AR033168A1 - Solucion oral de aripiprazol - Google Patents
Solucion oral de aripiprazolInfo
- Publication number
- AR033168A1 AR033168A1 ARP020101366A ARP020101366A AR033168A1 AR 033168 A1 AR033168 A1 AR 033168A1 AR P020101366 A ARP020101366 A AR P020101366A AR P020101366 A ARP020101366 A AR P020101366A AR 033168 A1 AR033168 A1 AR 033168A1
- Authority
- AR
- Argentina
- Prior art keywords
- solution
- oral
- aripiprazol
- acid
- aripiprazole
- Prior art date
Links
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229960004372 aripiprazole Drugs 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 239000003186 pharmaceutical solution Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se proporciona para una solucion farmacéutica adecuada para administracion oral que comprende aripiprazol, un sistema de solvente farmacéuticamente adecuado, uno o más agentes mejoradores/enmascarantes del sabor y uno o más agentes seleccionados del grupo que consiste de ácido láctico, ácido acético, ácido tartárico y ácido cítrico, en donde la solucion tiene un pH desde 2.5 hasta 4.5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28671801P | 2001-04-25 | 2001-04-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR033168A1 true AR033168A1 (es) | 2003-12-03 |
Family
ID=23099862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020101366A AR033168A1 (es) | 2001-04-25 | 2002-04-15 | Solucion oral de aripiprazol |
Country Status (37)
Country | Link |
---|---|
US (1) | US6977257B2 (es) |
EP (2) | EP1381367B1 (es) |
JP (1) | JP4401077B2 (es) |
KR (1) | KR100909329B1 (es) |
CN (1) | CN1512884B (es) |
AR (1) | AR033168A1 (es) |
AT (1) | ATE537831T1 (es) |
AU (1) | AU2002254722B2 (es) |
BG (1) | BG66177B1 (es) |
BR (1) | BR0208986A (es) |
CA (1) | CA2445276C (es) |
CY (1) | CY1112606T1 (es) |
CZ (1) | CZ306181B6 (es) |
DK (1) | DK1381367T3 (es) |
EE (1) | EE05581B1 (es) |
ES (1) | ES2377855T3 (es) |
GE (1) | GEP20053602B (es) |
HK (2) | HK1058316A1 (es) |
HR (1) | HRP20030870B1 (es) |
HU (1) | HU230456B1 (es) |
IL (2) | IL158202A0 (es) |
IS (1) | IS2863B (es) |
MX (1) | MXPA03009728A (es) |
MY (1) | MY129350A (es) |
NO (1) | NO324606B1 (es) |
NZ (1) | NZ528550A (es) |
PE (1) | PE20021086A1 (es) |
PL (1) | PL206882B1 (es) |
PT (1) | PT1381367E (es) |
RS (1) | RS52082B (es) |
RU (1) | RU2295960C2 (es) |
SK (1) | SK287948B6 (es) |
TW (1) | TWI337865B (es) |
UA (1) | UA76144C2 (es) |
UY (1) | UY27273A1 (es) |
WO (1) | WO2002085366A1 (es) |
ZA (1) | ZA200307797B (es) |
Families Citing this family (55)
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US6770478B2 (en) * | 2000-02-10 | 2004-08-03 | The Regents Of The University Of California | Erythrocytic cells and method for preserving cells |
UA79984C2 (en) * | 2002-08-20 | 2007-08-10 | Bristol Myers Squibb Co | Preparation on the basis of aripiprazole complex and use thereof |
ES2373042T3 (es) * | 2003-10-08 | 2012-01-30 | Mallinckrodt Llc | Solución de metilfenidato y procedimientos de administración y producción asociados. |
JP4836797B2 (ja) | 2003-10-23 | 2011-12-14 | 大塚製薬株式会社 | 放出制御性無菌注射アリピプラゾール製剤および方法 |
WO2005070390A2 (en) * | 2004-01-21 | 2005-08-04 | Janssen Pharmaceutica N.V. | Mitratapide oral solution |
CA2622758A1 (en) | 2005-09-15 | 2007-03-29 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
EP1808164B2 (en) * | 2006-01-05 | 2018-07-04 | Teva Pharmaceutical Industries Ltd | Wet granulation method for preparing pharmaceutical compositions of aripiprazole |
WO2007081367A1 (en) * | 2006-01-05 | 2007-07-19 | Teva Pharmaceutical Industries Ltd. | Dry formulations of aripiprazole |
JP4892264B2 (ja) * | 2006-03-30 | 2012-03-07 | 高田製薬株式会社 | リスペリドン水性液剤 |
ATE523602T1 (de) * | 2006-06-12 | 2011-09-15 | Hadasit Med Res Service | Mit durch antipsychotika induzierten extrapyramidalen symptomen assoziierte rgs2- genotypen |
GB0618879D0 (en) | 2006-09-26 | 2006-11-01 | Zysis Ltd | Pharmaceutical compositions |
AR067747A1 (es) | 2007-07-31 | 2009-10-21 | Otsuka Pharma Co Ltd | Metodos para producir suspension de aripiprazol y formulacion liofilizada |
WO2009042166A1 (en) * | 2007-09-25 | 2009-04-02 | Panacos Pharmaceuticals, Inc. | Liquid bevirimat dosage forms for oral administration |
GB2456183A (en) * | 2008-01-04 | 2009-07-08 | Gw Pharma Ltd | Anti-psychotic composition comprising cannabinoids and anti-psychotic medicament |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
TW201031675A (en) | 2008-12-23 | 2010-09-01 | Pharmasset Inc | Synthesis of purine nucleosides |
EP2376514A2 (en) | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Nucleoside analogs |
EP2376088B1 (en) | 2008-12-23 | 2017-02-22 | Gilead Pharmasset LLC | 6-O-Substituted-2-amino-purine nucleoside phosphoramidates |
TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US8815261B2 (en) * | 2009-06-19 | 2014-08-26 | Medrx Co., Ltd. | Composition for external application comprising aripiprazole and organic acid as active ingredients |
TR201000948A1 (tr) | 2010-02-09 | 2011-08-22 | Sanovel İlaç San.Ve Ti̇c.A.Ş. | Aripiprazol formülasyonları. |
UY33312A (es) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidato de nucleosido de purina |
UY33311A (es) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidatos de nucleosidos |
US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
US9034867B2 (en) | 2011-03-18 | 2015-05-19 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising sorbitan esters |
JO3410B1 (ar) | 2011-06-07 | 2019-10-20 | Otsuka Pharma Co Ltd | تركيبة أريبيبرازول مجفف بالتبريد |
CN102846543B (zh) * | 2011-06-27 | 2014-11-19 | 上海中西制药有限公司 | 一种阿立哌唑药物制剂及其制备方法 |
CN102846616B (zh) * | 2011-06-27 | 2015-05-06 | 上海中西制药有限公司 | 一种阿立哌唑制剂及其制备方法 |
AR088372A1 (es) * | 2011-10-19 | 2014-05-28 | Otsuka Pharma Co Ltd | Solucion para administracion oral |
JP6219918B2 (ja) | 2012-03-19 | 2017-10-25 | アルカームス ファーマ アイルランド リミテッド | グリセロールエステルを含む医薬組成物 |
NZ630643A (en) | 2012-03-19 | 2017-08-25 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising fatty acid esters |
CA2867137C (en) | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
EP2868319A4 (en) * | 2012-06-29 | 2016-02-24 | Maruishi Pharma | ORAL PHARMACEUTICAL PREPARATION OF ARIPIPRAZOLE |
JP5341282B1 (ja) * | 2012-06-29 | 2013-11-13 | 丸石製薬株式会社 | アリピプラゾールの経口医薬製剤 |
KR101571670B1 (ko) * | 2012-08-08 | 2015-11-25 | 주식회사 씨엠지제약 | 아리피프라졸을 포함하는 경구용 속용 필름 제제 |
US9193685B2 (en) | 2012-09-19 | 2015-11-24 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
EP2900217A1 (en) * | 2012-09-26 | 2015-08-05 | Bristol-Myers Squibb Company | Apixaban liquid formulations |
US8568747B1 (en) | 2012-10-05 | 2013-10-29 | Silvergate Pharmaceuticals, Inc. | Enalapril compositions |
US20140107130A1 (en) * | 2012-10-11 | 2014-04-17 | Antrim Pharmaceuticals, LLC | Oral Solution Formulations of Aripiprazole |
WO2014060324A1 (en) * | 2012-10-16 | 2014-04-24 | Sanovel Ilac Sanayi Ve Ticaret A.S | Aripiprazole formulations |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
JP6203682B2 (ja) * | 2013-07-10 | 2017-09-27 | 共和薬品工業株式会社 | アリピプラゾール含有水性液剤 |
CN103393594A (zh) * | 2013-08-22 | 2013-11-20 | 万特制药(海南)有限公司 | 一种新的阿立哌唑的制剂组合物 |
AU2015231278B2 (en) | 2014-03-20 | 2020-01-23 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
WO2016189504A1 (en) * | 2015-05-28 | 2016-12-01 | Leiutis Pharmaceuticals Pvt Ltd | Non-lyophilized compositions of aripiprazole and methods of preparation thereof |
JP6039849B1 (ja) * | 2015-06-12 | 2016-12-07 | 高田製薬株式会社 | アリピプラゾール含有内用液剤 |
WO2017025930A1 (en) * | 2015-08-12 | 2017-02-16 | Ftf Pharma Private Limited | Oral solution of aripiprazole |
US9463183B1 (en) | 2015-10-30 | 2016-10-11 | Silvergate Pharmaceuticals, Inc. | Lisinopril formulations |
US9669008B1 (en) | 2016-03-18 | 2017-06-06 | Silvergate Pharmaceuticals, Inc. | Enalapril formulations |
CN108434146A (zh) * | 2017-02-16 | 2018-08-24 | 天津国际生物医药联合研究院 | 一种hiv-1整合酶抑制剂的溶液剂及其制备方法和应用 |
CN109498556A (zh) * | 2017-09-15 | 2019-03-22 | 万特制药(海南)有限公司 | 阿立哌唑口服溶液及其制备方法 |
JP7384812B2 (ja) | 2018-03-05 | 2023-11-21 | アルカームス ファーマ アイルランド リミテッド | アリピプラゾール投与戦略 |
CN112666267B (zh) * | 2019-10-15 | 2023-09-26 | 上海上药中西制药有限公司 | 一种阿立哌唑药品有关物质的检测方法 |
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SU843739A3 (ru) | 1978-02-17 | 1981-06-30 | Карл Томэ Гмбх (Фирма) | Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ |
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JPS5959663A (ja) | 1982-09-29 | 1984-04-05 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体−シクロデキストリン包接化合物 |
US5006528A (en) | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
JP3265680B2 (ja) * | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
US5457099A (en) | 1992-07-02 | 1995-10-10 | Sawai Pharmaceutical Co., Ltd. | Carbostyril derivatives and antiallergic agent |
TW254855B (es) * | 1993-07-28 | 1995-08-21 | Otsuka Pharma Co Ltd | |
CN1252003A (zh) * | 1997-03-31 | 2000-05-03 | 强生消费者公司 | 增强药物化合物渗透作用的溶剂系统 |
US20030077227A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
EP1109452A2 (en) * | 1998-09-03 | 2001-06-27 | Alcide Corporation | Freeze-resistant topical germicides and methods related thereto |
CA2311734C (en) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
WO2003030868A1 (en) * | 2001-10-09 | 2003-04-17 | Bristol-Myers Squibb Company | Flashmelt oral dosage formulation |
-
2002
- 2002-03-28 MY MYPI20021124A patent/MY129350A/en unknown
- 2002-04-15 AR ARP020101366A patent/AR033168A1/es unknown
- 2002-04-19 TW TW091108139A patent/TWI337865B/zh not_active IP Right Cessation
- 2002-04-24 JP JP2002582939A patent/JP4401077B2/ja not_active Expired - Lifetime
- 2002-04-24 UA UA20031110599A patent/UA76144C2/uk unknown
- 2002-04-24 MX MXPA03009728A patent/MXPA03009728A/es active IP Right Grant
- 2002-04-24 PL PL364666A patent/PL206882B1/pl unknown
- 2002-04-24 CA CA002445276A patent/CA2445276C/en not_active Expired - Fee Related
- 2002-04-24 IL IL15820202A patent/IL158202A0/xx active IP Right Grant
- 2002-04-24 UY UY27273A patent/UY27273A1/es not_active Application Discontinuation
- 2002-04-24 BR BR0208986-6A patent/BR0208986A/pt active Search and Examination
- 2002-04-24 PT PT02723964T patent/PT1381367E/pt unknown
- 2002-04-24 DK DK02723964.9T patent/DK1381367T3/da active
- 2002-04-24 RS YU84703A patent/RS52082B/sr unknown
- 2002-04-24 US US10/131,304 patent/US6977257B2/en not_active Expired - Lifetime
- 2002-04-24 NZ NZ528550A patent/NZ528550A/en not_active IP Right Cessation
- 2002-04-24 CN CN028112148A patent/CN1512884B/zh not_active Ceased
- 2002-04-24 CZ CZ2003-2821A patent/CZ306181B6/cs not_active IP Right Cessation
- 2002-04-24 EP EP02723964A patent/EP1381367B1/en not_active Expired - Lifetime
- 2002-04-24 SK SK1264-2003A patent/SK287948B6/sk not_active IP Right Cessation
- 2002-04-24 HU HU0303946A patent/HU230456B1/hu not_active IP Right Cessation
- 2002-04-24 KR KR1020037013943A patent/KR100909329B1/ko active IP Right Grant
- 2002-04-24 WO PCT/US2002/013048 patent/WO2002085366A1/en active IP Right Grant
- 2002-04-24 EE EEP200300523A patent/EE05581B1/xx not_active IP Right Cessation
- 2002-04-24 GE GE5332A patent/GEP20053602B/en unknown
- 2002-04-24 ES ES02723964T patent/ES2377855T3/es not_active Expired - Lifetime
- 2002-04-24 AT AT02723964T patent/ATE537831T1/de active
- 2002-04-24 AU AU2002254722A patent/AU2002254722B2/en not_active Expired
- 2002-04-24 RU RU2003132426/15A patent/RU2295960C2/ru not_active IP Right Cessation
- 2002-04-24 EP EP11190103.9A patent/EP2436384B2/en not_active Expired - Lifetime
- 2002-04-25 PE PE2002000346A patent/PE20021086A1/es not_active Application Discontinuation
-
2003
- 2003-10-01 BG BG108216A patent/BG66177B1/bg unknown
- 2003-10-01 IL IL158202A patent/IL158202A/en not_active IP Right Cessation
- 2003-10-06 ZA ZA200307797A patent/ZA200307797B/en unknown
- 2003-10-14 IS IS6994A patent/IS2863B/is unknown
- 2003-10-21 NO NO20034705A patent/NO324606B1/no not_active IP Right Cessation
- 2003-10-24 HR HR20030870A patent/HRP20030870B1/xx not_active IP Right Cessation
-
2004
- 2004-02-19 HK HK04101190.2A patent/HK1058316A1/xx not_active IP Right Cessation
-
2012
- 2012-03-14 CY CY20121100273T patent/CY1112606T1/el unknown
- 2012-09-28 HK HK12109608.1A patent/HK1168792A1/xx not_active IP Right Cessation
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