AR033079A1 - Derivados de sapogeninas, sintesis y uso, y metodos en base a su uso - Google Patents

Derivados de sapogeninas, sintesis y uso, y metodos en base a su uso

Info

Publication number
AR033079A1
AR033079A1 ARP020101170A ARP020101170A AR033079A1 AR 033079 A1 AR033079 A1 AR 033079A1 AR P020101170 A ARP020101170 A AR P020101170A AR P020101170 A ARP020101170 A AR P020101170A AR 033079 A1 AR033079 A1 AR 033079A1
Authority
AR
Argentina
Prior art keywords
synthesis
derivatives
cognitive
sapogenine
methods based
Prior art date
Application number
ARP020101170A
Other languages
English (en)
Original Assignee
Phytotech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytotech Ltd filed Critical Phytotech Ltd
Priority to AT02708534T priority Critical patent/ATE416185T1/de
Priority to DE60230130T priority patent/DE60230130D1/de
Priority to AU2002242894A priority patent/AU2002242894B2/en
Priority to EP02708534A priority patent/EP1383787B1/en
Priority to ES03722713T priority patent/ES2323363T3/es
Priority to EP09154213A priority patent/EP2111864A3/en
Priority to JP2003580357A priority patent/JP4573157B2/ja
Priority to AR20030101078A priority patent/AR040402A1/es
Priority to PT03722713T priority patent/PT1490071E/pt
Priority to AU2003229877A priority patent/AU2003229877B8/en
Priority to RU2004130281/15A priority patent/RU2332999C2/ru
Priority to MXPA04009321A priority patent/MXPA04009321A/es
Priority to KR1020087007136A priority patent/KR20080031062A/ko
Priority to EP03722713A priority patent/EP1490071B1/en
Priority to NZ563183A priority patent/NZ563183A/en
Priority to PCT/GB2003/001380 priority patent/WO2003082893A2/en
Priority to CA2477787A priority patent/CA2477787C/en
Priority to NZ547897A priority patent/NZ547897A/en
Priority to KR1020107017081A priority patent/KR20100093621A/ko
Priority to US10/507,000 priority patent/US20050130948A1/en
Priority to DE60326437T priority patent/DE60326437D1/de
Priority to NZ535093A priority patent/NZ535093A/en
Priority to TW092106926A priority patent/TWI329016B/zh
Priority to KR1020047014567A priority patent/KR101130212B1/ko
Priority to PE2003000315A priority patent/PE20040306A1/es
Priority to CN038071886A priority patent/CN1642558B/zh
Priority to AT03722713T priority patent/ATE424211T1/de
Priority to NZ547344A priority patent/NZ547344A/en
Priority to KR1020127008441A priority patent/KR20120128596A/ko
Priority to TW097110333A priority patent/TWI357816B/zh
Priority to PL372941A priority patent/PL213697B1/pl
Priority to IL16416103A priority patent/IL164161A0/xx
Priority to CN2012101243618A priority patent/CN102727501A/zh
Priority to BR0308788-3A priority patent/BR0308788A/pt
Priority to NO20034364A priority patent/NO20034364L/no
Publication of AR033079A1 publication Critical patent/AR033079A1/es
Priority to ZA200407460A priority patent/ZA200407460B/xx
Priority to NO20044468A priority patent/NO20044468L/no
Priority to CO04105805A priority patent/CO5611142A2/es
Priority to HR20041009A priority patent/HRP20041009A2/xx
Priority to HK04110420.5A priority patent/HK1067546A1/xx
Priority to AU2008207565A priority patent/AU2008207565A1/en
Priority to JP2009245430A priority patent/JP2010031034A/ja
Priority to US13/085,225 priority patent/US20110190249A1/en
Priority to JP2012274636A priority patent/JP2013053163A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invencion revela ciertas sapogeninas esteroidales y derivados de las mismas, y su uso en la disfuncion cognitiva, neurodegeneracion no cognitiva, degeneracion neuromuscular no cognitiva, y pérdida de receptor en la ausencia de deficiencia cognitiva, neural y neuromuscular. También se divulgan los métodos de síntesis, tratamiento y composiciones farmacéuticas.
ARP020101170A 2001-03-28 2002-03-27 Derivados de sapogeninas, sintesis y uso, y metodos en base a su uso AR033079A1 (es)

Priority Applications (44)

Application Number Priority Date Filing Date Title
AT02708534T ATE416185T1 (de) 2001-03-28 2002-03-28 Sapogenin derivate, deren synthese und verwendung
DE60230130T DE60230130D1 (de) 2001-03-28 2002-03-28 Sapogenin derivate, deren synthese und verwendung
AU2002242894A AU2002242894B2 (en) 2001-03-28 2002-03-28 Sapogenin derivatives, their synthesis and use
EP02708534A EP1383787B1 (en) 2001-03-28 2002-03-28 Sapogenin derivatives, their synthesis and use
NZ535093A NZ535093A (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
CN038071886A CN1642558B (zh) 2002-03-27 2003-03-27 皂角苷配基及其衍生物的用途
JP2003580357A JP4573157B2 (ja) 2002-03-27 2003-03-27 治療方法ならびにサポゲニンおよびその誘導体の使用
AR20030101078A AR040402A1 (es) 2001-03-28 2003-03-27 Metodos y usos terapeuticos de sapogeninas y sus derivados
PT03722713T PT1490071E (pt) 2002-03-27 2003-03-27 Métodos terapêuticos e utilizações de sapogeninas e seus derivados
AU2003229877A AU2003229877B8 (en) 2002-03-27 2003-03-27 Theraputic methods and uses of sapogenins and their derivatives
RU2004130281/15A RU2332999C2 (ru) 2002-03-27 2003-03-27 Терапевтические способы и применения сапогенинов и их производных
MXPA04009321A MXPA04009321A (es) 2002-03-27 2003-03-27 Metodos y usos terapeuticos de sapogeninas y sus derivados.
KR1020087007136A KR20080031062A (ko) 2002-03-27 2003-03-27 사포게닌 및 그 유도체의 치료 방법 및 용도
EP03722713A EP1490071B1 (en) 2002-03-27 2003-03-27 Therapeutic uses of sapogenins
NZ563183A NZ563183A (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
PCT/GB2003/001380 WO2003082893A2 (en) 2002-03-27 2003-03-27 Theraputic methods and uses of sapogenins and their derivatives
CA2477787A CA2477787C (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
NZ547897A NZ547897A (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
KR1020107017081A KR20100093621A (ko) 2002-03-27 2003-03-27 사포게닌 및 그 유도체의 치료 방법 및 용도
US10/507,000 US20050130948A1 (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
DE60326437T DE60326437D1 (de) 2002-03-27 2003-03-27 Therapeutische verwendung von sapogeninen
ES03722713T ES2323363T3 (es) 2002-03-27 2003-03-27 Usos terapeuticos de sapogeninas.
TW092106926A TWI329016B (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
KR1020047014567A KR101130212B1 (ko) 2002-03-27 2003-03-27 사포게닌 및 그 유도체의 치료 방법 및 사용법
PE2003000315A PE20040306A1 (es) 2002-03-27 2003-03-27 Metodos terapeuticos de sapogeninas y sus derivados
EP09154213A EP2111864A3 (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
AT03722713T ATE424211T1 (de) 2002-03-27 2003-03-27 Therapeutische verwendung von sapogeninen
NZ547344A NZ547344A (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
KR1020127008441A KR20120128596A (ko) 2002-03-27 2003-03-27 사포게닌 및 그 유도체의 치료 방법 및 용도
TW097110333A TWI357816B (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and the
PL372941A PL213697B1 (pl) 2002-03-27 2003-03-27 Substancje czynne do stosowania w leczeniu chorób, zwlaszcza chorób neurodegeneracyjnych
IL16416103A IL164161A0 (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
CN2012101243618A CN102727501A (zh) 2002-03-27 2003-03-27 皂角苷配基及其衍生物的用途
BR0308788-3A BR0308788A (pt) 2002-03-27 2003-03-27 Processos terapêuticos e usos de sapogeninas e seus derivados
NO20034364A NO20034364L (no) 2001-03-28 2003-09-29 Sapogenin-derivater, deres syntese og anvendelse samt metoder basert pa deres anvendelse
ZA200407460A ZA200407460B (en) 2001-03-28 2004-09-16 Therapeutic methods and uses of sapogenins and their derivatives
NO20044468A NO20044468L (no) 2002-03-27 2004-10-20 Anvendelse av sapogeniner samt derav ved fremstilling av medikamenter
CO04105805A CO5611142A2 (es) 2002-03-27 2004-10-21 Metodo y usos terapeuticos de sapogeninas y sus derivados
HR20041009A HRP20041009A2 (en) 2002-03-27 2004-10-27 Theraputic methods and uses of sapogenins and their derivatives
HK04110420.5A HK1067546A1 (en) 2002-03-27 2004-12-31 Therapeutic uses of sapogenins
AU2008207565A AU2008207565A1 (en) 2002-03-27 2008-08-27 Therapeutic methods and uses of sapogenins and their derivatives
JP2009245430A JP2010031034A (ja) 2002-03-27 2009-10-26 治療方法ならびにサポゲニンおよびその誘導体の使用
US13/085,225 US20110190249A1 (en) 2002-03-27 2011-04-12 Therapeutic methods and uses of sapogenins and their derivatives
JP2012274636A JP2013053163A (ja) 2002-03-27 2012-12-17 治療方法ならびにサポゲニンおよびその誘導体の使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0107822.9A GB0107822D0 (en) 2001-03-28 2001-03-28 Sapogenin derivatives their synthesis and use methods based upon their use

Publications (1)

Publication Number Publication Date
AR033079A1 true AR033079A1 (es) 2003-12-03

Family

ID=9911795

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP020101170A AR033079A1 (es) 2001-03-28 2002-03-27 Derivados de sapogeninas, sintesis y uso, y metodos en base a su uso
AR20030101078A AR040402A1 (es) 2001-03-28 2003-03-27 Metodos y usos terapeuticos de sapogeninas y sus derivados

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR20030101078A AR040402A1 (es) 2001-03-28 2003-03-27 Metodos y usos terapeuticos de sapogeninas y sus derivados

Country Status (24)

Country Link
US (1) US20040147495A1 (es)
EP (1) EP1383787B1 (es)
JP (1) JP2004525945A (es)
KR (1) KR20040007479A (es)
CN (1) CN1678325A (es)
AR (2) AR033079A1 (es)
AT (1) ATE416185T1 (es)
AU (1) AU2002242894B2 (es)
BR (1) BR0208533A (es)
CA (1) CA2442150A1 (es)
CZ (1) CZ20032620A3 (es)
GB (1) GB0107822D0 (es)
HR (1) HRP20030770A2 (es)
IL (1) IL158115A0 (es)
MX (1) MXPA03008800A (es)
NO (1) NO20034364L (es)
NZ (1) NZ529136A (es)
PE (1) PE20021042A1 (es)
PL (1) PL364825A1 (es)
RU (1) RU2311423C2 (es)
TR (2) TR200700134T1 (es)
UA (1) UA78696C2 (es)
WO (1) WO2002079221A2 (es)
ZA (2) ZA200307478B (es)

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GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
NZ563183A (en) * 2002-03-27 2009-03-31 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
AU2003229877B8 (en) * 2002-03-27 2008-06-12 Phytopharm Plc Theraputic methods and uses of sapogenins and their derivatives
PT1558627E (pt) * 2002-10-28 2010-05-06 Phytopharm Plc Reduçao estereoespecífica de sapogen-3-onas
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
EP1618881A1 (en) * 2004-07-20 2006-01-25 Santhera Pharmaceuticals (Schweiz) GmbH Use of non-glucocorticoid steroids for the treatment of muscular dystrophy
GB0424528D0 (en) * 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
EP2389182A1 (en) 2009-01-24 2011-11-30 Phytopharm PLC Treatment of neurotrophic factor mediated disorders
CN101768202B (zh) * 2009-02-18 2013-10-30 沈阳药科大学 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途
US20130210786A1 (en) 2010-07-20 2013-08-15 Patrick Alexander Howson Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
TWI422378B (zh) * 2010-11-18 2014-01-11 Univ Chung Shan Medical 使用薯蕷皂素來改善與停經期症候群有關聯的認知缺陷
CN113956315B (zh) 2011-09-08 2024-08-09 萨奇治疗股份有限公司 神经活性类固醇、组合物、及其用途
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
EP3932932A1 (en) 2013-03-13 2022-01-05 Sage Therapeutics, Inc. Neuroactive steriods and methods of use thereof
KR101480982B1 (ko) * 2013-03-20 2015-02-03 (주)셀인바이오 골형성 유도 화합물 및 이의 응용
CN104177469A (zh) * 2013-05-28 2014-12-03 江苏柯菲平医药有限公司 一种知母中菝葜皂苷元衍生物的制备方法
CN104324038B (zh) * 2013-07-24 2018-11-06 四川京华创生物科技有限公司 一种薯蓣皂苷元-3-位衍生物的用途
US10259840B2 (en) 2014-06-18 2019-04-16 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MX2020011449A (es) 2015-07-06 2022-02-28 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos.
CA2991313C (en) 2015-07-06 2023-12-19 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10696712B2 (en) 2015-07-06 2020-06-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
AU2017240157B2 (en) 2016-04-01 2022-10-20 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MD3481846T2 (ro) 2016-07-07 2021-11-30 Sage Therapeutics Inc 24-Hidroxisteroli 11-substituiți pentru utilizare în tratamentul stărilor legate de NMDA
CA3038900A1 (en) 2016-09-30 2018-04-05 Sage Therapeutics, Inc. C7 substituted oxysterols and methods as nmda modulators
NZ752732A (en) 2016-10-18 2024-08-30 Sage Therapeutics Inc Oxysterols and methods of use thereof
AU2017345399B2 (en) 2016-10-18 2022-02-24 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CN109053854B (zh) * 2018-09-29 2021-05-14 深圳清博汇能医药科技有限公司 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用

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ZA200407460B (en) 2009-09-30
WO2002079221A2 (en) 2002-10-10
GB0107822D0 (en) 2001-05-23
TR200700134T1 (tr) 2007-02-21
EP1383787A2 (en) 2004-01-28
NZ529136A (en) 2005-12-23
HRP20030770A2 (en) 2005-08-31
NO20034364L (no) 2003-11-28
EP1383787B1 (en) 2008-12-03
ATE416185T1 (de) 2008-12-15
CA2442150A1 (en) 2002-10-10
BR0208533A (pt) 2004-04-20
ZA200307478B (en) 2009-04-29
WO2002079221A3 (en) 2003-04-17
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AU2002242894B2 (en) 2008-08-21
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KR20040007479A (ko) 2004-01-24
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CN1678325A (zh) 2005-10-05
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