IL150235A0 - Substituted n-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect - Google Patents

Substituted n-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect

Info

Publication number
IL150235A0
IL150235A0 IL15023500A IL15023500A IL150235A0 IL 150235 A0 IL150235 A0 IL 150235A0 IL 15023500 A IL15023500 A IL 15023500A IL 15023500 A IL15023500 A IL 15023500A IL 150235 A0 IL150235 A0 IL 150235A0
Authority
IL
Israel
Prior art keywords
indol
benzyl
substituted
acid derivatives
glyoxylic acid
Prior art date
Application number
IL15023500A
Other languages
English (en)
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of IL150235A0 publication Critical patent/IL150235A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
IL15023500A 1999-12-23 2000-12-19 Substituted n-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect IL150235A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP2000/012947 WO2001047913A2 (de) 1999-12-23 2000-12-19 Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung

Publications (1)

Publication Number Publication Date
IL150235A0 true IL150235A0 (en) 2002-12-01

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15023500A IL150235A0 (en) 1999-12-23 2000-12-19 Substituted n-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect

Country Status (31)

Country Link
US (1) US6432987B2 (xx)
EP (1) EP1240157B1 (xx)
JP (1) JP2003519137A (xx)
KR (1) KR100747425B1 (xx)
CN (1) CN1283637C (xx)
AR (1) AR027098A1 (xx)
AT (1) ATE259364T1 (xx)
AU (1) AU772745B2 (xx)
BG (1) BG106924A (xx)
BR (1) BR0016712A (xx)
CA (1) CA2395259A1 (xx)
CO (1) CO5251472A1 (xx)
CZ (1) CZ20022094A3 (xx)
DE (2) DE19962300A1 (xx)
DK (1) DK1240157T3 (xx)
ES (1) ES2215768T3 (xx)
HK (1) HK1054038B (xx)
HU (1) HUP0203716A3 (xx)
IL (1) IL150235A0 (xx)
MX (1) MXPA02006229A (xx)
NO (1) NO324750B1 (xx)
NZ (2) NZ533731A (xx)
PL (1) PL195014B1 (xx)
PT (1) PT1240157E (xx)
RU (1) RU2266280C2 (xx)
SK (1) SK8752002A3 (xx)
TR (1) TR200400601T4 (xx)
TW (1) TWI284128B (xx)
UA (1) UA75060C2 (xx)
WO (1) WO2001047913A2 (xx)
ZA (1) ZA200204896B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
KR101132599B1 (ko) * 2003-06-05 2012-06-21 아에테르나 젠타리스 게엠베하 아폽토시스 유도 효과를 갖는 인돌 유도체
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
AU2004270733B2 (en) 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
US9040558B2 (en) 2004-12-31 2015-05-26 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US8242149B2 (en) * 2005-03-11 2012-08-14 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
CA2660704A1 (en) * 2006-08-07 2008-02-14 Ironwood Pharmaceuticals, Inc. Indole compounds
EP2091532A1 (en) * 2006-11-28 2009-08-26 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
EP2424521A4 (en) 2009-04-29 2015-03-04 Amarin Pharmaceuticals Ie Ltd PHARMACEUTICAL COMPOSITIONS COMPRISING EPA AND CARDIOVASCULAR AGENT AND METHODS OF USE
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
CA2845284C (en) 2011-08-18 2018-03-06 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors
EP2760864B1 (en) 2011-09-27 2018-01-24 Dr. Reddy's Laboratories Ltd. 5-BENZYLAMINOMETHYL-6-AMINOPYRAZOLO[3,4-b]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023374A1 (en) * 1992-05-08 1993-11-25 Otsuka Pharmaceutical Factory, Inc. Indole derivative
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
ES2122555T3 (es) * 1994-02-22 1998-12-16 Merrell Pharma Inc Nuevos derivados indolicos utiles para tratar neoplasmas y trastornos relacionados con estrogenos.
CN1067054C (zh) * 1994-04-01 2001-06-13 伊莱利利公司 1H-吲哚-3-乙醛酰胺sPLA2抑制剂
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
WO1998037069A1 (fr) * 1997-02-20 1998-08-27 Shionogi & Co., Ltd. Derives d'acide indoldicarboxylique
US5972988A (en) * 1997-03-26 1999-10-26 Eli Lilly And Company Method for treatment of chronic bronchitis using indole compounds
WO1998047507A1 (en) * 1997-04-24 1998-10-29 Shionogi & Co., Ltd. Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds
TW455581B (en) * 1997-06-26 2001-09-21 Lilly Co Eli Process for preparing 4-substituted-1H-indole-3-glyoxamides
JP2001513555A (ja) * 1997-08-28 2001-09-04 イーライ・リリー・アンド・カンパニー 非リウマチ様関節炎の処置方法
EP1007056A1 (en) * 1997-09-26 2000-06-14 Eli Lilly And Company Method for the treatment of cystic fibrosis
US6177426B1 (en) * 1997-10-27 2001-01-23 Eli Lilly And Company Morpholino-N-ethyl ester prodrugs of indole sPLA2 inhibitors
WO1999021546A1 (en) * 1997-10-27 1999-05-06 Eli Lilly And Company N,N-DIETHYLGLYCOLAMIDO ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS
AU1200799A (en) * 1997-10-27 1999-05-17 Eli Lilly And Company Isopropyl ester prodrugs of indole spla2 inhibitors
WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
CA2310249A1 (en) * 1997-11-14 1999-05-27 August Masaru Watanabe Treatment for alzheimer's disease
CN1310706A (zh) * 1998-02-25 2001-08-29 遗传研究所有限公司 磷脂酶抑制剂
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DZ2770A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
EA003277B1 (ru) * 1998-05-01 2003-04-24 Эли Лилли Энд Компани СЛОЖНЫЙ ЭФИР-ИНГИБИТОР sPLA2
CZ20004052A3 (cs) * 1998-05-01 2002-05-15 Eli Lilly And Company Léčivo pro terapeutickou léčbu zánětlivého onemocnění střeva a prostředek pro tuto léčbu obsahující 1H-indol-3-glyoxylamid
AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action

Also Published As

Publication number Publication date
TR200400601T4 (tr) 2004-04-21
HUP0203716A2 (hu) 2003-03-28
JP2003519137A (ja) 2003-06-17
NZ519977A (en) 2004-08-27
WO2001047913A2 (de) 2001-07-05
TWI284128B (en) 2007-07-21
HK1054038A1 (en) 2003-11-14
AU2011901A (en) 2001-07-09
KR100747425B1 (ko) 2007-08-09
DE19962300A1 (de) 2001-06-28
EP1240157A2 (de) 2002-09-18
PL195014B1 (pl) 2007-07-31
CN1420880A (zh) 2003-05-28
CO5251472A1 (es) 2003-02-28
CA2395259A1 (en) 2001-07-05
ES2215768T3 (es) 2004-10-16
DK1240157T3 (da) 2004-06-14
CZ20022094A3 (cs) 2002-10-16
MXPA02006229A (es) 2003-01-28
SK8752002A3 (en) 2003-01-09
NO20023039L (no) 2002-08-09
EP1240157B1 (de) 2004-02-11
US20010014690A1 (en) 2001-08-16
ATE259364T1 (de) 2004-02-15
NO324750B1 (no) 2007-12-03
HK1054038B (zh) 2007-04-13
HUP0203716A3 (en) 2004-05-28
WO2001047913A3 (de) 2002-04-25
ZA200204896B (en) 2002-12-20
PL355684A1 (en) 2004-05-17
RU2002120462A (ru) 2004-01-10
BR0016712A (pt) 2002-09-03
BG106924A (bg) 2003-04-30
NO20023039D0 (no) 2002-06-21
CN1283637C (zh) 2006-11-08
PT1240157E (pt) 2004-06-30
US6432987B2 (en) 2002-08-13
AU772745B2 (en) 2004-05-06
AR027098A1 (es) 2003-03-12
NZ533731A (en) 2005-03-24
UA75060C2 (en) 2006-03-15
DE50005284D1 (de) 2004-03-18
KR20020063245A (ko) 2002-08-01
RU2266280C2 (ru) 2005-12-20

Similar Documents

Publication Publication Date Title
IL150235A0 (en) Substituted n-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect
EG23817A (en) 4-Phenyl-pyridine derivatives
IL139470A0 (en) Oxyiminoalkanoic acid derivatives
GC0000183A (en) 3-Phenyl-pyridine derivatives
PL345794A1 (en) Aminomethylcarboxylic acid derivatives
GC0000338A (en) 5-Phenyl-pyrimidine derivatives
HK1046400A1 (en) Substituted 2-dialkylaminoalkylbiphenyl derivatives
HK1044940A1 (zh) 異噁唑咪唑羧酰胺衍生物
IL147216A0 (en) Arylsulfonamido-substituted hydroxamic acid derivatives
HK1034969A1 (en) Dihydroxyhexanoic acid derivatives.
HK1047274A1 (zh) 氨基苯甲酸衍生物
GC0000191A (en) 4-Phenyl-pyrimidine derivatives
GB9912905D0 (en) An animal over-garment
GB9929979D0 (en) Hydroxamic acid derivatives
HK1047085A1 (zh) 二酰基肼衍生物
GB9925880D0 (en) B-Carboline derivatives
HK1045987A1 (zh) 3-氨基-2-苄基-1-苯基-丙烷衍生物
HK1048638A1 (zh) Cyclopenteneone衍生物
GC0000256A (en) Ethanesulfonyl-piperidine derivatives
AP2001002327A0 (en) 1-Trifluoromethyl-4-hydroxy-7- piperidinylaminomethy lchroman derivatives
SI1240157T1 (en) Substituted n-benzyl-indol-3-yl glyoxylic acid derivatives having an anti-tumoral effect
GB9907082D0 (en) The preparation of carboxylic acid derivatives
GB0125901D0 (en) Compositions stabilized dioxopiperazinyl derivatives
GB0017435D0 (en) 3-arylsulfonyl-2-hydroxy-2-methylpropanoic acid derivatives
GB9907134D0 (en) Antimor napthylcombretastatin derivatives

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees