CY1117790T1 - Ενωσεις αναστολεα 11-βητα-υδροξυστεροειδους αφυδρογονασης τυπου 1 - Google Patents

Ενωσεις αναστολεα 11-βητα-υδροξυστεροειδους αφυδρογονασης τυπου 1

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Publication number
CY1117790T1
CY1117790T1 CY20161100692T CY161100692T CY1117790T1 CY 1117790 T1 CY1117790 T1 CY 1117790T1 CY 20161100692 T CY20161100692 T CY 20161100692T CY 161100692 T CY161100692 T CY 161100692T CY 1117790 T1 CY1117790 T1 CY 1117790T1
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CY
Cyprus
Prior art keywords
beta
hydroxysteroid
suspension
inhibitor compounds
disorders
Prior art date
Application number
CY20161100692T
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English (en)
Inventor
Ruiz Juan Lorenzo Catena
Comas Carme Serra
Puiggros Oscar Rey
Hernandez Albert Antolin
Mas Ester Monlleo
Original Assignee
Laboratorios Salvat, S.A.
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43297307&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117790(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratorios Salvat, S.A. filed Critical Laboratorios Salvat, S.A.
Publication of CY1117790T1 publication Critical patent/CY1117790T1/el

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    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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Abstract

Οι ενώσεις του τύπου (I) προέρχονται από περυδροκινολίνη και περυδροϊσοκινολίνη και μπορούν να χρησιμοποιηθούν ως φαρμακευτικές δραστικές ενώσεις για την προφύλαξη ή τη θεραπεία ασθενειών που οφείλονται σε διαταραχές που συνδέονται με το ένζυμο 11-βήτα-υδροξυστεροειδούς αφυδρογονάσης τύπου 1 (11-βήτα-HSD1), όπως τα ακόλουθα : γλαύκωμα, αυξημένη οφθαλμική πίεση, μεταβολικές διαταραχές, παχυσαρκία, μεταβολικό σύνδρομο, δυσλιπιδαιμία, υπέρταση, διαβήτης, αθηροσκλήρωση, σύνδρομο Cushing, ψωρίαση, ρευματοειδής αρθρίτιδα, νοητικές διαταραχές, νόσος του Alzheimer ή νευροεκφυλισμός.
CY20161100692T 2009-06-04 2016-07-15 Ενωσεις αναστολεα 11-βητα-υδροξυστεροειδους αφυδρογονασης τυπου 1 CY1117790T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200901402A ES2350077B1 (es) 2009-06-04 2009-06-04 Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
PCT/ES2010/000258 WO2010139827A1 (es) 2009-06-04 2010-06-04 Compuestos inhibidores de 11 beta-hidroxiesteroide deshidrogenase de tipo 1

Publications (1)

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CY1117790T1 true CY1117790T1 (el) 2017-05-17

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US (2) US8524894B2 (el)
EP (1) EP2439202B1 (el)
JP (1) JP5593380B2 (el)
KR (1) KR101732989B1 (el)
CN (1) CN102834385B (el)
AU (1) AU2010255653B2 (el)
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CA (1) CA2764214C (el)
CY (1) CY1117790T1 (el)
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EA (1) EA020794B1 (el)
ES (2) ES2350077B1 (el)
HU (1) HUE029756T2 (el)
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WO2014018913A2 (en) * 2012-07-27 2014-01-30 University Of Connecticut Santacruzamate a compositions and analogs and methods of use
WO2017173048A1 (en) * 2016-03-31 2017-10-05 Merck Patent Gmbh Compounds for the inhibition of cyclophilins and uses thereof
WO2023239892A1 (en) * 2022-06-10 2023-12-14 Arkuda Therapeutics Compounds for modulation of cd68 and uses thereof
CN115433164B (zh) * 2022-09-14 2023-12-12 南京师范大学 烟酰胺衍生物及其制备方法和在抗衰老延长寿命中的应用

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