AR052034A1 - Sal potasica de un inhibidor de la integrasa de vih - Google Patents

Sal potasica de un inhibidor de la integrasa de vih

Info

Publication number
AR052034A1
AR052034A1 ARP050104911A ARP050104911A AR052034A1 AR 052034 A1 AR052034 A1 AR 052034A1 AR P050104911 A ARP050104911 A AR P050104911A AR P050104911 A ARP050104911 A AR P050104911A AR 052034 A1 AR052034 A1 AR 052034A1
Authority
AR
Argentina
Prior art keywords
inhibitor
hiv
integras
compound
potassic salt
Prior art date
Application number
ARP050104911A
Other languages
English (en)
Spanish (es)
Original Assignee
Merck & Co Inc
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36171569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR052034(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc, Angeletti P Ist Richerche Bio filed Critical Merck & Co Inc
Publication of AR052034A1 publication Critical patent/AR052034A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02Seven-membered rings
    • C07D313/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12[b,e]-condensed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ARP050104911A 2004-12-03 2005-11-24 Sal potasica de un inhibidor de la integrasa de vih AR052034A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63313204P 2004-12-03 2004-12-03

Publications (1)

Publication Number Publication Date
AR052034A1 true AR052034A1 (es) 2007-02-28

Family

ID=36171569

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP050104911A AR052034A1 (es) 2004-12-03 2005-11-24 Sal potasica de un inhibidor de la integrasa de vih
ARP140101707A AR101429A2 (es) 2004-12-03 2014-04-24 Sal potásica de un inhibidor de la integrasa de vih

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP140101707A AR101429A2 (es) 2004-12-03 2014-04-24 Sal potásica de un inhibidor de la integrasa de vih

Country Status (35)

Country Link
US (2) US7754731B2 (enExample)
EP (2) EP1819700B1 (enExample)
JP (1) JP4705956B2 (enExample)
KR (2) KR20130122031A (enExample)
CN (1) CN101068793B (enExample)
AR (2) AR052034A1 (enExample)
AT (2) ATE518844T1 (enExample)
AU (1) AU2005311671B8 (enExample)
BR (1) BRPI0518760A8 (enExample)
CA (1) CA2588398C (enExample)
CR (1) CR9146A (enExample)
CY (1) CY1112859T1 (enExample)
DK (1) DK1819700T3 (enExample)
EA (1) EA012418B1 (enExample)
ES (2) ES2375788T3 (enExample)
GE (1) GEP20105086B (enExample)
HR (1) HRP20120066T1 (enExample)
IL (1) IL183614A (enExample)
MA (1) MA29120B1 (enExample)
ME (1) ME01985B (enExample)
MX (1) MX2007006639A (enExample)
MY (1) MY144320A (enExample)
NI (1) NI200700138A (enExample)
NO (1) NO338784B1 (enExample)
NZ (1) NZ555376A (enExample)
PE (1) PE20061148A1 (enExample)
PL (1) PL1819700T3 (enExample)
PT (1) PT1819700E (enExample)
RS (1) RS52197B (enExample)
SI (1) SI1819700T1 (enExample)
TN (1) TNSN07215A1 (enExample)
TW (1) TWI344463B (enExample)
UA (1) UA87884C2 (enExample)
WO (2) WO2006060730A2 (enExample)
ZA (1) ZA200704130B (enExample)

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EP1819323B2 (en) * 2004-12-03 2023-03-22 Merck Sharp & Dohme Corp. Pharmaceutical composition containing an anti-nucleating agent
KR20070085702A (ko) * 2004-12-03 2007-08-27 머크 앤드 캄파니 인코포레이티드 Ugt1a1에 의해 대사된 약물의 약력학을 개선시키기위한 아타자나비르의 용도
EP1993513A4 (en) * 2006-03-14 2012-06-27 Merck Sharp & Dohme METHOD AND DEVICE FOR PREPARING CRYSTALLINE ORGANIC MICROPARTICLE COMPOSITIONS USING MICROMATES AND CRYSTALLIZING MICROSAMEN AND THEIR USE
JP2009543865A (ja) 2006-07-19 2009-12-10 ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド ピリジノンジケト酸:併用療法におけるhiv複製の阻害剤
US7687509B2 (en) 2007-07-09 2010-03-30 Concert Pharmaceuticals Inc. Pyrimidinecarboxamide derivatives
CN103254138A (zh) * 2008-01-08 2013-08-21 默沙东公司 用于制备n-取代的羟基嘧啶酮羧酰胺类化合物的方法
ES2549387T3 (es) 2009-06-02 2015-10-27 Hetero Research Foundation Procedimiento de preparación de raltegravir potásico amorfo
WO2011024192A2 (en) 2009-07-27 2011-03-03 Matrix Laboratories Ltd Novel polymorphs of raltegravir
EP3970702A1 (en) 2009-10-26 2022-03-23 Merck Sharp & Dohme Corp. Solid pharmaceutical compositions containing an integrase inhibitor
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ES2362598B1 (es) * 2009-12-17 2012-06-13 Consejo Superior De Investigaciones Científicas (Csic) Uso del raltegravir y derivados para la elaboración de medicamentos destinados al tratamiento de infecciones por herpesvirus.
JP5889275B2 (ja) * 2010-04-01 2016-03-22 テバ ファーマシューティカル インダストリーズ リミティド ラルテグラビル塩およびその結晶形
CA2999435A1 (en) * 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv
EP2575465A4 (en) * 2010-05-25 2013-11-20 Hetero Research Foundation Raltegravir SALTS
WO2012009446A1 (en) 2010-07-16 2012-01-19 Concert Pharmaceuticals Inc. Novel pyrimidinecarboxamide derivatives
CN101914067B (zh) * 2010-08-26 2012-07-11 陈岱岭 N-甲基嘧啶酮的合成方法
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
WO2012103105A1 (en) 2011-01-24 2012-08-02 Assia Chemical Industries Ltd. Processes for preparing raltegravir and intermediates in the processes
WO2012106534A2 (en) * 2011-02-02 2012-08-09 The Regents Of The University Of California Hiv integrase inhibitors
US9163009B2 (en) 2011-04-06 2015-10-20 Lupin Limited Salts of raltegravir
CA2833006A1 (en) * 2011-04-22 2012-10-26 Merck Sharp & Dohme Corp. Taste-masked formulations of raltegravir
US9968607B2 (en) 2011-04-25 2018-05-15 Hetero Research Foundation Pharmaceutical compositions of raltegravir, methods of preparation and methods of use therof
EP2522665A1 (en) 2011-05-03 2012-11-14 Sandoz Ag Crystalline sodium salt of an HIV integrase inhibitor
EP2529741B1 (en) 2011-06-01 2014-02-12 Ratiopharm GmbH Composition and Tablet Comprising Raltegravir
WO2013037731A1 (de) 2011-09-16 2013-03-21 Hexal Ag Neue polymorphe form von raltegravir-kalium
CN103130788B (zh) * 2011-11-24 2015-09-02 南开大学 嘧啶酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
CN103130787B (zh) * 2011-11-24 2015-06-10 南开大学 嘧啶酮酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
ES2825029T3 (es) 2011-12-26 2021-05-14 Emcure Pharmaceuticals Ltd Síntesis de raltegravir
KR20140114406A (ko) 2012-01-25 2014-09-26 루핀 리미티드 안정한 비정질 랄테그라빌 포타슘 프리믹스 및 이의 제조 방법
WO2014064711A2 (en) * 2012-10-22 2014-05-01 Hetero Research Foundation Methods of administering raltegravir and raltegravir compositions
EP2818470A1 (en) 2013-06-27 2014-12-31 Basf Se Cocrystals of raltegravir potassium
WO2015009927A1 (en) * 2013-07-17 2015-01-22 Ratiopharm Gmbh Dolutegravir salts
WO2015114608A1 (en) 2014-02-03 2015-08-06 Mylan Laboratories Ltd Processes for the preparation of intermediates of raltegravir
US10391178B2 (en) * 2014-03-21 2019-08-27 Mylan Laboratories Limited Premix of crystalline raltegravir potassium salt and a process for the preparation thereof
US10257840B2 (en) 2014-10-22 2019-04-09 Telefonaktiebolaget Lm Ericsson (Publ) Operation of wireless local area network in the presence of periodic interference
WO2016075605A1 (en) 2014-11-10 2016-05-19 Aurobindo Pharma Ltd An improved process for the preparation of raltegravir
EP3472134B1 (en) 2016-06-21 2021-10-20 Pharmathen S.A. Process for preparing compounds useful as intermediates for the preparation of raltegravir
EP3512854A1 (en) 2016-09-15 2019-07-24 Lupin Limited Process for the preparation of pure and stable crystalline raltegravir potassium form 3
CN108610338A (zh) * 2016-12-12 2018-10-02 天津国际生物医药联合研究院 一种嘧啶酮酰胺类化合物的制备方法
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CA2463976C (en) * 2001-10-26 2007-02-13 Benedetta Crescenzi N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
US7354932B2 (en) * 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
IL161784A0 (en) * 2001-12-21 2005-11-20 Anormed Inc Chemokine receptor binding heterocyclic compounds with enhanced efficacy
AR042095A1 (es) * 2002-11-20 2005-06-08 Japan Tobacco Inc Compuesto 4-oxoquinolina y aplicacion del mismo como inhibidor de integrasa de vih
KR20050087865A (ko) * 2002-12-27 2005-08-31 이스티투토 디 리세르쉐 디 비올로지아 몰레콜라레 피. 안젤레티에스.피.에이. HIV 인테그라제 억제제로서 유용한테트라하이드로-4H-피리도[1,2-a]피리미딘 및 관련화합물
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
EP1819323B2 (en) 2004-12-03 2023-03-22 Merck Sharp & Dohme Corp. Pharmaceutical composition containing an anti-nucleating agent
KR20070085702A (ko) 2004-12-03 2007-08-27 머크 앤드 캄파니 인코포레이티드 Ugt1a1에 의해 대사된 약물의 약력학을 개선시키기위한 아타자나비르의 용도
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Also Published As

Publication number Publication date
NO338784B1 (no) 2016-10-17
MX2007006639A (es) 2007-06-19
US20060122205A1 (en) 2006-06-08
TWI344463B (en) 2011-07-01
MA29120B1 (fr) 2007-12-03
AU2005311671B2 (en) 2011-01-27
TNSN07215A1 (en) 2008-11-21
WO2006060730A3 (en) 2006-08-17
UA87884C2 (uk) 2009-08-25
WO2006060730A2 (en) 2006-06-08
DK1819700T3 (da) 2012-03-19
TW200631944A (en) 2006-09-16
WO2006060712A2 (en) 2006-06-08
RS52197B (sr) 2012-10-31
JP4705956B2 (ja) 2011-06-22
CA2588398C (en) 2011-07-12
BRPI0518760A8 (pt) 2017-12-12
HRP20120066T1 (hr) 2012-03-31
HK1115011A1 (en) 2008-11-14
IL183614A (en) 2012-03-29
WO2006060712A9 (en) 2006-07-27
EA200701204A1 (ru) 2007-12-28
ES2370136T3 (es) 2011-12-13
NO20073404L (no) 2007-07-02
US8357798B2 (en) 2013-01-22
AU2005311671A1 (en) 2006-06-08
CR9146A (es) 2007-10-04
KR101350420B1 (ko) 2014-02-17
PL1819700T3 (pl) 2012-04-30
IL183614A0 (en) 2007-09-20
EP1819683B1 (en) 2011-08-03
US20100249410A1 (en) 2010-09-30
EP1819683A2 (en) 2007-08-22
ME01985B (me) 2012-10-31
ATE534645T1 (de) 2011-12-15
JP2008521933A (ja) 2008-06-26
WO2006060712A3 (en) 2006-09-21
KR20130122031A (ko) 2013-11-06
EP1819700A2 (en) 2007-08-22
MY144320A (en) 2011-08-29
CN101068793A (zh) 2007-11-07
GEP20105086B (en) 2010-10-11
CN101068793B (zh) 2011-05-25
PE20061148A1 (es) 2006-11-09
ES2375788T3 (es) 2012-03-06
EA012418B1 (ru) 2009-10-30
ATE518844T1 (de) 2011-08-15
CA2588398A1 (en) 2006-06-08
US7754731B2 (en) 2010-07-13
SI1819700T1 (sl) 2012-07-31
BRPI0518760A2 (pt) 2008-12-09
AU2005311671B8 (en) 2011-02-10
NZ555376A (en) 2009-11-27
AR101429A2 (es) 2016-12-21
KR20070089990A (ko) 2007-09-04
EP1819700B1 (en) 2011-11-23
NI200700138A (es) 2008-05-13
PT1819700E (pt) 2012-02-01
ZA200704130B (en) 2008-08-27
CY1112859T1 (el) 2016-04-13

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