AR059136A1 - Derivados de indol-3-il-carbonil-espiro-piperidina - Google Patents
Derivados de indol-3-il-carbonil-espiro-piperidinaInfo
- Publication number
- AR059136A1 AR059136A1 ARP070100032A ARP070100032A AR059136A1 AR 059136 A1 AR059136 A1 AR 059136A1 AR P070100032 A ARP070100032 A AR P070100032A AR P070100032 A ARP070100032 A AR P070100032A AR 059136 A1 AR059136 A1 AR 059136A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- halogen
- nririi
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Compuestos de la formula general (1) en la A se elige los siguientes grupos (a), (b), (c), (d), (e) y (f): X puede ser igual o diferente y es CRiiiRiv, NRiii u O, en las que en (a), solamente una X puede ser O, la otra es CRiiiEiv o NRiii; R1 es H, alquilo C1-6 opcionalmente sustituido por CN, o es arilo, heteroarilo de 5 o 6 eslabones o sulfonilarilo, que están opcionalmente sustituidos por uno o más B, o es -(CH2)m-Ra, en el que Ra es: R3 es H, o es halogeno, o es -(CO)-Rc, en el que Rc es: alquilo C1-6, -(CH2)n-NRiRii, -(CH2)n-NRiiiRiv, heterocicloalquilo de 5 o 6 eslabones opcionalmente sustituido por alquilo C1-6, o es alquilo C1-6 o arilo, que están opcionalmente sustituidos por halogeno, -O(CO)-alquilo C1-6, o por -NH(CO)Rd, en el que Rd es alquilo C1-6 opcionalmente sustituido por halogeno o nitro o Rd es arilo o un heteroarilo de 5 o 6 eslabones, que están opcionalmente sustituidos por halogeno, nitro, alquilo C1-6 o haloalquilo C1-6; R4 es uno o más de H, halogeno, alquilo C1-6 o alcoxi C1-6, CN o dos R4 pueden formar un puente oxo o dioxo junto con el anillo fenilo al que están unidos, B es halogeno, CN, NRiRii, alquilo C1-6 opcionalmente sustituido por CN, halogeno o alcoxi C1-6, alcoxi C1-6, haloalcoxi C1-6, cicloalquilo C3-6, -C(O)O-alquilo C1-6, -C(O)-NRiRii, -C(O)-alquilo C1-6, -S(O)2-alquilo C1-6, -S(O)2-NRiRii, (CRiiiRiv)n-fenilo o (CRiiiRIV)n-heteroarilo de 5 o 6 eslabones, dichos restos fenilo o heteroarilo de 5 o 6 eslabones están opcionalmente sustituidos por uno o más sustituyentes elegidos entre el grupo formado por: halogeno, CN, NRiRii, alquilo C1-6 opcionalmente sustituido por CN o alcoxi C1-6, alcoxi C1-6, haloalcoxi C1-6, cicloalquilo C3-6, -C(O)O-alquilo C1-6, - C(O)-NRiRii, -C(O)-alquilo C1-6, -S(O)2-alquilo C1-6, -S(O)2-NRiRii; Ri y Rii son H, alquilo C1-6, alquileno C1-6-NRiiiRiv, -(CO)O-alquilo C1-6, -C(O)-NRiiiRiv, -C(O)-alquilo C1-6, -S(O)2-alquilo C1-6 o -S(O)2-NRiiiRiv; Riii es H, alquilo C1-6 o alquileno C1-6-N(Riv)2; Riv es H o alquilo C1-6; m es un numero de 1 a 6; n es un numero de 0 a 4, así como las sales farmacéuticamente aceptables de los mismos. La invencion se refiere además a composiciones farmacéuticas que contienen dichos compuestos, a su utilizacion en medicamentos contra dismenorrea, hipertension, fallo cardíaco cronico, secrecion inapropiada de vasopresina, cirrosis hepática, síndrome nefrotico, trastorno obsesivo-compulsivo, ansiedad y trastornos depresivos y a métodos para la obtencion de dichos compuestos
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100118 | 2006-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059136A1 true AR059136A1 (es) | 2008-03-12 |
Family
ID=37989141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100032A AR059136A1 (es) | 2006-01-05 | 2007-01-04 | Derivados de indol-3-il-carbonil-espiro-piperidina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7351706B2 (es) |
| EP (1) | EP1973913A1 (es) |
| JP (1) | JP2009522318A (es) |
| KR (1) | KR101121349B1 (es) |
| CN (1) | CN101356174B (es) |
| AR (1) | AR059136A1 (es) |
| AU (1) | AU2006334423B2 (es) |
| BR (1) | BRPI0620951A2 (es) |
| CA (1) | CA2634120A1 (es) |
| IL (1) | IL192401A0 (es) |
| NO (1) | NO20082733L (es) |
| RU (1) | RU2420529C2 (es) |
| TW (1) | TW200734343A (es) |
| WO (1) | WO2007077122A1 (es) |
| ZA (1) | ZA200805574B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
| MX2007002033A (es) * | 2004-08-19 | 2007-04-26 | Vertex Pharma | Moduladores de receptores muscarinicos. |
| US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
| AU2005309365B2 (en) * | 2004-11-29 | 2011-10-06 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| DE602006018334D1 (de) * | 2005-09-28 | 2010-12-30 | Hoffmann La Roche | Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten |
| WO2007076070A2 (en) * | 2005-12-22 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| RU2008137593A (ru) | 2006-02-22 | 2010-03-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
| WO2008021375A2 (en) * | 2006-08-15 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| CA2660974A1 (en) * | 2006-08-18 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| JP2010511654A (ja) | 2006-12-07 | 2010-04-15 | エフ．ホフマン−ラ ロシュ アーゲー | スピロ−ピペリジン誘導体 |
| JP2010540640A (ja) * | 2007-10-03 | 2010-12-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン作用性レセプターのモジュレーター |
| US8846684B2 (en) | 2011-03-31 | 2014-09-30 | The Regents Of The University Of Michigan | Arbovirus inhibitors and uses thereof |
| WO2013138565A1 (en) | 2012-03-16 | 2013-09-19 | Vitae Pharmaceuticals, Inc. | Liver x receptor modulators |
| KR102069913B1 (ko) | 2012-03-16 | 2020-01-23 | 비타이 파마슈티컬즈, 엘엘씨 | 간 x 수용체 조절제 |
| KR102353431B1 (ko) | 2013-12-19 | 2022-01-20 | 에프. 호프만-라 로슈 아게 | 스피로-옥사졸론 |
| MX2020002436A (es) * | 2017-09-05 | 2020-07-13 | Blackthorn Therapeutics Inc | Antagonistas del receptor de vasopresina y productos y metodos relacionados a los mismos. |
| WO2020048826A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds |
| TW202024083A (zh) | 2018-09-03 | 2020-07-01 | 德商拜耳廠股份有限公司 | 3,9-二氮雜螺[5.5]十一烷化合物 |
| WO2020048830A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020048831A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4349549A (en) * | 1981-05-18 | 1982-09-14 | Syntex (U.S.A.) Inc. | Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s |
| EP1009405A4 (en) | 1997-08-28 | 2001-05-09 | Merck & Co Inc | MODULATORS OF PYRROLIDINE AND PIPERIDINE OF CHEMOKINE RECEPTOR ACTIVITY |
| US6013652A (en) | 1997-12-04 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| WO2001022919A2 (en) | 1999-09-30 | 2001-04-05 | Merck & Co., Inc. | Spiro[bicyclic -azacycloalkyl and -cycloalkyl] derivatives and uses thereof |
| GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
| BR0315047A (pt) | 2002-10-03 | 2005-08-23 | Hoffmann La Roche | Composto, composição fermacêutica que compreende o mesmo, processo para a preparação da composição farmacêutica, utilização dos compostos, método de tratamento e processo para a preparação do composto |
| BRPI0612988A2 (pt) | 2005-07-14 | 2010-12-14 | Hoffmann La Roche | derivados de indol-3-il-carbonil-espiro-piperidina como antagonistas de receptor v1a |
-
2006
- 2006-12-18 US US11/640,739 patent/US7351706B2/en not_active Expired - Fee Related
- 2006-12-19 CN CN2006800504473A patent/CN101356174B/zh not_active Expired - Fee Related
- 2006-12-19 WO PCT/EP2006/069897 patent/WO2007077122A1/en active Application Filing
- 2006-12-19 EP EP06841445A patent/EP1973913A1/en not_active Withdrawn
- 2006-12-19 JP JP2008548964A patent/JP2009522318A/ja not_active Ceased
- 2006-12-19 AU AU2006334423A patent/AU2006334423B2/en not_active Ceased
- 2006-12-19 CA CA002634120A patent/CA2634120A1/en not_active Abandoned
- 2006-12-19 RU RU2008125813/04A patent/RU2420529C2/ru not_active IP Right Cessation
- 2006-12-19 KR KR1020087016220A patent/KR101121349B1/ko not_active IP Right Cessation
- 2006-12-19 BR BRPI0620951-3A patent/BRPI0620951A2/pt not_active IP Right Cessation
-
2007
- 2007-01-02 TW TW096100068A patent/TW200734343A/zh unknown
- 2007-01-04 AR ARP070100032A patent/AR059136A1/es not_active Application Discontinuation
-
2008
- 2008-06-18 NO NO20082733A patent/NO20082733L/no not_active Application Discontinuation
- 2008-06-23 IL IL192401A patent/IL192401A0/en unknown
- 2008-06-25 ZA ZA200805574A patent/ZA200805574B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006334423A1 (en) | 2007-07-12 |
| ZA200805574B (en) | 2009-12-30 |
| CA2634120A1 (en) | 2007-07-12 |
| RU2420529C2 (ru) | 2011-06-10 |
| CN101356174B (zh) | 2011-11-23 |
| BRPI0620951A2 (pt) | 2011-11-29 |
| NO20082733L (no) | 2008-10-02 |
| US20070155761A1 (en) | 2007-07-05 |
| AU2006334423B2 (en) | 2011-09-22 |
| KR101121349B1 (ko) | 2012-03-09 |
| EP1973913A1 (en) | 2008-10-01 |
| KR20080073364A (ko) | 2008-08-08 |
| TW200734343A (en) | 2007-09-16 |
| CN101356174A (zh) | 2009-01-28 |
| US7351706B2 (en) | 2008-04-01 |
| RU2008125813A (ru) | 2010-02-10 |
| IL192401A0 (en) | 2008-12-29 |
| WO2007077122A1 (en) | 2007-07-12 |
| JP2009522318A (ja) | 2009-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |