HUP0203716A2 - Tumorellenes hatású szubsztituált (N-benzil-indol-3-il)-glioxilsav-származékok, ezeket tartalmazó gyógyszerkészítmények - Google Patents

Tumorellenes hatású szubsztituált (N-benzil-indol-3-il)-glioxilsav-származékok, ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0203716A2
HUP0203716A2 HU0203716A HUP0203716A HUP0203716A2 HU P0203716 A2 HUP0203716 A2 HU P0203716A2 HU 0203716 A HU0203716 A HU 0203716A HU P0203716 A HUP0203716 A HU P0203716A HU P0203716 A2 HUP0203716 A2 HU P0203716A2
Authority
HU
Hungary
Prior art keywords
indol
benzyl
substituted
acid derivatives
glyoxylic acid
Prior art date
Application number
HU0203716A
Other languages
English (en)
Inventor
Gerald Bacher
Peter Emig
Eckhard Günther
Guillaume Le Baut
Bernd Nickel
Dietmar Reichert
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of HUP0203716A2 publication Critical patent/HUP0203716A2/hu
Publication of HUP0203716A3 publication Critical patent/HUP0203716A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány tárgyát (I) általános képletű új, szubsztituált (N-benzil-indol-3-il)-glioxilsav-származékok, fiziológiásan elviselhetősavaddiciós sóik és N-oxidjaik képezik, valamint ezek alkalmazásadaganatos betegségek kezelésére. Továbbá a találmány tárgyát képezik afenti vegyületeket és adott esetben gyógyászatilag elfogadhatóhordozó- és/vagy hígító ill. segédanyagokat tartalmazógyógyszerkészítmények. Ó
HU0203716A 1999-12-23 2000-12-19 Substituted n-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect and pharmaceutical compositions containing them HUP0203716A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP2000/012947 WO2001047913A2 (de) 1999-12-23 2000-12-19 Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung

Publications (2)

Publication Number Publication Date
HUP0203716A2 true HUP0203716A2 (hu) 2003-03-28
HUP0203716A3 HUP0203716A3 (en) 2004-05-28

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203716A HUP0203716A3 (en) 1999-12-23 2000-12-19 Substituted n-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect and pharmaceutical compositions containing them

Country Status (31)

Country Link
US (1) US6432987B2 (hu)
EP (1) EP1240157B1 (hu)
JP (1) JP2003519137A (hu)
KR (1) KR100747425B1 (hu)
CN (1) CN1283637C (hu)
AR (1) AR027098A1 (hu)
AT (1) ATE259364T1 (hu)
AU (1) AU772745B2 (hu)
BG (1) BG106924A (hu)
BR (1) BR0016712A (hu)
CA (1) CA2395259A1 (hu)
CO (1) CO5251472A1 (hu)
CZ (1) CZ20022094A3 (hu)
DE (2) DE19962300A1 (hu)
DK (1) DK1240157T3 (hu)
ES (1) ES2215768T3 (hu)
HK (1) HK1054038B (hu)
HU (1) HUP0203716A3 (hu)
IL (1) IL150235A0 (hu)
MX (1) MXPA02006229A (hu)
NO (1) NO324750B1 (hu)
NZ (2) NZ519977A (hu)
PL (1) PL195014B1 (hu)
PT (1) PT1240157E (hu)
RU (1) RU2266280C2 (hu)
SK (1) SK8752002A3 (hu)
TR (1) TR200400601T4 (hu)
TW (1) TWI284128B (hu)
UA (1) UA75060C2 (hu)
WO (1) WO2001047913A2 (hu)
ZA (1) ZA200204896B (hu)

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DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
JP4878285B2 (ja) * 2003-06-05 2012-02-15 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング アポトーシス誘発作用を有するインドール誘導体
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
US7749999B2 (en) 2003-09-11 2010-07-06 Itherx Pharmaceuticals, Inc. Alpha-ketoamides and derivatives thereof
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
CN101443006B (zh) 2004-12-31 2012-10-10 雷迪美国治疗股份有限公司 作为cetp抑制剂的新颖的苄胺衍生物
EP2363128B1 (en) * 2005-03-11 2016-02-17 Vertex Pharmaceuticals Incorporated Indole modulators of ATP-binding cassette transporters
SG176477A1 (en) * 2006-08-07 2011-12-29 Ironwood Pharmaceuticals Inc Indole compounds
EP2091532A1 (en) * 2006-11-28 2009-08-26 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
CN106822080A (zh) 2009-04-29 2017-06-13 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
JP5964965B2 (ja) 2011-08-18 2016-08-03 ドクター レディズ ラボラトリーズ リミテッド コレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての置換複素環式アミン化合物
KR101803866B1 (ko) 2011-09-27 2017-12-04 닥터 레디스 레보러터리즈 리미티드 동맥경화증 치료에 유용한 콜레스테릴 에스테르-전달 단백질(cetp) 억제제로서 5-벤질아미노메틸-6-아미노피라졸로[3,4-b]피리딘 유도체

Family Cites Families (25)

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KR950701317A (ko) * 1992-05-08 1995-03-23 오오쓰까 아끼히꼬 인돌 유도체(Indole Derivative)
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
WO1995022524A1 (en) * 1994-02-22 1995-08-24 Merrell Pharmaceuticals Inc. Novel indole derivatives useful to treat estrogen-related neoplasms and disorders
UA47387C2 (uk) * 1994-04-01 2002-07-15 Елі Ліллі Енд Компані 1H-ІНДОЛ-3-ГЛІОКСИЛАМІДИ ЯК ІНГІБІТОРИ sPLA<sub>2</sub> ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
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WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
JP2001522883A (ja) * 1997-11-14 2001-11-20 イーライ・リリー・アンド・カンパニー アルツハイマー病の処置
CA2322162A1 (en) * 1998-02-25 1999-09-02 Genetics Institute, Llc Inhibitors of phospholipase enzymes
DE19814838C2 (de) 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DZ2770A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
SK16342000A3 (sk) * 1998-05-01 2002-04-04 Eli Lilly And Company Liečivo na liečbu zápalového ochorenia čreva obsahujúce 1H-indol-3-glyoxylamidy
ES2230847T3 (es) * 1998-05-01 2005-05-01 Eli Lilly And Company Esteres inhibidores de spla2.
WO2000067802A1 (en) * 1999-05-10 2000-11-16 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action

Also Published As

Publication number Publication date
IL150235A0 (en) 2002-12-01
NO20023039L (no) 2002-08-09
NO324750B1 (no) 2007-12-03
KR20020063245A (ko) 2002-08-01
BR0016712A (pt) 2002-09-03
US6432987B2 (en) 2002-08-13
AR027098A1 (es) 2003-03-12
NO20023039D0 (no) 2002-06-21
DE50005284D1 (de) 2004-03-18
HUP0203716A3 (en) 2004-05-28
CA2395259A1 (en) 2001-07-05
AU2011901A (en) 2001-07-09
WO2001047913A2 (de) 2001-07-05
RU2002120462A (ru) 2004-01-10
JP2003519137A (ja) 2003-06-17
DK1240157T3 (da) 2004-06-14
BG106924A (bg) 2003-04-30
PT1240157E (pt) 2004-06-30
WO2001047913A3 (de) 2002-04-25
HK1054038A1 (en) 2003-11-14
TR200400601T4 (tr) 2004-04-21
EP1240157B1 (de) 2004-02-11
PL355684A1 (en) 2004-05-17
DE19962300A1 (de) 2001-06-28
CZ20022094A3 (cs) 2002-10-16
RU2266280C2 (ru) 2005-12-20
EP1240157A2 (de) 2002-09-18
CO5251472A1 (es) 2003-02-28
CN1283637C (zh) 2006-11-08
ATE259364T1 (de) 2004-02-15
NZ519977A (en) 2004-08-27
CN1420880A (zh) 2003-05-28
UA75060C2 (en) 2006-03-15
ES2215768T3 (es) 2004-10-16
MXPA02006229A (es) 2003-01-28
SK8752002A3 (en) 2003-01-09
TWI284128B (en) 2007-07-21
PL195014B1 (pl) 2007-07-31
NZ533731A (en) 2005-03-24
AU772745B2 (en) 2004-05-06
KR100747425B1 (ko) 2007-08-09
HK1054038B (zh) 2007-04-13
ZA200204896B (en) 2002-12-20
US20010014690A1 (en) 2001-08-16

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Owner name: ZENTARIS GMBH, DE

Free format text: FORMER OWNER(S): ZENTARIS AG, DE; ZENTARIS GMBH, DE