BR0200536A - Compostos de sulfonilpiridazinana úteis como inibidores de aldose reductase - Google Patents

Compostos de sulfonilpiridazinana úteis como inibidores de aldose reductase

Info

Publication number
BR0200536A
BR0200536A BR0200536-0A BR0200536A BR0200536A BR 0200536 A BR0200536 A BR 0200536A BR 0200536 A BR0200536 A BR 0200536A BR 0200536 A BR0200536 A BR 0200536A
Authority
BR
Brazil
Prior art keywords
reductase inhibitors
aldose reductase
sulfonylpyridazinane
compounds useful
prodrug
Prior art date
Application number
BR0200536-0A
Other languages
English (en)
Inventor
William Holt Martin
Banavara Lakshman Mylarj
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0200536A publication Critical patent/BR0200536A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"COMPOSTOS DE SULFONILPIRIDAZINANA úTEIS COMO INIBIDORES DE ALDOSE REDUCTASE". Esta invenção refere-se a novos compostos de sulfonilpiridazinana úteis como inibidores de aldose reductase no tratamento ou prevenção de certas complicações derivadas da diabetes mellitus, composições farmacêuticas compreendendo o sulfonilpiridazinana, composições farmacêuticas compreendendo uma combinação da sulfonilpiridazinana com um segundo agente farmacêutico, métodos terapêuticos compreendendo a administração de compostos de sulfonilpiridazinana, métodos terapêuticos compreendendo a administração dos compostos de sulfonilpiridazinana em combinação com um segundo agente farmacêutico e compostos úteis como intermediários para a preparação dos compostos de sulfonilpiridazinana desta invenção.
BR0200536-0A 2001-02-28 2002-02-27 Compostos de sulfonilpiridazinana úteis como inibidores de aldose reductase BR0200536A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27225401P 2001-02-28 2001-02-28

Publications (1)

Publication Number Publication Date
BR0200536A true BR0200536A (pt) 2003-04-29

Family

ID=23039045

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0200536-0A BR0200536A (pt) 2001-02-28 2002-02-27 Compostos de sulfonilpiridazinana úteis como inibidores de aldose reductase

Country Status (9)

Country Link
US (1) US6730674B2 (pt)
EP (1) EP1236720B1 (pt)
JP (1) JP2003128657A (pt)
AT (1) ATE297902T1 (pt)
BR (1) BR0200536A (pt)
CA (1) CA2373395C (pt)
DE (1) DE60204611T2 (pt)
ES (1) ES2240657T3 (pt)
MX (1) MXPA02002252A (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003167A1 (en) 1996-07-24 1998-01-29 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
EP1392310A1 (en) * 2001-04-30 2004-03-03 Pfizer Products Inc. Combinations of aldose reductase inhibitors and cyclooxygenase-2 inhibitors
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
KR20030061051A (ko) * 2002-01-07 2003-07-18 대한민국 (경상대학교 총장) 신규한 아렌(혹은 알케인)술폰일피리다진온 유도체, 이의제조방법 및 유기반응에서의 용도
DE602005025755D1 (de) * 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
CA2614529C (en) * 2005-07-21 2011-06-28 F. Hoffmann-La Roche Ag Pyridazinone derivatives as thyroid hormone receptor agonists
SG157299A1 (en) 2008-05-09 2009-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
GB0907601D0 (en) * 2009-05-01 2009-06-10 Equateq Ltd Novel methods
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE574204A (fr) * 1958-12-24 1959-06-24 Henri Morren Dérives de sulfonyl-pyridazine
IE47592B1 (en) 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4939140A (en) 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
US4996204A (en) 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
FR2647676A1 (fr) 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
EP0582643A1 (en) * 1991-03-28 1994-02-16 Pfizer Inc. Pyridazinone acetic acids
TWI238064B (en) 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
EP1491540B1 (en) * 2001-03-30 2006-12-13 Pfizer Products Inc. Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia

Also Published As

Publication number Publication date
ATE297902T1 (de) 2005-07-15
US6730674B2 (en) 2004-05-04
US20030004139A1 (en) 2003-01-02
CA2373395A1 (en) 2002-08-28
DE60204611D1 (de) 2005-07-21
CA2373395C (en) 2006-01-10
EP1236720B1 (en) 2005-06-15
EP1236720A1 (en) 2002-09-04
JP2003128657A (ja) 2003-05-08
ES2240657T3 (es) 2005-10-16
MXPA02002252A (es) 2002-09-30
DE60204611T2 (de) 2006-05-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1980 DE 16/12/2008.