * | 2013-03-04 | 2015-06-26 | Virbac | Composition orale nutritionnelle et medicamenteuse a usage veterinaire |
CN103524511A (zh) * | 2013-10-21 | 2014-01-22 | 南京邮电大学 | 2,7,12-三溴-5,10,15-三烷基三并咔唑的制备方法 |
CN109862896A (zh) | 2016-08-03 | 2019-06-07 | 西玛贝医药公司 | 用于治疗炎症性胃肠疾病或胃肠病症的氧亚甲基芳基化合物 |
CN111423411B (zh) * | 2020-04-02 | 2021-04-16 | 南京生命源医药科技有限公司 | 一种新型肾素抑制剂 |
JP7473879B2 (ja) | 2020-08-07 | 2024-04-24 | 株式会社リコー | 画像形成装置およびクリーニング方法 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3278541A (en) * | 1966-10-11 | Di-substituted-n-alkyl piperidines | ||
US4559337A (en) | 1985-02-25 | 1985-12-17 | G.D. Searle & Co. | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides |
TW224941B (es) | 1989-11-08 | 1994-06-11 | Yamanouchi Pharma Co Ltd | |
SK56296A3 (en) | 1993-11-09 | 1997-02-05 | Merck & Co Inc | Piperidinal, pyrrolidinal and hexahydro-1h-azepinal derivatives, manufacturing process thereof and pharmaceutical compositions containing them |
US5721251A (en) * | 1993-12-10 | 1998-02-24 | Merck & Co., Inc. | Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone |
WO1997009311A1 (de) * | 1995-09-07 | 1997-03-13 | F. Hoffmann-La Roche Ag | Neue 4-(oxyalkoxyphenyl)-3-oxy-piperidine zur behandlung von herz- und niereninsuffizienz |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
WO1998006691A2 (en) | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | Low molecular weight dendritic compounds as pharmaceutical agents |
JP4066004B2 (ja) * | 1997-10-13 | 2008-03-26 | 忠弘 大見 | 上段部材取付けの基準となる孔を有する複数の下段部材の固定方法および固定用治具 |
CA2346537A1 (en) * | 1998-10-07 | 2000-04-13 | Gian Luca Araldi | Monomeric and dimeric heterocycles, and therapeutic uses thereof |
WO2000063173A1 (en) | 1999-04-14 | 2000-10-26 | F. Hoffmann-La Roche Ag | Process for the preparation of substituted piperidines |
US6376672B1 (en) * | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
US6197959B1 (en) | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
US20060079533A1 (en) | 2001-03-23 | 2006-04-13 | Nieman James A | Methods of treating alzheimer's disease |
JP2004534017A (ja) * | 2001-04-27 | 2004-11-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | Baceのインヒビター |
RS51155B (sr) | 2001-12-20 | 2010-10-31 | Bristol-Myers Squibb Company | DERIVATI α -(N-SULFONAMIDO)ACETAMIDA KAO INHIBITORI β -AMILOIDA |
EP1501830B1 (en) | 2002-04-29 | 2011-10-05 | Actelion Pharmaceuticals Ltd. | 7-aryl-3,9-diazabicyclo[3.3.1]non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases |
US20030216441A1 (en) | 2002-05-10 | 2003-11-20 | Gwaltney Stephen L. | Farnesyltransferase inhibitors |
EP1519920A1 (en) * | 2002-06-27 | 2005-04-06 | Actelion Pharmaceuticals Ltd. | Novel tetrahydropyridine derivatives as renin inhibitors |
AU2003299791A1 (en) * | 2002-12-20 | 2004-07-22 | Bayer Pharmaceuticals Corporation | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity |
US20040214832A1 (en) | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
US20040204455A1 (en) * | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
AU2004234040A1 (en) | 2003-04-28 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors |
BRPI0409881A (pt) | 2003-04-29 | 2006-05-23 | Actelion Pharmaceuticals Ltd | compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos |
CN1780663A (zh) | 2003-04-30 | 2006-05-31 | 埃科特莱茵药品有限公司 | 作为肾素抑制剂的新型3-位具有杂原子的9-氮杂双环壬烯衍生物 |
MXPA05011497A (es) | 2003-04-30 | 2005-12-15 | Actelion Pharmaceuticals Ltd | Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace). |
CN1780837A (zh) | 2003-04-30 | 2006-05-31 | 埃科特莱茵药品有限公司 | 新型氮杂二环壬烯衍生物 |
RU2005137571A (ru) | 2003-05-02 | 2006-05-10 | Актелион Фармасьютикалз Лтд. (Ch) | Новые производные диазабициклононена |
GB0319124D0 (en) | 2003-08-14 | 2003-09-17 | Smithkline Beecham Corp | Chemical compounds |
TW200513461A (en) | 2003-10-01 | 2005-04-16 | Speedel Experimenta Ag | Organische verbindungen |
BRPI0416976A (pt) | 2003-11-26 | 2007-02-21 | Novartis Ag | derivados de 4-fenilpiperidina como inibidores de renina |
AR053406A1 (es) | 2004-07-09 | 2007-05-09 | Speedel Experimenta Ag | Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas |
GB0428250D0 (en) | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
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- 2005-12-28 CN CN2005800450286A patent/CN101094848B/zh not_active Expired - Fee Related
- 2005-12-28 EP EP05820552A patent/EP1833816B1/en not_active Not-in-force
- 2005-12-28 WO PCT/EP2005/014102 patent/WO2006069788A1/en active Application Filing
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- 2005-12-28 AU AU2005321475A patent/AU2005321475B2/en not_active Ceased
- 2005-12-28 CA CA002587348A patent/CA2587348A1/en not_active Abandoned
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- 2005-12-28 JP JP2007548756A patent/JP5188814B2/ja not_active Expired - Fee Related
- 2005-12-28 EP EP09175034A patent/EP2177518A1/en not_active Withdrawn
- 2005-12-28 PT PT05820552T patent/PT1833816E/pt unknown
- 2005-12-28 AT AT05820552T patent/ATE448217T1/de not_active IP Right Cessation
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- 2005-12-29 TW TW094147340A patent/TW200635915A/zh unknown
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BRPI0519769A2 (pt) | 2009-02-17 |
PE20061332A1 (es) | 2006-12-27 |
CN101094848B (zh) | 2013-03-13 |
CN101094848A (zh) | 2007-12-26 |
US20090312304A1 (en) | 2009-12-17 |
US8178559B2 (en) | 2012-05-15 |
DE602005017665D1 (de) | 2009-12-24 |
US20110263560A1 (en) | 2011-10-27 |
PT1833816E (pt) | 2010-02-17 |
EP1833816A1 (en) | 2007-09-19 |
GT200500359A (es) | 2006-07-17 |
CA2587348A1 (en) | 2006-07-06 |
GB0428526D0 (en) | 2005-02-09 |
RU2007129090A (ru) | 2009-02-10 |
PL1833816T3 (pl) | 2010-04-30 |
RU2411239C2 (ru) | 2011-02-10 |
AU2005321475A1 (en) | 2006-07-06 |
EP1833816B1 (en) | 2009-11-11 |
MX2007008078A (es) | 2007-07-24 |
JP2008526701A (ja) | 2008-07-24 |
AU2005321475B2 (en) | 2009-11-12 |
WO2006069788A1 (en) | 2006-07-06 |
EP2177518A1 (en) | 2010-04-21 |
JP5188814B2 (ja) | 2013-04-24 |
US8084450B2 (en) | 2011-12-27 |
ATE448217T1 (de) | 2009-11-15 |
KR20070091174A (ko) | 2007-09-07 |
TW200635915A (en) | 2006-10-16 |
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