NO338784B1 - Vannfritt krystallinsk monokaliumsalt av en HIV-integraseinhibitor, farmasøytisk preparat derav, dets anvendelse i terapi, og dets anvendelse ved fremstilling av et medikament for behandling eller forebyggelse av HIV-infeksjon, eller for behandling, forebyggelse eller forsinkelse av begynnelsen av AIDS. - Google Patents

Vannfritt krystallinsk monokaliumsalt av en HIV-integraseinhibitor, farmasøytisk preparat derav, dets anvendelse i terapi, og dets anvendelse ved fremstilling av et medikament for behandling eller forebyggelse av HIV-infeksjon, eller for behandling, forebyggelse eller forsinkelse av begynnelsen av AIDS. Download PDF

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Publication number
NO338784B1
NO338784B1 NO20073404A NO20073404A NO338784B1 NO 338784 B1 NO338784 B1 NO 338784B1 NO 20073404 A NO20073404 A NO 20073404A NO 20073404 A NO20073404 A NO 20073404A NO 338784 B1 NO338784 B1 NO 338784B1
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Norway
Prior art keywords
compound
approximately
salt
prevention
treatment
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NO20073404A
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English (en)
Norwegian (no)
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NO20073404L (no
Inventor
Henry G Morrison
Kevin M Belyk
Philip Jones
Vincenzo Summa
Original Assignee
Merck Sharp & Dohme
Msd Italia Srl
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Application filed by Merck Sharp & Dohme, Msd Italia Srl filed Critical Merck Sharp & Dohme
Publication of NO20073404L publication Critical patent/NO20073404L/no
Publication of NO338784B1 publication Critical patent/NO338784B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20073404A 2004-12-03 2007-07-02 Vannfritt krystallinsk monokaliumsalt av en HIV-integraseinhibitor, farmasøytisk preparat derav, dets anvendelse i terapi, og dets anvendelse ved fremstilling av et medikament for behandling eller forebyggelse av HIV-infeksjon, eller for behandling, forebyggelse eller forsinkelse av begynnelsen av AIDS. NO338784B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63313204P 2004-12-03 2004-12-03
PCT/US2005/043728 WO2006060712A2 (en) 2004-12-03 2005-12-02 Potassium salt of an hiv integrase inhibitor

Publications (2)

Publication Number Publication Date
NO20073404L NO20073404L (no) 2007-07-02
NO338784B1 true NO338784B1 (no) 2016-10-17

Family

ID=36171569

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073404A NO338784B1 (no) 2004-12-03 2007-07-02 Vannfritt krystallinsk monokaliumsalt av en HIV-integraseinhibitor, farmasøytisk preparat derav, dets anvendelse i terapi, og dets anvendelse ved fremstilling av et medikament for behandling eller forebyggelse av HIV-infeksjon, eller for behandling, forebyggelse eller forsinkelse av begynnelsen av AIDS.

Country Status (35)

Country Link
US (2) US7754731B2 (enExample)
EP (2) EP1819700B1 (enExample)
JP (1) JP4705956B2 (enExample)
KR (2) KR20130122031A (enExample)
CN (1) CN101068793B (enExample)
AR (2) AR052034A1 (enExample)
AT (2) ATE518844T1 (enExample)
AU (1) AU2005311671B8 (enExample)
BR (1) BRPI0518760A8 (enExample)
CA (1) CA2588398C (enExample)
CR (1) CR9146A (enExample)
CY (1) CY1112859T1 (enExample)
DK (1) DK1819700T3 (enExample)
EA (1) EA012418B1 (enExample)
ES (2) ES2375788T3 (enExample)
GE (1) GEP20105086B (enExample)
HR (1) HRP20120066T1 (enExample)
IL (1) IL183614A (enExample)
MA (1) MA29120B1 (enExample)
ME (1) ME01985B (enExample)
MX (1) MX2007006639A (enExample)
MY (1) MY144320A (enExample)
NI (1) NI200700138A (enExample)
NO (1) NO338784B1 (enExample)
NZ (1) NZ555376A (enExample)
PE (1) PE20061148A1 (enExample)
PL (1) PL1819700T3 (enExample)
PT (1) PT1819700E (enExample)
RS (1) RS52197B (enExample)
SI (1) SI1819700T1 (enExample)
TN (1) TNSN07215A1 (enExample)
TW (1) TWI344463B (enExample)
UA (1) UA87884C2 (enExample)
WO (2) WO2006060730A2 (enExample)
ZA (1) ZA200704130B (enExample)

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MX2007006639A (es) 2007-06-19
US20060122205A1 (en) 2006-06-08
TWI344463B (en) 2011-07-01
MA29120B1 (fr) 2007-12-03
AU2005311671B2 (en) 2011-01-27
TNSN07215A1 (en) 2008-11-21
WO2006060730A3 (en) 2006-08-17
UA87884C2 (uk) 2009-08-25
WO2006060730A2 (en) 2006-06-08
DK1819700T3 (da) 2012-03-19
TW200631944A (en) 2006-09-16
WO2006060712A2 (en) 2006-06-08
RS52197B (sr) 2012-10-31
JP4705956B2 (ja) 2011-06-22
CA2588398C (en) 2011-07-12
BRPI0518760A8 (pt) 2017-12-12
HRP20120066T1 (hr) 2012-03-31
HK1115011A1 (en) 2008-11-14
AR052034A1 (es) 2007-02-28
IL183614A (en) 2012-03-29
WO2006060712A9 (en) 2006-07-27
EA200701204A1 (ru) 2007-12-28
ES2370136T3 (es) 2011-12-13
NO20073404L (no) 2007-07-02
US8357798B2 (en) 2013-01-22
AU2005311671A1 (en) 2006-06-08
CR9146A (es) 2007-10-04
KR101350420B1 (ko) 2014-02-17
PL1819700T3 (pl) 2012-04-30
IL183614A0 (en) 2007-09-20
EP1819683B1 (en) 2011-08-03
US20100249410A1 (en) 2010-09-30
EP1819683A2 (en) 2007-08-22
ME01985B (me) 2012-10-31
ATE534645T1 (de) 2011-12-15
JP2008521933A (ja) 2008-06-26
WO2006060712A3 (en) 2006-09-21
KR20130122031A (ko) 2013-11-06
EP1819700A2 (en) 2007-08-22
MY144320A (en) 2011-08-29
CN101068793A (zh) 2007-11-07
GEP20105086B (en) 2010-10-11
CN101068793B (zh) 2011-05-25
PE20061148A1 (es) 2006-11-09
ES2375788T3 (es) 2012-03-06
EA012418B1 (ru) 2009-10-30
ATE518844T1 (de) 2011-08-15
CA2588398A1 (en) 2006-06-08
US7754731B2 (en) 2010-07-13
SI1819700T1 (sl) 2012-07-31
BRPI0518760A2 (pt) 2008-12-09
AU2005311671B8 (en) 2011-02-10
NZ555376A (en) 2009-11-27
AR101429A2 (es) 2016-12-21
KR20070089990A (ko) 2007-09-04
EP1819700B1 (en) 2011-11-23
NI200700138A (es) 2008-05-13
PT1819700E (pt) 2012-02-01
ZA200704130B (en) 2008-08-27
CY1112859T1 (el) 2016-04-13

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