BRPI0416976A - derivados de 4-fenilpiperidina como inibidores de renina - Google Patents
derivados de 4-fenilpiperidina como inibidores de reninaInfo
- Publication number
- BRPI0416976A BRPI0416976A BRPI0416976-0A BRPI0416976A BRPI0416976A BR PI0416976 A BRPI0416976 A BR PI0416976A BR PI0416976 A BRPI0416976 A BR PI0416976A BR PI0416976 A BRPI0416976 A BR PI0416976A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- formula
- coronary syndrome
- renin inhibitors
- fibrosis
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
"DERIVADOS DE 4-FENILPIPERIDINA COMO INIBIDORES DE RENINA". Compostos da presente invenção tendo a fórmula (I) demonstram atividade inibidora sobre a enzima natural renina. Assim, compostos de fórmula (1) podem ser empregados para o tratamento de hipertensão, aterosclerose, síndrome coronária instável, falha cardíaca congestiva, hipertrofia cardíaca, fibrose cardíaca, cardiomiopatia após infarto, síndrome coronária instável, disfunção diastólica, doença de rim crónica, fibrose hepática, complicações resultantes de diabete, como nefropatia, vasculopatia e neuropatia, doenças dos vasos coronários, restenose após angioplastia, pressão intra-ocular aumentada, glaucoma, crescimento vascular anormal, hiperaldosteronismo, prejuízo cognitivo, mal de alzheimer, demência, estados de ansiedade e distúrbios cognitivos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52537503P | 2003-11-26 | 2003-11-26 | |
PCT/EP2004/013410 WO2005051911A1 (en) | 2003-11-26 | 2004-11-25 | 4-phenylpiperidine derivatives as renin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0416976A true BRPI0416976A (pt) | 2007-02-21 |
Family
ID=34632979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0416976-0A BRPI0416976A (pt) | 2003-11-26 | 2004-11-25 | derivados de 4-fenilpiperidina como inibidores de renina |
Country Status (15)
Country | Link |
---|---|
US (3) | US20070078164A1 (pt) |
EP (1) | EP1689712B1 (pt) |
JP (1) | JP4750712B2 (pt) |
KR (1) | KR20060120146A (pt) |
CN (1) | CN1906163A (pt) |
AT (1) | ATE440082T1 (pt) |
AU (1) | AU2004293177B2 (pt) |
BR (1) | BRPI0416976A (pt) |
CA (1) | CA2546264A1 (pt) |
DE (1) | DE602004022704D1 (pt) |
ES (1) | ES2332053T3 (pt) |
PL (1) | PL1689712T3 (pt) |
PT (1) | PT1689712E (pt) |
RU (1) | RU2374228C2 (pt) |
WO (1) | WO2005051911A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2546264A1 (en) * | 2003-11-26 | 2005-06-09 | Novartis Ag | 4-phenylpiperidine derivatives as renin inhibitors |
AU2005276624B2 (en) | 2004-08-25 | 2011-09-29 | Actelion Pharmaceuticals Ltd. | Bicyclononene derivatives as renin inhibitors |
ATE551052T1 (de) * | 2004-10-08 | 2012-04-15 | Novartis Ag | Verwendung von reninhemmern zur prävention oder behandlung von diastolischer dysfunktion oder diastolischer herzinsuffizienz |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
EP1707202A1 (de) * | 2005-03-31 | 2006-10-04 | Speedel Experimenta AG | Organische Verbindungen |
GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
WO2006129237A2 (en) | 2005-05-27 | 2006-12-07 | Actelion Pharmaceuticals Ltd | Novel piperidine carboxylic acid amide derivatives |
GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
PL2420491T3 (pl) | 2005-12-30 | 2013-12-31 | Novartis Ag | 3,5-Podstawione piperydyny jako inhibitory reniny |
GB0611696D0 (en) * | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
TW200821303A (en) * | 2006-08-08 | 2008-05-16 | Speedel Experimenta Ag | Organic compounds |
WO2008074450A2 (en) * | 2006-12-20 | 2008-06-26 | Nicox S.A. | Non-peptidic renin inhibitors nitroderivatives |
EP1987834A3 (en) * | 2007-02-13 | 2008-11-19 | Speedel Experimenta AG | Substituted piperidines as therapeutic compounds |
EP1958634A3 (en) * | 2007-02-14 | 2008-09-24 | Speedel Experimenta AG | Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease |
AU2008267287B2 (en) | 2007-06-25 | 2012-02-16 | Novartis Ag | N5-(2-ethoxyethyl)-N3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4616088A (en) * | 1984-10-29 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitor |
US5668151A (en) * | 1995-06-07 | 1997-09-16 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: piperidine derivatives |
CN1256326C (zh) * | 1995-09-07 | 2006-05-17 | 弗·哈夫曼-拉罗切有限公司 | 治疗心脏和肾功能不全的新型4-(氧烷氧基苯基)-3-氧哌啶化合物 |
WO2000063173A1 (en) | 1999-04-14 | 2000-10-26 | F. Hoffmann-La Roche Ag | Process for the preparation of substituted piperidines |
US6197959B1 (en) | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
US6376672B1 (en) * | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
US20060079533A1 (en) | 2001-03-23 | 2006-04-13 | Nieman James A | Methods of treating alzheimer's disease |
AU2002256418A1 (en) | 2001-04-27 | 2002-11-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
WO2004002549A1 (en) * | 2002-06-28 | 2004-01-08 | Novartis Ag | Use of organic compounds |
US20040214832A1 (en) | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
US20040204455A1 (en) | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
CA2546264A1 (en) * | 2003-11-26 | 2005-06-09 | Novartis Ag | 4-phenylpiperidine derivatives as renin inhibitors |
-
2004
- 2004-11-25 CA CA002546264A patent/CA2546264A1/en not_active Abandoned
- 2004-11-25 DE DE602004022704T patent/DE602004022704D1/de active Active
- 2004-11-25 PL PL04798086T patent/PL1689712T3/pl unknown
- 2004-11-25 CN CNA2004800409431A patent/CN1906163A/zh active Pending
- 2004-11-25 ES ES04798086T patent/ES2332053T3/es active Active
- 2004-11-25 WO PCT/EP2004/013410 patent/WO2005051911A1/en active Application Filing
- 2004-11-25 EP EP04798086A patent/EP1689712B1/en not_active Not-in-force
- 2004-11-25 AU AU2004293177A patent/AU2004293177B2/en not_active Ceased
- 2004-11-25 AT AT04798086T patent/ATE440082T1/de not_active IP Right Cessation
- 2004-11-25 BR BRPI0416976-0A patent/BRPI0416976A/pt not_active IP Right Cessation
- 2004-11-25 US US10/580,296 patent/US20070078164A1/en not_active Abandoned
- 2004-11-25 KR KR1020067010229A patent/KR20060120146A/ko not_active Application Discontinuation
- 2004-11-25 JP JP2006540386A patent/JP4750712B2/ja not_active Expired - Fee Related
- 2004-11-25 PT PT04798086T patent/PT1689712E/pt unknown
- 2004-11-25 RU RU2006122637/04A patent/RU2374228C2/ru not_active IP Right Cessation
-
2008
- 2008-06-27 US US12/163,038 patent/US7754727B2/en not_active Expired - Fee Related
-
2010
- 2010-05-28 US US12/789,892 patent/US8362040B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7754727B2 (en) | 2010-07-13 |
US8362040B2 (en) | 2013-01-29 |
CA2546264A1 (en) | 2005-06-09 |
KR20060120146A (ko) | 2006-11-24 |
RU2374228C2 (ru) | 2009-11-27 |
US20070078164A1 (en) | 2007-04-05 |
WO2005051911A1 (en) | 2005-06-09 |
ATE440082T1 (de) | 2009-09-15 |
AU2004293177B2 (en) | 2008-10-23 |
PT1689712E (pt) | 2009-11-25 |
AU2004293177A1 (en) | 2005-06-09 |
PL1689712T3 (pl) | 2010-01-29 |
DE602004022704D1 (de) | 2009-10-01 |
EP1689712B1 (en) | 2009-08-19 |
RU2006122637A (ru) | 2008-01-27 |
JP2007512282A (ja) | 2007-05-17 |
CN1906163A (zh) | 2007-01-31 |
JP4750712B2 (ja) | 2011-08-17 |
ES2332053T3 (es) | 2010-01-25 |
EP1689712A1 (en) | 2006-08-16 |
US20080269255A1 (en) | 2008-10-30 |
US20100240679A1 (en) | 2010-09-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |