MX2007006639A - Sal de potasio de un inhibidor de la integrasa del virus de inmunodeficiencia humana. - Google Patents

Sal de potasio de un inhibidor de la integrasa del virus de inmunodeficiencia humana.

Info

Publication number
MX2007006639A
MX2007006639A MX2007006639A MX2007006639A MX2007006639A MX 2007006639 A MX2007006639 A MX 2007006639A MX 2007006639 A MX2007006639 A MX 2007006639A MX 2007006639 A MX2007006639 A MX 2007006639A MX 2007006639 A MX2007006639 A MX 2007006639A
Authority
MX
Mexico
Prior art keywords
integrase inhibitor
hiv integrase
potassium salt
prophylaxis
aids
Prior art date
Application number
MX2007006639A
Other languages
English (en)
Inventor
Philip Jones
Kevin M Belyk
Vicenzo Summa
Henry G Morrison
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36171569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2007006639(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX2007006639A publication Critical patent/MX2007006639A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen sales potasicas del Compuesto A y procedimientos para su preparacion, en las que Compuesto A es de la formula; (ver Compuesto A) el Compuesto A es un inhibidor de la integrasa de VIH de utilidad para el tratamiento o la profilaxis de la infeccion por VIH, para retrasar el inicio del SIDA, y para el tratamiento o profilaxis de SIDA.
MX2007006639A 2004-12-03 2005-12-02 Sal de potasio de un inhibidor de la integrasa del virus de inmunodeficiencia humana. MX2007006639A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63313204P 2004-12-03 2004-12-03
PCT/US2005/043728 WO2006060712A2 (en) 2004-12-03 2005-12-02 Potassium salt of an hiv integrase inhibitor

Publications (1)

Publication Number Publication Date
MX2007006639A true MX2007006639A (es) 2007-06-19

Family

ID=36171569

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007006639A MX2007006639A (es) 2004-12-03 2005-12-02 Sal de potasio de un inhibidor de la integrasa del virus de inmunodeficiencia humana.

Country Status (36)

Country Link
US (2) US7754731B2 (es)
EP (2) EP1819700B1 (es)
JP (1) JP4705956B2 (es)
KR (2) KR101350420B1 (es)
CN (1) CN101068793B (es)
AR (2) AR052034A1 (es)
AT (2) ATE534645T1 (es)
AU (1) AU2005311671B8 (es)
BR (1) BRPI0518760A8 (es)
CA (1) CA2588398C (es)
CR (1) CR9146A (es)
CY (1) CY1112859T1 (es)
DK (1) DK1819700T3 (es)
EA (1) EA012418B1 (es)
ES (2) ES2375788T3 (es)
GE (1) GEP20105086B (es)
HK (1) HK1115011A1 (es)
HR (1) HRP20120066T1 (es)
IL (1) IL183614A (es)
MA (1) MA29120B1 (es)
ME (1) ME01985B (es)
MX (1) MX2007006639A (es)
MY (1) MY144320A (es)
NI (1) NI200700138A (es)
NO (1) NO338784B1 (es)
NZ (1) NZ555376A (es)
PE (1) PE20061148A1 (es)
PL (1) PL1819700T3 (es)
PT (1) PT1819700E (es)
RS (1) RS52197B (es)
SI (1) SI1819700T1 (es)
TN (1) TNSN07215A1 (es)
TW (1) TWI344463B (es)
UA (1) UA87884C2 (es)
WO (2) WO2006060730A2 (es)
ZA (1) ZA200704130B (es)

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ES2755273T3 (es) * 2004-12-03 2020-04-22 Merck Sharp & Dohme Formulación farmacéutica de inhibidores de la carboxamida VIH integrasa que contienen una composición de control de la velocidad de liberación
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EP2522665A1 (en) * 2011-05-03 2012-11-14 Sandoz Ag Crystalline sodium salt of an HIV integrase inhibitor
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EP2755968A1 (de) 2011-09-16 2014-07-23 Hexal AG Neue polymorphe form von raltegravir-kalium
CN103130788B (zh) * 2011-11-24 2015-09-02 南开大学 嘧啶酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
CN103130787B (zh) * 2011-11-24 2015-06-10 南开大学 嘧啶酮酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
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Also Published As

Publication number Publication date
IL183614A (en) 2012-03-29
NZ555376A (en) 2009-11-27
JP2008521933A (ja) 2008-06-26
HRP20120066T1 (hr) 2012-03-31
PL1819700T3 (pl) 2012-04-30
EA200701204A1 (ru) 2007-12-28
WO2006060730A3 (en) 2006-08-17
WO2006060730A2 (en) 2006-06-08
WO2006060712A2 (en) 2006-06-08
KR20130122031A (ko) 2013-11-06
ME01985B (me) 2012-10-31
NO20073404L (no) 2007-07-02
AR052034A1 (es) 2007-02-28
AU2005311671B8 (en) 2011-02-10
AR101429A2 (es) 2016-12-21
PE20061148A1 (es) 2006-11-09
EP1819700A2 (en) 2007-08-22
MY144320A (en) 2011-08-29
MA29120B1 (fr) 2007-12-03
BRPI0518760A2 (pt) 2008-12-09
EP1819683A2 (en) 2007-08-22
UA87884C2 (uk) 2009-08-25
DK1819700T3 (da) 2012-03-19
TWI344463B (en) 2011-07-01
US7754731B2 (en) 2010-07-13
ATE518844T1 (de) 2011-08-15
EP1819683B1 (en) 2011-08-03
HK1115011A1 (en) 2008-11-14
CA2588398A1 (en) 2006-06-08
RS52197B (en) 2012-10-31
ZA200704130B (en) 2008-08-27
KR101350420B1 (ko) 2014-02-17
CN101068793B (zh) 2011-05-25
CR9146A (es) 2007-10-04
ES2370136T3 (es) 2011-12-13
NO338784B1 (no) 2016-10-17
US20060122205A1 (en) 2006-06-08
ES2375788T3 (es) 2012-03-06
NI200700138A (es) 2008-05-13
PT1819700E (pt) 2012-02-01
TW200631944A (en) 2006-09-16
US8357798B2 (en) 2013-01-22
KR20070089990A (ko) 2007-09-04
IL183614A0 (en) 2007-09-20
EP1819700B1 (en) 2011-11-23
CY1112859T1 (el) 2016-04-13
CA2588398C (en) 2011-07-12
WO2006060712A9 (en) 2006-07-27
BRPI0518760A8 (pt) 2017-12-12
JP4705956B2 (ja) 2011-06-22
US20100249410A1 (en) 2010-09-30
SI1819700T1 (sl) 2012-07-31
WO2006060712A3 (en) 2006-09-21
AU2005311671B2 (en) 2011-01-27
AU2005311671A1 (en) 2006-06-08
CN101068793A (zh) 2007-11-07
ATE534645T1 (de) 2011-12-15
EA012418B1 (ru) 2009-10-30
TNSN07215A1 (en) 2008-11-21
GEP20105086B (en) 2010-10-11

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