ATE518844T1 - Kaliumsalz eines hiv-integrase-inhibitors - Google Patents

Kaliumsalz eines hiv-integrase-inhibitors

Info

Publication number
ATE518844T1
ATE518844T1 AT05852866T AT05852866T ATE518844T1 AT E518844 T1 ATE518844 T1 AT E518844T1 AT 05852866 T AT05852866 T AT 05852866T AT 05852866 T AT05852866 T AT 05852866T AT E518844 T1 ATE518844 T1 AT E518844T1
Authority
AT
Austria
Prior art keywords
potassium salt
hiv integrase
integrase inhibitor
inhibitor
hiv
Prior art date
Application number
AT05852866T
Other languages
English (en)
Inventor
Philip Pye
Remy Angelaud
Danny Mancheno
Original Assignee
Merck Sharp & Dohme
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36171569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE518844(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Angeletti P Ist Richerche Bio filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE518844T1 publication Critical patent/ATE518844T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02Seven-membered rings
    • C07D313/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05852866T 2004-12-03 2005-12-02 Kaliumsalz eines hiv-integrase-inhibitors ATE518844T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63313204P 2004-12-03 2004-12-03
PCT/US2005/043781 WO2006060730A2 (en) 2004-12-03 2005-12-02 Potassium salt of an hiv integrase inhibitor

Publications (1)

Publication Number Publication Date
ATE518844T1 true ATE518844T1 (de) 2011-08-15

Family

ID=36171569

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05852840T ATE534645T1 (de) 2004-12-03 2005-12-02 Kaliumsalz eines hiv-integrasehemmers
AT05852866T ATE518844T1 (de) 2004-12-03 2005-12-02 Kaliumsalz eines hiv-integrase-inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05852840T ATE534645T1 (de) 2004-12-03 2005-12-02 Kaliumsalz eines hiv-integrasehemmers

Country Status (36)

Country Link
US (2) US7754731B2 (de)
EP (2) EP1819700B1 (de)
JP (1) JP4705956B2 (de)
KR (2) KR101350420B1 (de)
CN (1) CN101068793B (de)
AR (2) AR052034A1 (de)
AT (2) ATE534645T1 (de)
AU (1) AU2005311671B8 (de)
BR (1) BRPI0518760A8 (de)
CA (1) CA2588398C (de)
CR (1) CR9146A (de)
CY (1) CY1112859T1 (de)
DK (1) DK1819700T3 (de)
EA (1) EA012418B1 (de)
ES (2) ES2375788T3 (de)
GE (1) GEP20105086B (de)
HK (1) HK1115011A1 (de)
HR (1) HRP20120066T1 (de)
IL (1) IL183614A (de)
MA (1) MA29120B1 (de)
ME (1) ME01985B (de)
MX (1) MX2007006639A (de)
MY (1) MY144320A (de)
NI (1) NI200700138A (de)
NO (1) NO338784B1 (de)
NZ (1) NZ555376A (de)
PE (1) PE20061148A1 (de)
PL (1) PL1819700T3 (de)
PT (1) PT1819700E (de)
RS (1) RS52197B (de)
SI (1) SI1819700T1 (de)
TN (1) TNSN07215A1 (de)
TW (1) TWI344463B (de)
UA (1) UA87884C2 (de)
WO (2) WO2006060730A2 (de)
ZA (1) ZA200704130B (de)

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JP2008521929A (ja) * 2004-12-03 2008-06-26 メルク エンド カムパニー インコーポレーテッド 抗核形成剤を含有する医薬組成物
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WO2011024192A2 (en) 2009-07-27 2011-03-03 Matrix Laboratories Ltd Novel polymorphs of raltegravir
HRP20211826T1 (hr) 2009-10-26 2022-03-04 Merck Sharp & Dohme Corp. Čvrste farmaceutske kompozicije koje sadrže inhibitor integraze
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CN101914067B (zh) * 2010-08-26 2012-07-11 陈岱岭 N-甲基嘧啶酮的合成方法
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
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WO2012106534A2 (en) * 2011-02-02 2012-08-09 The Regents Of The University Of California Hiv integrase inhibitors
AU2012241050B2 (en) 2011-04-06 2016-05-19 Lupin Limited Novel salts of raltegravir
EP2699094A4 (de) * 2011-04-22 2014-12-17 Merck Sharp & Dohme Geschmacksmaskierte formulierungen von raltegravir
US9968607B2 (en) 2011-04-25 2018-05-15 Hetero Research Foundation Pharmaceutical compositions of raltegravir, methods of preparation and methods of use therof
EP2522665A1 (de) * 2011-05-03 2012-11-14 Sandoz Ag Kristallinnatriumsalz eines HIV-Integrasehemmers
EP2529741B1 (de) 2011-06-01 2014-02-12 Ratiopharm GmbH Zusammensetzung und Tablette beinhaltend Raltegravir
EP2755968A1 (de) 2011-09-16 2014-07-23 Hexal AG Neue polymorphe form von raltegravir-kalium
CN103130788B (zh) * 2011-11-24 2015-09-02 南开大学 嘧啶酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
CN103130787B (zh) * 2011-11-24 2015-06-10 南开大学 嘧啶酮酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
ES2825029T3 (es) 2011-12-26 2021-05-14 Emcure Pharmaceuticals Ltd Síntesis de raltegravir
RU2014134257A (ru) 2012-01-25 2016-03-20 Люпин Лимитед Устойчивый аморфный премикс на основе ралтегравира калия и способ его получения
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WO2017220208A1 (en) * 2016-06-21 2017-12-28 Pharmathen S.A. Process for preparing compounds useful as intermediates for the preparation of raltegravir
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Also Published As

Publication number Publication date
IL183614A (en) 2012-03-29
NZ555376A (en) 2009-11-27
JP2008521933A (ja) 2008-06-26
HRP20120066T1 (hr) 2012-03-31
PL1819700T3 (pl) 2012-04-30
EA200701204A1 (ru) 2007-12-28
WO2006060730A3 (en) 2006-08-17
WO2006060730A2 (en) 2006-06-08
WO2006060712A2 (en) 2006-06-08
KR20130122031A (ko) 2013-11-06
ME01985B (me) 2012-10-31
NO20073404L (no) 2007-07-02
AR052034A1 (es) 2007-02-28
AU2005311671B8 (en) 2011-02-10
AR101429A2 (es) 2016-12-21
PE20061148A1 (es) 2006-11-09
EP1819700A2 (de) 2007-08-22
MY144320A (en) 2011-08-29
MA29120B1 (fr) 2007-12-03
BRPI0518760A2 (pt) 2008-12-09
EP1819683A2 (de) 2007-08-22
UA87884C2 (uk) 2009-08-25
DK1819700T3 (da) 2012-03-19
TWI344463B (en) 2011-07-01
US7754731B2 (en) 2010-07-13
EP1819683B1 (de) 2011-08-03
HK1115011A1 (en) 2008-11-14
MX2007006639A (es) 2007-06-19
CA2588398A1 (en) 2006-06-08
RS52197B (en) 2012-10-31
ZA200704130B (en) 2008-08-27
KR101350420B1 (ko) 2014-02-17
CN101068793B (zh) 2011-05-25
CR9146A (es) 2007-10-04
ES2370136T3 (es) 2011-12-13
NO338784B1 (no) 2016-10-17
US20060122205A1 (en) 2006-06-08
ES2375788T3 (es) 2012-03-06
NI200700138A (es) 2008-05-13
PT1819700E (pt) 2012-02-01
TW200631944A (en) 2006-09-16
US8357798B2 (en) 2013-01-22
KR20070089990A (ko) 2007-09-04
IL183614A0 (en) 2007-09-20
EP1819700B1 (de) 2011-11-23
CY1112859T1 (el) 2016-04-13
CA2588398C (en) 2011-07-12
WO2006060712A9 (en) 2006-07-27
BRPI0518760A8 (pt) 2017-12-12
JP4705956B2 (ja) 2011-06-22
US20100249410A1 (en) 2010-09-30
SI1819700T1 (sl) 2012-07-31
WO2006060712A3 (en) 2006-09-21
AU2005311671B2 (en) 2011-01-27
AU2005311671A1 (en) 2006-06-08
CN101068793A (zh) 2007-11-07
ATE534645T1 (de) 2011-12-15
EA012418B1 (ru) 2009-10-30
TNSN07215A1 (en) 2008-11-21
GEP20105086B (en) 2010-10-11

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